FI65253C - Foerfarande foer framstaellning av antibakteriellt verksamma 9-aminodeoxi-clavulansyraderivat - Google Patents
Foerfarande foer framstaellning av antibakteriellt verksamma 9-aminodeoxi-clavulansyraderivat Download PDFInfo
- Publication number
- FI65253C FI65253C FI781201A FI781201A FI65253C FI 65253 C FI65253 C FI 65253C FI 781201 A FI781201 A FI 781201A FI 781201 A FI781201 A FI 781201A FI 65253 C FI65253 C FI 65253C
- Authority
- FI
- Finland
- Prior art keywords
- acid
- benzyl
- formula
- evaporated
- water
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
Claims (5)
1 V/ \ch2-r7 )-N 0 co2A vari A och har samma betydelse som i formeln II, eller A betecknar en hydrogenolyserbar estergrupp, och R^ Sr en fenylgrupp, som kan vara substituerad med en eller flera av grupperna fluor, klor, alkyl, alkoxi, hydroxi eller alkanoylamino, eller b) hydrerar en förening med formeln H C0-0-CH2R? \^0 , CH„-N (XI) —Y W 2 \ch2-Ri )-N-Y 0 co2a vari A, R^ och har samma betydelse som i formeln X, och om det är önskvärt förestrar den medelst förfarandet a) eller b) etohällna amfotera föreningen tili bildning av estrar med formeln II, och om det är önskvärt omvandlar den erhällna produkten tili ett farmaceutiskt acceptabelt sait.
1. Förfarande för framställning av antibakteriellt verksamma 9-aminodeoxiclavulansyraderivat med formeln H s \/0. CH--NH-CH_-R.. i—T \=/ / (II) X-N CT \ \ C02A 65253 49 eller farmaceutiskt acceptabla salter därav, väri A är väteatom eller en alkylgrupp, som kan vara substituerad med alkoxi, fenyl, bensoyl eller bensyloxi, varvid fenylgrupperna kan vara substi-tuerade med halogen, nitro eller alkoxi, och är en väteatom, en alkylgrupp med 1-5 kolatomer, en hydroxialkylgrupp med 1-5 kolatomer eller en fenylgrupp, som kan vara substituerad med en eller flera av grupperna fluor, klor, alkyl, alkoxi, hydroxi eller alkanoylamino, kännetecknat av att man a) hydrerar en förening med formeln H CH2-R1 V °\ /CH2'N C (X>
2. Förfarande enligt patentkravet 1 för framställning av 9-N-bensylamino-deoxiclavulansyra, kännetecknat av att gruppen R·^ i formeln X eller XI för utgängsmaterialet är en fenylgrupp.
3. Förfarande enligt patentkravet 1 för framställning av 9-N-(2-hydroxiety1)-amino-deoxiclavulansyra, känneteck-
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1676477 | 1977-04-22 | ||
GB16764/77A GB1604822A (en) | 1977-04-22 | 1977-04-22 | N-monosubstituted-9-amino-9-deoxyclavulanic acid derivative |
GB3707277 | 1977-09-06 | ||
GB3707277 | 1977-09-06 | ||
GB5022977 | 1977-12-02 | ||
GB5022977 | 1977-12-02 | ||
GB5386677 | 1977-12-23 | ||
GB5386677 | 1977-12-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI781201A FI781201A (fi) | 1978-10-23 |
FI65253B FI65253B (fi) | 1983-12-30 |
FI65253C true FI65253C (fi) | 1984-04-10 |
Family
ID=27448369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI781201A FI65253C (fi) | 1977-04-22 | 1978-04-19 | Foerfarande foer framstaellning av antibakteriellt verksamma 9-aminodeoxi-clavulansyraderivat |
Country Status (22)
Country | Link |
---|---|
US (1) | US4435565A (sv) |
JP (1) | JPS53132593A (sv) |
AR (1) | AR221051A1 (sv) |
AT (1) | AT357673B (sv) |
BE (1) | BE866276A (sv) |
CA (1) | CA1102810A (sv) |
DE (1) | DE2817085A1 (sv) |
DK (1) | DK171678A (sv) |
ES (1) | ES469051A1 (sv) |
FI (1) | FI65253C (sv) |
FR (1) | FR2387986A1 (sv) |
GB (1) | GB1604822A (sv) |
GR (1) | GR65296B (sv) |
IE (1) | IE46623B1 (sv) |
IL (2) | IL54535A0 (sv) |
IT (1) | IT1105353B (sv) |
LU (1) | LU79494A1 (sv) |
NL (1) | NL7804273A (sv) |
NO (3) | NO781372L (sv) |
NZ (1) | NZ187018A (sv) |
PT (1) | PT67924B (sv) |
SE (3) | SE7804485L (sv) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0005014A1 (en) * | 1978-04-22 | 1979-10-31 | Beecham Group Plc | Clavulanic acid derivatives, preparation and compositions |
DE2963534D1 (en) * | 1978-07-29 | 1982-10-07 | Beecham Group Plc | Clavulanic acid derivatives, a process for their preparation, their use, and pharmaceutical compositions containing them |
EP0008884B1 (en) * | 1978-09-09 | 1983-08-17 | Beecham Group Plc | Derivatives of clavulanic acid, a process for their preparation and their compositions |
EP0009302B1 (en) * | 1978-09-09 | 1983-10-26 | Beecham Group Plc | Clavulanic acid derivatives and process for their preparation |
DE2965938D1 (en) * | 1978-10-25 | 1983-08-25 | Beecham Group Plc | Clavulanic acid derivatives, processes for their preparation and pharmaceutical compositions containing them |
ZA804670B (en) * | 1979-08-03 | 1981-07-29 | Beecham Group Ltd | Derivatives of clavulanic acid, a process for their preparation and their use |
EP0062407A1 (en) * | 1981-03-10 | 1982-10-13 | Beecham Group Plc | Therapeutic compounds containing beta-lactams |
US5566055A (en) * | 1995-03-03 | 1996-10-15 | Parker-Hannifin Corporation | Shieled enclosure for electronics |
EP1386527A1 (en) | 2001-05-10 | 2004-02-04 | Parker Hannifin Corporation | Manufacture of electronics enclosure having a metallized shielding layer |
WO2002093997A1 (en) | 2001-05-11 | 2002-11-21 | Parker Hannifin Corporation | Notched gasket for low closure force emi shielding applications |
US6809254B2 (en) | 2001-07-20 | 2004-10-26 | Parker-Hannifin Corporation | Electronics enclosure having an interior EMI shielding and cosmetic coating |
US20030091777A1 (en) * | 2001-08-14 | 2003-05-15 | Peter Jones | Clean release tape for EMI shielding |
WO2003030610A1 (en) | 2001-10-02 | 2003-04-10 | Parker Hannifin Corporation | Emi shielding gasket construction |
JP6169040B2 (ja) | 2014-05-12 | 2017-07-26 | 東京エレクトロン株式会社 | プラズマ処理装置の上部電極構造、プラズマ処理装置、及びプラズマ処理装置の運用方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU503489B2 (en) * | 1975-10-13 | 1979-09-06 | Beecham Group Limited | Substituted aminodeoxy clavulanic acid |
GB1585124A (en) * | 1976-06-04 | 1981-02-25 | Glaxo Lab Ltd | Clavulanic acid derivatives |
NZ187013A (en) | 1977-04-27 | 1985-04-30 | Beecham Group Ltd | 9-amino-9-deoxy-clavulanic acid derivatives and pharmaceutical compositions |
-
1977
- 1977-04-22 GB GB16764/77A patent/GB1604822A/en not_active Expired
-
1978
- 1978-04-18 IL IL54535A patent/IL54535A0/xx unknown
- 1978-04-18 GR GR56014A patent/GR65296B/el unknown
- 1978-04-19 NZ NZ187018A patent/NZ187018A/en unknown
- 1978-04-19 DK DK171678A patent/DK171678A/da active IP Right Grant
- 1978-04-19 FI FI781201A patent/FI65253C/fi not_active IP Right Cessation
- 1978-04-19 SE SE7804485A patent/SE7804485L/sv unknown
- 1978-04-19 NO NO781372A patent/NO781372L/no unknown
- 1978-04-19 DE DE19782817085 patent/DE2817085A1/de not_active Withdrawn
- 1978-04-20 PT PT67924A patent/PT67924B/pt unknown
- 1978-04-21 ES ES469051A patent/ES469051A1/es not_active Expired
- 1978-04-21 FR FR7811851A patent/FR2387986A1/fr active Granted
- 1978-04-21 BE BE187034A patent/BE866276A/xx not_active IP Right Cessation
- 1978-04-21 NL NL7804273A patent/NL7804273A/xx not_active Application Discontinuation
- 1978-04-21 CA CA301,662A patent/CA1102810A/en not_active Expired
- 1978-04-21 IE IE792/78A patent/IE46623B1/en unknown
- 1978-04-21 LU LU79494A patent/LU79494A1/xx unknown
- 1978-04-22 JP JP4829278A patent/JPS53132593A/ja active Pending
- 1978-04-24 IT IT49037/78A patent/IT1105353B/it active
- 1978-04-24 AT AT292078A patent/AT357673B/de not_active IP Right Cessation
- 1978-04-24 AR AR271869A patent/AR221051A1/es active
-
1980
- 1980-09-10 NO NO802686A patent/NO802686L/no unknown
- 1980-09-10 NO NO802682A patent/NO802682L/no unknown
-
1981
- 1981-03-16 US US06/244,098 patent/US4435565A/en not_active Expired - Fee Related
- 1981-06-11 IL IL63083A patent/IL63083A0/xx unknown
-
1983
- 1983-09-23 SE SE8305160A patent/SE8305160L/sv not_active Application Discontinuation
- 1983-09-23 SE SE8305161A patent/SE8305161L/sv not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPS53132593A (en) | 1978-11-18 |
IT1105353B (it) | 1985-10-28 |
PT67924B (en) | 1979-11-14 |
IL63083A0 (en) | 1981-09-13 |
SE8305161D0 (sv) | 1983-09-23 |
GR65296B (en) | 1980-08-01 |
NO781372L (no) | 1978-10-24 |
DE2817085A1 (de) | 1978-10-26 |
SE8305161L (sv) | 1983-09-23 |
FI781201A (fi) | 1978-10-23 |
AR221051A1 (es) | 1980-12-30 |
ES469051A1 (es) | 1980-01-16 |
GB1604822A (en) | 1981-12-16 |
SE8305160D0 (sv) | 1983-09-23 |
NO802682L (no) | 1978-10-24 |
NO802686L (no) | 1978-10-24 |
IL54535A0 (en) | 1978-07-31 |
ATA292078A (de) | 1979-12-15 |
FI65253B (fi) | 1983-12-30 |
FR2387986A1 (fr) | 1978-11-17 |
NZ187018A (en) | 1985-04-30 |
BE866276A (fr) | 1978-10-23 |
SE8305160L (sv) | 1983-09-23 |
CA1102810A (en) | 1981-06-09 |
FR2387986B1 (sv) | 1980-10-31 |
NL7804273A (nl) | 1978-10-24 |
LU79494A1 (fr) | 1978-09-29 |
AT357673B (de) | 1980-07-25 |
DK171678A (da) | 1978-10-23 |
PT67924A (en) | 1978-05-01 |
IE780792L (en) | 1978-10-22 |
IE46623B1 (en) | 1983-08-10 |
SE7804485L (sv) | 1978-10-23 |
IT7849037A0 (it) | 1978-04-24 |
US4435565A (en) | 1984-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: BEECHAM GROUP LTD |