FI871981A - Nya dopamin- -hydroxylas-inhibitorer. - Google Patents
Nya dopamin- -hydroxylas-inhibitorer. Download PDFInfo
- Publication number
- FI871981A FI871981A FI871981A FI871981A FI871981A FI 871981 A FI871981 A FI 871981A FI 871981 A FI871981 A FI 871981A FI 871981 A FI871981 A FI 871981A FI 871981 A FI871981 A FI 871981A
- Authority
- FI
- Finland
- Prior art keywords
- hydroxylash
- inhibitorer
- dopamin
- nya
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processing Of Solid Wastes (AREA)
- Fire-Extinguishing Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86026386A | 1986-05-06 | 1986-05-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI871981A0 FI871981A0 (fi) | 1987-05-05 |
| FI871981A true FI871981A (fi) | 1987-11-07 |
Family
ID=25332828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI871981A FI871981A (fi) | 1986-05-06 | 1987-05-05 | Nya dopamin- -hydroxylas-inhibitorer. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0244803B1 (fi) |
| JP (1) | JP2581556B2 (fi) |
| KR (1) | KR950013028B1 (fi) |
| CN (1) | CN87103323A (fi) |
| AT (2) | ATE113283T1 (fi) |
| AU (1) | AU596410B2 (fi) |
| CA (1) | CA1334199C (fi) |
| DE (1) | DE3750685T2 (fi) |
| DK (1) | DK229187A (fi) |
| ES (1) | ES2065881T3 (fi) |
| FI (1) | FI871981A (fi) |
| HU (1) | HU198479B (fi) |
| IL (1) | IL82401A0 (fi) |
| NO (1) | NO871861L (fi) |
| NZ (1) | NZ220184A (fi) |
| PT (1) | PT84823B (fi) |
| ZA (1) | ZA873176B (fi) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
| US4686231A (en) * | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
| FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
| EP0277384A3 (en) * | 1986-12-24 | 1990-05-23 | Janssen Pharmaceutica N.V. | 1h-imidazole-5-carboxylic acid derivatives |
| EP0285356A3 (en) * | 1987-03-30 | 1989-05-31 | Smithkline Beecham Corporation | Dopamine-beta-hydroxylase inhibitors |
| US4839375A (en) * | 1987-07-28 | 1989-06-13 | Merrell Dow Pharmaceuticals Inc. | (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their use as anti-hypertensive agents |
| HU202516B (en) * | 1987-10-02 | 1991-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing (2-thenyl)-thiourea derivatives and yield increasing agents comprising such compounds |
| CA2002247A1 (en) * | 1988-12-01 | 1990-06-01 | Lawrence I. Kruse | Dopamine-.beta.-hydroxylase inhibitors |
| CA2002246A1 (en) * | 1988-12-01 | 1990-06-01 | Lawrence I. Kruse | Dopamine-.beta.-hydroxylase inhibitors |
| EP0449445A3 (en) * | 1990-03-27 | 1993-08-25 | Pfizer Inc. | Preparation of beta-ketoesters useful in preparing quinolone antibiotics |
| US5635521A (en) * | 1991-09-23 | 1997-06-03 | Sandoz Ltd. | Imidazolylmethyl-pyridines |
| DE19627310A1 (de) * | 1996-06-27 | 1998-01-02 | Schering Ag | Imidazolderivate als Stickstoffmonoxid-Synthase-Inhibitoren |
| GB2393958A (en) * | 2002-10-11 | 2004-04-14 | Portela & Ca Sa | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| US7652018B2 (en) | 2006-08-15 | 2010-01-26 | Wyeth Llc | Imidazolidin-2-one derivatives useful as PR modulators |
| US7649007B2 (en) | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
| US7538107B2 (en) | 2006-08-15 | 2009-05-26 | Wyeth | Oxazinan-2-one derivatives useful as PR modulators |
| WO2008021338A2 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Tricyclic oxazolidone derivatives useful as pr modulators |
| WO2009097416A1 (en) * | 2008-01-29 | 2009-08-06 | Vanda Pharmaceuticals, Inc. | Imidazolylalkyl- pyridines as dbh inhibitors |
| CN103214421B (zh) * | 2012-12-11 | 2016-03-02 | 上海博康精细化工有限公司 | 2-巯基-1-甲基咪唑的工业化生产方法 |
| KR20230137374A (ko) | 2021-01-26 | 2023-10-04 | 장슈 야홍 메디텍 코퍼레이션 리미티드 | 경로 조절제, 이를 갖는 약학 조성물, 이의 용도 및 이를 이용한 치료 방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE312877C (fi) * | ||||
| NO120426B (fi) * | 1965-10-21 | 1970-10-19 | Geigy Ag J R | |
| FR2073427A1 (en) * | 1969-11-28 | 1971-10-01 | Sogeras | 4-methyl-5-ethyl-n-heterocyclic thiazoles - with antianoxic activity |
| DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
| GB2028317B (en) * | 1978-08-15 | 1982-11-10 | Pfizer Ltd | 2-(imidazol-1-ylmethyl)-pyridine and -quinoline thromboxane synthetase inhibitors |
| GR73560B (fi) * | 1979-02-24 | 1984-03-15 | Pfizer | |
| DE3128277A1 (de) * | 1981-07-17 | 1983-02-03 | A. Nattermann & Cie GmbH, 5000 Köln | (omega)-(5-(1-imidazolylmethyl)-thien-2-y1)-alkancarbonsaeuren und deren derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3228266A1 (de) * | 1982-07-29 | 1984-02-02 | A. Nattermann & Cie GmbH, 5000 Köln | Imidazolylalkylthiophene, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3300795A1 (de) * | 1983-01-12 | 1984-07-12 | Bayer Ag, 5090 Leverkusen | Substituierte 4-imidazolyl-pyrazole, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel |
| US4532331A (en) * | 1983-04-12 | 1985-07-30 | Smithkline Beckman Corporation | 1-Benzyl-2-aminomethyl imidazole derivatives |
| PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
| JPS6289956A (ja) * | 1985-06-19 | 1987-04-24 | Daicel Chem Ind Ltd | 光発色画像組成物 |
| US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
-
1987
- 1987-05-01 IL IL82401A patent/IL82401A0/xx not_active IP Right Cessation
- 1987-05-01 JP JP62106478A patent/JP2581556B2/ja not_active Expired - Fee Related
- 1987-05-04 PT PT84823A patent/PT84823B/pt not_active IP Right Cessation
- 1987-05-04 NZ NZ220184A patent/NZ220184A/en unknown
- 1987-05-04 AT AT87106440T patent/ATE113283T1/de not_active IP Right Cessation
- 1987-05-04 DE DE3750685T patent/DE3750685T2/de not_active Expired - Fee Related
- 1987-05-04 ZA ZA873176A patent/ZA873176B/xx unknown
- 1987-05-04 EP EP87106440A patent/EP0244803B1/en not_active Expired - Lifetime
- 1987-05-04 ES ES87106440T patent/ES2065881T3/es not_active Expired - Lifetime
- 1987-05-04 AU AU72463/87A patent/AU596410B2/en not_active Ceased
- 1987-05-05 FI FI871981A patent/FI871981A/fi not_active Application Discontinuation
- 1987-05-05 DK DK229187A patent/DK229187A/da not_active Application Discontinuation
- 1987-05-05 HU HU872013A patent/HU198479B/hu not_active IP Right Cessation
- 1987-05-05 CN CN198787103323A patent/CN87103323A/zh active Pending
- 1987-05-05 CA CA000536384A patent/CA1334199C/en not_active Expired - Fee Related
- 1987-05-05 NO NO871861A patent/NO871861L/no unknown
- 1987-05-06 KR KR1019870004414A patent/KR950013028B1/ko not_active IP Right Cessation
- 1987-10-12 AT AT0269087A patent/AT387967B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK229187A (da) | 1987-11-07 |
| JP2581556B2 (ja) | 1997-02-12 |
| DK229187D0 (da) | 1987-05-05 |
| KR950013028B1 (ko) | 1995-10-24 |
| HU198479B (en) | 1989-10-30 |
| EP0244803B1 (en) | 1994-10-26 |
| IL82401A0 (en) | 1987-11-30 |
| NZ220184A (en) | 1990-04-26 |
| AU7246387A (en) | 1987-11-12 |
| AU596410B2 (en) | 1990-05-03 |
| NO871861D0 (no) | 1987-05-05 |
| ZA873176B (en) | 1987-10-28 |
| EP0244803A3 (en) | 1991-01-16 |
| CN87103323A (zh) | 1988-02-03 |
| FI871981A0 (fi) | 1987-05-05 |
| ES2065881T3 (es) | 1995-03-01 |
| ATA269087A (de) | 1988-09-15 |
| KR870011104A (ko) | 1987-12-21 |
| ATE113283T1 (de) | 1994-11-15 |
| HUT44029A (en) | 1988-01-28 |
| DE3750685T2 (de) | 1995-03-02 |
| DE3750685D1 (de) | 1994-12-01 |
| NO871861L (no) | 1987-11-09 |
| PT84823A (en) | 1987-06-01 |
| CA1334199C (en) | 1995-01-31 |
| EP0244803A2 (en) | 1987-11-11 |
| AT387967B (de) | 1989-04-10 |
| PT84823B (pt) | 1989-12-29 |
| JPH01100160A (ja) | 1989-04-18 |
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| FI884454A0 (fi) | Nya aminoalkylsubstituerade heterocykliska svavelfoereningar. | |
| FI893163A (fi) | Menetelmä 19-hydroksylaasi-inhibiittoreina käyttökelpoisten 19-substituoitujen progesteronijohdannaisten valmistamiseksi | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed | ||
| FD | Application lapsed |
Owner name: MERRELL DOW PHARMACEUTICALS INC. |