FI59998C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 6- eller 7-cyan-3-metylkinoxalin-2-karboxamid-1,4-dioxidderivat - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara 6- eller 7-cyan-3-metylkinoxalin-2-karboxamid-1,4-dioxidderivat Download PDFInfo
- Publication number
- FI59998C FI59998C FI750017A FI750017A FI59998C FI 59998 C FI59998 C FI 59998C FI 750017 A FI750017 A FI 750017A FI 750017 A FI750017 A FI 750017A FI 59998 C FI59998 C FI 59998C
- Authority
- FI
- Finland
- Prior art keywords
- carboxamide
- compound
- dioxide
- formula
- cyano
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 22
- 230000001225 therapeutic effect Effects 0.000 title description 3
- 235000013399 edible fruits Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 53
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- 238000002360 preparation method Methods 0.000 claims description 9
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- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- YPEWWOUWRRQBAX-UHFFFAOYSA-N n,n-dimethyl-3-oxobutanamide Chemical compound CN(C)C(=O)CC(C)=O YPEWWOUWRRQBAX-UHFFFAOYSA-N 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical class OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- TZLVRPLSVNESQC-UHFFFAOYSA-N potassium azide Chemical compound [K+].[N-]=[N+]=[N-] TZLVRPLSVNESQC-UHFFFAOYSA-N 0.000 description 1
- RPDAUEIUDPHABB-UHFFFAOYSA-N potassium ethoxide Chemical compound [K+].CC[O-] RPDAUEIUDPHABB-UHFFFAOYSA-N 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- CGJMVNVWQHPASW-UHFFFAOYSA-N quinoxaline-2-carboxamide Chemical class C1=CC=CC2=NC(C(=O)N)=CN=C21 CGJMVNVWQHPASW-UHFFFAOYSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- MOODSJOROWROTO-UHFFFAOYSA-N salicylsulfuric acid Chemical class OC(=O)C1=CC=CC=C1OS(O)(=O)=O MOODSJOROWROTO-UHFFFAOYSA-N 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 150000003511 tertiary amides Chemical class 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- SEDZOYHHAIAQIW-UHFFFAOYSA-N trimethylsilyl azide Chemical compound C[Si](C)(C)N=[N+]=[N-] SEDZOYHHAIAQIW-UHFFFAOYSA-N 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43117074A | 1974-01-07 | 1974-01-07 | |
| US43117074 | 1974-01-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI750017A7 FI750017A7 (en)) | 1975-07-08 |
| FI59998B FI59998B (fi) | 1981-07-31 |
| FI59998C true FI59998C (fi) | 1981-11-10 |
Family
ID=23710775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI750017A FI59998C (fi) | 1974-01-07 | 1975-01-06 | Foerfarande foer framstaellning av terapeutiskt anvaendbara 6- eller 7-cyan-3-metylkinoxalin-2-karboxamid-1,4-dioxidderivat |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS6011034B2 (en)) |
| AR (1) | AR203585A1 (en)) |
| AT (1) | AT347467B (en)) |
| BE (1) | BE824065A (en)) |
| BG (1) | BG25990A3 (en)) |
| CA (1) | CA1033739A (en)) |
| CH (1) | CH602670A5 (en)) |
| CS (1) | CS191253B2 (en)) |
| DD (1) | DD116825A1 (en)) |
| DE (1) | DE2500447A1 (en)) |
| DK (1) | DK140838C (en)) |
| ES (1) | ES433593A1 (en)) |
| FI (1) | FI59998C (en)) |
| FR (1) | FR2256758B1 (en)) |
| GB (2) | GB1453677A (en)) |
| HU (1) | HU170490B (en)) |
| IE (1) | IE40469B1 (en)) |
| IT (1) | IT1047758B (en)) |
| LU (1) | LU71601A1 (en)) |
| NL (1) | NL7500097A (en)) |
| RO (1) | RO76604A (en)) |
| SU (1) | SU633478A3 (en)) |
| YU (1) | YU36512B (en)) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5352255B2 (ja) * | 2009-01-28 | 2013-11-27 | 日本エンバイロケミカルズ株式会社 | キノキサリン系化合物またはその塩、および工業用殺菌組成物 |
-
1974
- 1974-08-22 GB GB3703274A patent/GB1453677A/en not_active Expired
- 1974-08-22 GB GB2446976A patent/GB1453678A/en not_active Expired
- 1974-12-12 IE IE2560/74A patent/IE40469B1/xx unknown
- 1974-12-24 FR FR7442753A patent/FR2256758B1/fr not_active Expired
-
1975
- 1975-01-03 BE BE1006365A patent/BE824065A/xx not_active IP Right Cessation
- 1975-01-04 ES ES433593A patent/ES433593A1/es not_active Expired
- 1975-01-06 CA CA217,360A patent/CA1033739A/en not_active Expired
- 1975-01-06 DK DK1775A patent/DK140838C/da not_active IP Right Cessation
- 1975-01-06 FI FI750017A patent/FI59998C/fi not_active IP Right Cessation
- 1975-01-06 NL NL7500097A patent/NL7500097A/xx not_active Application Discontinuation
- 1975-01-06 YU YU00007/75A patent/YU36512B/xx unknown
- 1975-01-06 DE DE19752500447 patent/DE2500447A1/de not_active Ceased
- 1975-01-06 SU SU752097436A patent/SU633478A3/ru active
- 1975-01-06 HU HUPI442A patent/HU170490B/hu unknown
- 1975-01-07 JP JP50004618A patent/JPS6011034B2/ja not_active Expired
- 1975-01-07 CS CS75116A patent/CS191253B2/cs unknown
- 1975-01-07 RO RO7581062A patent/RO76604A/ro unknown
- 1975-01-07 LU LU71601A patent/LU71601A1/xx unknown
- 1975-01-07 AT AT7475A patent/AT347467B/de not_active IP Right Cessation
- 1975-01-07 BG BG028670A patent/BG25990A3/xx unknown
- 1975-01-07 AR AR257213D patent/AR203585A1/es active
- 1975-01-07 CH CH10475A patent/CH602670A5/xx not_active IP Right Cessation
- 1975-01-07 DD DD183530A patent/DD116825A1/xx unknown
- 1975-01-07 IT IT47535/75A patent/IT1047758B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| YU36512B (en) | 1984-02-29 |
| CS191253B2 (en) | 1979-06-29 |
| NL7500097A (nl) | 1975-07-09 |
| DK1775A (en)) | 1975-08-25 |
| IE40469L (en) | 1975-07-07 |
| JPS50105678A (en)) | 1975-08-20 |
| CH602670A5 (en)) | 1978-07-31 |
| BE824065A (fr) | 1975-07-03 |
| DE2500447A1 (de) | 1975-07-17 |
| DK140838B (da) | 1979-11-26 |
| JPS6011034B2 (ja) | 1985-03-22 |
| CA1033739A (en) | 1978-06-27 |
| AT347467B (de) | 1978-12-27 |
| IE40469B1 (en) | 1979-06-06 |
| AR203585A1 (es) | 1975-09-22 |
| GB1453677A (en) | 1976-10-27 |
| FR2256758B1 (en)) | 1979-05-04 |
| FR2256758A1 (en)) | 1975-08-01 |
| HU170490B (en)) | 1977-06-28 |
| DD116825A1 (en)) | 1975-12-12 |
| FI750017A7 (en)) | 1975-07-08 |
| AU7691074A (en) | 1976-07-01 |
| RO76604A (ro) | 1981-04-30 |
| ATA7475A (de) | 1978-05-15 |
| GB1453678A (en) | 1976-10-27 |
| IT1047758B (it) | 1980-10-20 |
| FI59998B (fi) | 1981-07-31 |
| BG25990A3 (bg) | 1979-01-12 |
| ES433593A1 (es) | 1977-02-16 |
| DK140838C (da) | 1980-04-21 |
| YU775A (en) | 1982-02-25 |
| SU633478A3 (ru) | 1978-11-15 |
| LU71601A1 (en)) | 1975-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: PFIZER INC. |