FI871736A - Vaevnadsplasminogenaktivator (tpa)-derivat och framstaellning av detta. - Google Patents

Vaevnadsplasminogenaktivator (tpa)-derivat och framstaellning av detta. Download PDF

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Publication number
FI871736A
FI871736A FI871736A FI871736A FI871736A FI 871736 A FI871736 A FI 871736A FI 871736 A FI871736 A FI 871736A FI 871736 A FI871736 A FI 871736A FI 871736 A FI871736 A FI 871736A
Authority
FI
Finland
Prior art keywords
vaevnadsplasminogenaktivator
detta
derivat
tpa
framstaellning
Prior art date
Application number
FI871736A
Other languages
English (en)
Other versions
FI871736A0 (fi
Inventor
Ralf Mattes
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI871736A0 publication Critical patent/FI871736A0/fi
Publication of FI871736A publication Critical patent/FI871736A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
FI871736A 1986-04-21 1987-04-21 Vaevnadsplasminogenaktivator (tpa)-derivat och framstaellning av detta. FI871736A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3613402 1986-04-21
DE19863643158 DE3643158A1 (de) 1986-04-21 1986-12-17 Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung

Publications (2)

Publication Number Publication Date
FI871736A0 FI871736A0 (fi) 1987-04-21
FI871736A true FI871736A (fi) 1987-10-22

Family

ID=25843080

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871736A FI871736A (fi) 1986-04-21 1987-04-21 Vaevnadsplasminogenaktivator (tpa)-derivat och framstaellning av detta.

Country Status (9)

Country Link
EP (1) EP0242836A1 (fi)
KR (1) KR870010191A (fi)
AU (1) AU599372B2 (fi)
DE (1) DE3643158A1 (fi)
DK (1) DK202687A (fi)
FI (1) FI871736A (fi)
HU (1) HUT43877A (fi)
IL (1) IL82272A0 (fi)
NZ (1) NZ220051A (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0299053A1 (en) * 1987-01-30 1989-01-18 American Home Products Corporation Des-epidermal growth factor plasminogen activators
DK302288A (da) * 1987-06-04 1989-02-03 Zymogenetics Inc Vaevsplasminogenaktivator med modificeret kringledomaene
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
AU618039B2 (en) * 1987-10-29 1991-12-12 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3830734A1 (de) * 1988-09-09 1990-03-22 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
DK0643772T3 (da) * 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
GB2273931A (en) * 1992-09-28 1994-07-06 Unilever Plc Mutant polypeptides
DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
PT82326B (pt) * 1985-04-04 1988-10-14 Beecham Group Plc Processo para a preparacao de activador de plasminogenio de tipo tissular fibrinoliticamente activo

Also Published As

Publication number Publication date
EP0242836A1 (de) 1987-10-28
AU599372B2 (en) 1990-07-19
DK202687D0 (da) 1987-04-21
DE3643158A1 (de) 1987-11-19
NZ220051A (en) 1990-02-26
IL82272A0 (en) 1987-10-30
AU7180287A (en) 1988-06-23
FI871736A0 (fi) 1987-04-21
KR870010191A (ko) 1987-11-30
DK202687A (da) 1987-10-22
HUT43877A (en) 1987-12-28

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Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: BOEHRINGER MANNHEIM GMBH