ES549457A0 - Un procedimiento para preparar nuevos dipeptidos con actividad inhibidora de renina. - Google Patents
Un procedimiento para preparar nuevos dipeptidos con actividad inhibidora de renina.Info
- Publication number
- ES549457A0 ES549457A0 ES549457A ES549457A ES549457A0 ES 549457 A0 ES549457 A0 ES 549457A0 ES 549457 A ES549457 A ES 549457A ES 549457 A ES549457 A ES 549457A ES 549457 A0 ES549457 A0 ES 549457A0
- Authority
- ES
- Spain
- Prior art keywords
- renina
- procedure
- inhibiting activity
- preparing new
- dipeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25287884 | 1984-11-30 | ||
JP26803584 | 1984-12-19 | ||
JP1517785 | 1985-01-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8800958A1 ES8800958A1 (es) | 1987-12-01 |
ES549457A0 true ES549457A0 (es) | 1987-12-01 |
Family
ID=27280905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES549457A Expired ES8800958A1 (es) | 1984-11-30 | 1985-11-29 | Un procedimiento para preparar nuevos dipeptidos con actividad inhibidora de renina. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0186977A3 (es) |
KR (1) | KR910001721B1 (es) |
DK (1) | DK554685A (es) |
ES (1) | ES8800958A1 (es) |
FI (1) | FI854747A (es) |
HU (1) | HUT39463A (es) |
NO (1) | NO854825L (es) |
SU (1) | SU1676454A3 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60163899A (ja) * | 1984-02-03 | 1985-08-26 | Sankyo Co Ltd | レニン阻害ペプチド類 |
KR870005013A (ko) * | 1985-11-29 | 1987-06-04 | 가와무라 요시부미 | 레닌-억제 올리고펩티드, 그의 제조방법 및 용도 |
DE3601248A1 (de) * | 1986-01-17 | 1987-07-23 | Hoechst Ag | Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
DE3610593A1 (de) * | 1986-03-29 | 1987-10-01 | Hoechst Ag | Substituierte 4-amino-3-hydroxybuttersaeure-derivate verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
US4735933A (en) * | 1986-12-15 | 1988-04-05 | Warner-Lambert Company | Renin inhibitors III |
US4895834A (en) * | 1986-12-15 | 1990-01-23 | Warner-Lambert Company | Renin inhibitors III |
ES2062988T3 (es) * | 1986-12-19 | 1995-01-01 | Sankyo Co | Nuevos oligopeptidos inhibidores de la renina, su preparacion y su uso. |
US5024994A (en) * | 1986-12-23 | 1991-06-18 | Warner-Lambert Company | Renin inhibitors IV |
NZ222755A (en) * | 1986-12-23 | 1989-11-28 | Warner Lambert Co | Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions |
US4804743A (en) * | 1987-01-29 | 1989-02-14 | Warner-Lambert Copmany | Proline-containing renin inhibitors |
US4863905A (en) * | 1987-02-04 | 1989-09-05 | Warner-Lambert Company | Renin inhibitors II |
US5162527A (en) * | 1987-10-26 | 1992-11-10 | Warner-Lambert Company | Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them |
EP0389535A1 (en) * | 1987-10-26 | 1990-10-03 | Warner-Lambert Company | Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them |
US5063207A (en) * | 1987-10-26 | 1991-11-05 | Warner-Lambert Company | Renin inhibitors, method for using them, and compositions containing them |
US5036054A (en) * | 1988-02-11 | 1991-07-30 | Warner-Lambert Company | Renin inhibitors containing alpha-heteroatom amino acids |
CA2004846A1 (en) * | 1988-12-19 | 1990-06-19 | Yutaka Koike | N-substituted acylamino acid compounds, process for their production and their use |
US5106835A (en) * | 1988-12-27 | 1992-04-21 | American Cyanamid Company | Renin inhibitors |
DK0383635T3 (da) * | 1989-02-16 | 1995-11-20 | Sankyo Co | Peptider med renin-inhiberende virkning samt deres fremstilling og anvendelse |
CA2100171A1 (en) * | 1991-01-31 | 1992-08-01 | Kazumi Shiosaki | Endothelin converting enzyme inhibitors |
US5223535A (en) * | 1991-10-29 | 1993-06-29 | G. D. Searle & Co. | Propargyl glycine amino propargyl diol compounds for treatment of hypertension |
US5227401A (en) * | 1991-10-29 | 1993-07-13 | G. D. Searle & Co. | Ethynyl alanine amino diol compounds for treatment of hypertension |
EP0539976A1 (en) * | 1991-10-29 | 1993-05-05 | G.D. Searle & Co. | Ethynyl-alanine-amino-diol compounds for treatment of hypertension |
US5330996A (en) * | 1991-10-29 | 1994-07-19 | G. D. Searle & Co. | Amino acyl amino propargyl diol compounds for treatment of hypertension |
US5314920A (en) * | 1992-07-20 | 1994-05-24 | G. D. Searle & Co. | Ethynyl-alanine aryl/alkylsulfonyl-terminated amino-diol compounds for treatment of hypertension |
US5268391A (en) * | 1992-07-20 | 1993-12-07 | C. D. Searle & Co. | Propargyl-terminated cycloalkylalkyl-P2-site substituted aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension |
US5246969A (en) * | 1992-07-20 | 1993-09-21 | G. D. Searle & Co. | Di-propargyl-containing aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension |
US5317039A (en) * | 1992-07-20 | 1994-05-31 | G. D. Searle & Co. | Cyclopropyl-alanine aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension |
US5422349A (en) * | 1992-08-14 | 1995-06-06 | G. D. Seale & Co. | Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5252591A (en) * | 1992-08-14 | 1993-10-12 | G. D. Searle & Company | Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5298505A (en) * | 1992-08-14 | 1994-03-29 | G. D. Searle & Co. | Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension |
US5373017A (en) * | 1992-08-14 | 1994-12-13 | G. D. Searle & Co. | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5212185A (en) * | 1992-08-14 | 1993-05-18 | G. D. Searle & Co. | Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5312838A (en) * | 1992-09-21 | 1994-05-17 | G. D. Searle & Co. | β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension |
US5414018A (en) * | 1993-09-24 | 1995-05-09 | G. D. Searle & Co. | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension |
US5416119A (en) * | 1993-10-25 | 1995-05-16 | G. D. Searle & Co. | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension |
US5432201A (en) * | 1993-11-22 | 1995-07-11 | G. D. Searle & Co. | Alkylaminoalkyl-sulfonyl-terminated β-alanineamide amino-diol compounds for treatment of hypertension |
US5508466A (en) * | 1994-04-13 | 1996-04-16 | G.D. Searle & Co. | Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent |
US5780494A (en) * | 1994-11-14 | 1998-07-14 | G. D. Searle & Co. | Piperidinyl-terminated alkylamino ethynl alanine amino diol compounds for treatment of hypertension |
JP6007262B2 (ja) * | 2012-01-06 | 2016-10-12 | ノーバス・インターナショナル・インコーポレイテッドNovus International,Inc. | スルホキシドベース界面活性剤 |
US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4070458A (en) * | 1974-02-28 | 1978-01-24 | Sanraku-Ocean Co., Ltd. | Novel physiologically active peptide and its n-acyl derivatives and processes for producing thereof |
JPS59227851A (ja) * | 1983-06-09 | 1984-12-21 | Sankyo Co Ltd | レニン阻害作用を有するペプチド類 |
JPS61152967A (ja) * | 1984-12-26 | 1986-07-11 | Toyota Motor Corp | 内燃機関の着火時期センサ |
-
1985
- 1985-11-28 SU SU853987362A patent/SU1676454A3/ru active
- 1985-11-29 HU HU854584A patent/HUT39463A/hu unknown
- 1985-11-29 DK DK554685A patent/DK554685A/da not_active Application Discontinuation
- 1985-11-29 FI FI854747A patent/FI854747A/fi not_active Application Discontinuation
- 1985-11-29 ES ES549457A patent/ES8800958A1/es not_active Expired
- 1985-11-30 KR KR1019850008981A patent/KR910001721B1/ko active IP Right Grant
- 1985-12-02 EP EP85308759A patent/EP0186977A3/en not_active Ceased
- 1985-12-02 NO NO854825A patent/NO854825L/no unknown
Also Published As
Publication number | Publication date |
---|---|
KR910001721B1 (ko) | 1991-03-22 |
FI854747A0 (fi) | 1985-11-29 |
HUT39463A (en) | 1986-09-29 |
ES8800958A1 (es) | 1987-12-01 |
KR860004080A (ko) | 1986-06-16 |
DK554685A (da) | 1986-05-31 |
SU1676454A3 (ru) | 1991-09-07 |
DK554685D0 (da) | 1985-11-29 |
EP0186977A3 (en) | 1987-09-16 |
FI854747A (fi) | 1986-05-31 |
EP0186977A2 (en) | 1986-07-09 |
NO854825L (no) | 1986-06-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971001 |