FI62283C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-2'-karboxifenyl-4-klorantranilsyraderivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-2'-karboxifenyl-4-klorantranilsyraderivat Download PDF

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Publication number
FI62283C
FI62283C FI761677A FI761677A FI62283C FI 62283 C FI62283 C FI 62283C FI 761677 A FI761677 A FI 761677A FI 761677 A FI761677 A FI 761677A FI 62283 C FI62283 C FI 62283C
Authority
FI
Finland
Prior art keywords
test compound
acid
carboxyphenyl
test
effect
Prior art date
Application number
FI761677A
Other languages
English (en)
Finnish (fi)
Other versions
FI62283B (fi
FI761677A (sv
Inventor
Mitsuru Tanemura
Teizo Shinozaki
Minoru Shindo
Schun-Ichi Hata
Koji Mizuno
Masayoshi Ono
Kiyoshige Wakabayashi
Toshiaki Nakano
Yasuho Nishii
Takashi Matsuno
Yoshiyuki Ohsugi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2526092A external-priority patent/DE2526092C2/de
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of FI761677A publication Critical patent/FI761677A/fi
Publication of FI62283B publication Critical patent/FI62283B/fi
Application granted granted Critical
Publication of FI62283C publication Critical patent/FI62283C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (3)

1. Förfarande för framställning av terapeutiskt användbara N-2'-karboxifenyl-4-klorantranilsyraderivat med formeln COOH R1 0- hn H02 a) Cl COOK väri R^ och R2 oberoende av varandra är väteatomer, halogenatomer eller alkylgrupper med 1-6 kolatomer, kännetecknat därav, att ett 4-klorbensoesyraderivat med formeln COOH r väri X är en halogen eller en aminogrupp, omsätts med en förening med formeln (III) doOH väri R1 och R2 har ovan nämnda betydelse, och Y är en aminogrupp, när X är halogen, och Y är halogen, när X är en aminogrupp.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att en molekvivalent eller mera, baserat pä totala molmängden föreningar (II) och (III), av en alkalisk substans, säsom kaliumkarbo-nat, natriumkarbonat, eller kopparkarbonat och en mycket liten mänqd av en metall eller en metallhaltig förening, slsom kopparpulver, koppar(1)klorid, koppar(1)bromid eller koppar(2)acetat tillsätts reaktionssystemet som katalysator.
FI761677A 1975-06-11 1976-06-11 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-2'-karboxifenyl-4-klorantranilsyraderivat FI62283C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2526092 1975-06-11
DE2526092A DE2526092C2 (de) 1975-06-11 1975-06-11 Aminobenzoesäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
JP4104176 1976-04-12
JP51041041A JPS606355B2 (ja) 1975-06-11 1976-04-12 新規アミノ安息香酸誘導体、その製法及び医薬組成物

Publications (3)

Publication Number Publication Date
FI761677A FI761677A (sv) 1976-12-12
FI62283B FI62283B (fi) 1982-08-31
FI62283C true FI62283C (fi) 1982-12-10

Family

ID=25769022

Family Applications (1)

Application Number Title Priority Date Filing Date
FI761677A FI62283C (fi) 1975-06-11 1976-06-11 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-2'-karboxifenyl-4-klorantranilsyraderivat

Country Status (10)

Country Link
US (1) US4092426A (sv)
AR (1) AR212814A1 (sv)
CA (1) CA1066303A (sv)
CH (1) CH630605A5 (sv)
ES (1) ES448761A1 (sv)
FI (1) FI62283C (sv)
FR (1) FR2313921A1 (sv)
GB (1) GB1520179A (sv)
NL (1) NL185405C (sv)
SE (1) SE412907B (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5791914A (en) * 1980-11-28 1982-06-08 Chugai Pharmaceut Co Ltd Peptic unti-ulcer
GB2171012B (en) * 1985-01-22 1989-01-05 Chugai Pharmaceutical Co Ltd Nephritis treating agent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3390172A (en) * 1964-03-27 1968-06-25 Parke Davis & Co Nu-(3-trifluoromethylphenyl)-anthranilic acids
US3369042A (en) * 1964-04-07 1968-02-13 Parke Davis & Co N-(substituted phenyl)anthranilic acids, salts, and esters thereof
US3313848A (en) * 1964-06-18 1967-04-11 Parke Davis & Co Anthranilic acids and derivatives
IT1061780B (it) * 1966-09-03 1983-04-30 Italfarmaco Spa Acido n 4 carbossifenil antrantiico suoi derivati e processo per la loro preparazione
JPS5230511B2 (sv) * 1972-05-11 1977-08-09

Also Published As

Publication number Publication date
FI62283B (fi) 1982-08-31
GB1520179A (en) 1978-08-02
AR212814A1 (es) 1978-10-13
NL185405B (nl) 1989-11-01
NL7606309A (nl) 1976-12-14
NL185405C (nl) 1990-04-02
CA1066303A (en) 1979-11-13
SE412907B (sv) 1980-03-24
SE7606592L (sv) 1976-12-12
ES448761A1 (es) 1977-12-16
FR2313921B1 (sv) 1979-09-28
FI761677A (sv) 1976-12-12
FR2313921A1 (fr) 1977-01-07
CH630605A5 (de) 1982-06-30
US4092426A (en) 1978-05-30

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MM Patent lapsed

Owner name: CHUGAI SEIYAKU KABUSHIKI KAISHA