FI55194C - Foerfarande foer framstaellning av 6-substituerade 4-amino-1,2-dihydro-1-hydroxi-2-iminopyrimidiner - Google Patents

Foerfarande foer framstaellning av 6-substituerade 4-amino-1,2-dihydro-1-hydroxi-2-iminopyrimidiner Download PDF

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Publication number
FI55194C
FI55194C FI828/71A FI82871A FI55194C FI 55194 C FI55194 C FI 55194C FI 828/71 A FI828/71 A FI 828/71A FI 82871 A FI82871 A FI 82871A FI 55194 C FI55194 C FI 55194C
Authority
FI
Finland
Prior art keywords
carbon atoms
dihydro
amino
hydroxy
formula
Prior art date
Application number
FI828/71A
Other languages
English (en)
Finnish (fi)
Other versions
FI55194B (fi
Inventor
William Crawford Anthony
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI55194B publication Critical patent/FI55194B/fi
Application granted granted Critical
Publication of FI55194C publication Critical patent/FI55194C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Phase Diffusion Into Metallic Material Surfaces (AREA)
FI828/71A 1970-03-31 1971-03-23 Foerfarande foer framstaellning av 6-substituerade 4-amino-1,2-dihydro-1-hydroxi-2-iminopyrimidiner FI55194C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2435170A 1970-03-31 1970-03-31
US2435170 1970-03-31

Publications (2)

Publication Number Publication Date
FI55194B FI55194B (fi) 1979-02-28
FI55194C true FI55194C (fi) 1981-05-18

Family

ID=21820134

Family Applications (1)

Application Number Title Priority Date Filing Date
FI828/71A FI55194C (fi) 1970-03-31 1971-03-23 Foerfarande foer framstaellning av 6-substituerade 4-amino-1,2-dihydro-1-hydroxi-2-iminopyrimidiner

Country Status (10)

Country Link
US (1) US3644364A (no)
JP (1) JPS551259B1 (no)
CH (1) CH551979A (no)
DE (1) DE2114887C3 (no)
DK (2) DK128116B (no)
FI (1) FI55194C (no)
FR (1) FR2087936A5 (no)
NL (1) NL7104019A (no)
NO (2) NO131420C (no)
SE (2) SE384504B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931181A (en) * 1973-07-27 1976-01-06 Hoffmann-La Roche Inc. 2,4-Diamino-5-benzylpyrimidines
US4013778A (en) * 1974-08-05 1977-03-22 Warner-Lambert Company Method for reducing blood pressure
US4175190A (en) * 1977-02-04 1979-11-20 Hoffmann-La Roche Inc. 6-Chloro-2,4-pyrimidine-dicarbamate-3-oxides
US4175189A (en) * 1977-02-04 1979-11-20 Hoffmann-La Roche Inc. 6-Chloro-2,4-pyrimidine-dicarbamate-3-oxides
US5196533A (en) * 1983-04-11 1993-03-23 South Alabama Medical Science Foundation, Usa Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines
HU196067B (en) * 1986-07-10 1988-09-28 Richter Gedeon Vegyeszet Process for production of 6-amin-1,2-dihydro-1-hydroxi-2-imino-4-piperidin-piramidin
FI864046A (fi) * 1986-10-07 1988-04-08 Farmos Oy Foerfarande foer framstaellning av en terapeutiskt aktiv foerening.
US6465514B1 (en) 1986-12-29 2002-10-15 Kenneth M. Hallam Methods and compositions for the promotion of hair growth
US4927626A (en) * 1988-10-28 1990-05-22 Devillez Richard L Method for enhancement of unguis growth
US4959475A (en) * 1989-01-04 1990-09-25 Lonza Ltd. Process for the production of 2,4-diamino-6-piperidinyl-pyrimidine-3-N-oxide
FR2651122B1 (fr) * 1989-08-29 1994-10-28 Oreal Compositions destinees a etre utilisees pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives de l'amino-2 pyrimidine oxyde-3 et nouveaux composes derives de l'amino-2 pyrimidine oxyde-3.
ATE120190T1 (de) * 1990-11-14 1995-04-15 Upjohn Co 5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls.
US5502050A (en) * 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
FR2753378B1 (fr) * 1996-09-17 1998-11-20 Oreal Utilisation dans une composition en tant que stimulateur de tyrosinase d'au moins un derive de pyrimidine 3-oxyde, substitue en 6
US20050163811A1 (en) * 2004-01-23 2005-07-28 Richard Lee Topical solutions comprising high concentrations of piperidinopyrimidine derivatives and methods of use thereof
EP2730271B1 (en) 2012-11-11 2018-01-24 Symrise AG Aqeuous compositions
CN107129470A (zh) * 2017-06-12 2017-09-05 常州市天华制药有限公司 一种米诺地尔的合成与精制方法
CN107235919B (zh) * 2017-06-22 2020-05-12 安徽拜善晟制药有限公司 一种米诺地尔的合成工艺
CN114213340B (zh) 2022-02-22 2022-06-07 北京蓝晶微生物科技有限公司 2,4-二氨基嘧啶氧化物的制备方法
CN115572265A (zh) * 2022-10-10 2023-01-06 江苏海悦康医药科技有限公司 一种高纯度米诺地尔的绿色合成工艺

Also Published As

Publication number Publication date
DE2114887C3 (de) 1980-09-11
NO140011C (no) 1979-06-20
DK128116B (da) 1974-03-04
NL7104019A (no) 1971-10-04
US3644364A (en) 1972-02-22
FI55194B (fi) 1979-02-28
SE384368B (sv) 1976-05-03
NO741201L (no) 1971-10-01
NO131420B (no) 1975-02-17
JPS551259B1 (no) 1980-01-12
NO131420C (no) 1975-05-28
DK128539B (da) 1974-05-20
FR2087936A5 (no) 1971-12-31
CH551979A (de) 1974-07-31
NO140011B (no) 1979-03-12
SE384504B (sv) 1976-05-10
DE2114887A1 (de) 1971-10-14
DE2114887B2 (de) 1980-01-17

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