FI87213B - Foerfarande foer framstaellning av antikolinerga foereningar. - Google Patents
Foerfarande foer framstaellning av antikolinerga foereningar. Download PDFInfo
- Publication number
- FI87213B FI87213B FI874937A FI874937A FI87213B FI 87213 B FI87213 B FI 87213B FI 874937 A FI874937 A FI 874937A FI 874937 A FI874937 A FI 874937A FI 87213 B FI87213 B FI 87213B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- formula
- methyl
- azabicyclo
- carboxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Claims (7)
1. Förfarande för framställning av farmakologiskt användbara föreningar med formeln (I) R4-0-C-CH-^ ^ (I) COOR1 där R1 är en rak eller förgrenad alkyl eller cykloalky1grupp med 1-8 kolatomer, och R4 är Rl RS N \ v\ N. \ --\ eller __ där är en alkylgrupp med 1-5 kolatomer eller kvaternära ammoniumsalt av en förening med formeln I med en förening med formeln R?Y, där R^ är en alkylgrupp med 1-5 kolatomer och Y är en farmaceutiskt godtagbar anjon, kännetecknat därav, att en syraklorid med formeln I /r\ Cl-C-CH-(/ \) I ! \=/ COOR-1· där R·^ är ovan definierad, omsätts med en alkohol med formeln 8721 3 58 R5 R5^ OH θ' OH där är ovan definierad, och om ett kvaternärt salt av en fö-rening med formeln (I) önskas kvatern?seras den erhällna föreningen med formeln (I) med en alkylerings- förening med formel R1 2Y, där R2 och Y är ovan definierade.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen med formeln (I) är etyl (±)~(α-karboxi)-8-mety1-8-azabicyklo[3.2.1]okt-3-yl-bensenacetatdimetylsulfat.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen med formeln (I) är butyl (±)-(α-karboxi)-8-mety1-8-azabicyklo[3.2.1]okt-3-yl-bensenacetatdimetylsulfat.
4. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen med formeln (I) är cyklohexy1 (±)-(α-karboxi)-8-mety1-8-azabicyklo[3.2.1]okt-3-y1-bensenacetatdimety 1 sul fat.
5. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen med formeln (I) är etyl (±)-(α-karboxi)-6,7-epoxi-8-mety1-8-azabicyklo[3.2.1]okt- 3-yl-bensenacetatdimetylsulfat. Förfarande enligt patentkravet 1, kännetecknat 2 därav, att den framställda föreningen med formeln (I) är 59 8721 3 propyl (±) - (α-karboxi)-6,7-epoxi-8-mety1-8-azabicyklo[3.2.1]-okt-3-yl-bensenacetatdimety1sulfat.
7. Förfarande enligt patentkravet 1, kännetecknat därav, att den framställda föreningen med formeln (I) är butyl (±)-(a-karboxi)-6,7-epoxi-8-mety1-8-azabicyklo[3.2.1]-okt-3-yl-bensenacetatdimetylsulfat.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83994186A | 1986-03-17 | 1986-03-17 | |
| US83994186 | 1986-03-17 | ||
| PCT/US1987/000533 WO1987005603A1 (en) | 1986-03-17 | 1987-03-17 | Anticholinergic compounds, pharmaceutical compositions and method of treatment |
| US8700533 | 1987-03-17 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI874937A0 FI874937A0 (fi) | 1987-11-09 |
| FI874937A FI874937A (fi) | 1987-11-09 |
| FI87213B true FI87213B (fi) | 1992-08-31 |
| FI87213C FI87213C (sv) | 1992-12-10 |
Family
ID=25281041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI874937A FI87213C (sv) | 1986-03-17 | 1987-11-09 | Förfarande för framställning av antikolinerga föreningar |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0238982B1 (sv) |
| JP (1) | JP2672311B2 (sv) |
| KR (1) | KR900007218B1 (sv) |
| AT (1) | ATE86622T1 (sv) |
| CA (1) | CA1328106C (sv) |
| DE (1) | DE3784531T2 (sv) |
| DK (1) | DK170560B1 (sv) |
| ES (1) | ES2044851T3 (sv) |
| FI (1) | FI87213C (sv) |
| IE (1) | IE60645B1 (sv) |
| NO (1) | NO874765L (sv) |
| NZ (1) | NZ219653A (sv) |
| WO (1) | WO1987005603A1 (sv) |
| ZA (1) | ZA871948B (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR046225A1 (es) * | 2003-11-04 | 2005-11-30 | Glaxo Group Ltd | Compuesto de 8-azoniabiciclo(3.2.1)octano, composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos que lo comprende y uso del compuesto para preparar dicha composicion |
| US20080027094A1 (en) * | 2004-08-30 | 2008-01-31 | Ono Pharmaceutical Co., Ltd. | Tropane Compounds and Pharmaceutical Compositions Comprising the Same as an Active Ingredient |
| CN113321648B (zh) * | 2021-05-21 | 2022-02-11 | 常州康普药业有限公司 | 一种硫酸阿托品的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2814623A (en) * | 1955-12-05 | 1957-11-26 | Upjohn Co | Certain esters of n-methyl scopolamine quaternary ammonium salts |
| DE1670048C3 (de) * | 1966-01-26 | 1980-09-04 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue Norscopolaminderivate |
| NL7002588A (sv) * | 1969-03-04 | 1970-09-08 | ||
| US3998815A (en) * | 1974-06-24 | 1976-12-21 | Interx Research Corporation | 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts |
-
1987
- 1987-03-16 IE IE69887A patent/IE60645B1/en not_active IP Right Cessation
- 1987-03-16 CA CA000532123A patent/CA1328106C/en not_active Expired - Fee Related
- 1987-03-17 ZA ZA871948A patent/ZA871948B/xx unknown
- 1987-03-17 NZ NZ219653A patent/NZ219653A/xx unknown
- 1987-03-17 ES ES87103868T patent/ES2044851T3/es not_active Expired - Lifetime
- 1987-03-17 DE DE8787103868T patent/DE3784531T2/de not_active Expired - Lifetime
- 1987-03-17 WO PCT/US1987/000533 patent/WO1987005603A1/en active IP Right Grant
- 1987-03-17 JP JP62502072A patent/JP2672311B2/ja not_active Expired - Lifetime
- 1987-03-17 EP EP87103868A patent/EP0238982B1/en not_active Expired - Lifetime
- 1987-03-17 AT AT87103868T patent/ATE86622T1/de not_active IP Right Cessation
- 1987-03-17 KR KR1019870701055A patent/KR900007218B1/ko not_active IP Right Cessation
- 1987-10-30 DK DK567887A patent/DK170560B1/da not_active IP Right Cessation
- 1987-11-09 FI FI874937A patent/FI87213C/sv not_active IP Right Cessation
- 1987-11-16 NO NO874765A patent/NO874765L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI874937A0 (fi) | 1987-11-09 |
| DE3784531T2 (de) | 1993-06-24 |
| DK170560B1 (da) | 1995-10-23 |
| IE60645B1 (en) | 1994-08-10 |
| IE870698L (en) | 1987-09-17 |
| JP2672311B2 (ja) | 1997-11-05 |
| KR880701230A (ko) | 1988-07-26 |
| DE3784531D1 (de) | 1993-04-15 |
| KR900007218B1 (ko) | 1990-10-05 |
| AU595307B2 (en) | 1990-03-29 |
| DK567887A (da) | 1987-10-30 |
| ES2044851T3 (es) | 1994-01-16 |
| ZA871948B (en) | 1987-09-07 |
| WO1987005603A1 (en) | 1987-09-24 |
| JPS63502898A (ja) | 1988-10-27 |
| AU7203187A (en) | 1987-10-09 |
| NO874765L (no) | 1988-01-14 |
| NO874765D0 (no) | 1987-11-16 |
| FI87213C (sv) | 1992-12-10 |
| FI874937A (fi) | 1987-11-09 |
| CA1328106C (en) | 1994-03-29 |
| ATE86622T1 (de) | 1993-03-15 |
| EP0238982B1 (en) | 1993-03-10 |
| EP0238982A1 (en) | 1987-09-30 |
| NZ219653A (en) | 1990-02-26 |
| DK567887D0 (da) | 1987-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: UNIVERSITY OF FLORIDA |