FI73416B - Foerfarande foer framstaellning av terapeutiskt aktiva 4-(fenylalkenyl)-imidazolderivat. - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktiva 4-(fenylalkenyl)-imidazolderivat. Download PDF

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Publication number
FI73416B
FI73416B FI810389A FI810389A FI73416B FI 73416 B FI73416 B FI 73416B FI 810389 A FI810389 A FI 810389A FI 810389 A FI810389 A FI 810389A FI 73416 B FI73416 B FI 73416B
Authority
FI
Finland
Prior art keywords
sub
imidazole
compounds
hydrochloride
hydrogen
Prior art date
Application number
FI810389A
Other languages
English (en)
Finnish (fi)
Other versions
FI810389L (fi
FI73416C (sv
Inventor
Arto Johannes Karjalainen
Kauko Oiva Antero Kurkela
Original Assignee
Farmos Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Oy filed Critical Farmos Oy
Publication of FI810389L publication Critical patent/FI810389L/fi
Publication of FI73416B publication Critical patent/FI73416B/fi
Application granted granted Critical
Publication of FI73416C publication Critical patent/FI73416C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Claims (3)

1 Patent t ivaat imus Analogiamenetelraä terapeuttisesti aktiivisten 4-( fenyylialkenyy-li)-imidatsolijohdannaisten, joiden kaava on N-π-CH-CH-(CH2)irYOVRl fX. 10 jossa Rj, R2 ja R3, jotka voivat olla samanlaisia tai erilaisia, ovat vety, kloori, metyyli, etyyli tai metoksi; R4 on vety tai metyyli; ja n on kokonaisluku 0-3, 15 sekä niiden myrkyttömien farmaseuttisesti hyväksyttävien happo-additiosuolojen valmistamiseksi, tunnet tu siitä, että a) lohkaistaan vettä yhdisteestä, jonka kaava on 20 ?H /-\ /V— r4 \r3 H 25 jossa Rj, R2» R3 ja R4 merkitsevät samaa kuin aikaisemmin ja n on 1-4, joko keittämällä palautuksella sopivassa happamassa liuoksessa 30 tai kuumentamalla vedettömän kaliumvetysulfaatin kanssa, b) saatetaan imidatsolialdehydi, jonka kaava on <xL 20 7341 6 1 jossa R4 merkitsee samaa kuin ennen, reagoimaan aralkylideeni-trifenyylifosforaanin kanssa, jonka kaava on 5 (C6H5)3P=CH-(CH2)n— jossa Rj, R2 ja R3 merkitsevät samaa kuin aikaisemmin ja n on 0-3. 11 7341 6
1 Patentkrav Analogi för far and e för framstäl lning av terapeutiskt aktiva 4-(fenylalkenyl)-iraidazolderivat med formeln N-η-^Η-ΟΗ-(θΗ2)-/0\_Κι IfX H ^R3 10 i vilken R^, R2 och R3, soin kan vara samma eller olika, betyder väte, klor, metyl, etyl eller raetoxi; R^ är väte eller raetyl; och n 'ar ett helt tai 0-3, 15 samt deras ieke-toxiska, farmaceutiskt acceptable syraadditions-salter, kännetecknat därav, att a) fran en förening med formeln
20 OH --- Λ,—w*-<2fc;£ 25 i vilken Rj, R2, R3 och R^ betyder samma sora tidigare och n är 1-4, avspjälkes vatten antingen genom äterflödeskokning i en lämplig eur lösning eller genom upphettning med kaiiumväte-sulfat,
FI810389A 1980-02-13 1981-02-11 Förfarande för framställning av terapeutiskt aktiva 4-(fenylalkenyl)-i midazolderivat. FI73416C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8004748 1980-02-13
GB8004748A GB2069481B (en) 1980-02-13 1980-02-13 Substituted imidazole derivatives

Publications (3)

Publication Number Publication Date
FI810389L FI810389L (fi) 1981-08-14
FI73416B true FI73416B (fi) 1987-06-30
FI73416C FI73416C (sv) 1987-10-09

Family

ID=10511309

Family Applications (2)

Application Number Title Priority Date Filing Date
FI810250A FI73415C (sv) 1980-02-13 1981-01-29 Förfarande för framställning av terapeutiskt aktiva 4-substituerade im idazolderivat.
FI810389A FI73416C (sv) 1980-02-13 1981-02-11 Förfarande för framställning av terapeutiskt aktiva 4-(fenylalkenyl)-i midazolderivat.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI810250A FI73415C (sv) 1980-02-13 1981-01-29 Förfarande för framställning av terapeutiskt aktiva 4-substituerade im idazolderivat.

Country Status (17)

Country Link
US (3) US4333947A (sv)
EP (2) EP0034473B1 (sv)
JP (2) JPS56128767A (sv)
AT (2) ATE2322T1 (sv)
AU (2) AU528275B2 (sv)
CA (2) CA1167454A (sv)
DD (1) DD156260A1 (sv)
DE (2) DE3160905D1 (sv)
DK (2) DK157861C (sv)
FI (2) FI73415C (sv)
GB (1) GB2069481B (sv)
IE (2) IE50771B1 (sv)
IL (2) IL62110A (sv)
NO (2) NO154089C (sv)
NZ (2) NZ196251A (sv)
SU (1) SU1074404A3 (sv)
ZA (2) ZA81977B (sv)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
HU194808B (en) * 1983-08-17 1988-03-28 Syntex Inc Process for producing new alpha-allene-alpha-aminoacids and pharmaceutical compositions containing them as active components
JPH062746B2 (ja) * 1984-07-23 1994-01-12 三井石油化学工業株式会社 イミダゾ−ル類の製造方法
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
GB8523255D0 (en) * 1985-09-20 1985-10-23 Shell Int Research Imidazoles
DE3539629A1 (de) * 1985-11-08 1987-05-14 Basf Ag Dialkoxyketone und ein verfahren zu ihrer herstellung
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
GB2210875B (en) * 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
GB8726110D0 (en) * 1987-11-06 1987-12-09 Shell Int Research Imidazole ketone derivatives
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5304569A (en) * 1989-11-13 1994-04-19 Orion-Yhtyma Oy Compositions and their use in lowering intraocular pressure
DE4003243A1 (de) * 1990-02-03 1991-08-08 Basf Ag Verwendung von trialkanolaminpolyethern als demulgatoren von oel-in-wasser-emulsionen
DE4006255A1 (de) * 1990-02-28 1991-08-29 Basf Ag Als emulgatoren von oel-in-wasser-emulsionen geeignete kondensationsprodukte
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
DE4136661A1 (de) * 1991-11-07 1993-05-13 Basf Ag Erdoelemulsionsspalter
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
FR2732017B1 (fr) * 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
PT841922E (pt) * 1995-05-30 2002-07-31 Gliatech Inc Derivados de ih-imidazole 4(5)-substituidos
JPH099441A (ja) * 1995-06-21 1997-01-10 Yoshinari Denki Kogyosho:Kk ケーブルベンダー
EP1140858A2 (en) * 1998-12-23 2001-10-10 AstraZeneca AB Arylpropenylimidazoles as farnesyl-protein transferase inhibitors
US8044206B2 (en) 2003-03-07 2011-10-25 Astellas Pharma Inc. Nitrogen—containing heterocyclic derivatives having 2,6-disubstituted styryl
EP1918282A1 (en) * 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Method for preparing medetomidine and its salts
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
WO2023137554A1 (en) * 2022-01-20 2023-07-27 Benderdour Mohamed Resolvin analogs compounds, methods and uses thereof

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US2946804A (en) * 1958-12-29 1960-07-26 Abbott Lab (5-methyl-4-imidazolyl)-diphenyl carbinol salts and lower alkyl quaternaries
US3050520A (en) * 1960-03-31 1962-08-21 Air Prod & Chem Process of preparing 2-olefinic imidazoles
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US3202660A (en) * 1961-10-09 1965-08-24 Boehringer Sohn Ingelheim Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes
US3448108A (en) * 1965-04-16 1969-06-03 Schering Corp Substituted phenethyl heterocycles and their derivatives
US3502661A (en) * 1967-02-14 1970-03-24 Pfizer & Co C Process for making 1,4,5,6-tetrahydro-2-((2-substituted)vinyl) pyrimidines and 2-((2-substituted)vinyl)-2-imidazolines
BE793407A (fr) * 1971-12-28 1973-06-28 Hoechst Ag Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation
US3812111A (en) * 1972-12-04 1974-05-21 Commercial Solvents Corp Imidazoline tranquilizing agents
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
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US4085209A (en) * 1975-02-05 1978-04-18 Rohm And Haas Company Preparation and safening effect of 1-substituted imidazole metal salt complexes
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Also Published As

Publication number Publication date
DK57181A (da) 1981-08-14
IE50771B1 (en) 1986-07-09
US4568686A (en) 1986-02-04
AU528275B2 (en) 1983-04-21
DE3160905D1 (en) 1983-10-27
JPH0215538B2 (sv) 1990-04-12
CA1160238A (en) 1984-01-10
ATE4709T1 (de) 1983-10-15
NO154089B (no) 1986-04-07
NZ196250A (en) 1983-06-17
AU6716381A (en) 1981-08-20
NO810478L (no) 1981-08-14
US4333947A (en) 1982-06-08
EP0034474B1 (en) 1983-01-26
ZA81978B (en) 1982-03-31
SU1074404A3 (ru) 1984-02-15
FI810389L (fi) 1981-08-14
US4684659A (en) 1987-08-04
ATE2322T1 (de) 1983-02-15
FI810250L (fi) 1981-08-14
NO154089C (no) 1986-07-16
FI73415C (sv) 1987-10-09
AU6716481A (en) 1981-08-20
DE3160036D1 (en) 1983-03-03
GB2069481A (en) 1981-08-26
EP0034473A3 (en) 1981-11-18
DK57281A (da) 1981-08-14
IE810275L (en) 1981-08-13
IL62111A (en) 1985-03-31
IE810274L (en) 1981-08-13
DK157861C (da) 1990-07-30
JPH0249308B2 (sv) 1990-10-29
EP0034474A1 (en) 1981-08-26
CA1167454A (en) 1984-05-15
EP0034473A2 (en) 1981-08-26
IE50772B1 (en) 1986-07-09
AU537028B2 (en) 1984-05-31
FI73416C (sv) 1987-10-09
JPS56128767A (en) 1981-10-08
NZ196251A (en) 1983-05-31
DD156260A1 (de) 1982-08-11
FI73415B (fi) 1987-06-30
NO810479L (no) 1981-08-14
GB2069481B (en) 1983-07-27
NO153455C (no) 1986-05-07
NO153455B (no) 1985-12-16
DK151627B (da) 1987-12-21
JPS56128768A (en) 1981-10-08
IL62110A (en) 1986-01-31
DK151627C (da) 1988-06-20
EP0034473B1 (en) 1983-09-21
DK157861B (da) 1990-02-26
ZA81977B (en) 1982-03-31

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Owner name: FARMOS-YHTYMAE OY