FI57757B - Foerfarande foer framstaellning av terapeutiskt anvaendbara tioxantenderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara tioxantenderivat Download PDF

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Publication number
FI57757B
FI57757B FI3395/74A FI339574A FI57757B FI 57757 B FI57757 B FI 57757B FI 3395/74 A FI3395/74 A FI 3395/74A FI 339574 A FI339574 A FI 339574A FI 57757 B FI57757 B FI 57757B
Authority
FI
Finland
Prior art keywords
formula
thioxanthene
trifluoromethyl
compound
fluoro
Prior art date
Application number
FI3395/74A
Other languages
English (en)
Finnish (fi)
Other versions
FI339574A (sv
FI57757C (fi
Inventor
Georg Ujvari
Peter Bregnedal Hansen
Original Assignee
Kefalas As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kefalas As filed Critical Kefalas As
Publication of FI339574A publication Critical patent/FI339574A/fi
Publication of FI57757B publication Critical patent/FI57757B/fi
Application granted granted Critical
Publication of FI57757C publication Critical patent/FI57757C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Claims (2)

1. Förfarande för framställning av terapeutiskt användbara tioxantenderivat och farmaceutiskt godtagbara syraadditionssait därav med formeln Ö . S CH=CH*CH -IT £ ' ' . 1 . p väri R betecknar en kloratom eller en tnfluormetylgrupp, R betecknar en väte-
3 U 3 li eller en fluoratom och R och R betecknar vardera metylgruppen eller R och R tagna tillsammans med kväveatomen bildar en piperazin- eller piperidinring even-tuellt substituerad i ^-ställningen med en metylgrupp eller en 2-hydroxietylgrupp, som ifall önskvärt, är förestrad med en alifatisk karbonsyra med 16 kolatomer, kännetecknat därav, att det omfattar reagerande av en förening med formeln R1 0 S \= CH-CH=CH2 II f~A E2 1 2 „ väri R och R ar som tidigare definierats, med en anin med formeln R3 HN^ u III ^ R 3 1| väri R och R ar som tidigare definierats, vid ca rumstemperatur och med ute-n.luLtuido uv Ijuit, och iuolerande av föroningon med formeln I som den fria basen
FI3395/74A 1973-11-30 1974-11-22 Foerfarande foer framstaellning av terapeutiskt anvaendbara tioxantenderivat FI57757C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB55759/73A GB1480593A (en) 1973-11-30 1973-11-30 Xanthene and thioxanthene derivatives having pharmaceutical activity
GB5575973 1973-11-30

Publications (3)

Publication Number Publication Date
FI339574A FI339574A (sv) 1975-05-31
FI57757B true FI57757B (fi) 1980-06-30
FI57757C FI57757C (fi) 1980-10-10

Family

ID=10474807

Family Applications (1)

Application Number Title Priority Date Filing Date
FI3395/74A FI57757C (fi) 1973-11-30 1974-11-22 Foerfarande foer framstaellning av terapeutiskt anvaendbara tioxantenderivat

Country Status (16)

Country Link
US (1) US3951961A (sv)
JP (1) JPS5093973A (sv)
AT (1) AT336013B (sv)
BE (1) BE822710A (sv)
CA (1) CA1048038A (sv)
CH (1) CH605895A5 (sv)
DE (1) DE2456098C3 (sv)
DK (1) DK137575B (sv)
ES (1) ES432439A1 (sv)
FI (1) FI57757C (sv)
FR (1) FR2253510B1 (sv)
GB (1) GB1480593A (sv)
IE (1) IE40261B1 (sv)
NL (1) NL7415177A (sv)
NO (1) NO140795C (sv)
SE (1) SE415659B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE409860B (sv) * 1977-07-04 1979-09-10 Astra Laekemedel Ab En ny mellanprodukt for framstellning av terapeutiskt aktiva pyridinforeningar
SE7909514L (sv) * 1979-11-16 1981-05-17 Astra Laekemedel Ab Nya halofenyl-pyridyl-allylaminderivat
JP2001501629A (ja) 1996-10-04 2001-02-06 ノボ ノルディスク アクティーゼルスカブ Ｎ―置換アザ複素環式化合物
CN102786511B (zh) * 2011-05-18 2014-10-15 重庆圣华曦药业股份有限公司 一种制备盐酸氟哌噻吨中间体的改进方法
EP2998303B1 (en) 2014-09-17 2018-06-13 B & G Partners, LLC Phenothiazine derivatives and methods for treating tumors
CN115850232B (zh) * 2023-02-16 2023-05-26 广州佳途科技股份有限公司 一种氟哌噻吨ep杂质h的制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE557002A (sv) * 1956-07-09
US3192204A (en) * 1960-03-07 1965-06-29 Smith Kline French Lab Trifluoromethylthiaxanthene and -xanthene derivatives
US3282930A (en) * 1962-08-17 1966-11-01 Smith Kline French Lab Hydroxyalkylenepiperazine derivatives and analogs thereof
US3310553A (en) * 1962-09-25 1967-03-21 Pfizer & Co C Alkylated thioxathenesulfonamides
US3157658A (en) * 1963-07-05 1964-11-17 Searle & Co 1-carbalkoxy-4-(9-xanthenyl) piperazines and related compounds
US3681346A (en) * 1969-06-20 1972-08-01 Kefalas As {60 -isomer of the decanoic acid ester of 10-{8 3,-(4-hydroxyethyl-1-piperazinyl)propylidene{9 -2-trifluoro-methyl thiaxanthene, acid addition salts thereof, method of use and compositions

Also Published As

Publication number Publication date
AU7561574A (en) 1976-05-27
DK624774A (sv) 1975-07-28
DE2456098A1 (de) 1975-06-05
DK137575C (sv) 1978-09-11
AT336013B (de) 1977-04-12
SE415659B (sv) 1980-10-20
FR2253510A1 (sv) 1975-07-04
DE2456098C3 (de) 1979-01-18
DK137575B (da) 1978-03-28
NO140795B (no) 1979-08-06
NL7415177A (nl) 1975-06-03
US3951961A (en) 1976-04-20
IE40261B1 (en) 1979-04-25
ES432439A1 (es) 1976-11-16
CH605895A5 (sv) 1978-10-13
ATA952174A (de) 1976-08-15
DE2456098B2 (de) 1978-04-27
IE40261L (en) 1975-05-30
NO744310L (sv) 1975-06-23
SE7414983L (sv) 1975-06-02
CA1048038A (en) 1979-02-06
BE822710A (fr) 1975-05-28
FR2253510B1 (sv) 1977-12-09
GB1480593A (en) 1977-07-20
NO140795C (no) 1979-11-14
JPS5093973A (sv) 1975-07-26
FI339574A (sv) 1975-05-31
FI57757C (fi) 1980-10-10

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