FI71307C - Foerfarande foer framstaellning av terapeutiskt aktiv n-/3-merkaptoacetylamino)bensoyl/glycin - Google Patents
Foerfarande foer framstaellning av terapeutiskt aktiv n-/3-merkaptoacetylamino)bensoyl/glycin Download PDFInfo
- Publication number
- FI71307C FI71307C FI781866A FI781866A FI71307C FI 71307 C FI71307 C FI 71307C FI 781866 A FI781866 A FI 781866A FI 781866 A FI781866 A FI 781866A FI 71307 C FI71307 C FI 71307C
- Authority
- FI
- Finland
- Prior art keywords
- mercaptoacetylamino
- benzoyl
- glycine
- salt
- prepared
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (11)
1. Förfarande för framställning av terapeutiskt aktiv N-/3-(merkaptoacetylamino)bensoy1/glycin med formeln (I) och farmaceu-tiskt godtagbara salter därav, ° 0 HSCH_CNH ^ I_CNHCH_CO_H (I) 2 2 2 kännetecknat därav, att en tioester med formeln (V) O O O ch3cs-ch2cnh--cnhch2co2ch3 (V) hydrolyseras under användning av en alkoxid, säsom tili exempel natrium- eller kaliummetoxid, eller en bas, säsom tili exempel natriumhydroxid eller kaliumhydroxid, i ett reaktionsinert lös-ningsmedel, företrädesvis i kväveatmosfär, och reaktionsbland-ningen surgörs, varefter den sä erhällna föreningen med formeln (I) omvandlas tili ett farmaceutiskt godtagbart sait därav, om sä önskas.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att det framställs ett sait av föreningen med formeln (I) i en stabil kristallin form.
3. Förfarande enligt patentkravet 2, kännetecknat därav, att det framställs ett natriumsalt av N-/3-(merkaptoacetyl-amino)bensoyl7glycin.
4. Förfarande enligt patentkravet 2, kännetecknat därav, att det framställs ett 3,5-hydratnatriumsalt av N-/3-(mer-kaptoacetylamino)bensoyl7glycin.
5. Förfarande enligt patentkravet 2, kännetecknat därav, att det framställs ett 1,2-etandiammoniumsalt av N-/”3-(mer-kaptoacetylamino)bensoyl7glycin.
6. Förfarande enligt patentkravet 2, kännetecknat därav, att det framställs ett kaliumsalt av N-/3-(merkaptoacetyl-amino)bensoy17glycin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80687777 | 1977-06-15 | ||
US05/806,877 US4093739A (en) | 1977-06-15 | 1977-06-15 | Mercaptoacylamidobenzoyl glycine and mucolytic process |
Publications (3)
Publication Number | Publication Date |
---|---|
FI781866A FI781866A (fi) | 1978-12-16 |
FI71307B FI71307B (fi) | 1986-09-09 |
FI71307C true FI71307C (fi) | 1986-12-19 |
Family
ID=25195031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI781866A FI71307C (fi) | 1977-06-15 | 1978-06-12 | Foerfarande foer framstaellning av terapeutiskt aktiv n-/3-merkaptoacetylamino)bensoyl/glycin |
Country Status (21)
Country | Link |
---|---|
US (2) | US4093739A (sv) |
JP (1) | JPS545933A (sv) |
AU (1) | AU520094B2 (sv) |
BE (1) | BE868114A (sv) |
CA (1) | CA1132607A (sv) |
CH (1) | CH635067A5 (sv) |
DE (1) | DE2825931C2 (sv) |
DK (1) | DK268478A (sv) |
ES (1) | ES470825A1 (sv) |
FI (1) | FI71307C (sv) |
FR (1) | FR2394526A1 (sv) |
GB (1) | GB2001958B (sv) |
GR (1) | GR73530B (sv) |
IE (1) | IE46995B1 (sv) |
IT (1) | IT1107483B (sv) |
LU (1) | LU79805A1 (sv) |
NL (1) | NL7806360A (sv) |
PH (1) | PH13512A (sv) |
SE (1) | SE441526B (sv) |
YU (1) | YU40195B (sv) |
ZA (1) | ZA783443B (sv) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296500A (en) * | 1991-08-30 | 1994-03-22 | The Procter & Gamble Company | Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy |
SE9103572D0 (sv) * | 1991-11-29 | 1991-11-29 | Astra Ab | Organic salts of n,n'-diacetyl cystine |
US5432186A (en) * | 1993-11-16 | 1995-07-11 | Ciba-Geigy Corporation | Cyclic amino acid derivatives |
PT655461E (pt) * | 1993-11-16 | 2000-11-30 | Novartis Ag | Derivados ciclicos de aminoacidos |
US5451405A (en) * | 1994-04-25 | 1995-09-19 | Chesebrough-Pond's Usa Co. | Skin treatment composition |
JP3261969B2 (ja) * | 1996-02-29 | 2002-03-04 | 豊田合成株式会社 | ホースとその製造方法 |
US6294695B1 (en) | 1998-03-26 | 2001-09-25 | Mount Sinai School Of Medicine Of The City University Of New York | Aminobenzoic acid derivatives having anti-tumorigenic activity methods of making and using the same |
US6797319B2 (en) * | 2002-05-31 | 2004-09-28 | Kimberly-Clark Worldwide, Inc. | Application of foam to tissue products using a liquid permeable partition |
CA3075035A1 (en) | 2017-09-07 | 2019-03-14 | The Children's Hospital Of Philadelphia | Compositions and methods for treatment of hereditary cystatin c amyloid angiopathy (hccaa) and other neurodegenerative disorders associated with aberrant amyloid deposits |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2520293A (en) * | 1947-01-30 | 1950-08-29 | Endo Products Inc | Mercaptoacetanilide derivatives |
US3091569A (en) * | 1960-08-26 | 1963-05-28 | Mead Johnson & Co | Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus |
US3663690A (en) * | 1969-08-12 | 1972-05-16 | Hoechst Co American | Mucolytic composition and method of treatment of broncho-pulmonary disorders therewith |
BE789811A (fr) * | 1971-10-07 | 1973-04-06 | Bristol Myers Co | 1,4-bis-acylpiperazines |
BE789838A (fr) * | 1971-10-13 | 1973-02-01 | Cerm Cent Europ Rech Mauvernay | Nouveaux derives de la cysteine et leur application en therapeutique |
FR2187327B1 (sv) * | 1972-06-15 | 1975-06-20 | Rech Pharm Scientifiques | |
US3971828A (en) * | 1972-10-03 | 1976-07-27 | Santen Pharmaceutical Co. Ltd. | N-(mercaptoacyl)aminoacids |
US3857951A (en) * | 1973-09-14 | 1974-12-31 | Cassenne Lab Sa | Use of 2-mercaptopropionylglycine and its alkali metal salts in treating respiratory diseases |
US4005222A (en) * | 1975-05-21 | 1977-01-25 | Mead Johnson & Company | Mucolytic mercaptoacylamidobenzoic and benzenesulfonic acid compounds and process |
-
1977
- 1977-06-15 US US05/806,877 patent/US4093739A/en not_active Expired - Lifetime
-
1978
- 1978-03-24 US US05/889,674 patent/US4132803A/en not_active Expired - Lifetime
- 1978-04-21 CA CA301,723A patent/CA1132607A/en not_active Expired
- 1978-06-09 YU YU1375/78A patent/YU40195B/xx unknown
- 1978-06-10 GR GR56494A patent/GR73530B/el unknown
- 1978-06-12 NL NL7806360A patent/NL7806360A/xx not_active Application Discontinuation
- 1978-06-12 FI FI781866A patent/FI71307C/fi not_active IP Right Cessation
- 1978-06-13 LU LU79805A patent/LU79805A1/xx unknown
- 1978-06-13 JP JP7046078A patent/JPS545933A/ja active Granted
- 1978-06-14 IT IT49864/78A patent/IT1107483B/it active
- 1978-06-14 DK DK268478A patent/DK268478A/da not_active Application Discontinuation
- 1978-06-14 FR FR7817799A patent/FR2394526A1/fr active Granted
- 1978-06-14 GB GB7826928A patent/GB2001958B/en not_active Expired
- 1978-06-14 AU AU37112/78A patent/AU520094B2/en not_active Expired
- 1978-06-14 BE BE188564A patent/BE868114A/xx not_active IP Right Cessation
- 1978-06-14 IE IE1194/78A patent/IE46995B1/en unknown
- 1978-06-14 DE DE2825931A patent/DE2825931C2/de not_active Expired
- 1978-06-14 SE SE7806880A patent/SE441526B/sv not_active IP Right Cessation
- 1978-06-15 ZA ZA00783443A patent/ZA783443B/xx unknown
- 1978-06-15 CH CH655278A patent/CH635067A5/de not_active IP Right Cessation
- 1978-06-15 ES ES470825A patent/ES470825A1/es not_active Expired
- 1978-06-19 PH PH21281A patent/PH13512A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IT7849864A0 (it) | 1978-06-14 |
AU3711278A (en) | 1979-12-20 |
LU79805A1 (fr) | 1979-02-02 |
AU520094B2 (en) | 1982-01-14 |
US4132803A (en) | 1979-01-02 |
FI71307B (fi) | 1986-09-09 |
GB2001958B (en) | 1982-02-03 |
ZA783443B (en) | 1979-06-27 |
JPS545933A (en) | 1979-01-17 |
GR73530B (sv) | 1984-03-12 |
YU137578A (en) | 1983-01-21 |
NL7806360A (nl) | 1978-12-19 |
CA1132607A (en) | 1982-09-28 |
BE868114A (fr) | 1978-12-14 |
DE2825931C2 (de) | 1987-01-29 |
SE441526B (sv) | 1985-10-14 |
JPS6225657B2 (sv) | 1987-06-04 |
IT1107483B (it) | 1985-11-25 |
PH13512A (en) | 1980-06-03 |
IE46995B1 (en) | 1983-11-30 |
SE7806880L (sv) | 1978-12-16 |
GB2001958A (en) | 1979-02-14 |
IE781194L (en) | 1978-12-15 |
US4093739A (en) | 1978-06-06 |
CH635067A5 (de) | 1983-03-15 |
FR2394526B1 (sv) | 1980-07-04 |
DE2825931A1 (de) | 1979-01-04 |
DK268478A (da) | 1978-12-16 |
ES470825A1 (es) | 1979-10-01 |
YU40195B (en) | 1985-08-31 |
FI781866A (fi) | 1978-12-16 |
FR2394526A1 (fr) | 1979-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: BRISTOL-MYERS CO |