DK202687A - VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION - Google Patents

VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION

Info

Publication number
DK202687A
DK202687A DK202687A DK202687A DK202687A DK 202687 A DK202687 A DK 202687A DK 202687 A DK202687 A DK 202687A DK 202687 A DK202687 A DK 202687A DK 202687 A DK202687 A DK 202687A
Authority
DK
Denmark
Prior art keywords
vaevs
tpa
derivative
preparation
plasminogen activator
Prior art date
Application number
DK202687A
Other languages
Danish (da)
Other versions
DK202687D0 (en
Inventor
Ralf Mattes
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK202687D0 publication Critical patent/DK202687D0/en
Publication of DK202687A publication Critical patent/DK202687A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DK202687A 1986-04-21 1987-04-21 VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION DK202687A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3613402 1986-04-21
DE19863643158 DE3643158A1 (en) 1986-04-21 1986-12-17 TISSUE PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PRODUCTION

Publications (2)

Publication Number Publication Date
DK202687D0 DK202687D0 (en) 1987-04-21
DK202687A true DK202687A (en) 1987-10-22

Family

ID=25843080

Family Applications (1)

Application Number Title Priority Date Filing Date
DK202687A DK202687A (en) 1986-04-21 1987-04-21 VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION

Country Status (9)

Country Link
EP (1) EP0242836A1 (en)
KR (1) KR870010191A (en)
AU (1) AU599372B2 (en)
DE (1) DE3643158A1 (en)
DK (1) DK202687A (en)
FI (1) FI871736A (en)
HU (1) HUT43877A (en)
IL (1) IL82272A0 (en)
NZ (1) NZ220051A (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1295088A (en) * 1987-01-30 1988-08-24 American Home Products Corporation Des-epidermal growth factor plasminogen activators
NO179754C (en) * 1987-06-04 1996-12-11 Zymogenetics Inc A method of producing a t-PA analog, DNA sequence encoding the t-PA analog, expression vector comprising the DNA sequence and host cell comprising this
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
AU618039B2 (en) * 1987-10-29 1991-12-12 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
DE3825253A1 (en) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-PA DERIVATIVE AND ITS PRODUCTION
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3830734A1 (en) * 1988-09-09 1990-03-22 Basf Ag NEW POLYPEPTIDES, THEIR PRODUCTION AND USE
DE3832898A1 (en) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh PRAEPARATE OF EXPRESSED PLASMINOGEN ACTIVATOR IN PROKARYONS
DE3903581A1 (en) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE
DE3923339A1 (en) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE
DK0643772T3 (en) * 1992-06-03 1998-02-02 Genentech Inc Glycosylation variants of tissue plasminogen activator with improved therapeutic properties
GB2273931A (en) * 1992-09-28 1994-07-06 Unilever Plc Mutant polypeptides
DE10153601A1 (en) 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
PT82326B (en) * 1985-04-04 1988-10-14 Beecham Group Plc METHOD FOR THE PREPARATION OF FIBRINOLITICALLY ACTIVE TISSULAR TYPE PLASMINOGEN ACTIVATOR

Also Published As

Publication number Publication date
IL82272A0 (en) 1987-10-30
HUT43877A (en) 1987-12-28
DK202687D0 (en) 1987-04-21
AU599372B2 (en) 1990-07-19
AU7180287A (en) 1988-06-23
EP0242836A1 (en) 1987-10-28
FI871736A (en) 1987-10-22
KR870010191A (en) 1987-11-30
NZ220051A (en) 1990-02-26
DE3643158A1 (en) 1987-11-19
FI871736A0 (en) 1987-04-21

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