FI58923C - Foerfarande foer framstaellning av nya terapeutiskt aktiva 0-substituerade oximer av 3-formylrifamycin sv 3-formyl-16,17,18,19,28,29-hexahydro-rifamycin sv och 25-desacetyl-3-formylrifamycin sv - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt aktiva 0-substituerade oximer av 3-formylrifamycin sv 3-formyl-16,17,18,19,28,29-hexahydro-rifamycin sv och 25-desacetyl-3-formylrifamycin sv Download PDFInfo
- Publication number
- FI58923C FI58923C FI1449/72A FI144972A FI58923C FI 58923 C FI58923 C FI 58923C FI 1449/72 A FI1449/72 A FI 1449/72A FI 144972 A FI144972 A FI 144972A FI 58923 C FI58923 C FI 58923C
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- Finland
- Prior art keywords
- rifamycin
- formylrifamycin
- formyl
- iii
- lower alkyl
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- XIQUJVRFXPBMHS-UHFFFAOYSA-N hydron;o-prop-2-enylhydroxylamine;chloride Chemical compound Cl.NOCC=C XIQUJVRFXPBMHS-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000009399 inbreeding Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- RQIDGZHMTWSMMC-TZNPKLQUSA-N juvenile hormone I Chemical compound COC(=O)/C=C(C)/CC\C=C(/CC)CC[C@H]1O[C@@]1(C)CC RQIDGZHMTWSMMC-TZNPKLQUSA-N 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000011565 manganese chloride Substances 0.000 description 1
- 235000002867 manganese chloride Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- AQFWNELGMODZGC-UHFFFAOYSA-N o-ethylhydroxylamine Chemical compound CCON AQFWNELGMODZGC-UHFFFAOYSA-N 0.000 description 1
- CEFBXYRCGUITCZ-UHFFFAOYSA-N o-prop-2-ynylhydroxylamine;hydrochloride Chemical compound Cl.NOCC#C CEFBXYRCGUITCZ-UHFFFAOYSA-N 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 125000005646 oximino group Chemical group 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 229940080469 phosphocellulose Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 210000004910 pleural fluid Anatomy 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 235000020079 raki Nutrition 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2549371 | 1971-06-07 | ||
| IT2549371 | 1971-06-07 | ||
| IT8960771 | 1971-06-24 | ||
| IT8960771A IT1045053B (it) | 1971-06-24 | 1971-06-24 | Perivati della 3 fornil rifamicina sv |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI58923B FI58923B (fi) | 1981-01-30 |
| FI58923C true FI58923C (fi) | 1981-05-11 |
Family
ID=26328602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI1449/72A FI58923C (fi) | 1971-06-07 | 1972-05-24 | Foerfarande foer framstaellning av nya terapeutiskt aktiva 0-substituerade oximer av 3-formylrifamycin sv 3-formyl-16,17,18,19,28,29-hexahydro-rifamycin sv och 25-desacetyl-3-formylrifamycin sv |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS517679B1 (Direct) |
| AR (1) | AR192938A1 (Direct) |
| BE (1) | BE784533A (Direct) |
| CA (1) | CA966481A (Direct) |
| CH (1) | CH562248A5 (Direct) |
| DD (1) | DD99782A5 (Direct) |
| DE (1) | DE2227087C2 (Direct) |
| DK (1) | DK137992B (Direct) |
| ES (1) | ES403548A1 (Direct) |
| FI (1) | FI58923C (Direct) |
| FR (1) | FR2140534B1 (Direct) |
| GB (1) | GB1338740A (Direct) |
| HU (1) | HU163900B (Direct) |
| IE (1) | IE37664B1 (Direct) |
| IL (1) | IL39305A (Direct) |
| LU (1) | LU65461A1 (Direct) |
| NL (1) | NL153202B (Direct) |
| NO (1) | NO135316C (Direct) |
| RO (1) | RO62437A (Direct) |
| SU (1) | SU432721A3 (Direct) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR208F (Direct) * | 1964-07-31 |
-
1972
- 1972-04-25 IL IL39305A patent/IL39305A/xx unknown
- 1972-05-02 GB GB1945772A patent/GB1338740A/en not_active Expired
- 1972-05-04 AR AR241803A patent/AR192938A1/es active
- 1972-05-11 IE IE633/72A patent/IE37664B1/xx unknown
- 1972-05-16 NO NO1747/72A patent/NO135316C/no unknown
- 1972-05-24 FI FI1449/72A patent/FI58923C/fi active
- 1972-06-02 JP JP47054997A patent/JPS517679B1/ja active Pending
- 1972-06-03 DE DE2227087A patent/DE2227087C2/de not_active Expired
- 1972-06-05 DD DD163437A patent/DD99782A5/xx unknown
- 1972-06-05 CA CA143,914A patent/CA966481A/en not_active Expired
- 1972-06-05 LU LU65461D patent/LU65461A1/xx unknown
- 1972-06-05 CH CH827772A patent/CH562248A5/xx not_active IP Right Cessation
- 1972-06-05 SU SU1789260A patent/SU432721A3/ru active
- 1972-06-06 ES ES403548A patent/ES403548A1/es not_active Expired
- 1972-06-06 HU HULE658A patent/HU163900B/hu unknown
- 1972-06-06 RO RO7200071158A patent/RO62437A/ro unknown
- 1972-06-06 DK DK279572AA patent/DK137992B/da unknown
- 1972-06-07 NL NL727207698A patent/NL153202B/xx not_active IP Right Cessation
- 1972-06-07 FR FR7220488A patent/FR2140534B1/fr not_active Expired
- 1972-06-07 BE BE784533A patent/BE784533A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA966481A (en) | 1975-04-22 |
| DK137992B (da) | 1978-06-19 |
| FI58923B (fi) | 1981-01-30 |
| FR2140534B1 (Direct) | 1975-10-31 |
| IE37664B1 (en) | 1977-09-14 |
| HU163900B (Direct) | 1973-11-28 |
| DK137992C (Direct) | 1978-11-13 |
| NO135316B (Direct) | 1976-12-13 |
| IL39305A0 (en) | 1972-06-28 |
| GB1338740A (en) | 1973-11-28 |
| NL7207698A (Direct) | 1972-12-11 |
| DE2227087C2 (de) | 1982-09-02 |
| JPS517679B1 (Direct) | 1976-03-10 |
| LU65461A1 (Direct) | 1972-10-23 |
| DE2227087A1 (de) | 1973-04-12 |
| DD99782A5 (Direct) | 1973-08-20 |
| FR2140534A1 (Direct) | 1973-01-19 |
| RO62437A (fr) | 1978-01-15 |
| ES403548A1 (es) | 1975-05-01 |
| IE37664L (en) | 1972-12-07 |
| AR192938A1 (es) | 1973-03-21 |
| NO135316C (Direct) | 1977-03-23 |
| BE784533A (fr) | 1972-10-02 |
| CH562248A5 (Direct) | 1975-05-30 |
| NL153202B (nl) | 1977-05-16 |
| IL39305A (en) | 1975-08-31 |
| SU432721A3 (ru) | 1974-06-15 |
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