FI68618C - Foerfarande foer framstaellning av terapeutiskt anvaendbara imdazolidinderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara imdazolidinderivat Download PDF

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Publication number
FI68618C
FI68618C FI783170A FI783170A FI68618C FI 68618 C FI68618 C FI 68618C FI 783170 A FI783170 A FI 783170A FI 783170 A FI783170 A FI 783170A FI 68618 C FI68618 C FI 68618C
Authority
FI
Finland
Prior art keywords
formula
compound
imino
trifluoromethyl
group
Prior art date
Application number
FI783170A
Other languages
English (en)
Finnish (fi)
Other versions
FI783170A (fi
FI68618B (fi
Inventor
Karl Bernauer
Helmut Link
Harro Stohler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH546578A external-priority patent/CH642944A5/de
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI783170A publication Critical patent/FI783170A/fi
Application granted granted Critical
Publication of FI68618B publication Critical patent/FI68618B/fi
Publication of FI68618C publication Critical patent/FI68618C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI783170A 1977-10-28 1978-10-18 Foerfarande foer framstaellning av terapeutiskt anvaendbara imdazolidinderivat FI68618C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
LU78407 1977-10-28
LU78407 1977-10-28
CH546578A CH642944A5 (en) 1978-05-19 1978-05-19 Urea derivatives
CH546578 1978-05-19
CH936778 1978-09-06
CH936778 1978-09-06

Publications (3)

Publication Number Publication Date
FI783170A FI783170A (fi) 1979-04-29
FI68618B FI68618B (fi) 1985-06-28
FI68618C true FI68618C (fi) 1985-10-10

Family

ID=27175218

Family Applications (1)

Application Number Title Priority Date Filing Date
FI783170A FI68618C (fi) 1977-10-28 1978-10-18 Foerfarande foer framstaellning av terapeutiskt anvaendbara imdazolidinderivat

Country Status (26)

Country Link
US (2) US4407814A (no)
EP (1) EP0001813B1 (no)
JP (1) JPS5470271A (no)
AR (2) AR219560A1 (no)
AT (2) AT366374B (no)
AU (1) AU522536B2 (no)
BR (1) BR7807097A (no)
CA (1) CA1107744A (no)
CU (1) CU34980A (no)
DE (2) DE2846946A1 (no)
DK (1) DK481678A (no)
ES (3) ES474592A1 (no)
FI (1) FI68618C (no)
FR (1) FR2422643A1 (no)
GB (1) GB2008102B (no)
GR (1) GR70681B (no)
IE (1) IE47962B1 (no)
IL (1) IL55773A (no)
IT (1) IT1099450B (no)
MC (1) MC1220A1 (no)
NL (1) NL7810563A (no)
NO (1) NO151461C (no)
NZ (1) NZ188721A (no)
PH (1) PH13569A (no)
PT (1) PT68705A (no)
SE (1) SE7811194L (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI801184A (fi) * 1979-04-24 1980-10-25 Hoffmann La Roche Foerfarande foer framstaellning av imidazolidinderivat
DE2933917A1 (de) * 1979-08-22 1981-03-26 Basf Ag, 67063 Ludwigshafen 5-imino-imidazolidin-2-one und diese enthaltende herbizide.
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
EP0091596B1 (de) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Neue Hydantoine, ihre Herstellung und Verwendung
US5112983A (en) * 1987-09-28 1992-05-12 Olin Corporation Process for producing 1,2,4-triazol-5-one using organic sulfonic acids and polymers thereof as a catalyst
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2671348B1 (fr) * 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
USRE35956E (en) * 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2724169B1 (fr) * 1994-09-06 1997-01-03 Roussel Uclaf Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2715402B1 (fr) * 1994-01-05 1996-10-04 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2741346B1 (fr) * 1995-11-16 1997-12-19 Roussel Uclaf Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
JP2004509072A (ja) * 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
JP2007514442A (ja) * 2003-12-19 2007-06-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 前立腺癌治療を評価するための方法および物質
NZ550102A (en) * 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
HUE053877T2 (hu) 2006-03-27 2021-07-28 Univ California Androgén receptormodulátor a prosztatarák és az androgén receptorral összefüggõ betegségek kezeléséhez
NZ572374A (en) 2006-03-29 2011-12-22 Univ California Diarylthiohydantoin compounds
CA2703635C (en) 2007-10-26 2017-06-27 Michael E. Jung Diarylhydantoin compounds as androgen receptor modulators
CN106983749A (zh) 2010-02-16 2017-07-28 亚拉冈制药公司 雄激素受体调节剂及其用途
BR112015006705A8 (pt) 2012-09-26 2019-08-27 Aragon Pharmaceuticals Inc antiandrogênios para o tratamento de câncer de próstata resistente à castração não metastático e usos destes
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CA3079135A1 (en) 2017-10-16 2019-04-25 Arturo Molina Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE629779A (no) *
US3134663A (en) * 1957-07-23 1964-05-26 Geigy Chem Corp Herbicidal composition and method employing hydantoins
FR1405725A (fr) * 1963-08-23 1965-07-09 Shell Int Research Procédé de préparation de la 5, 5-diméthyl-4-iminohydantoine
NO124370B (no) * 1968-03-28 1972-04-10 Ciba Geigy Ag
US3690863A (en) * 1968-04-19 1972-09-12 Du Pont Esters of 3-(carboxyamino)-and 3-(thiocarboxyamino)-2-substituted crotonamides andtheir use as herbicides
DK123717B (da) * 1968-11-25 1972-07-24 Sumitomo Chemical Co 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning.
JPS4916937B1 (no) * 1970-01-21 1974-04-25
US3676456A (en) * 1970-02-27 1972-07-11 Ciba Geigy Corp Derivatives of 3-aryl-5-alkylhydantoins
JPS5136332B1 (no) * 1970-12-09 1976-10-07
US4044021A (en) * 1971-10-21 1977-08-23 American Cyanamid Company Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism
IL45459A (en) * 1973-09-03 1978-01-31 Ciba Geigy Ag 1-(dichlorofluoromethylthio)-3-phenyl-imidazolidine-2,4-dione derivatives their preparation and their use as bactericides and fungicides
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
JPS5315373A (en) * 1976-07-29 1978-02-13 Mitsubishi Chem Ind Ltd Hydantoin derivatives and fungicides containing same for agriculture and horiticulture
CA1138334A (en) * 1977-10-28 1982-12-28 Karl Bernauer Pharmaceutical preparations containing certain urea derivatives
US4358606A (en) * 1981-06-19 1982-11-09 Zoecon Corporation Esters of phenalkyloxycarbonylamino acids

Also Published As

Publication number Publication date
AR220004A1 (es) 1980-09-30
AU522536B2 (en) 1982-06-10
BR7807097A (pt) 1979-05-08
US4482739A (en) 1984-11-13
FR2422643A1 (fr) 1979-11-09
IT1099450B (it) 1985-09-18
GB2008102A (en) 1979-05-31
AT366671B (de) 1982-04-26
DE2846946A1 (de) 1979-05-03
ES480109A1 (es) 1980-04-01
CA1107744A (en) 1981-08-25
NO151461C (no) 1985-04-17
NZ188721A (en) 1984-11-09
FI783170A (fi) 1979-04-29
DK481678A (da) 1979-04-29
CU34980A (es) 1981-12-04
GR70681B (no) 1982-12-20
US4407814A (en) 1983-10-04
ES480114A1 (es) 1980-04-01
FR2422643B1 (no) 1982-10-29
ATA768978A (de) 1981-08-15
PT68705A (en) 1978-11-01
ES474592A1 (es) 1980-04-01
IE47962B1 (en) 1984-08-08
DE2861289D1 (en) 1982-01-14
PH13569A (en) 1980-06-26
EP0001813B1 (de) 1981-11-04
GB2008102B (en) 1982-07-07
EP0001813A1 (de) 1979-05-16
AT366374B (de) 1982-04-13
IT7829040A0 (it) 1978-10-24
JPS625145B2 (no) 1987-02-03
FI68618B (fi) 1985-06-28
IL55773A0 (en) 1978-12-17
SE7811194L (sv) 1979-04-29
NO151461B (no) 1985-01-02
ATA18281A (de) 1981-09-15
IE782130L (en) 1979-04-28
NL7810563A (nl) 1979-05-02
JPS5470271A (en) 1979-06-05
AU4096178A (en) 1980-05-01
AR219560A1 (es) 1980-08-29
IL55773A (en) 1982-02-28
NO783642L (no) 1979-05-02
MC1220A1 (fr) 1979-07-20

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: F. HOFFMANN-LA ROCHE & CO. AKTIENGESELL-