FI791533A - Diagnostiskt medel foer bestaemning av ammoniak eller substrat som reagerar under bildande av ammoniak - Google Patents
Diagnostiskt medel foer bestaemning av ammoniak eller substrat som reagerar under bildande av ammoniakInfo
- Publication number
- FI791533A FI791533A FI791533A FI791533A FI791533A FI 791533 A FI791533 A FI 791533A FI 791533 A FI791533 A FI 791533A FI 791533 A FI791533 A FI 791533A FI 791533 A FI791533 A FI 791533A
- Authority
- FI
- Finland
- Prior art keywords
- ammonia
- reager
- eller
- substrate
- diagnostic media
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/10—Quaternary compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/171538—Urea or blood urea nitrogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/173845—Amine and quaternary ammonium
- Y10T436/175383—Ammonia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782821469 DE2821469A1 (de) | 1978-05-17 | 1978-05-17 | Diagnostisches mittel zur bestimmung von harnstoff |
Publications (1)
Publication Number | Publication Date |
---|---|
FI791533A true FI791533A (fi) | 1979-11-18 |
Family
ID=6039528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI791533A FI791533A (fi) | 1978-05-17 | 1979-05-14 | Diagnostiskt medel foer bestaemning av ammoniak eller substrat som reagerar under bildande av ammoniak |
Country Status (16)
Country | Link |
---|---|
US (1) | US4223089A (fi) |
EP (1) | EP0005519B1 (fi) |
JP (1) | JPS54151096A (fi) |
AR (1) | AR217373A1 (fi) |
AT (1) | ATE3086T1 (fi) |
AU (1) | AU521129B2 (fi) |
BR (1) | BR7903035A (fi) |
CA (1) | CA1113356A (fi) |
DD (1) | DD143662A5 (fi) |
DE (2) | DE2821469A1 (fi) |
DK (1) | DK199579A (fi) |
ES (1) | ES480618A1 (fi) |
FI (1) | FI791533A (fi) |
IL (1) | IL57259A0 (fi) |
PL (3) | PL120537B1 (fi) |
ZA (1) | ZA792362B (fi) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3029579C2 (de) * | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
US4816224A (en) * | 1980-08-05 | 1989-03-28 | Boehringer Mannheim Gmbh | Device for separating plasma or serum from whole blood and analyzing the same |
DE3048799A1 (de) * | 1980-12-23 | 1982-07-08 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagenzstreifen fuer analytische zwecke |
JPS5877661A (ja) * | 1981-11-02 | 1983-05-11 | Fuji Photo Film Co Ltd | アンモニアまたはアンモニア生成基質分析用一体型多層分析材料および検出法 |
JPH0616033B2 (ja) * | 1982-04-19 | 1994-03-02 | 株式会社京都第一科学 | アンモニアおよび尿素の分析具 |
US4839296A (en) * | 1985-10-18 | 1989-06-13 | Chem-Elec, Inc. | Blood plasma test method |
US4719085A (en) * | 1985-12-24 | 1988-01-12 | Eastman Kodak Company | Mount for ammonia-sensitive test elements |
DE3630999A1 (de) * | 1986-09-12 | 1988-03-17 | Boehringer Mannheim Gmbh | Mehrschichtiger testtraeger |
DE3638654A1 (de) * | 1986-11-12 | 1988-05-26 | Boehringer Mannheim Gmbh | Testtraeger zur analytischen bestimmung eines bestandteils einer koerperfluessigkeit |
US5047206A (en) * | 1987-03-11 | 1991-09-10 | Wayne State University | Reagent test strip |
US4952516A (en) * | 1987-06-12 | 1990-08-28 | Pall Corporation | Self-venting diagnostic test device |
US5340539A (en) * | 1989-03-16 | 1994-08-23 | Chemtrak, Inc. | Non-instrumented cholesterol assay |
DE3919946A1 (de) * | 1989-06-19 | 1991-01-17 | Brinkhaus H Gmbh Co Kg | Verfahren zur bestimmung der gebrauchsintensitaet von textilstuecken und vorrichtung zur durchfuehrung des verfahrens |
CA2031975A1 (en) * | 1990-01-12 | 1991-07-13 | Brian R. Barkes | Device and method of separating and assaying whole blood |
US5183763A (en) * | 1990-06-06 | 1993-02-02 | Southwest Research Institute | Composition and method for detecting vapor and liquid reactants |
US5877028A (en) * | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
US5607863A (en) * | 1991-05-29 | 1997-03-04 | Smithkline Diagnostics, Inc. | Barrier-controlled assay device |
US5998220A (en) * | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
US5468648A (en) * | 1991-05-29 | 1995-11-21 | Smithkline Diagnostics, Inc. | Interrupted-flow assay device |
US5869345A (en) * | 1991-05-29 | 1999-02-09 | Smithkline Diagnostics, Inc. | Opposable-element assay device employing conductive barrier |
US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
US5186843A (en) * | 1991-07-22 | 1993-02-16 | Ahlstrom Filtration, Inc. | Blood separation media and method for separating plasma from whole blood |
US5314804A (en) * | 1992-03-24 | 1994-05-24 | Serim Research Corporation | Test for Helicobacter pylori |
DE4436948A1 (de) * | 1994-10-15 | 1996-04-18 | Merck Patent Gmbh | Mittel und Verfahren zur Bestimmung von Ammoniumionen |
US5945343A (en) * | 1997-08-05 | 1999-08-31 | Bayer Corporation | Fluorescent polymeric sensor for the detection of urea |
US5958786A (en) * | 1997-08-05 | 1999-09-28 | Bayer Corporation | Fluorescent polymeric sensor for the detection of creatinine |
US6013529A (en) * | 1997-08-05 | 2000-01-11 | Bayer Corporation | Hydrophobic fluorescent polymer membrane for the detection of ammonia |
US7033839B1 (en) * | 1999-03-16 | 2006-04-25 | Hach Company | Quick acting toxic ammonia test for aqueous samples |
EP1410001A4 (en) * | 2000-10-25 | 2006-05-31 | Michael M Miller | MULTI-LAYERED ANALYTICAL ELEMENT AND METHOD OF DETERMINING ANALYTES IN FLUIDS CONTAINING INTERFERING SUBSTANCES |
US20050180879A1 (en) * | 2004-02-03 | 2005-08-18 | Eva Hrboticka | One step tester for ammonia |
US20050191704A1 (en) * | 2004-03-01 | 2005-09-01 | Kimberly-Clark Worldwide, Inc. | Assay devices utilizing chemichromic dyes |
WO2005106457A1 (de) * | 2004-04-21 | 2005-11-10 | Merck Patent Gmbh | Test-kit und verfahren zur bestimmung von stickstoffkomponenten in wein |
US8409864B2 (en) * | 2006-01-06 | 2013-04-02 | Renal Solutions, Inc. | Ammonia sensor and system for use |
AU2007207242B2 (en) | 2006-01-19 | 2012-08-02 | Lattec I/S | Dry stick device and method for determining an analyte in a sample |
EP3516388B1 (de) * | 2016-09-20 | 2024-06-12 | Merck Patent GmbH | Verfahren zur bestimmung von ammonium |
CA3097508A1 (en) * | 2017-04-17 | 2018-10-25 | Dignity Health | Salivary urea nitrogen rapid detection |
WO2018196802A1 (zh) | 2017-04-28 | 2018-11-01 | 利多(香港)有限公司 | 一种检测装置和可直观读取检测结果的样本检测方法 |
CN113533312A (zh) * | 2020-04-20 | 2021-10-22 | 杭州微策生物技术股份有限公司 | 一种光化学poct多合一测试卡 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2632761A (en) * | 1950-05-10 | 1953-03-24 | Bristol Lab Inc | Substituted pyridinium salts |
NL101441C (fi) * | 1959-03-13 | |||
US3145086A (en) * | 1960-05-05 | 1964-08-18 | Miles Lab | Diagnostic composition |
US3249513A (en) * | 1963-09-19 | 1966-05-03 | Warner Lambert Pharmaceutical | Purification of urease |
JPS5016191B1 (fi) * | 1966-11-11 | 1975-06-11 | ||
US3427225A (en) * | 1967-06-05 | 1969-02-11 | Jeanne T Harvill | Test composition,device and method for detecting urea in aqueous fluids |
US3607093A (en) * | 1968-02-15 | 1971-09-21 | Schering Corp | Devices for testing biological liquids |
US3528780A (en) * | 1968-04-05 | 1970-09-15 | Us Air Force | Visual ammonia detector |
US3791933A (en) * | 1971-02-25 | 1974-02-12 | Geomet | Rapid methods for assay of enzyme substrates and metabolites |
DE2118455B1 (de) * | 1971-04-16 | 1972-09-21 | Boehringer Mannheim Gmbh | Teststreifen |
US3723064A (en) * | 1971-07-26 | 1973-03-27 | L Liotta | Method and device for determining the concentration of a material in a liquid |
US3798004A (en) * | 1972-04-18 | 1974-03-19 | Ames Yissum Ltd | Test device |
US3846247A (en) * | 1972-09-27 | 1974-11-05 | Warner Lambert Co | Moisture barrier |
ZA733612B (en) * | 1972-10-11 | 1974-04-24 | Merck Patent Gmbh | Container for test strips |
ZA733611B (en) * | 1972-10-11 | 1974-04-24 | Merck Patent Gmbh | Indicator for the determination of urea |
US3809617A (en) * | 1972-11-15 | 1974-05-07 | American Cyanamid Co | Device for detecting anticholinesterase materials |
US3926734A (en) * | 1973-12-21 | 1975-12-16 | Owens Illinois Inc | Urea analysis |
US3901657A (en) * | 1974-04-29 | 1975-08-26 | Sun Scient Inc | Device for testing solutions and body fluids |
DE2436598C2 (de) * | 1974-07-30 | 1983-04-07 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabiler Teststreifen zum Nachweis von Inhaltsstoffen in Flüssigkeiten |
DE2626367C2 (de) * | 1975-06-20 | 1982-04-22 | Eastman Kodak Co., 14650 Rochester, N.Y. | Analytisches Material für die analytische Bestimmung eines Stoffes in einer Flüssigkeitsprobe |
US4074972A (en) * | 1976-11-10 | 1978-02-21 | American Monitor Corporation | Urea assay |
US4160008A (en) * | 1978-01-26 | 1979-07-03 | Miles Laboratories, Inc. | Multilayered test device for determining the presence of a liquid sample component, and method of use |
-
1978
- 1978-05-17 DE DE19782821469 patent/DE2821469A1/de not_active Withdrawn
-
1979
- 1979-04-30 US US06/034,719 patent/US4223089A/en not_active Expired - Lifetime
- 1979-05-08 CA CA327,187A patent/CA1113356A/en not_active Expired
- 1979-05-11 IL IL57259A patent/IL57259A0/xx unknown
- 1979-05-11 AU AU46929/79A patent/AU521129B2/en not_active Ceased
- 1979-05-11 DE DE7979101446T patent/DE2965181D1/de not_active Expired
- 1979-05-11 AT AT79101446T patent/ATE3086T1/de active
- 1979-05-11 AR AR276482A patent/AR217373A1/es active
- 1979-05-11 EP EP79101446A patent/EP0005519B1/de not_active Expired
- 1979-05-14 FI FI791533A patent/FI791533A/fi not_active Application Discontinuation
- 1979-05-15 DD DD79212892A patent/DD143662A5/de unknown
- 1979-05-15 DK DK199579A patent/DK199579A/da not_active Application Discontinuation
- 1979-05-16 ES ES480618A patent/ES480618A1/es not_active Expired
- 1979-05-16 BR BR7903035A patent/BR7903035A/pt unknown
- 1979-05-16 PL PL1979215622A patent/PL120537B1/pl unknown
- 1979-05-16 ZA ZA792362A patent/ZA792362B/xx unknown
- 1979-05-16 PL PL21566279A patent/PL215662A1/xx unknown
- 1979-05-16 PL PL1979227316A patent/PL118524B1/pl unknown
- 1979-05-16 JP JP5920579A patent/JPS54151096A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
IL57259A0 (en) | 1979-09-30 |
EP0005519A3 (en) | 1980-09-17 |
ZA792362B (en) | 1980-06-25 |
DE2965181D1 (en) | 1983-05-19 |
PL120537B1 (en) | 1982-03-31 |
ATE3086T1 (de) | 1983-04-15 |
CA1113356A (en) | 1981-12-01 |
BR7903035A (pt) | 1979-12-04 |
PL215662A1 (fi) | 1980-02-11 |
PL118524B1 (en) | 1981-10-31 |
DD143662A5 (de) | 1980-09-03 |
AR217373A1 (es) | 1980-03-14 |
EP0005519B1 (de) | 1983-04-13 |
JPS54151096A (en) | 1979-11-27 |
EP0005519A2 (de) | 1979-11-28 |
DE2821469A1 (de) | 1979-11-22 |
AU4692979A (en) | 1979-11-22 |
ES480618A1 (es) | 1980-01-16 |
DK199579A (da) | 1979-11-18 |
AU521129B2 (en) | 1982-03-18 |
US4223089A (en) | 1980-09-16 |
JPS6243500B2 (fi) | 1987-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |
Owner name: BOEHRINGER MANNHEIM GMBH |