GB1338740A - 3-formylrifamycin sv derivatives - Google Patents
3-formylrifamycin sv derivativesInfo
- Publication number
- GB1338740A GB1338740A GB1945772A GB1945772A GB1338740A GB 1338740 A GB1338740 A GB 1338740A GB 1945772 A GB1945772 A GB 1945772A GB 1945772 A GB1945772 A GB 1945772A GB 1338740 A GB1338740 A GB 1338740A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formylrifamycin
- alkyl
- oximes
- mono
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1338740 3-formylrifamycin SV oximes GRUPPO LEPETIT SpA 2 May 1972 [7 June 1971 24 June 1971] 19457/72 Heading C2A The invention comprises 3-formylrifamycin SV oximes of general Formula I wherein R is alkyl of at least two carbon atoms, alkenyl, alkynyl, cycloalkyl, alkoxyalkyl, cycloalkoxyalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamyl alkyl, cyanoalkyl, nitroalkyl, aryloxyalkyl, aralkoxyalkyl, heterocycloxyalkyl, aminoalkyl, mono and di-alkylaminoalkyl, substituted benzyl, mono- and poly-aryl substituted C 2 -C 8 alkyl or alkyl substituted with 1 to 3 mono or polynuclear heterocyclic rings containing at least one heteroatom selected from O, N and S, with the exclusion of morpholine and R 1 is hydrogen or acetyl and the derivatives of the same oximes hydrogenated in the positions 16, 17, 18, 19, 28, 29. A process for preparing an oxime of Formula I comprises reacting a compound selected from 3-formylrifamycin SV, 25-desacetyl-3-formylrifamycin SV and their derivatives hydrogenated in the positions 16, 17, 18, 19, 28, 29 with about an equimolar amount of an O-substitutedhydroxylamine of the general formula RONH 2 . Therapeutic compositions comprise as the active ingredient a compound of Formula I together with a pharmaceutically acceptable carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2549371 | 1971-06-07 | ||
| IT8960771A IT1045053B (en) | 1971-06-24 | 1971-06-24 | Oximes of 3-formylrifamycin - as antibiotics and dna polymerase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1338740A true GB1338740A (en) | 1973-11-28 |
Family
ID=26328602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1945772A Expired GB1338740A (en) | 1971-06-07 | 1972-05-02 | 3-formylrifamycin sv derivatives |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS517679B1 (en) |
| AR (1) | AR192938A1 (en) |
| BE (1) | BE784533A (en) |
| CA (1) | CA966481A (en) |
| CH (1) | CH562248A5 (en) |
| DD (1) | DD99782A5 (en) |
| DE (1) | DE2227087C2 (en) |
| DK (1) | DK137992B (en) |
| ES (1) | ES403548A1 (en) |
| FI (1) | FI58923C (en) |
| FR (1) | FR2140534B1 (en) |
| GB (1) | GB1338740A (en) |
| HU (1) | HU163900B (en) |
| IE (1) | IE37664B1 (en) |
| IL (1) | IL39305A (en) |
| LU (1) | LU65461A1 (en) |
| NL (1) | NL153202B (en) |
| NO (1) | NO135316C (en) |
| RO (1) | RO62437A (en) |
| SU (1) | SU432721A3 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR208F (en) * | 1964-07-31 |
-
1972
- 1972-04-25 IL IL39305A patent/IL39305A/en unknown
- 1972-05-02 GB GB1945772A patent/GB1338740A/en not_active Expired
- 1972-05-04 AR AR241803A patent/AR192938A1/en active
- 1972-05-11 IE IE633/72A patent/IE37664B1/en unknown
- 1972-05-16 NO NO1747/72A patent/NO135316C/no unknown
- 1972-05-24 FI FI1449/72A patent/FI58923C/en active
- 1972-06-02 JP JP47054997A patent/JPS517679B1/ja active Pending
- 1972-06-03 DE DE2227087A patent/DE2227087C2/en not_active Expired
- 1972-06-05 CA CA143,914A patent/CA966481A/en not_active Expired
- 1972-06-05 DD DD163437A patent/DD99782A5/xx unknown
- 1972-06-05 LU LU65461D patent/LU65461A1/xx unknown
- 1972-06-05 SU SU1789260A patent/SU432721A3/en active
- 1972-06-05 CH CH827772A patent/CH562248A5/xx not_active IP Right Cessation
- 1972-06-06 DK DK279572AA patent/DK137992B/en unknown
- 1972-06-06 RO RO7200071158A patent/RO62437A/en unknown
- 1972-06-06 HU HULE658A patent/HU163900B/hu unknown
- 1972-06-06 ES ES403548A patent/ES403548A1/en not_active Expired
- 1972-06-07 NL NL727207698A patent/NL153202B/en not_active IP Right Cessation
- 1972-06-07 FR FR7220488A patent/FR2140534B1/fr not_active Expired
- 1972-06-07 BE BE784533A patent/BE784533A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2140534A1 (en) | 1973-01-19 |
| FI58923C (en) | 1981-05-11 |
| NL7207698A (en) | 1972-12-11 |
| DD99782A5 (en) | 1973-08-20 |
| DE2227087A1 (en) | 1973-04-12 |
| IL39305A0 (en) | 1972-06-28 |
| NO135316C (en) | 1977-03-23 |
| JPS517679B1 (en) | 1976-03-10 |
| LU65461A1 (en) | 1972-10-23 |
| DK137992C (en) | 1978-11-13 |
| FI58923B (en) | 1981-01-30 |
| NL153202B (en) | 1977-05-16 |
| DE2227087C2 (en) | 1982-09-02 |
| IE37664B1 (en) | 1977-09-14 |
| RO62437A (en) | 1978-01-15 |
| ES403548A1 (en) | 1975-05-01 |
| DK137992B (en) | 1978-06-19 |
| AR192938A1 (en) | 1973-03-21 |
| CH562248A5 (en) | 1975-05-30 |
| IL39305A (en) | 1975-08-31 |
| FR2140534B1 (en) | 1975-10-31 |
| HU163900B (en) | 1973-11-28 |
| NO135316B (en) | 1976-12-13 |
| BE784533A (en) | 1972-10-02 |
| SU432721A3 (en) | 1974-06-15 |
| IE37664L (en) | 1972-12-07 |
| CA966481A (en) | 1975-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |