IL82272A0 - Tissue-type plasminogen activator and process for preparation thereof - Google Patents

Tissue-type plasminogen activator and process for preparation thereof

Info

Publication number
IL82272A0
IL82272A0 IL82272A IL8227287A IL82272A0 IL 82272 A0 IL82272 A0 IL 82272A0 IL 82272 A IL82272 A IL 82272A IL 8227287 A IL8227287 A IL 8227287A IL 82272 A0 IL82272 A0 IL 82272A0
Authority
IL
Israel
Prior art keywords
tissue
preparation
plasminogen activator
type plasminogen
type
Prior art date
Application number
IL82272A
Other languages
English (en)
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of IL82272A0 publication Critical patent/IL82272A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
IL82272A 1986-04-21 1987-04-21 Tissue-type plasminogen activator and process for preparation thereof IL82272A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3613402 1986-04-21
DE19863643158 DE3643158A1 (de) 1986-04-21 1986-12-17 Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung

Publications (1)

Publication Number Publication Date
IL82272A0 true IL82272A0 (en) 1987-10-30

Family

ID=25843080

Family Applications (1)

Application Number Title Priority Date Filing Date
IL82272A IL82272A0 (en) 1986-04-21 1987-04-21 Tissue-type plasminogen activator and process for preparation thereof

Country Status (9)

Country Link
EP (1) EP0242836A1 (fi)
KR (1) KR870010191A (fi)
AU (1) AU599372B2 (fi)
DE (1) DE3643158A1 (fi)
DK (1) DK202687A (fi)
FI (1) FI871736A (fi)
HU (1) HUT43877A (fi)
IL (1) IL82272A0 (fi)
NZ (1) NZ220051A (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376547A (en) * 1987-01-30 1994-12-27 American Home Products Corporation Des-epidermal growth factor plasminogen activators
ES2058180T3 (es) * 1987-06-04 1994-11-01 Zymogenetics Inc T-pa mutante con reemplazo de kringle.
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
AU618039B2 (en) * 1987-10-29 1991-12-12 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3830734A1 (de) * 1988-09-09 1990-03-22 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
DE3923339A1 (de) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator-derivat
ATE246000T1 (de) * 1992-06-03 2003-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
GB2273931A (en) * 1992-09-28 1994-07-06 Unilever Plc Mutant polypeptides
DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
NZ215660A (en) * 1985-04-04 1990-03-27 Beecham Group Plc Tissue plasminogen activator modified in the growth factor domain

Also Published As

Publication number Publication date
AU7180287A (en) 1988-06-23
KR870010191A (ko) 1987-11-30
DK202687D0 (da) 1987-04-21
DK202687A (da) 1987-10-22
EP0242836A1 (de) 1987-10-28
FI871736A (fi) 1987-10-22
FI871736A0 (fi) 1987-04-21
AU599372B2 (en) 1990-07-19
HUT43877A (en) 1987-12-28
NZ220051A (en) 1990-02-26
DE3643158A1 (de) 1987-11-19

Similar Documents

Publication Publication Date Title
IL82272A0 (en) Tissue-type plasminogen activator and process for preparation thereof
PT82226A (en) Process for the preparation of 3-aryluraciles and pesticeides therewith
HUT64746A (en) Process for the production of 1-cycloalkyl-piperidines and medical preparations containing them
EP0196920A3 (en) Degraded species of tissue-type plasminogen activator, pharmaceutical composition and method of preparation
AU5330286A (en) Modified tissue-type plasminogen activator
ZA868127B (en) Process for the preparation of halogenated(2,2)-paracyclophanes and mixtures of resultant halogenated(2,2)-paracyclophanes
PT81835B (en) Process for the preparation of spirodioxolanes spirodithiolanes and spirooxothiolanes
HU886790D0 (en) Neutrophilous activating factor and process for its preparation
AU7090687A (en) Modified tissue-type plasminogen activators
AU576047B2 (en) Fibrinophilic urokinase complex and process for its preparation
EP0208486A3 (en) Process for producing tissue plasminogen activator
HUT47975A (en) Modified plasminogen activators and process for producing same
GB2138824B (en) Novel plasminogen activator process for its preparation and thrombolytic drug containing the same
EP0248401A3 (en) Enzyme and process for its preparation
AU602681B2 (en) Modified plasminogen activators
GB2200112B (en) Process for the selective para-bromination of phenol and its derivatives
EP0263309A3 (en) Bromofluoroethylhypofluorite and process for its preparation
ZA879286B (en) New plasminogen activators
ZA861619B (en) Glycoside and process for preparation thereof
EP0251806A3 (en) Plasminogen activator production
DE3660220D1 (en) Process for the preparation of chloronitroanilines and chloronitrophenols
ZA86911B (en) Modified enzyme and process for its preparation
EP0191401A3 (en) Novel antiallergic agents and process for their preparation
NZ223291A (en) Modified tissue-type plasminogen activator
IE860355L (en) Modified tissue-type plasminogen activator