FI832959A7 - Spiro/2h-1,4-benzodiazepin-3(5h)4'-piperidin och 3'-pyrrolidin/foereningar, foerfarande foer deras framstaellning och deras anvaendning som laekemedel - Google Patents

Spiro/2h-1,4-benzodiazepin-3(5h)4'-piperidin och 3'-pyrrolidin/foereningar, foerfarande foer deras framstaellning och deras anvaendning som laekemedel Download PDF

Info

Publication number
FI832959A7
FI832959A7 FI832959A FI832959A FI832959A7 FI 832959 A7 FI832959 A7 FI 832959A7 FI 832959 A FI832959 A FI 832959A FI 832959 A FI832959 A FI 832959A FI 832959 A7 FI832959 A7 FI 832959A7
Authority
FI
Finland
Prior art keywords
och
deras
foereningar
benzodiazepin
pyrrolidin
Prior art date
Application number
FI832959A
Other languages
English (en)
Finnish (fi)
Other versions
FI832959A0 (fi
Inventor
Raymond W Kosley Jr
Robert J Cherill
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI832959A0 publication Critical patent/FI832959A0/fi
Publication of FI832959A7 publication Critical patent/FI832959A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI832959A 1982-08-20 1983-08-18 Spiro/2h-1,4-benzodiazepin-3(5h)4'-piperidin och 3'-pyrrolidin/foereningar, foerfarande foer deras framstaellning och deras anvaendning som laekemedel FI832959A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/410,155 US4405631A (en) 1982-08-20 1982-08-20 Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'pyrrolidine] compounds and their use as antihypertensive agents

Publications (2)

Publication Number Publication Date
FI832959A0 FI832959A0 (fi) 1983-08-18
FI832959A7 true FI832959A7 (fi) 1984-02-21

Family

ID=23623465

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832959A FI832959A7 (fi) 1982-08-20 1983-08-18 Spiro/2h-1,4-benzodiazepin-3(5h)4'-piperidin och 3'-pyrrolidin/foereningar, foerfarande foer deras framstaellning och deras anvaendning som laekemedel

Country Status (20)

Country Link
US (1) US4405631A (enExample)
EP (1) EP0102034B1 (enExample)
JP (1) JPS5953489A (enExample)
KR (1) KR840005729A (enExample)
AT (1) ATE33656T1 (enExample)
AU (1) AU576473B2 (enExample)
CA (1) CA1210764A (enExample)
DE (1) DE3376327D1 (enExample)
DK (1) DK381983A (enExample)
ES (2) ES525013A0 (enExample)
FI (1) FI832959A7 (enExample)
GR (1) GR78667B (enExample)
HU (1) HU191874B (enExample)
IL (1) IL69525A0 (enExample)
MA (1) MA19881A1 (enExample)
NO (1) NO833001L (enExample)
NZ (1) NZ205320A (enExample)
PH (1) PH18839A (enExample)
PT (1) PT77223B (enExample)
ZA (1) ZA836127B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4521537A (en) * 1982-08-20 1985-06-04 Hoechst-Roussel Pharmaceuticals Incorporated Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents
US4472580A (en) * 1982-08-20 1984-09-18 Hoechst-Roussel Pharmaceuticals Incorporated Spiro (2H-1,4-benzodioxepin-3 (5H)4-piperidine and -3-pyrrolidine) compounds and their use as anti-hypertensive agents
US4751223A (en) * 1986-10-14 1988-06-14 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1312894A (fr) * 1962-01-29 1962-12-21 Geigy Ag J R Nouveaux composés hétérocycliques à 2 atomes d'oxygène dans le cycle et leur préparation
CH469736A (de) * 1966-06-28 1969-03-15 Geigy Ag J R Verfahren zur Herstellung von neuen Heterospiroalkanen
US3679666A (en) * 1969-04-03 1972-07-25 Hoffmann La Roche 4-(4-hydroxypiperidino)-4'-fluorobutyrophenones

Also Published As

Publication number Publication date
ATE33656T1 (de) 1988-05-15
ZA836127B (en) 1984-04-25
KR840005729A (ko) 1984-11-16
ES540841A0 (es) 1985-12-01
ES8602800A1 (es) 1985-12-01
DK381983A (da) 1984-02-21
HU191874B (en) 1987-04-28
EP0102034A1 (en) 1984-03-07
PH18839A (en) 1985-10-10
PT77223A (en) 1983-09-01
ES8505685A1 (es) 1985-06-01
AU1816983A (en) 1984-02-23
ES525013A0 (es) 1985-06-01
PT77223B (en) 1986-03-18
AU576473B2 (en) 1988-09-01
DE3376327D1 (en) 1988-05-26
NZ205320A (en) 1987-05-29
GR78667B (enExample) 1984-09-27
DK381983D0 (da) 1983-08-19
MA19881A1 (fr) 1984-04-01
FI832959A0 (fi) 1983-08-18
EP0102034B1 (en) 1988-04-20
NO833001L (no) 1984-02-21
IL69525A0 (en) 1983-11-30
CA1210764A (en) 1986-09-02
US4405631A (en) 1983-09-20
JPS5953489A (ja) 1984-03-28

Similar Documents

Publication Publication Date Title
FI834184L (fi) Vaexelriktare med en belastningskrets som innehaoller en serieresonanskrets och en urladdningslampa.
FI834698A7 (fi) Karboxiamidoderivat av 5h-1,3,4- tiadiazolo/3,2-a/ pyridiner och foerfarande foer framstaellning av dessa.
FI834552A7 (fi) Tvaettmedel i pulverform och som goer textilerna mjuka.
FI834709A0 (fi) Substituerade fenylsulfonyloxibenzimidazolkarbamater, foerfarande foer deras framstaellning och deranvaendning som laekemedel
FI832784L (fi) Kondenserade 4h-1,4-benzotiaziner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
FI832959A7 (fi) Spiro/2h-1,4-benzodiazepin-3(5h)4'-piperidin och 3'-pyrrolidin/foereningar, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
AU1961883A (en) 3-aryl-5, 6-dihydro-1, 4, 2-oxathiazines
FI841238A7 (fi) Substituerade 6-aryl-1,2,4- triazolo/4, 3-b/pyridaziner, deras framstaellning och anvaendning.
FI871980A0 (fi) Pyrazolo/3,4-b/pyridinderivat, foerfaranden och mellanprodukter foer deras framstaellning och deras anvaendning som herbicider.
FI832783A0 (fi) 4h, 1,4-benzotiazinderivat, foerfarande foer deras framstaellning och deras anvaendning som laekemefodertillsatsaemnen och konserveringsmedel
FI843282A7 (fi) Foerbaettringar i och beroerande pyrimido /4,5-g/kinoliner och mellanprodukter.
AU1383883A (en) Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones
FI832782L (fi) 4h-1,4-benzotiaziner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
FI812332L (fi) Pyridazino/4,5-b/kinoxalin-5,10-dioxinderivat; foerfarande foer deras framstaellning och dessa innehaollande produkter
ES513622A0 (es) "un procedimiento para la preparacion de pirrolo (3,4-d) (2)-benzacepinas".
ZW24583A1 (en) Novel herbicides:n,n-dialkyl-2-(4'-substituted-1'-naphthoxy)-propionamides
IE831943L (en) Spiro {2h-1,4 benzodioxepin - 3(5h)4'- piperidine & 3'-¹pyrrolidino compounds)
FI841221L (fi) 7,8,9,10-tetrahydrotieno/3,2- e/pyrido/4,3-b/indoler, foerfarande foer deras framstaellning och dessa innehaollande laekemedel.
FI810878L (fi) Imidazo /4,5-b/ pyridinderivat anvaendbara som hjaertmedicin och dess framstaellning
FI811969L (fi) Indolo/2',3':3,4/pyrido/2,1-b/kinatsolin-5-oner och deras framstaellningsfoerfarande
FI834549A0 (fi) Pyrazolo /4,3-b//1,4/oxaziner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
GB2078224B (en) The preparation of indolo(2'3';3'4)-pyrido-(2,1-b)quinazolin-5-ones
FI833137A7 (fi) 1,8-naftyridin och 1,5,8-azanaftyridinderivater
IL80849A (en) Diazaspiro(4.4)-nonane derivatives
ES514453A0 (es) "central de intermitencia".

Legal Events

Date Code Title Description
FA Application withdrawn [patent]

Owner name: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED