FI64160B - Nytt foerfarande foer framstaellning av antivirala substituerade purinfoereningar - Google Patents

Nytt foerfarande foer framstaellning av antivirala substituerade purinfoereningar Download PDF

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Publication number
FI64160B
FI64160B FI772548A FI772548A FI64160B FI 64160 B FI64160 B FI 64160B FI 772548 A FI772548 A FI 772548A FI 772548 A FI772548 A FI 772548A FI 64160 B FI64160 B FI 64160B
Authority
FI
Finland
Prior art keywords
mixture
hydroxy
formula
acid
process according
Prior art date
Application number
FI772548A
Other languages
English (en)
Finnish (fi)
Other versions
FI64160C (fi
FI772548A (fi
Inventor
Howard John Schaeffer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27109837&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI64160(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/773,135 external-priority patent/US4146715A/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI772548A publication Critical patent/FI772548A/fi
Publication of FI64160B publication Critical patent/FI64160B/fi
Application granted granted Critical
Publication of FI64160C publication Critical patent/FI64160C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (9)

1. Förfarande för framställning av föreningar med formeln (I) '1 N \ Λ,.Jk / H N ^ \ N 1 CI!2OCH2CH2OH väri R är amino eller hydroxi, kännetecknat därav, att man i närvaro av en bas hydrolyserar en förening med formeln (II) R1 ✓ Vv (II) , il X^-C-NR " ^N' 0 CI^O ClijCI^-O-C-X2 1 . 2 112 väri R är hydroxi eller -NR .C.X , och X och X är lika eller olika ir och vardera betecknar n u 2 1 en alkyl- eller fenylgrupp, och R är väte eller -CX , pä det villkor I» o att da R* är hydroxi, är R^ väte.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att alkylgruppen innehäller 1-H kolatomer.
3. Förfarande enligt patentkravet. 1 eller 2, kanne- 1 2 t e c k n a t därav, att X och X är lika och vardera betecknar en metylgrupp.
4. Förfarande enligt nägot av de föregäende patentkraven, kännetecknat därav, att basen är en vatten- eller alkoholhaltig primär eller sekundär alifatisk amin, en alkoxid i alkohol eller vatten- eller alkoholhaltig hydroxid.
FI772548A 1976-08-27 1977-08-26 Nytt foerfarande foer framstaellning av antivirala substituerade purinfoereningar FI64160C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71810576A 1976-08-27 1976-08-27
US71810576 1976-08-27
US77313577 1977-02-28
US05/773,135 US4146715A (en) 1975-08-27 1977-02-28 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines

Publications (3)

Publication Number Publication Date
FI772548A FI772548A (fi) 1978-02-28
FI64160B true FI64160B (fi) 1983-06-30
FI64160C FI64160C (fi) 1983-10-10

Family

ID=27109837

Family Applications (1)

Application Number Title Priority Date Filing Date
FI772548A FI64160C (fi) 1976-08-27 1977-08-26 Nytt foerfarande foer framstaellning av antivirala substituerade purinfoereningar

Country Status (12)

Country Link
AT (1) AT357566B (sv)
CA (2) CA1096863A (sv)
CH (1) CH634843A5 (sv)
CS (1) CS196384B2 (sv)
DD (1) DD131856A6 (sv)
DK (1) DK147857C (sv)
FI (1) FI64160C (sv)
GB (1) GB1567671A (sv)
NL (1) NL7709458A (sv)
NO (2) NO147186C (sv)
SE (2) SE432764B (sv)
YU (1) YU41079B (sv)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4918219A (en) * 1983-10-31 1990-04-17 Warner-Lambert Company Glycerine derivatives
YU45690B (sh) * 1984-12-22 1992-07-20 Krka Tovarna Zdraviln.Sol.O. Postopek za pripravo 9-(2-hidroksietoksimetil)-gvanina
EP0289992B1 (en) * 1987-05-04 1994-04-27 Kemijski Institut Process for preparing purine derivates
DK0717744T3 (da) * 1993-09-10 1997-12-08 Recordati Chem Pharm Fremgangsmåde til fremstilling af 9-(-2-hydroxy)-ethoxymethylguanin
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
IT1276126B1 (it) * 1995-11-14 1997-10-27 Archimica Spa Procedimento per la preparazine di 9-((2-idrossietossi)metil) guanina
WO1997024357A1 (en) * 1995-12-28 1997-07-10 Mallinckrodt Chemical, Inc. Process for synthesis and purification of a compound useful in the preparation of acyclovir

Also Published As

Publication number Publication date
YU41079B (en) 1986-12-31
NO147186B (no) 1982-11-08
SE447113B (sv) 1986-10-27
NO150119B (no) 1984-05-14
AT357566B (de) 1980-07-25
YU202277A (en) 1983-02-28
CS196384B2 (en) 1980-03-31
NO147186C (no) 1983-02-16
NO150119C (no) 1984-08-22
DK380377A (da) 1978-02-28
NO772959L (no) 1978-02-28
DD131856A6 (de) 1978-07-26
DK147857C (da) 1985-06-10
CA1096864A (en) 1981-03-03
ATA620177A (de) 1979-12-15
CA1096863A (en) 1981-03-03
GB1567671A (en) 1980-05-21
SE8304549L (sv) 1983-08-23
DK147857B (da) 1984-12-24
SE432764B (sv) 1984-04-16
CH634843A5 (en) 1983-02-28
FI64160C (fi) 1983-10-10
FI772548A (fi) 1978-02-28
NL7709458A (nl) 1978-03-01
SE7709606L (sv) 1978-02-28
NO822502L (no) 1978-02-28
SE8304549D0 (sv) 1983-08-23

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Owner name: THE WELLCOME FOUNDATION LIMITED