FI58941C - Foerfarande foer aktivering av levande immobiliserade mikroorganismer som anvaendes som transformerare i 1-dehydrogenerings- eller 11beta-hydroxyleringsreaktioner av steroider och i transformationsreaktioner av benzylpenicillin - Google Patents
Foerfarande foer aktivering av levande immobiliserade mikroorganismer som anvaendes som transformerare i 1-dehydrogenerings- eller 11beta-hydroxyleringsreaktioner av steroider och i transformationsreaktioner av benzylpenicillin Download PDFInfo
- Publication number
- FI58941C FI58941C FI772012A FI772012A FI58941C FI 58941 C FI58941 C FI 58941C FI 772012 A FI772012 A FI 772012A FI 772012 A FI772012 A FI 772012A FI 58941 C FI58941 C FI 58941C
- Authority
- FI
- Finland
- Prior art keywords
- medium
- som
- peptone
- immobilized
- cortisol
- Prior art date
Links
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 82
- 239000002609 medium Substances 0.000 description 49
- 230000000694 effects Effects 0.000 description 45
- 239000001888 Peptone Substances 0.000 description 44
- 108010080698 Peptones Proteins 0.000 description 44
- 239000000499 gel Substances 0.000 description 44
- 235000019319 peptone Nutrition 0.000 description 44
- 229960000890 hydrocortisone Drugs 0.000 description 41
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 38
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 36
- 241000430521 Alyssum Species 0.000 description 27
- 238000006243 chemical reaction Methods 0.000 description 26
- 244000005700 microbiome Species 0.000 description 23
- 229960005205 prednisolone Drugs 0.000 description 22
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 21
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 20
- 239000008103 glucose Substances 0.000 description 20
- 229940056360 penicillin g Drugs 0.000 description 19
- 229910001868 water Inorganic materials 0.000 description 18
- 230000009466 transformation Effects 0.000 description 17
- 230000004913 activation Effects 0.000 description 16
- 239000000648 calcium alginate Substances 0.000 description 15
- 235000010410 calcium alginate Nutrition 0.000 description 15
- 229960002681 calcium alginate Drugs 0.000 description 15
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 15
- 238000002474 experimental method Methods 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- 150000003431 steroids Chemical class 0.000 description 13
- 241000203720 Pimelobacter simplex Species 0.000 description 12
- 238000011534 incubation Methods 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 description 10
- 238000006356 dehydrogenation reaction Methods 0.000 description 10
- 229920002401 polyacrylamide Polymers 0.000 description 9
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 241000588724 Escherichia coli Species 0.000 description 8
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 8
- 240000008042 Zea mays Species 0.000 description 8
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 8
- 239000001110 calcium chloride Substances 0.000 description 8
- 229910001628 calcium chloride Inorganic materials 0.000 description 8
- 235000011148 calcium chloride Nutrition 0.000 description 8
- 239000003054 catalyst Substances 0.000 description 8
- 238000004128 high performance liquid chromatography Methods 0.000 description 8
- 235000015097 nutrients Nutrition 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 7
- 235000005822 corn Nutrition 0.000 description 7
- 238000005805 hydroxylation reaction Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 235000019371 penicillin G benzathine Nutrition 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 241000223211 Curvularia lunata Species 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 239000003246 corticosteroid Substances 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 5
- 230000003213 activating effect Effects 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 238000004448 titration Methods 0.000 description 5
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 4
- 101710088194 Dehydrogenase Proteins 0.000 description 4
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 4
- 229940072056 alginate Drugs 0.000 description 4
- 235000010443 alginic acid Nutrition 0.000 description 4
- 229920000615 alginic acid Polymers 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 229910001629 magnesium chloride Inorganic materials 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229960001334 corticosteroids Drugs 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 239000012737 fresh medium Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 229960003424 phenylacetic acid Drugs 0.000 description 3
- 239000003279 phenylacetic acid Substances 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000000844 transformation Methods 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 description 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 229910021580 Cobalt(II) chloride Inorganic materials 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229910021577 Iron(II) chloride Inorganic materials 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 2
- 235000019797 dipotassium phosphate Nutrition 0.000 description 2
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- PSFDQSOCUJVVGF-UHFFFAOYSA-N harman Chemical compound C12=CC=CC=C2NC2=C1C=CN=C2C PSFDQSOCUJVVGF-UHFFFAOYSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000033444 hydroxylation Effects 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 238000013383 initial experiment Methods 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 2
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- 239000011837 N,N-methylenebisacrylamide Substances 0.000 description 1
- 108010073038 Penicillin Amidase Proteins 0.000 description 1
- 108010087702 Penicillinase Proteins 0.000 description 1
- 239000004159 Potassium persulphate Substances 0.000 description 1
- 241000277284 Salvelinus fontinalis Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000007809 chemical reaction catalyst Substances 0.000 description 1
- 150000001885 cortisol derivatives Chemical class 0.000 description 1
- 150000001886 cortisols Chemical class 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000006481 glucose medium Substances 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 210000001822 immobilized cell Anatomy 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 229950009506 penicillinase Drugs 0.000 description 1
- -1 phenylacetyl Chemical group 0.000 description 1
- 235000019394 potassium persulphate Nutrition 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7607698A SE427116B (sv) | 1976-07-06 | 1976-07-06 | Transformation av steroider och antibiotika med immobiliserade levande mikroorganismer som aktiveras |
| SE7607698 | 1976-07-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI772012A7 FI772012A7 (de) | 1978-01-07 |
| FI58941B FI58941B (fi) | 1981-01-30 |
| FI58941C true FI58941C (fi) | 1981-05-11 |
Family
ID=20328400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI772012A FI58941C (fi) | 1976-07-06 | 1977-06-28 | Foerfarande foer aktivering av levande immobiliserade mikroorganismer som anvaendes som transformerare i 1-dehydrogenerings- eller 11beta-hydroxyleringsreaktioner av steroider och i transformationsreaktioner av benzylpenicillin |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5326383A (de) |
| AT (1) | AT372403B (de) |
| BE (1) | BE856358A (de) |
| CA (1) | CA1101348A (de) |
| CH (1) | CH634348A5 (de) |
| DE (1) | DE2729490A1 (de) |
| DK (1) | DK292677A (de) |
| ES (1) | ES460368A1 (de) |
| FI (1) | FI58941C (de) |
| FR (1) | FR2357507A1 (de) |
| GB (1) | GB1560850A (de) |
| IE (1) | IE45676B1 (de) |
| IT (1) | IT1079745B (de) |
| NL (1) | NL7707449A (de) |
| SE (1) | SE427116B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE441009B (sv) * | 1982-03-08 | 1985-09-02 | Kjell Nilsson | Sett att immobilisera levande biomaterial i perlformiga polymerer |
| DE3241829A1 (de) * | 1982-11-09 | 1984-05-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Biokatalysator |
| GB2162198B (en) * | 1984-07-27 | 1987-12-02 | Ki Med I | Process for producing dense nutrient medium for culturing microorganisms and macroorganism cell cultures |
| GB9622884D0 (en) * | 1996-11-02 | 1997-01-08 | Duramed Europ Ltd | A method for th e preparation of steroids in the pregene class |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3767790A (en) * | 1972-02-11 | 1973-10-23 | Nat Patent Dev Corp | Microorganisms |
| FR2320349A1 (fr) * | 1975-08-06 | 1977-03-04 | Agronomique Inst Nat Rech | Procede enzymatique utilisant des microorganismes inclus |
-
1976
- 1976-07-06 SE SE7607698A patent/SE427116B/xx unknown
-
1977
- 1977-06-28 FI FI772012A patent/FI58941C/fi not_active IP Right Cessation
- 1977-06-30 DK DK292677A patent/DK292677A/da not_active Application Discontinuation
- 1977-06-30 AT AT0465577A patent/AT372403B/de not_active IP Right Cessation
- 1977-06-30 DE DE19772729490 patent/DE2729490A1/de not_active Ceased
- 1977-07-01 BE BE178985A patent/BE856358A/xx not_active IP Right Cessation
- 1977-07-04 ES ES460368A patent/ES460368A1/es not_active Expired
- 1977-07-05 FR FR7720678A patent/FR2357507A1/fr active Granted
- 1977-07-05 IE IE1392/77A patent/IE45676B1/en unknown
- 1977-07-05 NL NL7707449A patent/NL7707449A/xx not_active Application Discontinuation
- 1977-07-05 CA CA282,058A patent/CA1101348A/en not_active Expired
- 1977-07-05 GB GB28177/77A patent/GB1560850A/en not_active Expired
- 1977-07-05 IT IT50134/77A patent/IT1079745B/it active
- 1977-07-06 CH CH835577A patent/CH634348A5/de not_active IP Right Cessation
- 1977-07-06 JP JP8086277A patent/JPS5326383A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IE45676L (en) | 1978-01-06 |
| SE427116B (sv) | 1983-03-07 |
| ES460368A1 (es) | 1978-10-01 |
| FR2357507B1 (de) | 1981-10-16 |
| SE7607698L (sv) | 1978-01-07 |
| FI772012A7 (de) | 1978-01-07 |
| AT372403B (de) | 1983-10-10 |
| CH634348A5 (en) | 1983-01-31 |
| JPS5326383A (en) | 1978-03-11 |
| ATA465577A (de) | 1983-02-15 |
| DE2729490A1 (de) | 1978-01-12 |
| CA1101348A (en) | 1981-05-19 |
| GB1560850A (en) | 1980-02-13 |
| FR2357507A1 (fr) | 1978-02-03 |
| NL7707449A (nl) | 1978-01-10 |
| IE45676B1 (en) | 1982-10-20 |
| FI58941B (fi) | 1981-01-30 |
| DK292677A (da) | 1978-01-07 |
| IT1079745B (it) | 1985-05-13 |
| BE856358A (fr) | 1978-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mosbach et al. | Preparation and application of polymer‐entrapped enzymes and microorganisms in microbial transformation processes with special reference to steroid 11‐β‐hydroxylation and Δ1‐dehydrogenation | |
| US4355105A (en) | Glutaraldehyde/polyethylenimine immobilization of whole microbial cells | |
| DE2911192A1 (de) | Neuartiges immobilisiertes glucoseoxidase-katalasepraeparat und seine verwendung zur enzymatischen glucoseoxidation | |
| Koshcheyenko et al. | Immobilization of living microbial cells and their application for steroid transformations | |
| Nakajima et al. | Entrapment of Lavandula vera cells with synthetic resin prepolymers and its application to pigment production | |
| JPS6023838B2 (ja) | 微生物の全細胞におけるスクロ−ス・ムタ−ゼの固定化方法 | |
| FI58941C (fi) | Foerfarande foer aktivering av levande immobiliserade mikroorganismer som anvaendes som transformerare i 1-dehydrogenerings- eller 11beta-hydroxyleringsreaktioner av steroider och i transformationsreaktioner av benzylpenicillin | |
| CN102206696A (zh) | 11，17α-被取代的孕甾-1，4-二烯-3，20-二酮的制备方法 | |
| US4208482A (en) | Immobilization of glucose isomerase | |
| Jones et al. | Examination of parameters affecting the 5β-hydroxylation of digitoxigenin by immobilised cells of Daucus carota | |
| Shirai | Catechol production from benzene through reaction with resting and immobilized cells of a mutant strain of Pseudomonas | |
| WO2023004969A1 (zh) | 酯酶突变体及其应用 | |
| Kim et al. | Steroid modification with immobilized mycelium of Aspergillus phoenicis | |
| Baklashova et al. | Hydroxylation of indolyl-3-acetic acid by immobilized mycelium of Aspergillus niger | |
| Atrat et al. | Steroidtransformation with immobilized microorganisms VI. The reverse reaction of steroid‐1‐dehydrogenases from different micoorganisms in immobilized state | |
| CN113604515A (zh) | 一种在生物反应器内利用半疏水晶胶基全细胞催化剂合成苯乳酸的方法 | |
| US3787288A (en) | Method for preparing alpha-aminobenzylpenicillin | |
| US4246346A (en) | Antibiotic and steroid transformation process | |
| Donova et al. | Poly-N-vinylcaprolactam gel: A novel matrix for entrapment of microorganisms | |
| KR920006400B1 (ko) | 생세포 고정화계를 이용한 코오지산의 고농도 생산방법 | |
| SU494382A1 (ru) | Способ получени гидрокортизона и ацетата кортизона | |
| JPS58116690A (ja) | Ｄ−β−ヒドロキシアミノ酸の製造法 | |
| SU750804A1 (ru) | Способ получени водонерастворимых биологически активных соединений | |
| SU1742330A1 (ru) | Способ получени биокатализатора в полисахаридном носителе | |
| JPH0327198B2 (de) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: AB FERMENTA |