FI854747A - Renin-inhiberande dipeptider, process foer deras framstaellning och anvaendning av dem. - Google Patents
Renin-inhiberande dipeptider, process foer deras framstaellning och anvaendning av dem. Download PDFInfo
- Publication number
- FI854747A FI854747A FI854747A FI854747A FI854747A FI 854747 A FI854747 A FI 854747A FI 854747 A FI854747 A FI 854747A FI 854747 A FI854747 A FI 854747A FI 854747 A FI854747 A FI 854747A
- Authority
- FI
- Finland
- Prior art keywords
- inhiberated
- dipeptider
- ripin
- dem
- development
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25287884 | 1984-11-30 | ||
JP26803584 | 1984-12-19 | ||
JP1517785 | 1985-01-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI854747A0 FI854747A0 (fi) | 1985-11-29 |
FI854747A true FI854747A (fi) | 1986-05-31 |
Family
ID=27280905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI854747A FI854747A (fi) | 1984-11-30 | 1985-11-29 | Renin-inhiberande dipeptider, process foer deras framstaellning och anvaendning av dem. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0186977A3 (fi) |
KR (1) | KR910001721B1 (fi) |
DK (1) | DK554685A (fi) |
ES (1) | ES8800958A1 (fi) |
FI (1) | FI854747A (fi) |
HU (1) | HUT39463A (fi) |
NO (1) | NO854825L (fi) |
SU (1) | SU1676454A3 (fi) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60163899A (ja) * | 1984-02-03 | 1985-08-26 | Sankyo Co Ltd | レニン阻害ペプチド類 |
KR870005013A (ko) * | 1985-11-29 | 1987-06-04 | 가와무라 요시부미 | 레닌-억제 올리고펩티드, 그의 제조방법 및 용도 |
DE3601248A1 (de) * | 1986-01-17 | 1987-07-23 | Hoechst Ag | Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
DE3610593A1 (de) * | 1986-03-29 | 1987-10-01 | Hoechst Ag | Substituierte 4-amino-3-hydroxybuttersaeure-derivate verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
US4735933A (en) * | 1986-12-15 | 1988-04-05 | Warner-Lambert Company | Renin inhibitors III |
US4895834A (en) * | 1986-12-15 | 1990-01-23 | Warner-Lambert Company | Renin inhibitors III |
EP0274259B1 (en) * | 1986-12-19 | 1994-02-16 | Sankyo Company Limited | New renin-inhibitory oligopeptides, their preparaton and their use |
NZ222755A (en) * | 1986-12-23 | 1989-11-28 | Warner Lambert Co | Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions |
US5024994A (en) * | 1986-12-23 | 1991-06-18 | Warner-Lambert Company | Renin inhibitors IV |
US4804743A (en) * | 1987-01-29 | 1989-02-14 | Warner-Lambert Copmany | Proline-containing renin inhibitors |
US4863905A (en) * | 1987-02-04 | 1989-09-05 | Warner-Lambert Company | Renin inhibitors II |
KR890701619A (ko) * | 1987-10-26 | 1989-12-22 | 크리스틴 에이.트러트웨인 | 레닌 억제제, 그의 제조 방법, 그 사용 방법 및 이들을 함유한 조성물 |
US5063207A (en) * | 1987-10-26 | 1991-11-05 | Warner-Lambert Company | Renin inhibitors, method for using them, and compositions containing them |
US5162527A (en) * | 1987-10-26 | 1992-11-10 | Warner-Lambert Company | Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them |
US5036054A (en) * | 1988-02-11 | 1991-07-30 | Warner-Lambert Company | Renin inhibitors containing alpha-heteroatom amino acids |
CA2004846A1 (en) * | 1988-12-19 | 1990-06-19 | Yutaka Koike | N-substituted acylamino acid compounds, process for their production and their use |
US5106835A (en) * | 1988-12-27 | 1992-04-21 | American Cyanamid Company | Renin inhibitors |
CA2010260A1 (en) * | 1989-02-16 | 1990-08-16 | Mitsuru Kataoka | Peptides having renin inhibitory activity their preparation and their use |
EP0569487A1 (en) * | 1991-01-31 | 1993-11-18 | Abbott Laboratories | Endothelin converting enzyme inhibitors |
US5223535A (en) * | 1991-10-29 | 1993-06-29 | G. D. Searle & Co. | Propargyl glycine amino propargyl diol compounds for treatment of hypertension |
US5330996A (en) * | 1991-10-29 | 1994-07-19 | G. D. Searle & Co. | Amino acyl amino propargyl diol compounds for treatment of hypertension |
EP0539976A1 (en) * | 1991-10-29 | 1993-05-05 | G.D. Searle & Co. | Ethynyl-alanine-amino-diol compounds for treatment of hypertension |
US5227401A (en) * | 1991-10-29 | 1993-07-13 | G. D. Searle & Co. | Ethynyl alanine amino diol compounds for treatment of hypertension |
US5317039A (en) * | 1992-07-20 | 1994-05-31 | G. D. Searle & Co. | Cyclopropyl-alanine aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension |
US5314920A (en) * | 1992-07-20 | 1994-05-24 | G. D. Searle & Co. | Ethynyl-alanine aryl/alkylsulfonyl-terminated amino-diol compounds for treatment of hypertension |
US5246969A (en) * | 1992-07-20 | 1993-09-21 | G. D. Searle & Co. | Di-propargyl-containing aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension |
US5268391A (en) * | 1992-07-20 | 1993-12-07 | C. D. Searle & Co. | Propargyl-terminated cycloalkylalkyl-P2-site substituted aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension |
US5252591A (en) * | 1992-08-14 | 1993-10-12 | G. D. Searle & Company | Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5373017A (en) * | 1992-08-14 | 1994-12-13 | G. D. Searle & Co. | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5422349A (en) * | 1992-08-14 | 1995-06-06 | G. D. Seale & Co. | Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5298505A (en) * | 1992-08-14 | 1994-03-29 | G. D. Searle & Co. | Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension |
US5212185A (en) * | 1992-08-14 | 1993-05-18 | G. D. Searle & Co. | Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5312838A (en) * | 1992-09-21 | 1994-05-17 | G. D. Searle & Co. | β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension |
US5414018A (en) * | 1993-09-24 | 1995-05-09 | G. D. Searle & Co. | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension |
US5416119A (en) * | 1993-10-25 | 1995-05-16 | G. D. Searle & Co. | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension |
US5432201A (en) * | 1993-11-22 | 1995-07-11 | G. D. Searle & Co. | Alkylaminoalkyl-sulfonyl-terminated β-alanineamide amino-diol compounds for treatment of hypertension |
US5508466A (en) * | 1994-04-13 | 1996-04-16 | G.D. Searle & Co. | Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent |
US5780494A (en) * | 1994-11-14 | 1998-07-14 | G. D. Searle & Co. | Piperidinyl-terminated alkylamino ethynl alanine amino diol compounds for treatment of hypertension |
PL2800737T3 (pl) * | 2012-01-06 | 2020-11-02 | Novus International Inc. | Środki powierzchniowo czynne na bazie sulfotlenku |
US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4070458A (en) * | 1974-02-28 | 1978-01-24 | Sanraku-Ocean Co., Ltd. | Novel physiologically active peptide and its n-acyl derivatives and processes for producing thereof |
JPS59227851A (ja) * | 1983-06-09 | 1984-12-21 | Sankyo Co Ltd | レニン阻害作用を有するペプチド類 |
JPS61152967A (ja) * | 1984-12-26 | 1986-07-11 | Toyota Motor Corp | 内燃機関の着火時期センサ |
-
1985
- 1985-11-28 SU SU853987362A patent/SU1676454A3/ru active
- 1985-11-29 FI FI854747A patent/FI854747A/fi not_active Application Discontinuation
- 1985-11-29 ES ES549457A patent/ES8800958A1/es not_active Expired
- 1985-11-29 DK DK554685A patent/DK554685A/da not_active Application Discontinuation
- 1985-11-29 HU HU854584A patent/HUT39463A/hu unknown
- 1985-11-30 KR KR1019850008981A patent/KR910001721B1/ko active IP Right Grant
- 1985-12-02 EP EP85308759A patent/EP0186977A3/en not_active Ceased
- 1985-12-02 NO NO854825A patent/NO854825L/no unknown
Also Published As
Publication number | Publication date |
---|---|
HUT39463A (en) | 1986-09-29 |
NO854825L (no) | 1986-06-02 |
FI854747A0 (fi) | 1985-11-29 |
SU1676454A3 (ru) | 1991-09-07 |
KR860004080A (ko) | 1986-06-16 |
ES8800958A1 (es) | 1987-12-01 |
DK554685D0 (da) | 1985-11-29 |
EP0186977A2 (en) | 1986-07-09 |
KR910001721B1 (ko) | 1991-03-22 |
ES549457A0 (es) | 1987-12-01 |
EP0186977A3 (en) | 1987-09-16 |
DK554685A (da) | 1986-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |
Owner name: SANKYO COMPANY LIMITED |