FI752626A7 - - Google Patents

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Info

Publication number
FI752626A7
FI752626A7 FI752626A FI752626A FI752626A7 FI 752626 A7 FI752626 A7 FI 752626A7 FI 752626 A FI752626 A FI 752626A FI 752626 A FI752626 A FI 752626A FI 752626 A7 FI752626 A7 FI 752626A7
Authority
FI
Finland
Application number
FI752626A
Other languages
Finnish (fi)
Inventor
Ulf Fischer
Eckehard Lorch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI752626A7 publication Critical patent/FI752626A7/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24Y being a hetero atom
    • C07C279/26X and Y being nitrogen atoms, i.e. biguanides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI752626A 1974-10-11 1975-09-19 FI752626A7 (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1369774A CH602612A5 (enExample) 1974-10-11 1974-10-11

Publications (1)

Publication Number Publication Date
FI752626A7 true FI752626A7 (enExample) 1976-04-12

Family

ID=4394567

Family Applications (1)

Application Number Title Priority Date Filing Date
FI752626A FI752626A7 (enExample) 1974-10-11 1975-09-19

Country Status (26)

Country Link
US (1) US4028402A (enExample)
JP (1) JPS51125718A (enExample)
AR (1) AR209457A1 (enExample)
AT (1) AT343676B (enExample)
BE (1) BE834369A (enExample)
BR (1) BR7506595A (enExample)
CA (1) CA1053258A (enExample)
CH (1) CH602612A5 (enExample)
CU (1) CU34371A (enExample)
DD (1) DD123322A5 (enExample)
DE (1) DE2542598A1 (enExample)
DK (1) DK140834B (enExample)
ES (1) ES441673A1 (enExample)
FI (1) FI752626A7 (enExample)
FR (1) FR2287221A1 (enExample)
GB (1) GB1473256A (enExample)
IE (1) IE41807B1 (enExample)
IL (1) IL48116A (enExample)
LU (1) LU73557A1 (enExample)
NL (1) NL7511890A (enExample)
NO (1) NO753447L (enExample)
PH (1) PH12279A (enExample)
PL (1) PL95259B1 (enExample)
SE (1) SE7511357L (enExample)
SU (1) SU572200A3 (enExample)
ZA (1) ZA755861B (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2401898A1 (fr) * 1977-09-05 1979-03-30 Aec Chim Organ Biolog Nouveau sel de l'acide patoique
DE19616486C5 (de) 1996-04-25 2016-06-30 Royalty Pharma Collection Trust Verfahren zur Senkung des Blutglukosespiegels in Säugern
US20020006899A1 (en) * 1998-10-06 2002-01-17 Pospisilik Andrew J. Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
EP1004304A4 (en) 1996-12-24 2002-10-16 Sumitomo Pharma COMPOSITION CONTAINING ASCORBIC ACID
DE19823831A1 (de) * 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828114A1 (de) 1998-06-24 2000-01-27 Probiodrug Ges Fuer Arzneim Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19828113A1 (de) 1998-06-24 2000-01-05 Probiodrug Ges Fuer Arzneim Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de) 1998-07-31 2000-02-03 Probiodrug Ges Fuer Arzneim Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
DE19926233C1 (de) 1999-06-10 2000-10-19 Probiodrug Ges Fuer Arzneim Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de) * 1999-08-24 2001-03-01 Probiodrug Ges Fuer Arzneim Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
CA2386379C (en) 1999-10-06 2009-12-15 Toshio Miyata Carbonyl stress-decreasing agent
US20080076811A1 (en) * 2000-01-21 2008-03-27 Bork Balkan Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
PT2055302E (pt) 2000-03-31 2014-12-03 Royalty Pharma Collection Trust Processo para a melhoria da sinalização de ilhéus em diabetes mellitus e para a sua prevenção
FR2809310B1 (fr) 2000-05-26 2004-02-13 Centre Nat Rech Scient Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant
JP2005097117A (ja) * 2000-06-30 2005-04-14 Chugai Pharmaceut Co Ltd 糖尿病治療剤
EP1328271B1 (en) * 2000-10-27 2008-06-25 Probiodrug AG Treatment of neurological and neuropsychological disorders
US7132104B1 (en) 2000-10-27 2006-11-07 Probiodrug Ag Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
US6890905B2 (en) 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
US20030130199A1 (en) 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
DE10150203A1 (de) 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
EP1492525A2 (en) * 2001-08-16 2005-01-05 Probiodrug AG Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
JP2005527504A (ja) 2002-02-28 2005-09-15 プロシディオン・リミテッド グルタミニルを基礎するdpiv阻害剤
US20030232761A1 (en) * 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
US20040033051A1 (en) * 2002-08-16 2004-02-19 Ip Kiril Kun Wan Method and system for producing and displaying visual presentations which inhibit off-screen duplication
EP1543023B1 (en) * 2002-09-18 2010-03-17 Prosidion Limited Secondary binding site of dipeptidyl peptidase iv (dp iv)
US20040058876A1 (en) * 2002-09-18 2004-03-25 Torsten Hoffmann Secondary binding site of dipeptidyl peptidase IV (DP IV)
KR20100106630A (ko) 2003-05-05 2010-10-01 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
JP4806628B2 (ja) 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
AU2004283461B2 (en) * 2003-10-15 2010-02-11 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
US20100099721A1 (en) * 2003-11-03 2010-04-22 Probiodrug Ag Novel compounds for the treatment of neurological disorders
US20050171112A1 (en) * 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
JP4996926B2 (ja) 2004-02-05 2012-08-08 プロビオドルグ エージー グルタミニルシクラーゼの新規の阻害剤
EP2109447B1 (en) * 2007-01-29 2015-06-10 HanAll Biopharma Co., Ltd. N, n- dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same
US20080188457A1 (en) * 2007-02-02 2008-08-07 Braincells, Inc. Modulation of Neurogenesis with Biguanides and GSK3-beta Agents
JP5292404B2 (ja) * 2007-09-21 2013-09-18 ハンオル バイオファーマ カンパニー,リミテッド N,n−ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物
KR101104912B1 (ko) 2008-01-08 2012-01-12 한올바이오파마주식회사 N,n―디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물
ES2450148T3 (es) * 2008-06-26 2014-03-24 Laboratorios Silanes, S.A. De C.V. Una nueva sal de glicinato de metformina para el control de la glucosa en sangre
US20110021634A1 (en) 2009-06-18 2011-01-27 Patel Pranav Dushyant Processes for preparing metformin hydrochloride
WO2011049400A2 (ko) * 2009-10-23 2011-04-28 한올바이오파마주식회사 N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물
KR101324283B1 (ko) 2010-04-27 2013-11-01 한올바이오파마주식회사 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
US11510886B2 (en) 2016-09-30 2022-11-29 Laboratorios Silanes, S.A. De C.V. Metformin amino acid compounds and methods of using the same
BR112019006401A2 (pt) 2016-09-30 2019-06-25 Laboratorios Silanes S A De C V glicinato de metformina, composições farmacêuticas que compreendem o mesmo e métodos de uso do mesmo
CN106986791A (zh) * 2017-05-11 2017-07-28 杜剑平 一种治疗肿瘤的药物化合物及其制备方法和应用
CN107118130A (zh) * 2017-05-11 2017-09-01 杜剑平 一类治疗肿瘤的药物化合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179562A (en) * 1961-08-23 1965-04-20 Du Pont Treatment of diabetes with alpha, alpha substituted acetic acid derivatives

Also Published As

Publication number Publication date
IL48116A0 (en) 1975-11-25
DK140834C (enExample) 1980-04-28
GB1473256A (en) 1977-05-11
ATA776375A (de) 1977-10-15
AR209457A1 (es) 1977-04-29
BR7506595A (pt) 1976-08-17
IL48116A (en) 1979-07-25
IE41807L (en) 1976-04-11
ES441673A1 (es) 1977-04-01
JPS51125718A (en) 1976-11-02
CA1053258A (en) 1979-04-24
ZA755861B (en) 1976-08-25
IE41807B1 (en) 1980-03-26
DD123322A5 (enExample) 1976-12-12
DE2542598A1 (de) 1976-04-22
LU73557A1 (enExample) 1977-05-24
AT343676B (de) 1978-06-12
AU8497775A (en) 1977-03-24
NL7511890A (nl) 1976-04-13
CU34371A (es) 1979-06-01
PL95259B1 (pl) 1977-10-31
CH602612A5 (enExample) 1978-07-31
DK140834B (da) 1979-11-26
FR2287221A1 (fr) 1976-05-07
SE7511357L (sv) 1976-04-12
PH12279A (en) 1978-12-12
US4028402A (en) 1977-06-07
NO753447L (enExample) 1976-04-13
SU572200A3 (ru) 1977-09-05
BE834369A (fr) 1976-04-12
DK457475A (enExample) 1976-04-12

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: F. HOFFMANN-LA ROCHE & CO.