FI81361B - Foerfarande foer framstaellning av terapeutiskt aktiva 1-alkyl-androsta-1,4-dien-3,17-dioner. - Google Patents
Foerfarande foer framstaellning av terapeutiskt aktiva 1-alkyl-androsta-1,4-dien-3,17-dioner. Download PDFInfo
- Publication number
- FI81361B FI81361B FI842457A FI842457A FI81361B FI 81361 B FI81361 B FI 81361B FI 842457 A FI842457 A FI 842457A FI 842457 A FI842457 A FI 842457A FI 81361 B FI81361 B FI 81361B
- Authority
- FI
- Finland
- Prior art keywords
- androsta
- dione
- diene
- group
- prepared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (10)
1. Förfarande för framställning av terapeutiskt aktiva 1-alkyl-androsta-l,4-dien-3,17-dioner med der» all-5 männa formeln I O 1° (I)
0 R7 *6 15 väri Rt är en metyl, etyl-, hydroximetyl-, C1.3-alkoximetyl-eller C1.4-alkanoyloximetylgrupp, R6 är en väteatom eller metylgrupp och R7 är en väteatom eller en metylgrupp i 7a- eller 7B-ställ-ning, kännetecknat därav, att 20 a) 17-hydroxigruppen i en 17-hydroxisteroid med den allmänna formeln II ηΛ 25 fl (II) oW\, 30 6 väri Rr, R6 och R7 är ovan definierade, oxideras tili 17-oxogrupp, eller b) en i A-ringen mättad eller enkelt omättad steroid med den allmänna formeln III 35 19 81 361 Γ J'j (III) *6 10 väri X är O, H(0H) eller H(OAc), varvid Ac är en lägre, 1-4 C-atomer innehällande acylgrupp, och Rx, R6 och R7 är ovan definierade och A4-dubbelbindningen är fakultativ, dehydreras i 1,2- eller 1,2- och 4,5-ställning och en fri 15 eller frisatt 17-hydroxigrupp oxideras, eller, c) en i A-ringen mättad steroid med den allmänna formeln IV X
20 Rj j 'j } 0^\^· (IV) H I
25 R6 väri X är 0, H(0H) eller H(OAc), varvid Ac är en lägre, 1-4 C-atomer innehällande acylgrupp, och Rx, R6 och R7 är ovan definierade, dehydreras i 1,2- och 4,5-ställning, och en 30 fri eller frisatt 17-hydroxigrupp oxideras, eller d) alkanoyloxigruppen i en 1-alkanoyloximetylste-roid med den allmänna formeln I' 35 20 81 361 o CH2OAcI 5 ιΎι (I) *6 10 väri Ac är en alkanoylgrupp med 1-4 kolatomer och R6 och r7 är ovan definierade, hydrolyseras och eventuellt överförs den frisatta hydroxigruppen i 1-hydroximetylsteroiden i en C1_3-alkyleter eller C1.4-alkanoylester.
2. Förfarande enligt patentkravet 1, k ä n n e - 15 tecknat därav, att man framställer 1-metyl-andros- ta-1,4-dien-3,17-dion.
3. Förfarande enligt patentkravet 1, känne-tecknat därav, att man framställer 1,7a-dimetyl-androsta-1,4-dien-3,17-dion och 1,78-dimetyl-androsta-l,4- 20 dien-3,17-dion.
4. Förfarande enligt patentkravet 1, k ä n n e -tecknat därav, att man framställer 1,6a-dimetyl-androsta-1,4-dien-3,17-dion.
5. Förfarande enligt patentkravet 1, känne- 25 tecknat därav, att man framställer 1-etyl-androsta- l,4-dien-3,17-dion.
5. Förfarande enligt patentkravet 1, känne-tecknat därav, att man framställer 1-acetoximetyl-androsta-1,4-dien-3,17-dion. 30 7. Förfarande enligt patentkravet 1, känne- tecknat därav, att man framställer 1-hydroximetyl-androsta-1,4-dien-3,17-dion.
8. Förfarande enligt patentkravet 1, känne-tecknat därav, att man framställer 1-etoximetyl-35 androsta-1,4-dien-3,17-dion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI901031A FI84487C (sv) | 1983-06-18 | 1990-03-01 | 1-alkyl-androsta-1,4-dien-3,17-dioner som används för kontraseption oc h en komposition innehållande desamma |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3322285 | 1983-06-18 | ||
| DE3322285A DE3322285A1 (de) | 1983-06-18 | 1983-06-18 | 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI842457A0 FI842457A0 (fi) | 1984-06-18 |
| FI842457A FI842457A (fi) | 1984-12-19 |
| FI81361B true FI81361B (fi) | 1990-06-29 |
| FI81361C FI81361C (sv) | 1990-10-10 |
Family
ID=6201972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI842457A FI81361C (sv) | 1983-06-18 | 1984-06-18 | Förfarande för framställning av terapeutiskt aktiva 1-alkyl-androsta-1 ,4-dien-3,17-dioner |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4591585A (sv) |
| EP (1) | EP0129500B1 (sv) |
| JP (1) | JPS6013796A (sv) |
| AT (1) | ATE28752T1 (sv) |
| AU (1) | AU562646B2 (sv) |
| CA (1) | CA1223251A (sv) |
| DD (1) | DD218623A5 (sv) |
| DE (2) | DE3322285A1 (sv) |
| DK (1) | DK158358C (sv) |
| ES (1) | ES8502709A1 (sv) |
| FI (1) | FI81361C (sv) |
| GR (1) | GR82160B (sv) |
| HU (1) | HU189415B (sv) |
| IE (1) | IE57621B1 (sv) |
| IL (1) | IL72067A (sv) |
| NO (1) | NO159278C (sv) |
| NZ (1) | NZ208552A (sv) |
| PT (1) | PT78743B (sv) |
| ZA (1) | ZA844603B (sv) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5275936A (en) * | 1985-04-03 | 1994-01-04 | Schering Aktiengesellschaft | Process for the preparation of 1-methyl-1,4-androstadiene-3,17-dione |
| DE3512328A1 (de) * | 1985-04-03 | 1987-03-19 | Schering Ag | Verahren zur herstellung von 1-methyl-1,4-androstadien-3,17-dion |
| GB8517360D0 (en) * | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
| DE3539244A1 (de) * | 1985-11-01 | 1987-05-07 | Schering Ag | 1-methyl-15(alpha)-alkyl-androsta- 1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| GB8617107D0 (en) * | 1986-07-14 | 1986-08-20 | Erba Farmitalia | 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives |
| DE3703722A1 (de) * | 1987-02-04 | 1988-08-18 | Schering Ag | 1-methyl-15(alpha)-(1,2-dialkanoyloxyalkyl)-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3705990A1 (de) * | 1987-02-20 | 1988-09-01 | Schering Ag | 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3715869A1 (de) * | 1987-05-07 | 1988-11-17 | Schering Ag | Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren |
| GB8720856D0 (en) * | 1987-09-04 | 1987-10-14 | Emi Plc Thorn | Matrix addressing |
| EP0310542B1 (de) * | 1987-10-01 | 1994-06-08 | Schering Aktiengesellschaft | Antigestagen- und antiöstrogenwirksame Verbindungen zur Behandlung hormonabhängiger Tumoren |
| EP0582713B1 (en) * | 1991-03-28 | 1997-06-04 | Teikoku Hormone Mfg. Co., Ltd. | -New D-homo-17-oxa and D-homo-17-aza-androstane derivatives |
| NZ256130A (en) * | 1992-09-30 | 1996-05-28 | Teikoku Hormone Mfg Co Ltd | 7-substituted oxasteroid derivatives; pharmaceutical compositions |
| GB9222669D0 (en) * | 1992-10-28 | 1992-12-09 | Erba Carlo Spa | 6,7 alpha-difluoromethylenandrosta-1,4-dien-3-one derivatives and process for their preparation |
| DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| WO1996015253A1 (de) * | 1994-11-14 | 1996-05-23 | Schering Aktiengesellschaft | Verfahren zur herstellung von 1-hydroxymethyl-1.4-androstadien-3.17-dion |
| ZA9510926B (en) | 1994-12-23 | 1996-07-03 | Schering Ag | Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception |
| EP0943333A1 (de) * | 1998-03-18 | 1999-09-22 | S.W. Patentverwertungs GmbH | Medikament zur Prophylaxe und/oder Behandlung des Mammakarzinoms enthaltend einen Hemmer der Bildung von Oestrogenen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3006929A (en) * | 1957-09-24 | 1961-10-31 | Searle & Co | 1-methyl-17-alkyl-19-nortestosterones |
| DE1174776B (de) * | 1962-08-04 | 1964-07-30 | Schering Ag | Verfahren zur Herstellung von 1ª‡, 7ª‡-Dimethyl-steroiden der Androstanreihe |
| DE1174778B (de) * | 1962-08-16 | 1964-07-30 | Schering Ag | Verfahren zur Herstellung von 3, 4-Dimethyl-?-oestratrien-1, 17ª‰-diol |
| DE1249268B (de) * | 1964-12-02 | 1967-09-07 | Schermg Aktiengesellschaft, Berlin | Verfahren zur Herstellung von 1 7a-Dimethyl - A1 - androstcnolondenvaten |
| DE2943776A1 (de) * | 1979-10-26 | 1981-05-14 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung |
| US4474701A (en) * | 1983-03-10 | 1984-10-02 | Veb Jenapharm Jena | Process for the separation of 4-androsten-3,17-dione and 1,4-androstadien-3,17-dione |
-
1983
- 1983-06-18 DE DE3322285A patent/DE3322285A1/de not_active Withdrawn
-
1984
- 1984-06-08 DK DK282784A patent/DK158358C/da not_active IP Right Cessation
- 1984-06-08 ES ES533261A patent/ES8502709A1/es not_active Expired
- 1984-06-10 IL IL72067A patent/IL72067A/xx unknown
- 1984-06-13 AT AT84730063T patent/ATE28752T1/de not_active IP Right Cessation
- 1984-06-13 EP EP84730063A patent/EP0129500B1/de not_active Expired
- 1984-06-13 DE DE8484730063T patent/DE3465201D1/de not_active Expired
- 1984-06-15 AU AU29399/84A patent/AU562646B2/en not_active Expired
- 1984-06-15 DD DD84264192A patent/DD218623A5/de not_active IP Right Cessation
- 1984-06-15 HU HU842322A patent/HU189415B/hu unknown
- 1984-06-15 NO NO842408A patent/NO159278C/no not_active IP Right Cessation
- 1984-06-15 PT PT78743A patent/PT78743B/pt unknown
- 1984-06-15 GR GR75032A patent/GR82160B/el unknown
- 1984-06-15 IE IE1494/84A patent/IE57621B1/en not_active IP Right Cessation
- 1984-06-15 CA CA000456730A patent/CA1223251A/en not_active Expired
- 1984-06-18 NZ NZ208552A patent/NZ208552A/en unknown
- 1984-06-18 FI FI842457A patent/FI81361C/sv not_active IP Right Cessation
- 1984-06-18 ZA ZA844603A patent/ZA844603B/xx unknown
- 1984-06-18 US US06/621,769 patent/US4591585A/en not_active Expired - Lifetime
- 1984-06-18 JP JP59123911A patent/JPS6013796A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FI842457A0 (fi) | 1984-06-18 |
| ATE28752T1 (de) | 1987-08-15 |
| EP0129500A2 (de) | 1984-12-27 |
| IL72067A (en) | 1987-08-31 |
| IE57621B1 (en) | 1993-02-10 |
| FI81361C (sv) | 1990-10-10 |
| DK158358C (da) | 1990-10-08 |
| PT78743B (de) | 1986-07-14 |
| JPH0132235B2 (sv) | 1989-06-29 |
| NO842408L (no) | 1984-12-19 |
| ES533261A0 (es) | 1985-02-01 |
| EP0129500B1 (de) | 1987-08-05 |
| DE3322285A1 (de) | 1984-12-20 |
| DK158358B (da) | 1990-05-07 |
| HU189415B (en) | 1986-07-28 |
| IE841494L (en) | 1984-12-18 |
| EP0129500A3 (en) | 1985-05-15 |
| ES8502709A1 (es) | 1985-02-01 |
| FI842457A (fi) | 1984-12-19 |
| HUT34513A (en) | 1985-03-28 |
| PT78743A (de) | 1984-07-01 |
| CA1223251A (en) | 1987-06-23 |
| GR82160B (sv) | 1984-12-13 |
| JPS6013796A (ja) | 1985-01-24 |
| DD218623A5 (de) | 1985-02-13 |
| US4591585A (en) | 1986-05-27 |
| DK282784A (da) | 1984-12-19 |
| NZ208552A (en) | 1986-11-12 |
| AU2939984A (en) | 1984-12-20 |
| DK282784D0 (da) | 1984-06-08 |
| AU562646B2 (en) | 1987-06-18 |
| NO159278B (no) | 1988-09-05 |
| ZA844603B (en) | 1985-02-27 |
| IL72067A0 (en) | 1984-10-31 |
| NO159278C (no) | 1988-12-14 |
| DE3465201D1 (en) | 1987-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: SCHERING AKTIENGESELLSCHAFT |