PT69451A - Process for preparing of 4-aza-17-substituted-5alpha-androstan-3-ones useful as 5alpha-reductase inhibitors - Google Patents

Process for preparing of 4-aza-17-substituted-5alpha-androstan-3-ones useful as 5alpha-reductase inhibitors

Info

Publication number
PT69451A
PT69451A PT69451A PT6945179A PT69451A PT 69451 A PT69451 A PT 69451A PT 69451 A PT69451 A PT 69451A PT 6945179 A PT6945179 A PT 6945179A PT 69451 A PT69451 A PT 69451A
Authority
PT
Portugal
Prior art keywords
5alpha
androstan
aza
substituted
preparing
Prior art date
Application number
PT69451A
Other languages
English (en)
Inventor
David Bruce Randolph Johnston
Gary Henry Rasmusson
Donald Floyd Reinhold
Torleif Utne
Ronald Bradford Jobson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT69451A publication Critical patent/PT69451A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT69451A 1978-04-13 1979-04-06 Process for preparing of 4-aza-17-substituted-5alpha-androstan-3-ones useful as 5alpha-reductase inhibitors PT69451A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/896,120 US4179453A (en) 1978-04-13 1978-04-13 Process for preparing 17β-carboxy-5-androsten-3-ones

Publications (1)

Publication Number Publication Date
PT69451A true PT69451A (en) 1979-05-01

Family

ID=25405660

Family Applications (1)

Application Number Title Priority Date Filing Date
PT69451A PT69451A (en) 1978-04-13 1979-04-06 Process for preparing of 4-aza-17-substituted-5alpha-androstan-3-ones useful as 5alpha-reductase inhibitors

Country Status (11)

Country Link
US (1) US4179453A (pt)
AR (7) AR231991A1 (pt)
AT (1) AT377767B (pt)
DK (2) DK165325C (pt)
ES (1) ES479576A1 (pt)
FI (1) FI67389C (pt)
GR (1) GR68531B (pt)
NO (1) NO153141C (pt)
PL (2) PL126826B1 (pt)
PT (1) PT69451A (pt)
YU (1) YU86879A (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
US4970205A (en) * 1988-12-23 1990-11-13 Smithkline Beecham Corporation Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
US5360881A (en) * 1989-06-14 1994-11-01 Societe Francaise Hoechst Method of cross-linking ethylene monomers using diallyloxyacetic acid and its basic addition salts as cross-linking agents
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
FR2724174B1 (fr) * 1994-09-06 1997-01-17 Roussel Uclaf Procede de preparation d'un derive steroide 17beta-carboxy et nouveaux intermediaires

Also Published As

Publication number Publication date
US4179453A (en) 1979-12-18
PL223577A1 (pt) 1981-11-27
FI67389B (fi) 1984-11-30
DK152579A (da) 1979-10-14
AR228037A1 (es) 1983-01-14
PL126826B1 (en) 1983-09-30
DK92192D0 (da) 1992-07-15
AR222391A1 (es) 1981-05-15
AT377767B (de) 1985-04-25
YU86879A (en) 1983-10-31
ES479576A1 (es) 1979-12-01
AR225045A1 (es) 1982-02-15
DK165325C (da) 1993-03-29
AR241488A1 (es) 1992-07-31
NO153141B (no) 1985-10-14
GR68531B (pt) 1982-01-14
AR222390A1 (es) 1981-05-15
AR231991A1 (es) 1985-04-30
DK165325B (da) 1992-11-09
FI791193A (fi) 1979-10-14
NO791220L (no) 1979-10-16
NO153141C (no) 1986-01-22
AR224011A1 (es) 1981-10-15
DK92192A (da) 1992-07-15
FI67389C (fi) 1985-03-11
ATA275079A (de) 1984-09-15
PL214881A1 (pt) 1981-12-11

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Legal Events

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MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19980530