GB1389100A - 3-alkenyl derivatives of rifamycin sv - Google Patents
3-alkenyl derivatives of rifamycin svInfo
- Publication number
- GB1389100A GB1389100A GB5983372A GB5983372A GB1389100A GB 1389100 A GB1389100 A GB 1389100A GB 5983372 A GB5983372 A GB 5983372A GB 5983372 A GB5983372 A GB 5983372A GB 1389100 A GB1389100 A GB 1389100A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- hydrazono
- oximino
- compound
- imino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1389100 3-Alkenyl derivatives of Rifamycin SV GRUPPO LEPETIT SpA 28 Dec 1972 [19 Jan 1972] 59833/72 Heading C2C Novel 3-alkenyl derivatives of rifamycin SV of the general Formula (I) and the corresponding 16, 17, 18, 19, 28, 29- hexahydro derivatives, wherein R is hydrogen, alkyl or aryl-C 1-8 alkyl; R 1 is hydrogen or acetyl; R 2 is hydrogen, C 1-8 alkyl or tert.-butoxycarbonyl; and X is oxygen, imino, N-substituted imino, oximino, O-substituted oximino, hydrazono, N-mono-substituted hydrazono or N-disubstituted hydrazono in which the two substituents are either separate or form a heterocyclic ring together with the common nitrogen atom; are prepared by reacting 3- formylrifamycin SV or its 25-desacetyl or 16, 17, 18, 19, 28, 29-hexahydro derivative with a compound of formula Z=CR 2 -CO-R wherein Z is H 2 or (C 6 H 5 ) 3 P, and R and R 2 are as defined above to give a compound (I) wherein X is oxygen, and when a compound (I) is desired in which X is imino, N-substituted imino, oximino, O-substituted oximino, hydrazono or N-substituted hydrazono, reacting the compound (I) in which X is oxygen with a primary amine, a secondary amine, hydroxylamine, an O-substituted hydroxylamine hydrazine or an N- mono or di-substituted hydrazine respectively. The compounds (I) have antibiotic, anti-viral and anti-tumour activity, and may be admixed with a pharmaceutical carrier to provide pharmaceutical compositions having such activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1952472 | 1972-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1389100A true GB1389100A (en) | 1975-04-03 |
Family
ID=11158754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5983372A Expired GB1389100A (en) | 1972-01-19 | 1972-12-28 | 3-alkenyl derivatives of rifamycin sv |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS4880599A (en) |
| AR (1) | AR195212A1 (en) |
| AT (1) | AT320854B (en) |
| AU (1) | AU467970B2 (en) |
| BE (1) | BE794297A (en) |
| CA (1) | CA1010027A (en) |
| CH (1) | CH557377A (en) |
| DD (1) | DD103237A5 (en) |
| DE (1) | DE2301767A1 (en) |
| DK (1) | DK136479B (en) |
| ES (1) | ES410754A1 (en) |
| FR (1) | FR2181675B1 (en) |
| GB (1) | GB1389100A (en) |
| HU (1) | HU164927B (en) |
| IE (1) | IE38562B1 (en) |
| IL (1) | IL41018A (en) |
| LU (1) | LU66845A1 (en) |
| NL (1) | NL7300611A (en) |
| RO (1) | RO62775A (en) |
| SE (1) | SE380525B (en) |
| ZA (1) | ZA728307B (en) |
-
0
- BE BE794297D patent/BE794297A/en unknown
-
1972
- 1972-11-23 ZA ZA728307A patent/ZA728307B/en unknown
- 1972-11-30 IE IE1665/72A patent/IE38562B1/en unknown
- 1972-12-06 IL IL41018A patent/IL41018A/en unknown
- 1972-12-28 GB GB5983372A patent/GB1389100A/en not_active Expired
-
1973
- 1973-01-09 CA CA160,835A patent/CA1010027A/en not_active Expired
- 1973-01-15 DE DE2301767A patent/DE2301767A1/en active Pending
- 1973-01-15 AU AU51103/73A patent/AU467970B2/en not_active Expired
- 1973-01-15 CH CH52973A patent/CH557377A/en not_active IP Right Cessation
- 1973-01-16 NL NL7300611A patent/NL7300611A/xx not_active Application Discontinuation
- 1973-01-16 AR AR246142A patent/AR195212A1/en active
- 1973-01-16 DD DD168273A patent/DD103237A5/xx unknown
- 1973-01-17 AT AT36873A patent/AT320854B/en not_active IP Right Cessation
- 1973-01-17 LU LU66845A patent/LU66845A1/xx unknown
- 1973-01-18 FR FR7301783A patent/FR2181675B1/fr not_active Expired
- 1973-01-18 DK DK28073AA patent/DK136479B/en unknown
- 1973-01-18 ES ES410754A patent/ES410754A1/en not_active Expired
- 1973-01-18 HU HULE674A patent/HU164927B/hu unknown
- 1973-01-18 SE SE7300710A patent/SE380525B/en unknown
- 1973-01-18 JP JP48008229A patent/JPS4880599A/ja active Pending
- 1973-01-19 RO RO7300073553A patent/RO62775A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU439987A3 (en) | 1974-08-15 |
| DE2301767A1 (en) | 1973-07-26 |
| DK136479C (en) | 1978-03-13 |
| AT320854B (en) | 1975-03-10 |
| IL41018A0 (en) | 1973-02-28 |
| AU467970B2 (en) | 1975-12-18 |
| IL41018A (en) | 1976-05-31 |
| HU164927B (en) | 1974-05-28 |
| ZA728307B (en) | 1973-07-25 |
| ES410754A1 (en) | 1976-01-01 |
| RO62775A (en) | 1977-10-15 |
| DD103237A5 (en) | 1974-01-12 |
| CH557377A (en) | 1974-12-31 |
| BE794297A (en) | 1973-05-16 |
| SE380525B (en) | 1975-11-10 |
| AU5110373A (en) | 1974-07-18 |
| CA1010027A (en) | 1977-05-10 |
| IE38562L (en) | 1973-07-19 |
| LU66845A1 (en) | 1973-03-19 |
| DK136479B (en) | 1977-10-17 |
| JPS4880599A (en) | 1973-10-29 |
| AR195212A1 (en) | 1973-09-19 |
| IE38562B1 (en) | 1978-04-12 |
| FR2181675B1 (en) | 1976-05-14 |
| FR2181675A1 (en) | 1973-12-07 |
| NL7300611A (en) | 1973-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |