FI69305C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 7-oxo-pgi2-derivat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 7-oxo-pgi2-derivat Download PDFInfo
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- FI69305C FI69305C FI803466A FI803466A FI69305C FI 69305 C FI69305 C FI 69305C FI 803466 A FI803466 A FI 803466A FI 803466 A FI803466 A FI 803466A FI 69305 C FI69305 C FI 69305C
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- methyl
- hydrogen
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- same
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- 230000001225 therapeutic effect Effects 0.000 title 2
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- 239000001257 hydrogen Substances 0.000 claims description 45
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- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 25
- 125000006239 protecting group Chemical group 0.000 claims description 22
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- 239000002674 ointment Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002892 organic cations Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- YYCIBTCQCMPCMU-XKZHYVMSSA-M sodium;(5z)-5-[(3ar,4r,5r,6as)-5-hydroxy-4-[(e,3s)-3-hydroxyoct-1-enyl]-3-oxo-4,5,6,6a-tetrahydro-3ah-cyclopenta[b]furan-2-ylidene]pentanoate Chemical class [Na+].O1\C(=C/CCCC([O-])=O)C(=O)[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 YYCIBTCQCMPCMU-XKZHYVMSSA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- DHHKPEUQJIEKOA-UHFFFAOYSA-N tert-butyl 2-[6-(nitromethyl)-6-bicyclo[3.2.0]hept-3-enyl]acetate Chemical compound C1C=CC2C(CC(=O)OC(C)(C)C)(C[N+]([O-])=O)CC21 DHHKPEUQJIEKOA-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI001988 HU182013B (en) | 1979-11-12 | 1979-11-12 | Process for producing 7-oxo-pgi-two down and analogous compounds |
| HUCI001988 | 1979-11-12 | ||
| HUCI001987 | 1979-11-12 | ||
| HU79CI1987A HU182012B (en) | 1979-11-12 | 1979-11-12 | Process for preparing 6-substituted-7-oxo-pgi down 1 derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI803466L FI803466L (fi) | 1981-05-13 |
| FI69305B FI69305B (fi) | 1985-09-30 |
| FI69305C true FI69305C (fi) | 1986-01-10 |
Family
ID=26318432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI803466A FI69305C (fi) | 1979-11-12 | 1980-11-06 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 7-oxo-pgi2-derivat |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT380016B (enrdf_load_stackoverflow) |
| CS (1) | CS222191B2 (enrdf_load_stackoverflow) |
| DD (1) | DD154295A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3066636D1 (enrdf_load_stackoverflow) |
| DK (1) | DK160497C (enrdf_load_stackoverflow) |
| FI (1) | FI69305C (enrdf_load_stackoverflow) |
| GR (1) | GR71859B (enrdf_load_stackoverflow) |
| IL (1) | IL61421A (enrdf_load_stackoverflow) |
| PL (1) | PL129277B1 (enrdf_load_stackoverflow) |
| SU (1) | SU1056899A3 (enrdf_load_stackoverflow) |
| YU (1) | YU287880A (enrdf_load_stackoverflow) |
-
1980
- 1980-11-05 IL IL61421A patent/IL61421A/xx unknown
- 1980-11-06 FI FI803466A patent/FI69305C/fi not_active IP Right Cessation
- 1980-11-08 DE DE8080106884T patent/DE3066636D1/de not_active Expired
- 1980-11-11 PL PL22777180A patent/PL129277B1/pl unknown
- 1980-11-11 CS CS760780A patent/CS222191B2/cs unknown
- 1980-11-11 SU SU803005355A patent/SU1056899A3/ru active
- 1980-11-11 GR GR63330A patent/GR71859B/el unknown
- 1980-11-11 DK DK480480A patent/DK160497C/da not_active IP Right Cessation
- 1980-11-11 YU YU287880A patent/YU287880A/xx unknown
- 1980-11-12 AT AT556280A patent/AT380016B/de not_active IP Right Cessation
- 1980-11-12 DD DD22513280A patent/DD154295A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK160497C (da) | 1991-09-16 |
| PL129277B1 (en) | 1984-04-30 |
| IL61421A (en) | 1984-08-31 |
| FI69305B (fi) | 1985-09-30 |
| DK160497B (da) | 1991-03-18 |
| DD154295A5 (de) | 1982-03-10 |
| IL61421A0 (en) | 1980-12-31 |
| DE3066636D1 (en) | 1984-03-22 |
| FI803466L (fi) | 1981-05-13 |
| DK480480A (da) | 1981-05-13 |
| PL227771A1 (enrdf_load_stackoverflow) | 1981-07-24 |
| GR71859B (enrdf_load_stackoverflow) | 1983-07-05 |
| ATA556280A (de) | 1985-08-15 |
| AT380016B (de) | 1986-03-25 |
| CS222191B2 (en) | 1983-05-27 |
| SU1056899A3 (ru) | 1983-11-23 |
| YU287880A (en) | 1983-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: CHINOIN GYOGUSZER ES VEGYESZETI TERMEKEK |