FI77447B - Foerfarande foer framstaellning av nya bensoyl-fenyl-piperidinderivat. - Google Patents

Foerfarande foer framstaellning av nya bensoyl-fenyl-piperidinderivat. Download PDF

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Publication number
FI77447B
FI77447B FI822215A FI822215A FI77447B FI 77447 B FI77447 B FI 77447B FI 822215 A FI822215 A FI 822215A FI 822215 A FI822215 A FI 822215A FI 77447 B FI77447 B FI 77447B
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FI
Finland
Prior art keywords
group
formula
phenyl
process according
derivatives
Prior art date
Application number
FI822215A
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English (en)
Finnish (fi)
Other versions
FI822215L (fi
FI77447C (sv
FI822215A0 (fi
Inventor
Bernard Majoie
Francois Bellamy
Pierre Dodey
Jacques Robin
Original Assignee
Fournier Innovation Synergie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Innovation Synergie filed Critical Fournier Innovation Synergie
Publication of FI822215A0 publication Critical patent/FI822215A0/fi
Publication of FI822215L publication Critical patent/FI822215L/fi
Application granted granted Critical
Publication of FI77447B publication Critical patent/FI77447B/fi
Publication of FI77447C publication Critical patent/FI77447C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Claims (5)

1. Förfarande för framställning av nya terapeutiskt nyttiga, i synnerhet som immunostimulerande och immu-noadjuvanta substanser användbara derivat av bensoyl-fenyl-piperidiner, vilka är utvalda bland en grupp av 5 2-piperidinobensofenoner, som representeras av den allmänna formeln R3^ I / ,R 20. vilken R^, och R^, identiska eller olika, represente-rar var en väteatom, en hydroxidgrupp, en CF^-grupp, en halogen, en lägre alkylgrupp eller en lägre alkoxigrupp,
25. R^ och Rg, identiska eller olika, representerar var en väteatom, en lägre alkylgrupp, en OH-grupp, en fenylgrupp eller en bensylgrupp, varvid ätminstone en av de nämnda radikalerna R^, R2, R^, R5 och Rg är annan än väte,
30. R4 representerar en N02-grupp eller en NH2~grupp, samt derivatens syra-additionsalter, varvid förfaran-det är kännetecknad därav, att II 19 77447 (i) en 2-halogeno-5-nitrobensofenon änligt den bifo-gade formeln II fi Λ p » x 10 ... i vilken R^, R£ och R^ ar bestamt sasom ovan, varvid X representerar en halogenatom (företrädesvis Cl och F) , bringas att reagera med en möjligtvis substitue- rad piperidin med formeln 15 /-VR5 H-N > (ΠΙ) \_ 1 vilken Rc och R<- ar bestamt sasom ovan, for att er-d 0 halla nitroförening enligt den bifogade formeln I , ' A (ii) och, om nödvändigt, den erhällna föreningen I bringas till reduktionsreaktion för att omsättanitro- gruppen till en aminogrupp för att erhälla aminoföre- ningen enligt formeln I, i vilken R. = NH_. 35 4 2
FI822215A 1981-06-29 1982-06-21 Förfarande för framställning av nya bensoyl-fenyl-piperidinderivat. FI77447C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8112745 1981-06-29
FR8112745A FR2508445A1 (fr) 1981-06-29 1981-06-29 Nouveaux derives de benzoyl-phenyl-piperidine, leur procede de preparation et leur application, notamment en therapeutique

Publications (4)

Publication Number Publication Date
FI822215A0 FI822215A0 (fi) 1982-06-21
FI822215L FI822215L (fi) 1982-12-30
FI77447B true FI77447B (fi) 1988-11-30
FI77447C FI77447C (sv) 1989-03-10

Family

ID=9259970

Family Applications (1)

Application Number Title Priority Date Filing Date
FI822215A FI77447C (sv) 1981-06-29 1982-06-21 Förfarande för framställning av nya bensoyl-fenyl-piperidinderivat.

Country Status (26)

Country Link
US (2) US4528294A (sv)
EP (1) EP0069012B1 (sv)
JP (1) JPS588061A (sv)
KR (1) KR880001298B1 (sv)
AR (1) AR230048A1 (sv)
AT (1) ATE9795T1 (sv)
AU (1) AU550320B2 (sv)
CA (1) CA1187501A (sv)
CS (1) CS235542B2 (sv)
DD (1) DD202557A5 (sv)
DE (1) DE3260949D1 (sv)
DK (1) DK152668C (sv)
ES (1) ES8304936A1 (sv)
FI (1) FI77447C (sv)
FR (1) FR2508445A1 (sv)
GR (1) GR76401B (sv)
HU (1) HU189150B (sv)
IE (1) IE53189B1 (sv)
IL (2) IL66123A (sv)
NO (1) NO160136C (sv)
OA (1) OA07133A (sv)
PH (1) PH17368A (sv)
PT (1) PT75135B (sv)
SU (1) SU1147251A3 (sv)
YU (1) YU43799B (sv)
ZA (1) ZA824536B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL82573A0 (en) * 1986-05-30 1987-11-30 Sori Soc Rech Ind Preparation of benzoylphenyl-piperidine derivatives
FR2620027A1 (fr) * 1987-09-09 1989-03-10 Fournier Innovation Synergie Nouvelle utilisation de la (5-amino-2-(4-methyl-1-piperidinyl)phenyl)-(4-chlorophenyl)-methanone
WO2000071519A2 (en) * 1999-05-21 2000-11-30 Eli Lilly And Company Immunopotentiator agents
WO2001068637A2 (en) * 2000-03-10 2001-09-20 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202655A (en) * 1962-04-27 1965-08-24 Yvon G Perron 6-[alpha-substituted-alpha-(2-or 3-heterocyclic) acetamido] penicillanic acid and nontoxic salts thereof
FR1375300A (fr) * 1962-11-13 1964-10-16 Hoffmann La Roche Dérivés de benzophénone et leur préparation
NL124621C (sv) * 1962-11-13
FR1403939A (fr) * 1963-06-07 1965-06-25 Hoffmann La Roche Procédé pour la préparation de dérivés de benzodiazépine
FR1526708A (fr) * 1966-06-13 1968-05-24 Upjohn Co 1.3-amino-alcools, leurs intermédiaires et dérivés et leur procédé de préparation
US3668199A (en) * 1966-06-13 1972-06-06 Upjohn Co 1,3-aminoalcohols
FR1530393A (fr) * 1966-07-11 1968-06-21 Hoffmann La Roche Procédé pour la préparation de dérivés de pipéridine
IE34545B1 (en) * 1969-10-01 1975-06-11 Continental Pharma Amino-alcohols,their salts and process for preparing the same
HU167949B (sv) * 1973-07-26 1976-01-28
US4064121A (en) * 1973-07-26 1977-12-20 Richter Gedeon Vegyeszeti Gyar Rt. Substituted nitrobenzophenone derivatives and a process for the preparation thereof
HU167950B (sv) * 1973-07-26 1976-01-28
US4021563A (en) * 1975-02-06 1977-05-03 Sven Eric Harry Hernestam Method of treating cardiac arrhythmia with γ-piperidino-butyrophenones
IE49998B1 (en) * 1979-08-06 1986-01-22 Merrell Dow Pharma 4-(naphthalenyloxy)piperidine derivatives

Also Published As

Publication number Publication date
NO822185L (no) 1982-12-30
SU1147251A3 (ru) 1985-03-23
EP0069012A1 (fr) 1983-01-05
DK152668B (da) 1988-04-11
CS235542B2 (en) 1985-05-15
GR76401B (sv) 1984-08-10
FI822215L (fi) 1982-12-30
ATE9795T1 (de) 1984-10-15
YU43799B (en) 1989-12-31
IL66123A (en) 1986-02-28
FI77447C (sv) 1989-03-10
CA1187501A (en) 1985-05-21
PT75135A (fr) 1982-07-01
NO160136C (no) 1989-03-15
DK289382A (da) 1982-12-30
IE821475L (en) 1982-12-29
DE3260949D1 (en) 1984-11-15
ES513565A0 (es) 1983-03-16
US4528294A (en) 1985-07-09
IE53189B1 (en) 1988-08-17
EP0069012B1 (fr) 1984-10-10
HU189150B (en) 1986-06-30
PH17368A (en) 1984-08-06
PT75135B (fr) 1984-05-25
OA07133A (fr) 1984-03-31
AR230048A1 (es) 1984-02-29
ES8304936A1 (es) 1983-03-16
JPH0127062B2 (sv) 1989-05-26
NO160136B (no) 1988-12-05
DD202557A5 (de) 1983-09-21
KR880001298B1 (ko) 1988-07-22
JPS588061A (ja) 1983-01-18
FR2508445A1 (fr) 1982-12-31
US4680402A (en) 1987-07-14
AU550320B2 (en) 1986-03-20
DK152668C (da) 1988-09-19
KR840000514A (ko) 1984-02-22
ZA824536B (en) 1983-04-27
IL66123A0 (en) 1982-09-30
FI822215A0 (fi) 1982-06-21
IL76287A0 (en) 1986-01-31
YU141582A (en) 1985-03-20
FR2508445B1 (sv) 1984-02-10
AU8542982A (en) 1983-01-06

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Owner name: FOURNIER INNOVATION ET SYNERGIE