FI77781C - Kontraseptiva (preventiv-) vaginaltabletter och foerfarande foer framstaellning av dessa. - Google Patents
Kontraseptiva (preventiv-) vaginaltabletter och foerfarande foer framstaellning av dessa. Download PDFInfo
- Publication number
- FI77781C FI77781C FI842284A FI842284A FI77781C FI 77781 C FI77781 C FI 77781C FI 842284 A FI842284 A FI 842284A FI 842284 A FI842284 A FI 842284A FI 77781 C FI77781 C FI 77781C
- Authority
- FI
- Finland
- Prior art keywords
- weight
- parts
- tablets
- vitamin
- vaginal
- Prior art date
Links
- 230000003449 preventive effect Effects 0.000 title description 3
- 239000003826 tablet Substances 0.000 claims abstract description 32
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 24
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000004327 boric acid Substances 0.000 claims abstract description 16
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000002906 tartaric acid Nutrition 0.000 claims abstract description 15
- 239000011975 tartaric acid Substances 0.000 claims abstract description 15
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 13
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 13
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 13
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 13
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 11
- 239000003433 contraceptive agent Substances 0.000 claims abstract description 10
- 239000000003 vaginal tablet Substances 0.000 claims abstract description 10
- 230000002254 contraceptive effect Effects 0.000 claims abstract description 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 14
- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 claims description 8
- 229940010250 vitamin k 2 Drugs 0.000 claims description 8
- QJQRNDGUWQVAEV-AAFSJPGBSA-M sodium bisulfite adduct Chemical compound [Na+].[O-]S(=O)(=O)C([C@H]1N(C(C2=C3)=O)C=C(C1)/C=C/C(=O)N(C)C)NC2=CC1=C3OCO1 QJQRNDGUWQVAEV-AAFSJPGBSA-M 0.000 claims description 5
- 229940044977 vaginal tablet Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 20
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract description 11
- 239000008101 lactose Substances 0.000 abstract description 11
- 239000000843 powder Substances 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 229960004051 menadione sodium bisulfite Drugs 0.000 abstract 3
- XDPFHGWVCTXHDX-UHFFFAOYSA-M menadione sodium sulfonate Chemical compound [Na+].C1=CC=C2C(=O)C(C)(S([O-])(=O)=O)CC(=O)C2=C1 XDPFHGWVCTXHDX-UHFFFAOYSA-M 0.000 abstract 3
- 239000000126 substance Substances 0.000 description 16
- 238000002360 preparation method Methods 0.000 description 6
- 239000000654 additive Substances 0.000 description 5
- 230000000996 additive effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000003054 hormonal effect Effects 0.000 description 5
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 4
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 4
- 210000001215 vagina Anatomy 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 235000019175 phylloquinone Nutrition 0.000 description 3
- 239000011772 phylloquinone Substances 0.000 description 3
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 3
- 229960001898 phytomenadione Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- RYWSYCQQUDFMAU-UHFFFAOYSA-N Acetomenaphthone Chemical compound C1=CC=C2C(OC(=O)C)=CC(C)=C(OC(C)=O)C2=C1 RYWSYCQQUDFMAU-UHFFFAOYSA-N 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 210000003679 cervix uteri Anatomy 0.000 description 2
- 229940124558 contraceptive agent Drugs 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 229940005561 1,4-benzoquinone Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010027540 Microcytosis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 208000031271 Unwanted pregnancy Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000009189 diving Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 229960003540 oxyquinoline Drugs 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- ZOCLAPYLSUCOGI-UHFFFAOYSA-M potassium hydrosulfide Chemical compound [SH-].[K+] ZOCLAPYLSUCOGI-UHFFFAOYSA-M 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 206010040400 serum sickness Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 230000001150 spermicidal effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 208000030401 vitamin deficiency disease Diseases 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Absorbent Articles And Supports Therefor (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU321182 | 1982-10-07 | ||
| HU823211A HU186134B (en) | 1982-10-07 | 1982-10-07 | Process for the production of contraceptive suppository tablets |
| PCT/HU1983/000052 WO1984001502A1 (en) | 1982-10-07 | 1983-10-07 | Contraceptive vaginal tablets and manufacturing method thereof |
| HU8300052 | 1983-10-07 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI842284A0 FI842284A0 (fi) | 1984-06-06 |
| FI842284A7 FI842284A7 (fi) | 1984-06-06 |
| FI77781B FI77781B (fi) | 1989-01-31 |
| FI77781C true FI77781C (fi) | 1989-05-10 |
Family
ID=10963124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI842284A FI77781C (fi) | 1982-10-07 | 1984-06-06 | Kontraseptiva (preventiv-) vaginaltabletter och foerfarande foer framstaellning av dessa. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4565694A (en:Method) |
| EP (1) | EP0121543B1 (en:Method) |
| JP (1) | JPS59501949A (en:Method) |
| AT (1) | ATE19947T1 (en:Method) |
| AU (1) | AU558286B2 (en:Method) |
| DE (1) | DE3363794D1 (en:Method) |
| DK (1) | DK156619C (en:Method) |
| FI (1) | FI77781C (en:Method) |
| HU (1) | HU186134B (en:Method) |
| IL (1) | IL70051A (en:Method) |
| IN (1) | IN162846B (en:Method) |
| WO (1) | WO1984001502A1 (en:Method) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU199615B (en) * | 1986-06-23 | 1990-02-28 | Agardi Mezoegazdasagi Kom | Method and apparatus for pulsation drying granular capillary-porous matters particularly cereals by predried medium |
| IT1213323B (it) * | 1986-08-07 | 1989-12-20 | Crinos Industria Farmaco | Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida |
| US5116619A (en) * | 1988-08-30 | 1992-05-26 | Lee Roy Morgan | Vaginal progesterone tablet |
| WO2006087733A1 (en) * | 2005-01-19 | 2006-08-24 | Kamalinder Kaur Singh | Herbal contraceptive formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3062715A (en) * | 1953-11-18 | 1962-11-06 | George S Pfaus | Vaginal tablet |
| NL272519A (en:Method) * | 1961-12-14 | 1964-08-17 | ||
| US4031202A (en) * | 1975-12-08 | 1977-06-21 | The Procter & Gamble Company | Controlled release contraceptive article |
| DE2602297B1 (de) * | 1976-01-22 | 1977-01-13 | Merz & Co | Vaginalzaepfchen zur empfaengnisverhuetung mit einem gehalt an milchalbumin |
| JPS5845403B2 (ja) * | 1976-02-14 | 1983-10-08 | エーザイ株式会社 | 補酵素ｑを主成分とする膵機能亢進剤 |
| US4242359A (en) * | 1977-04-01 | 1980-12-30 | Cornell Research Foundation, Inc. | Spermicidal agents |
| US4439441A (en) * | 1979-01-11 | 1984-03-27 | Syntex (U.S.A.) Inc. | Contraceptive compositions and methods employing 1-substituted imidazole derivatives |
| US4432967A (en) * | 1982-06-25 | 1984-02-21 | National Starch And Chemical Corp. | Contraceptive composition |
-
1982
- 1982-10-07 HU HU823211A patent/HU186134B/hu not_active IP Right Cessation
-
1983
- 1983-10-07 AU AU20759/83A patent/AU558286B2/en not_active Ceased
- 1983-10-07 JP JP83503243A patent/JPS59501949A/ja active Pending
- 1983-10-07 EP EP83903196A patent/EP0121543B1/de not_active Expired
- 1983-10-07 WO PCT/HU1983/000052 patent/WO1984001502A1/en not_active Ceased
- 1983-10-07 DE DE8383903196T patent/DE3363794D1/de not_active Expired
- 1983-10-07 US US06/621,905 patent/US4565694A/en not_active Expired - Fee Related
- 1983-10-07 AT AT83903196T patent/ATE19947T1/de not_active IP Right Cessation
- 1983-10-26 IL IL70051A patent/IL70051A/xx unknown
- 1983-11-29 IN IN1462/CAL/83A patent/IN162846B/en unknown
-
1984
- 1984-06-06 FI FI842284A patent/FI77781C/fi not_active IP Right Cessation
- 1984-06-06 DK DK279184A patent/DK156619C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU186134B (en) | 1985-06-28 |
| DK279184A (da) | 1984-06-06 |
| US4565694A (en) | 1986-01-21 |
| EP0121543A1 (en) | 1984-10-17 |
| JPS59501949A (ja) | 1984-11-22 |
| DE3363794D1 (en) | 1986-07-03 |
| IN162846B (en:Method) | 1988-07-16 |
| DK156619C (da) | 1990-02-12 |
| FI842284A0 (fi) | 1984-06-06 |
| ATE19947T1 (de) | 1986-06-15 |
| IL70051A (en) | 1986-12-31 |
| AU558286B2 (en) | 1987-01-22 |
| FI842284A7 (fi) | 1984-06-06 |
| AU2075983A (en) | 1984-05-04 |
| FI77781B (fi) | 1989-01-31 |
| WO1984001502A1 (en) | 1984-04-26 |
| DK156619B (da) | 1989-09-18 |
| EP0121543B1 (de) | 1986-05-28 |
| DK279184D0 (da) | 1984-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: SZEBENI, RUDOLF Owner name: KOESZEGI, BELA Owner name: KOVACS, ANDRAS |