DK202687A - VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION - Google Patents

VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION

Info

Publication number
DK202687A
DK202687A DK202687A DK202687A DK202687A DK 202687 A DK202687 A DK 202687A DK 202687 A DK202687 A DK 202687A DK 202687 A DK202687 A DK 202687A DK 202687 A DK202687 A DK 202687A
Authority
DK
Denmark
Prior art keywords
vaevs
tpa
derivative
preparation
plasminogen activator
Prior art date
Application number
DK202687A
Other languages
Danish (da)
Other versions
DK202687D0 (en
Inventor
Ralf Mattes
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK202687D0 publication Critical patent/DK202687D0/en
Publication of DK202687A publication Critical patent/DK202687A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DK202687A 1986-04-21 1987-04-21 VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION DK202687A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3613402 1986-04-21
DE19863643158 DE3643158A1 (en) 1986-04-21 1986-12-17 TISSUE PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PRODUCTION

Publications (2)

Publication Number Publication Date
DK202687D0 DK202687D0 (en) 1987-04-21
DK202687A true DK202687A (en) 1987-10-22

Family

ID=25843080

Family Applications (1)

Application Number Title Priority Date Filing Date
DK202687A DK202687A (en) 1986-04-21 1987-04-21 VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION

Country Status (9)

Country Link
EP (1) EP0242836A1 (en)
KR (1) KR870010191A (en)
AU (1) AU599372B2 (en)
DE (1) DE3643158A1 (en)
DK (1) DK202687A (en)
FI (1) FI871736A (en)
HU (1) HUT43877A (en)
IL (1) IL82272A0 (en)
NZ (1) NZ220051A (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0299053A1 (en) * 1987-01-30 1989-01-18 American Home Products Corporation Des-epidermal growth factor plasminogen activators
DK302288A (en) * 1987-06-04 1989-02-03 Zymogenetics Inc Tissue Plasma Minogen Activator with Modified Circumstances
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
AU618039B2 (en) * 1987-10-29 1991-12-12 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
DE3825253A1 (en) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-PA DERIVATIVE AND ITS PRODUCTION
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3830734A1 (en) * 1988-09-09 1990-03-22 Basf Ag NEW POLYPEPTIDES, THEIR PRODUCTION AND USE
DE3832898A1 (en) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh PRAEPARATE OF EXPRESSED PLASMINOGEN ACTIVATOR IN PROKARYONS
DE3903581A1 (en) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE
DE3923339A1 (en) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE
DK0643772T3 (en) * 1992-06-03 1998-02-02 Genentech Inc Glycosylation variants of tissue plasminogen activator with improved therapeutic properties
GB2273931A (en) * 1992-09-28 1994-07-06 Unilever Plc Mutant polypeptides
DE10153601A1 (en) 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (en) * 1982-05-05 1992-10-30 Genentech Inc Human tissue plasminogen activator, pharmaceutical compositions containing it, processes for making it, and dna and transformed cell intermediates therefor
PT82326B (en) * 1985-04-04 1988-10-14 Beecham Group Plc METHOD FOR THE PREPARATION OF FIBRINOLITICALLY ACTIVE TISSULAR TYPE PLASMINOGEN ACTIVATOR

Also Published As

Publication number Publication date
EP0242836A1 (en) 1987-10-28
AU599372B2 (en) 1990-07-19
DK202687D0 (en) 1987-04-21
FI871736A (en) 1987-10-22
DE3643158A1 (en) 1987-11-19
NZ220051A (en) 1990-02-26
IL82272A0 (en) 1987-10-30
AU7180287A (en) 1988-06-23
FI871736A0 (en) 1987-04-21
KR870010191A (en) 1987-11-30
HUT43877A (en) 1987-12-28

Similar Documents

Publication Publication Date Title
DK202687D0 (en) VAEVS PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PREPARATION
NO872729D0 (en) CEPHALOSPORINHYDRATE AND PROCEDURE FOR ITS PREPARATION.
DK330087D0 (en) SOLFILTER CONNECTION AND COMPOSITION CONTAINING SAME
DK609689D0 (en) FOLIAMINATE AND ITS APPLICATION
NO163780C (en) ALKALIMETAL SILICATE MIXTURES AND APPLICATION OF THESE.
DK424084A (en) PREPARATIONS WITH INCREASED COLLAGENOLYTIC ACTIVITY AND PHARMACEUTICAL AGENTS CONTAINING THIS PREPARATION
DK551187D0 (en) THERAPEUTIC PREPARATION AND ITS PREPARATION
NO875232D0 (en) STABLE PREPARATIONS OF RICIN-TOXIN-A-CHAIN AND OF RTA-IMMUNOCONJUGATES AND STABILIZER-SORTING METHODS THEREOF.
DK479284A (en) PYRAZOLD DERIVATIVE AND ITS USE AS HERBICID
NO901659L (en) THROMBOLYTIC ACTIVATOR COMPLEX AND ITS PREPARATION.
DK96787A (en) HUMAN VAEVS PLASMINOGEN ACTIVATOR
DK84588A (en) PHENYLGUANIDINE AND TETRAHYDROPYRIMIDE CONTAINING ANTHELMIC SUMMARY, ITS PREPARATION AND USE
DK68486D0 (en) FURNITURE WHEELS AND PROCEDURES FOR ITS MANUFACTURING
DK455089D0 (en) DEVELOPING AGENT AND ITS APPLICATION
DK381886A (en) MEDICAL PREPARATION AND PROCEDURE FOR ITS PREPARATION
DK50387A (en) RECOMBINANT-HUMANT INTERLEUKIN-2 PREPARATION AND PROCEDURE FOR ITS PREPARATION
DK413187A (en) SEMICARBAZONS AND THIOSEMICARBAZONS
DK405887D0 (en) WAVE PLASMINOGEN ACTIVATOR-CONTAINING COMBINATION
DK455986D0 (en) ESSENTIAL PRODUCT PROCEDURE FOR ITS MANUFACTURING AND USE THEREOF
DK422984A (en) AMINOCYCLOPENTANES AND PHARMACEUTICAL PREPARATIONS THEREOF
DK162086A (en) PHARMACEUTICAL CONTAINING PLASMINOGEN ACTIVATOR, ITS MANUFACTURING AND USE
NO875220D0 (en) MALEIMIDES AND THERMO-HARD MIXTURES CONTAINING SUCH MALEIMIDES.
DK367189D0 (en) T-PA DERIVATIVES AND ITS MANUFACTURING
DK72186D0 (en) SOLVENT AND ITS APPLICATION
ZA872694B (en) Tissue plasminogen activator(tpa)derivative and its preparation