FI66534B - Foerfarande foer framstaellning av immunoglobulin som innehaoller antikroppar och aer laempligt foer intravenoes administration - Google Patents
Foerfarande foer framstaellning av immunoglobulin som innehaoller antikroppar och aer laempligt foer intravenoes administration Download PDFInfo
- Publication number
- FI66534B FI66534B FI792757A FI792757A FI66534B FI 66534 B FI66534 B FI 66534B FI 792757 A FI792757 A FI 792757A FI 792757 A FI792757 A FI 792757A FI 66534 B FI66534 B FI 66534B
- Authority
- FI
- Finland
- Prior art keywords
- immunoglobulin
- solution
- precipitate
- polyethylene glycol
- purification step
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Electronic Switches (AREA)
Claims (7)
1. Förfarande för framställning av immunoglobulin, som inne-häller antikroppar ooh är lämpligt för intravenös administration, varvid människans blodplasma fraktioneras och frän den immunoglo-bulinhaltiga fraktionen avlägsnas de icke-önskade proteinförore-ningarna genom behandling av densamma med ett sait av en flervärd oorganisk syra och en eller flera gänger med polyetylenglykol, kännetecknat därav, att man a) i ett första reningssteg behandlar den immunoglobulinhaltiga fraktionen med en vattenlösning av ett ammoniumsulfat- eller alkali-metallfosfatsalt, och separerar och kastar bort den härvid bildade fällningen, b) behandlar den frän steget a) erhällna lösningen med en vattenlösning av ett ammoniumsulfat- eller alkalimetallfosfatsalt, vilken har en högre salthalt än den i steget a) använda lösningen, varvid fällningen inneh&llande immunoglobulinet utfälls, och utvinner fällningen och kastar bort lösningen, c) löser den immunoglobulinhaltiga fällningen i vatten, och avlägs-nar saltet frän lösningen, företrädesvis genom dialys, d) underkastar den äterstäende immunoglobulinhaltiga lösningen ett ytterligare reningssteg i närvaro av en monosackarid eller disackarid vid en jonstyrka av minst 0,15 genom behandling av densamma med polyetylenglykol, varvid det bildas en fällning, som man kastar bort, e) behandlar den äterstäende frän reningssteget d) erhällna lösningen ännu en gäng med polyetylenglykol, vars koncentration är större än i steget d), varvid man erhäller en frän skadliga föroreningar fri immunoglobulinhaltig lösning och en fällning, och den senare kastar man bort, f) behandlar den frän steget e) erhällna lösningen med en vattenlös-lig polymer, t.ex. att polymert polyol-utfällningsmedel, varvid immunoglobulinet utfälls.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man i det första reningssteget a) behandlar den immunoglobulinhaltiga fraktionen med en ammoniumsulfatlösning, vars koncentration är 145-208 g/1, vid ett pH-värde av 5,9-6,5.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT675378A AT359641B (de) | 1978-09-19 | 1978-09-19 | Verfahren zur herstellung eines intravenoes ver- abreichbaren antikoerperhaeltigen immunglobulin- praeparates |
AT675378 | 1978-09-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI792757A FI792757A (fi) | 1980-03-20 |
FI66534B true FI66534B (fi) | 1984-07-31 |
FI66534C FI66534C (fi) | 1984-11-12 |
Family
ID=3589418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI792757A FI66534C (fi) | 1978-09-19 | 1979-09-05 | Foerfarande foer framstaellning av immunoglobulin som innehaoller antikroppar och aer laempligt foer intravenoes administration |
Country Status (17)
Country | Link |
---|---|
US (1) | US4276283A (sv) |
JP (1) | JPS5547628A (sv) |
AT (1) | AT359641B (sv) |
BE (1) | BE878688A (sv) |
CA (1) | CA1112166A (sv) |
CH (1) | CH646608A5 (sv) |
DE (1) | DE2936047A1 (sv) |
DK (1) | DK154267C (sv) |
ES (1) | ES484292A1 (sv) |
FI (1) | FI66534C (sv) |
FR (1) | FR2436604A1 (sv) |
GB (1) | GB2030150B (sv) |
IT (1) | IT1123200B (sv) |
NL (1) | NL191670C (sv) |
NO (1) | NO154255C (sv) |
SE (1) | SE447790B (sv) |
YU (1) | YU44151B (sv) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4374763A (en) * | 1979-09-17 | 1983-02-22 | Morishita Pharmaceutical Co., Ltd. | Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof |
JPS5855432A (ja) * | 1981-09-29 | 1983-04-01 | Fujirebio Inc | 静脈注射用免疫グロブリンの製法 |
JPS58180433A (ja) * | 1982-04-16 | 1983-10-21 | Fujirebio Inc | 免疫グロブリンから抗補体作用物質の除去法 |
US4434093A (en) | 1982-07-26 | 1984-02-28 | Ortho Diagnostic Systems Inc. | Methods for preparation of HBs Ag free gamma globulins |
DE3382394D1 (de) * | 1982-08-30 | 1991-10-02 | Baxter Travenol Lab | Verfahren zur herstellung von gamma-globulin enthaltenden zusammensetzungen. |
US4639513A (en) * | 1984-02-02 | 1987-01-27 | Cuno Inc. | Intravenously injectable immunoglobulin G (IGG) and method for producing same |
DK166763B1 (da) * | 1983-03-16 | 1993-07-12 | Immuno Ag | Immunoglobulin-g-holdig fraktion |
AT383739B (de) * | 1983-03-16 | 1987-08-10 | Immuno Ag | Verfahren zur inaktivierung von unvertraeglichkeitsreaktionen verursachenden substanzen in immunglobulinhaeltigen blutfraktionen |
US5234685A (en) * | 1983-03-16 | 1993-08-10 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of determining incompatibility-reaction-causing substances in blood products as well as a method of inactivating said incompatibility-reaction-causing substances |
US4482483A (en) * | 1983-04-06 | 1984-11-13 | Armour Pharmceutical Company | Composition of intravenous immune globulin |
DE3344656A1 (de) * | 1983-12-09 | 1985-06-13 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer serumproteinloesung |
US4623541A (en) * | 1984-06-26 | 1986-11-18 | Candian Patents And Development Limited | Production of purified porcine immunoglobulins |
EP0256190A1 (en) * | 1986-08-20 | 1988-02-24 | Canadian Patents and Development Limited Société Canadienne des Brevets et d'Exploitation Limitée | Production of purified porcine immunoglobulins |
US4835257A (en) * | 1984-07-07 | 1989-05-30 | Armour Pharma Gmbh | Process for preparing gamma globulin suitable for intravenous administration using peg and a citrate buffer |
DE3483784D1 (de) * | 1984-07-07 | 1991-01-31 | Woelm Pharma Gmbh & Co | Verfahren zur herstellung von gamma-globulin zur intravenoesen anwendung. |
US5019557A (en) * | 1986-09-15 | 1991-05-28 | Pitts Jr Ferris N | Method for the effective treatment of disease conditions in humans associated with HTLV-III infection |
DE3641115A1 (de) * | 1986-12-02 | 1988-06-16 | Lentia Gmbh | Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins |
AT389817B (de) * | 1987-01-22 | 1990-02-12 | Schwab & Co Ges Mbh | Verfahren zur herstellung eines in fluessiger form stabilen immunglobulins zur intravenoesen anwendung |
CA1308023C (en) * | 1988-07-29 | 1992-09-29 | William Austin James Mcauley | Immunoglobulin extraction utilizing properties of colloidal solutions |
JPH0552008U (ja) * | 1991-04-04 | 1993-07-09 | 株式会社日本アルミ | 伸縮継手装置の耐火帯構造 |
DE4344824C1 (de) * | 1993-12-28 | 1995-08-31 | Immuno Ag | Hochkonzentriertes Immunglobulin-Präparat und Verfahren zu seiner Herstellung |
DE4424935C1 (de) * | 1994-07-14 | 1996-03-21 | Immuno Ag | Humanes virussicheres monomeres Immunglobulin A und Verfahren zu seiner Herstellung |
SI1324776T2 (en) | 2000-10-12 | 2018-06-29 | Genentech, Inc. | Concentrated protein formulations with reduced viscosity |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
BR0213298A (pt) * | 2001-10-16 | 2006-11-07 | Rxkinetix Inc | formulações com alta concentração de proteìna e processo de fabricação |
EP2121753A2 (en) * | 2007-02-14 | 2009-11-25 | Amgen, Inc | Method of isolating antibodies by precipitation |
SG174258A1 (en) | 2009-03-06 | 2011-10-28 | Genentech Inc | Antibody formulation |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1350895A (fr) * | 1962-01-03 | 1964-01-31 | South African Inventions | Précipitation des colloïdes organiques |
NL286954A (sv) * | 1962-01-03 | |||
SE348942B (sv) * | 1970-06-02 | 1972-09-18 | Statens Bakteriologiska Labor | |
DE2234069A1 (de) * | 1971-07-16 | 1973-02-08 | South African Inventions | Verfahren zur herstellung eines gereinigten gamma-globulins |
US3763135A (en) * | 1971-11-08 | 1973-10-02 | Baxter Laboratories Inc | Gamma globulin production from cohn fraction iii using polyethylene glycol |
JPS49101516A (sv) * | 1973-01-13 | 1974-09-25 | ||
DE2364792A1 (de) * | 1973-01-15 | 1974-07-18 | South African Inventions | Verfahren zum reinigen von gammaglobulin |
DE2500076C3 (de) * | 1975-01-02 | 1982-11-18 | SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld | Verfahren zur Gewinnung von intravenös-verträglichen Gammaglobulinen |
CA1064396A (en) * | 1975-02-18 | 1979-10-16 | Myer L. Coval | Fractional precipitation of gamma globulin with polyethylene glycol |
US4126605A (en) * | 1975-12-29 | 1978-11-21 | Plasmesco Ag | Process of improving the compatibility of gamma globulins |
US4165370A (en) * | 1976-05-21 | 1979-08-21 | Coval M L | Injectable gamma globulin |
JPS6016406B2 (ja) * | 1976-08-06 | 1985-04-25 | マイヤ−、ル−イス、コ−バル | 静脈内に投与可能なガンマ・グロブリンの製造法ならびにそれにより調製したガンマ・グロブリン |
JPS5347515A (en) * | 1976-10-13 | 1978-04-28 | Green Cross Corp:The | Gamma-globulin pharmaceutical preparation for intravenous injection |
US4124576A (en) * | 1976-12-03 | 1978-11-07 | Coval M L | Method of producing intravenously injectable gamma globulin |
DE2658334C3 (de) * | 1976-12-23 | 1987-05-07 | Behringwerke Ag, 3550 Marburg | Verfahren zum Herstellen von Immunglobulinpräparationen mit verminderter Komplementaktivität und ein diese enthaltendes Arzneimittel |
-
1978
- 1978-09-19 AT AT675378A patent/AT359641B/de not_active IP Right Cessation
-
1979
- 1979-08-23 SE SE7907045A patent/SE447790B/sv not_active IP Right Cessation
- 1979-08-31 FR FR7921922A patent/FR2436604A1/fr active Granted
- 1979-09-03 DK DK368579A patent/DK154267C/da not_active IP Right Cessation
- 1979-09-05 FI FI792757A patent/FI66534C/fi not_active IP Right Cessation
- 1979-09-06 DE DE19792936047 patent/DE2936047A1/de active Granted
- 1979-09-06 NL NL7906685A patent/NL191670C/xx not_active IP Right Cessation
- 1979-09-07 CA CA335,211A patent/CA1112166A/en not_active Expired
- 1979-09-10 BE BE0/197072A patent/BE878688A/xx not_active IP Right Cessation
- 1979-09-10 US US06/074,257 patent/US4276283A/en not_active Expired - Lifetime
- 1979-09-13 CH CH830779A patent/CH646608A5/de not_active IP Right Cessation
- 1979-09-13 GB GB7931744A patent/GB2030150B/en not_active Expired
- 1979-09-13 JP JP11679879A patent/JPS5547628A/ja active Granted
- 1979-09-17 YU YU2259/79A patent/YU44151B/xx unknown
- 1979-09-18 NO NO793001A patent/NO154255C/no unknown
- 1979-09-18 IT IT7925778A patent/IT1123200B/it active
- 1979-09-19 ES ES484292A patent/ES484292A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IT7925778A0 (it) | 1979-09-18 |
ES484292A1 (es) | 1980-05-16 |
DK154267C (da) | 1989-03-28 |
NL7906685A (nl) | 1980-03-21 |
NO793001L (no) | 1980-03-20 |
JPS5547628A (en) | 1980-04-04 |
GB2030150B (en) | 1982-11-03 |
BE878688A (fr) | 1979-12-31 |
DE2936047A1 (de) | 1980-03-27 |
JPH0253408B2 (sv) | 1990-11-16 |
DK368579A (da) | 1980-03-20 |
FR2436604A1 (fr) | 1980-04-18 |
GB2030150A (en) | 1980-04-02 |
IT1123200B (it) | 1986-04-30 |
AT359641B (de) | 1980-11-25 |
NO154255C (no) | 1986-08-20 |
YU225979A (en) | 1983-10-31 |
FI792757A (fi) | 1980-03-20 |
FR2436604B1 (sv) | 1982-11-05 |
NL191670B (nl) | 1995-10-02 |
CH646608A5 (de) | 1984-12-14 |
DE2936047C2 (sv) | 1988-10-27 |
NL191670C (nl) | 1996-02-05 |
YU44151B (en) | 1990-02-28 |
FI66534C (fi) | 1984-11-12 |
SE7907045L (sv) | 1980-03-20 |
SE447790B (sv) | 1986-12-15 |
US4276283A (en) | 1981-06-30 |
ATA675378A (de) | 1980-04-15 |
NO154255B (no) | 1986-05-12 |
CA1112166A (en) | 1981-11-10 |
DK154267B (da) | 1988-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |
Owner name: "IMMUNO" AKTIENGESELLSCHAFT FUER |