AU7180287A - Tissue-type plasminogen activator (tPA) derivatives and processes for the preparation thereof - Google Patents

Tissue-type plasminogen activator (tPA) derivatives and processes for the preparation thereof

Info

Publication number
AU7180287A
AU7180287A AU71802/87A AU7180287A AU7180287A AU 7180287 A AU7180287 A AU 7180287A AU 71802/87 A AU71802/87 A AU 71802/87A AU 7180287 A AU7180287 A AU 7180287A AU 7180287 A AU7180287 A AU 7180287A
Authority
AU
Australia
Prior art keywords
tpa
tissue
derivatives
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU71802/87A
Other versions
AU599372B2 (en
Inventor
Ralf Mattes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU7180287A publication Critical patent/AU7180287A/en
Application granted granted Critical
Publication of AU599372B2 publication Critical patent/AU599372B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU71802/87A 1986-04-21 1987-04-21 Tissue-type plasminogen activator (tPA) derivatives and processes for the preparation thereof Ceased AU599372B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3613402 1986-04-21
DE3613402 1986-04-21
DE19863643158 DE3643158A1 (en) 1986-04-21 1986-12-17 TISSUE PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PRODUCTION
DE3643158 1986-12-17

Publications (2)

Publication Number Publication Date
AU7180287A true AU7180287A (en) 1988-06-23
AU599372B2 AU599372B2 (en) 1990-07-19

Family

ID=25843080

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71802/87A Ceased AU599372B2 (en) 1986-04-21 1987-04-21 Tissue-type plasminogen activator (tPA) derivatives and processes for the preparation thereof

Country Status (9)

Country Link
EP (1) EP0242836A1 (en)
KR (1) KR870010191A (en)
AU (1) AU599372B2 (en)
DE (1) DE3643158A1 (en)
DK (1) DK202687A (en)
FI (1) FI871736A (en)
HU (1) HUT43877A (en)
IL (1) IL82272A0 (en)
NZ (1) NZ220051A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618039B2 (en) * 1987-10-29 1991-12-12 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5612029A (en) * 1992-06-03 1997-03-18 Genentech, Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
US5614190A (en) * 1988-09-02 1997-03-25 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376547A (en) * 1987-01-30 1994-12-27 American Home Products Corporation Des-epidermal growth factor plasminogen activators
DE3851259T2 (en) * 1987-06-04 1994-12-15 Zymogenetics Inc Mutated t-PA with Kringle replacement.
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
DE3825253A1 (en) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-PA DERIVATIVE AND ITS PRODUCTION
DE3830734A1 (en) * 1988-09-09 1990-03-22 Basf Ag NEW POLYPEPTIDES, THEIR PRODUCTION AND USE
DE3832898A1 (en) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh PRAEPARATE OF EXPRESSED PLASMINOGEN ACTIVATOR IN PROKARYONS
DE3903581A1 (en) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE
DE3923339A1 (en) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE
GB2273931A (en) * 1992-09-28 1994-07-06 Unilever Plc Mutant polypeptides
DE10153601A1 (en) 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
DK149786A (en) * 1985-04-04 1986-10-04 Beecham Group Plc PROTEOLYTIC ENZYM

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618039B2 (en) * 1987-10-29 1991-12-12 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5614190A (en) * 1988-09-02 1997-03-25 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5616486A (en) * 1988-09-02 1997-04-01 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5728567A (en) * 1988-09-02 1998-03-17 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5770426A (en) * 1988-09-02 1998-06-23 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5821105A (en) * 1988-09-02 1998-10-13 Genentech, Inc. Tissue plasminogen activator having zymognic or fibrin specific properties
US5840564A (en) * 1988-09-02 1998-11-24 Genentech, Inc. Tussue plasminogen activator having zymogenic or fibrin specific properties
US5612029A (en) * 1992-06-03 1997-03-18 Genentech, Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties

Also Published As

Publication number Publication date
KR870010191A (en) 1987-11-30
NZ220051A (en) 1990-02-26
IL82272A0 (en) 1987-10-30
EP0242836A1 (en) 1987-10-28
FI871736A0 (en) 1987-04-21
AU599372B2 (en) 1990-07-19
HUT43877A (en) 1987-12-28
DK202687A (en) 1987-10-22
DE3643158A1 (en) 1987-11-19
FI871736A (en) 1987-10-22
DK202687D0 (en) 1987-04-21

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