FI56931B - Foerfarande foer framstaellning av ett terapeutiskt aktivt stabilt tretinoingelpreparat ur vilket tretinoinet laett frigoeres och absorberas i huden - Google Patents
Foerfarande foer framstaellning av ett terapeutiskt aktivt stabilt tretinoingelpreparat ur vilket tretinoinet laett frigoeres och absorberas i huden Download PDFInfo
- Publication number
- FI56931B FI56931B FI760089A FI760089A FI56931B FI 56931 B FI56931 B FI 56931B FI 760089 A FI760089 A FI 760089A FI 760089 A FI760089 A FI 760089A FI 56931 B FI56931 B FI 56931B
- Authority
- FI
- Finland
- Prior art keywords
- tretinoin
- gel
- och
- vitamin
- tretinoingelpreparat
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 41
- 229960001727 tretinoin Drugs 0.000 claims description 32
- 238000002360 preparation method Methods 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 12
- 229930002330 retinoic acid Natural products 0.000 claims description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 239000011877 solvent mixture Substances 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 230000003078 antioxidant effect Effects 0.000 claims description 4
- 235000006708 antioxidants Nutrition 0.000 claims description 4
- 239000003349 gelling agent Substances 0.000 claims description 4
- 206010000496 acne Diseases 0.000 description 31
- 239000000499 gel Substances 0.000 description 25
- 208000002874 Acne Vulgaris Diseases 0.000 description 15
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 10
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 10
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 10
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 10
- 239000006071 cream Substances 0.000 description 10
- 210000003491 skin Anatomy 0.000 description 9
- 229920002125 Sokalan® Polymers 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- 239000002674 ointment Substances 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 5
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 3
- 229940043276 diisopropanolamine Drugs 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 206010037888 Rash pustular Diseases 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000003791 organic solvent mixture Substances 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- -1 polyoxy Polymers 0.000 description 2
- 208000029561 pustule Diseases 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010027146 Melanoderma Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000004508 retinoic acid derivatives Chemical class 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54190675A | 1975-01-17 | 1975-01-17 | |
| US54190675 | 1975-01-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI760089A7 FI760089A7 (en, 2012) | 1976-07-18 |
| FI56931B true FI56931B (fi) | 1980-01-31 |
Family
ID=24161582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI760089A FI56931B (fi) | 1975-01-17 | 1976-01-16 | Foerfarande foer framstaellning av ett terapeutiskt aktivt stabilt tretinoingelpreparat ur vilket tretinoinet laett frigoeres och absorberas i huden |
Country Status (18)
| Country | Link |
|---|---|
| AT (1) | AT363191B (en, 2012) |
| AU (1) | AU499339B2 (en, 2012) |
| BE (1) | BE837662A (en, 2012) |
| CA (1) | CA1063515A (en, 2012) |
| DE (1) | DE2601489A1 (en, 2012) |
| DK (1) | DK157781C (en, 2012) |
| FI (1) | FI56931B (en, 2012) |
| FR (1) | FR2354092A1 (en, 2012) |
| GB (1) | GB1476717A (en, 2012) |
| IN (1) | IN142640B (en, 2012) |
| LU (1) | LU74195A1 (en, 2012) |
| NL (1) | NL7600388A (en, 2012) |
| NO (1) | NO760149L (en, 2012) |
| NZ (1) | NZ179755A (en, 2012) |
| PH (1) | PH18090A (en, 2012) |
| PT (1) | PT64709B (en, 2012) |
| SE (1) | SE429924B (en, 2012) |
| ZA (1) | ZA76251B (en, 2012) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4214000A (en) | 1978-10-30 | 1980-07-22 | Johnson & Johnson | Zinc salt of all-trans-retinoic acid for the treatment of acne |
| JPS58164508A (ja) * | 1982-03-26 | 1983-09-29 | Eisai Co Ltd | イソプレニルカルボン酸含有外用組成物 |
| CH655656B (en, 2012) * | 1982-10-07 | 1986-05-15 | ||
| US4889847A (en) * | 1986-11-03 | 1989-12-26 | Ortho Pharmaceutical Corporation | Prevention of glucocorticoid-induced skin atrophy |
| MY105521A (en) * | 1989-04-17 | 1994-10-31 | Healthpoint Ltd | Moisturizing vehicle for topical application of vitamin a acid. |
| JP2671248B2 (ja) * | 1991-10-23 | 1997-10-29 | ブロック・ドラッグ・カンパニー・インコーポレイテッド | 薬効または化粧効果成分の浸透性増進方法 |
| GB9125712D0 (en) * | 1991-12-03 | 1992-01-29 | Smithkline Beecham Plc | Skin care composition |
| AU670777B2 (en) * | 1992-04-16 | 1996-08-01 | Ortho Pharmaceutical Corporation | Aqueous gel vehicles for retinoids |
| GB2268402A (en) * | 1992-06-19 | 1994-01-12 | Ian Donald Morrison | Compositions for treating skin disorders |
| FR2761600B1 (fr) | 1998-06-19 | 2000-03-31 | Oreal | Composition moussante pour le lavage et le traitement des cheveux et/ou du cuir chevelu a base d'un principe actif, d'un tensioactif anionique, d'un tensioactif amphotere et d'un agent propenetrant |
| CN100464741C (zh) * | 2002-12-12 | 2009-03-04 | 盖尔德马研究及发展公司 | 含有酚衍生物和类维生素a的含水醇脱色素凝胶 |
| EP1572176A2 (en) * | 2002-12-12 | 2005-09-14 | Galderma Research & Development, S.N.C. | Aqueous-alcoholic depigmenting gel containing a phenolic derivative and a retinoid |
| FR2857266B1 (fr) * | 2003-07-07 | 2007-09-21 | Jean Noel Thorel | Composition a usage dermatologique et/ou cosmetique, comprenant a titre de principe actif au moins un antioxydant lipophile |
| BRPI0609728A2 (pt) * | 2005-03-24 | 2010-04-20 | Anacor Pharmaceuticals Inc | formulações tópicas de antibióticos de ácido borìnico e métodos de uso do mesmo |
| US20100215700A1 (en) | 2009-02-25 | 2010-08-26 | Conopco, Inc., D/B/A Unilever | Shear Gels and Compositions Comprising Shear Gels |
| CN118121574A (zh) * | 2022-12-02 | 2024-06-04 | 南京毓浠医药技术有限公司 | 一种含维a酸组合物及其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL257621A (en, 2012) * | 1959-11-23 | |||
| US3729568A (en) * | 1969-09-23 | 1973-04-24 | Johnson & Johnson | Acne treatment |
-
1976
- 1976-01-12 IN IN74/CAL/1976A patent/IN142640B/en unknown
- 1976-01-13 NZ NZ179755A patent/NZ179755A/xx unknown
- 1976-01-13 FR FR7600725A patent/FR2354092A1/fr active Granted
- 1976-01-14 CA CA243,496A patent/CA1063515A/en not_active Expired
- 1976-01-15 NL NL7600388A patent/NL7600388A/xx not_active Application Discontinuation
- 1976-01-16 FI FI760089A patent/FI56931B/fi not_active Application Discontinuation
- 1976-01-16 NO NO760149A patent/NO760149L/no unknown
- 1976-01-16 DK DK018276A patent/DK157781C/da active
- 1976-01-16 LU LU74195A patent/LU74195A1/xx unknown
- 1976-01-16 SE SE7600436A patent/SE429924B/xx not_active IP Right Cessation
- 1976-01-16 AT AT0027276A patent/AT363191B/de not_active IP Right Cessation
- 1976-01-16 ZA ZA760251A patent/ZA76251B/xx unknown
- 1976-01-16 PH PH17983A patent/PH18090A/en unknown
- 1976-01-16 AU AU10351/76A patent/AU499339B2/en not_active Expired
- 1976-01-16 BE BE163589A patent/BE837662A/xx not_active IP Right Cessation
- 1976-01-16 GB GB181076A patent/GB1476717A/en not_active Expired
- 1976-01-16 DE DE19762601489 patent/DE2601489A1/de active Granted
- 1976-01-17 PT PT64709A patent/PT64709B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7600388A (nl) | 1976-07-20 |
| DE2601489C2 (en, 2012) | 1990-02-01 |
| DE2601489A1 (de) | 1976-07-22 |
| PT64709B (fr) | 1978-01-04 |
| AU1035176A (en) | 1977-07-21 |
| AU499339B2 (en) | 1979-04-12 |
| DK18276A (da) | 1976-07-18 |
| FI760089A7 (en, 2012) | 1976-07-18 |
| BE837662A (fr) | 1976-07-16 |
| NZ179755A (en) | 1978-06-20 |
| FR2354092B1 (en, 2012) | 1981-09-18 |
| AT363191B (de) | 1981-07-10 |
| GB1476717A (en) | 1977-06-16 |
| CA1063515A (en) | 1979-10-02 |
| NO760149L (en, 2012) | 1976-07-20 |
| ATA27276A (de) | 1980-12-15 |
| DK157781B (da) | 1990-02-19 |
| LU74195A1 (en, 2012) | 1976-05-18 |
| DK157781C (da) | 1990-08-13 |
| ZA76251B (en) | 1977-08-31 |
| SE7600436L (sv) | 1976-07-18 |
| PT64709A (fr) | 1976-02-01 |
| IN142640B (en, 2012) | 1977-08-06 |
| SE429924B (sv) | 1983-10-10 |
| PH18090A (en) | 1985-03-20 |
| FR2354092A1 (fr) | 1978-01-06 |
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