FI48064B - - Google Patents

Info

Publication number
FI48064B
FI48064B FI02535/67A FI253567A FI48064B FI 48064 B FI48064 B FI 48064B FI 02535/67 A FI02535/67 A FI 02535/67A FI 253567 A FI253567 A FI 253567A FI 48064 B FI48064 B FI 48064B
Authority
FI
Finland
Application number
FI02535/67A
Other versions
FI48064C (fi
Inventor
W Bolhofer
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI48064B publication Critical patent/FI48064B/fi
Application granted granted Critical
Publication of FI48064C publication Critical patent/FI48064C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48Y being a hydrogen or a carbon atom
    • C07C275/50Y being a hydrogen or an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI672535A 1966-10-03 1967-09-22 Menetelmä (3-trifluorimetyylifenoksi)-(4-halogeenifenyyli)-etikkahapon terapeuttisesti aktiivisten esterien valmistamiseksi FI48064C (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58393766A 1966-10-03 1966-10-03

Publications (2)

Publication Number Publication Date
FI48064B true FI48064B (fi) 1974-02-28
FI48064C FI48064C (fi) 1974-06-10

Family

ID=24335223

Family Applications (1)

Application Number Title Priority Date Filing Date
FI672535A FI48064C (fi) 1966-10-03 1967-09-22 Menetelmä (3-trifluorimetyylifenoksi)-(4-halogeenifenyyli)-etikkahapon terapeuttisesti aktiivisten esterien valmistamiseksi

Country Status (19)

Country Link
US (1) US3517050A (fi)
AT (2) AT279590B (fi)
BE (1) BE704574A (fi)
BR (1) BR6793319D0 (fi)
CH (1) CH512422A (fi)
CS (1) CS170496B2 (fi)
CY (1) CY650A (fi)
DE (1) DE1643460A1 (fi)
DK (1) DK120955B (fi)
ES (1) ES345582A1 (fi)
FI (1) FI48064C (fi)
FR (2) FR1573841A (fi)
GB (1) GB1182007A (fi)
GR (1) GR34667B (fi)
MY (1) MY7300079A (fi)
NL (1) NL149484B (fi)
NO (1) NO121787B (fi)
SE (1) SE332182B (fi)
YU (1) YU32921B (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923855A (en) * 1972-07-13 1975-12-02 Merck & Co Inc 2-sulfonyloxyethyl 3-trifluoromethylphenoxy-4{40 -chlorophenyl acetate
US4110351A (en) * 1973-04-02 1978-08-29 Richardson-Merrell Inc. Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts
DK115374A (fi) 1974-03-04 1975-11-03 Byk Gulden Lomberg Chem Fab
IL48707A0 (en) * 1974-12-30 1976-02-29 Synthelabo Novel phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them
FR2424247A2 (fr) * 1978-04-27 1979-11-23 Science Union & Cie Nouveaux derives d'acides arylalcanoiques a action hypolipemiante et leurs procedes d'obtention
US4250191A (en) * 1978-11-30 1981-02-10 Edwards K David Preventing renal failure
US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US6624194B1 (en) * 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US7091230B2 (en) * 2001-02-09 2006-08-15 Merck & Co., Inc. 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders
WO2004112774A1 (en) * 2003-06-20 2004-12-29 Metabolex, Inc. RESOLUTION OF α-(PHENOXY)PHENYLACETIC ACID DERIVATIVES
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
CN100525757C (zh) * 2003-06-20 2009-08-12 麦它波莱克斯股份有限公司 α-(苯氧基)苯乙酸衍生物的拆分
CN1922143A (zh) 2004-02-18 2007-02-28 麦它波莱克斯股份有限公司 作为抗糖尿病药的α-(三氟甲基-取代的芳氧基、芳基氨基、芳硫基或芳基甲基)-三氟甲基-取代的苯乙酸和衍生物
RU2006145872A (ru) * 2004-05-25 2008-06-27 Метаболекс, Инк. (Us) Замещенные триазолы в качестве модуляторов ppar и способы их получения
WO2005115384A2 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
US8288438B2 (en) 2005-03-21 2012-10-16 Metabolex, Inc. Methods for avoiding edema in the treatment or prevention of PPARγ-responsive diseases, including cancer
US7432394B2 (en) * 2005-09-23 2008-10-07 Metabolex, Inc. Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
WO2009121940A1 (en) * 2008-04-03 2009-10-08 Janssen Pharmaceutica Nv Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester
US9023856B2 (en) 2011-11-04 2015-05-05 Cymabay Therapeutics, Inc. Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
US9060987B2 (en) 2011-11-04 2015-06-23 Cymabay Therapeutics, Inc. Methods for treating gout flares
CA2873089A1 (en) * 2012-05-10 2013-11-14 Cellixbio Private Limited Compositions and methods for the treatment of metabolic syndrome
EA028385B1 (ru) * 2013-01-18 2017-11-30 Саймабэй Терапьютикс, Инк. Опосредуемое dcc сочетание для получения галофената

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES251290A1 (es) * 1958-08-21 1960-04-01 Parke Davis & Co Un procedimiento para la producciën de alcohilaminas arilsustituidas

Also Published As

Publication number Publication date
NL6712584A (fi) 1968-04-04
NO121787B (fi) 1971-04-13
US3517050A (en) 1970-06-23
MY7300079A (en) 1973-12-31
BR6793319D0 (pt) 1973-05-24
ES345582A1 (es) 1970-02-01
GB1182007A (en) 1970-02-25
CH512422A (de) 1971-09-15
YU32921B (en) 1975-12-31
FR1573841A (fi) 1969-07-11
CS170496B2 (fi) 1976-08-27
CY650A (en) 1972-07-12
DK120955B (da) 1971-08-09
FI48064C (fi) 1974-06-10
AT282617B (de) 1970-07-10
FR8372M (fi) 1971-02-22
YU185167A (en) 1975-06-30
SE332182B (fi) 1971-02-01
BE704574A (fi) 1968-04-02
GR34667B (el) 1968-06-05
AT279590B (de) 1970-03-10
NL149484B (nl) 1976-05-17
DE1643460A1 (de) 1971-01-28

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