FI67389C - Framstaellning av saosom 5alfa-reduktas-inhibitorer anvaendbara 4-aza-17-substituerad-5alfa-androstan-3-oner - Google Patents

Framstaellning av saosom 5alfa-reduktas-inhibitorer anvaendbara 4-aza-17-substituerad-5alfa-androstan-3-oner Download PDF

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Publication number
FI67389C
FI67389C FI791193A FI791193A FI67389C FI 67389 C FI67389 C FI 67389C FI 791193 A FI791193 A FI 791193A FI 791193 A FI791193 A FI 791193A FI 67389 C FI67389 C FI 67389C
Authority
FI
Finland
Prior art keywords
methyl
compound
aza
androstan
formula
Prior art date
Application number
FI791193A
Other languages
English (en)
Finnish (fi)
Other versions
FI791193A (fi
FI67389B (fi
Inventor
David Bruce Randolph Johnston
Gary Henry Rasmusson
Donald Floyd Reinhold
Torleif Utne
Ronald Bradford Jobson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI791193A publication Critical patent/FI791193A/fi
Application granted granted Critical
Publication of FI67389B publication Critical patent/FI67389B/fi
Publication of FI67389C publication Critical patent/FI67389C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI791193A 1978-04-13 1979-04-11 Framstaellning av saosom 5alfa-reduktas-inhibitorer anvaendbara 4-aza-17-substituerad-5alfa-androstan-3-oner FI67389C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/896,120 US4179453A (en) 1978-04-13 1978-04-13 Process for preparing 17β-carboxy-5-androsten-3-ones
US89612078 1978-04-13

Publications (3)

Publication Number Publication Date
FI791193A FI791193A (fi) 1979-10-14
FI67389B FI67389B (fi) 1984-11-30
FI67389C true FI67389C (fi) 1985-03-11

Family

ID=25405660

Family Applications (1)

Application Number Title Priority Date Filing Date
FI791193A FI67389C (fi) 1978-04-13 1979-04-11 Framstaellning av saosom 5alfa-reduktas-inhibitorer anvaendbara 4-aza-17-substituerad-5alfa-androstan-3-oner

Country Status (11)

Country Link
US (1) US4179453A (pl)
AR (7) AR231991A1 (pl)
AT (1) AT377767B (pl)
DK (2) DK165325C (pl)
ES (1) ES479576A1 (pl)
FI (1) FI67389C (pl)
GR (1) GR68531B (pl)
NO (1) NO153141C (pl)
PL (2) PL223577A1 (pl)
PT (1) PT69451A (pl)
YU (1) YU86879A (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US4970205A (en) * 1988-12-23 1990-11-13 Smithkline Beecham Corporation Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
US5360881A (en) * 1989-06-14 1994-11-01 Societe Francaise Hoechst Method of cross-linking ethylene monomers using diallyloxyacetic acid and its basic addition salts as cross-linking agents
IE76452B1 (en) 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
FR2724174B1 (fr) * 1994-09-06 1997-01-17 Roussel Uclaf Procede de preparation d'un derive steroide 17beta-carboxy et nouveaux intermediaires

Also Published As

Publication number Publication date
AR224011A1 (es) 1981-10-15
DK165325C (da) 1993-03-29
NO153141B (no) 1985-10-14
PL223577A1 (pl) 1981-11-27
AR228037A1 (es) 1983-01-14
FI791193A (fi) 1979-10-14
DK165325B (da) 1992-11-09
PT69451A (en) 1979-05-01
AT377767B (de) 1985-04-25
AR241488A1 (es) 1992-07-31
ATA275079A (de) 1984-09-15
PL126826B1 (en) 1983-09-30
FI67389B (fi) 1984-11-30
AR222390A1 (es) 1981-05-15
ES479576A1 (es) 1979-12-01
DK92192D0 (da) 1992-07-15
YU86879A (en) 1983-10-31
US4179453A (en) 1979-12-18
AR225045A1 (es) 1982-02-15
PL214881A1 (pl) 1981-12-11
DK92192A (da) 1992-07-15
NO153141C (no) 1986-01-22
GR68531B (pl) 1982-01-14
AR222391A1 (es) 1981-05-15
NO791220L (no) 1979-10-16
AR231991A1 (es) 1985-04-30
DK152579A (da) 1979-10-14

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Legal Events

Date Code Title Description
MM Patent lapsed
FC Application refused
MM Patent lapsed

Owner name: MERCK & CO INC.