FI3615674T3 - Menetelmiä reumatoidin artriitin hoitoon HLA-geenin RNA-ohjattua genomin muokkausta käyttämällä - Google Patents
Menetelmiä reumatoidin artriitin hoitoon HLA-geenin RNA-ohjattua genomin muokkausta käyttämällä Download PDFInfo
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- FI3615674T3 FI3615674T3 FIEP18791113.6T FI18791113T FI3615674T3 FI 3615674 T3 FI3615674 T3 FI 3615674T3 FI 18791113 T FI18791113 T FI 18791113T FI 3615674 T3 FI3615674 T3 FI 3615674T3
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- Prior art keywords
- cell
- nucleic acid
- codon
- guide rna
- template nucleic
- Prior art date
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- 238000000034 method Methods 0.000 title claims 11
- 206010039073 rheumatoid arthritis Diseases 0.000 title claims 3
- 238000010362 genome editing Methods 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 108091033409 CRISPR Proteins 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 108020004705 Codon Proteins 0.000 claims 11
- 108020005004 Guide RNA Proteins 0.000 claims 11
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 10
- 108700028369 Alleles Proteins 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 108010029657 HLA-DRB1*04:01 antigen Proteins 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 7
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- 210000000601 blood cell Anatomy 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 230000010354 integration Effects 0.000 claims 3
- 241000713666 Lentivirus Species 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 claims 1
- 108010039343 HLA-DRB1 Chains Proteins 0.000 claims 1
- 101150018610 HLA-DRB1 gene Proteins 0.000 claims 1
- 108091028664 Ribonucleotide Proteins 0.000 claims 1
- 241000713675 Spumavirus Species 0.000 claims 1
- 210000003995 blood forming stem cell Anatomy 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000003643 myeloid progenitor cell Anatomy 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000002336 ribonucleotide Substances 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- A01K2267/00—Animals characterised by purpose
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- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491487P | 2017-04-28 | 2017-04-28 | |
| PCT/US2018/029302 WO2018200635A1 (en) | 2017-04-28 | 2018-04-25 | Methods of treating rheumatoid arthritis using rna-guided genome editing of hla gene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3615674T3 true FI3615674T3 (fi) | 2024-06-18 |
Family
ID=63918677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP18791113.6T FI3615674T3 (fi) | 2017-04-28 | 2018-04-25 | Menetelmiä reumatoidin artriitin hoitoon HLA-geenin RNA-ohjattua genomin muokkausta käyttämällä |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11932867B2 (https=) |
| EP (2) | EP3615674B1 (https=) |
| JP (2) | JP7457302B2 (https=) |
| AU (2) | AU2018258061B2 (https=) |
| CA (1) | CA3061614A1 (https=) |
| DK (1) | DK3615674T3 (https=) |
| ES (1) | ES2981611T3 (https=) |
| FI (1) | FI3615674T3 (https=) |
| HR (1) | HRP20240806T1 (https=) |
| HU (1) | HUE069314T2 (https=) |
| LT (1) | LT3615674T (https=) |
| SI (1) | SI3615674T1 (https=) |
| WO (1) | WO2018200635A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3615674T (lt) | 2017-04-28 | 2024-09-25 | The Regents Of The University Of Colorado, A Body Corporate | Reumatoidinio artrito gydymo būdai, naudojant nukreipiančios rnr hla geno redagavimą genome |
| KR20240023035A (ko) | 2021-05-10 | 2024-02-20 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 | 자가면역 치료를 위한 hla 조작 방법 및 조성물 |
| WO2025195458A1 (en) * | 2024-03-20 | 2025-09-25 | Nanjing Legend Biotech Co., Ltd. | Methods for producing immune-compatible cells |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| JP4285766B2 (ja) | 1994-03-23 | 2009-06-24 | オハイオ ユニバーシティ | 緻密にした核酸および細胞へのデリバリ |
| US5965787A (en) * | 1995-08-31 | 1999-10-12 | Mayo Foundation For Medical Education And Research | HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6667175B1 (en) | 1999-06-15 | 2003-12-23 | The Trustees Of Columbia University | Generation of antigen specific T suppressor cells for treatment of rejection |
| AU776576B2 (en) | 1999-12-06 | 2004-09-16 | Sangamo Biosciences, Inc. | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
| US6689558B2 (en) | 2000-02-08 | 2004-02-10 | Sangamo Biosciences, Inc. | Cells for drug discovery |
| US20060062761A1 (en) | 2001-03-02 | 2006-03-23 | Carr Francis J | Modified interferon alpha with reduced immunogenicity |
| US8790345B2 (en) | 2007-08-21 | 2014-07-29 | Zimmer, Inc. | Titanium alloy with oxidized zirconium for a prosthetic implant |
| US9175280B2 (en) | 2010-10-12 | 2015-11-03 | Sangamo Biosciences, Inc. | Methods and compositions for treating hemophilia B |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
| US8969254B2 (en) * | 2010-12-16 | 2015-03-03 | Dana-Farber Cancer Institute, Inc. | Oligonucleotide array for tissue typing |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| JP6598860B2 (ja) * | 2014-08-06 | 2019-10-30 | カレッジ オブ メディシン ポチョン チャ ユニバーシティ インダストリー−アカデミック コーオペレイション ファウンデーション | Ｈｌａをコードする遺伝子のヌクレアーゼ媒介編集により作製される免疫適合性細胞 |
| CN108026526B (zh) * | 2015-06-09 | 2023-05-12 | 爱迪塔斯医药公司 | 用于改善移植的crispr/cas相关方法和组合物 |
| CA2996887A1 (en) | 2015-09-11 | 2017-03-16 | Agenus Inc. | Engineered host cells and methods of use thereof |
| LT3615674T (lt) | 2017-04-28 | 2024-09-25 | The Regents Of The University Of Colorado, A Body Corporate | Reumatoidinio artrito gydymo būdai, naudojant nukreipiančios rnr hla geno redagavimą genome |
| RU2763798C1 (ru) | 2017-12-23 | 2022-01-11 | Рубиус Терапьютикс, Инк. | Искусственные антигенпрезентирующие клетки и способы их применения |
| GB201802338D0 (en) | 2018-02-13 | 2018-03-28 | Univ Oslo | Antigen binding proteins |
| GB201807410D0 (en) | 2018-05-04 | 2018-06-20 | Univ Oxford Innovation Ltd | Diagnostic method and therapy |
| US11918610B2 (en) | 2018-06-29 | 2024-03-05 | Viktor Veniaminovich Tets | Methods for diagnosis and treatment of type 1 diabetes |
| JP2022522405A (ja) | 2019-03-06 | 2022-04-19 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| WO2020181272A1 (en) | 2019-03-06 | 2020-09-10 | Cue Biopharma, Inc. | Antigen-presenting polypeptides with chemical conjugation sites and methods of use thereof |
| EP3935079A4 (en) | 2019-03-06 | 2023-03-22 | Cue Biopharma, Inc. | T-CELL MODULATING ANTIGEN PRESENT POLYPEPTIDES AND METHODS OF USE THEREOF |
| EP3719033A1 (en) | 2019-04-02 | 2020-10-07 | imusyn GmbH & Co. KG | Stabilized mhc i |
| KR20240023035A (ko) | 2021-05-10 | 2024-02-20 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 | 자가면역 치료를 위한 hla 조작 방법 및 조성물 |
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- 2018-04-25 FI FIEP18791113.6T patent/FI3615674T3/fi active
- 2018-04-25 SI SI201831109T patent/SI3615674T1/sl unknown
- 2018-04-25 CA CA3061614A patent/CA3061614A1/en active Pending
- 2018-04-25 US US16/609,175 patent/US11932867B2/en active Active
- 2018-04-25 WO PCT/US2018/029302 patent/WO2018200635A1/en not_active Ceased
- 2018-04-25 ES ES18791113T patent/ES2981611T3/es active Active
- 2018-04-25 HR HRP20240806TT patent/HRP20240806T1/hr unknown
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| AU2018258061A1 (en) | 2019-11-28 |
| LT3615674T (lt) | 2024-09-25 |
| EP3615674B1 (en) | 2024-03-13 |
| WO2018200635A1 (en) | 2018-11-01 |
| US11932867B2 (en) | 2024-03-19 |
| JP2024075603A (ja) | 2024-06-04 |
| EP3615674A4 (en) | 2021-03-24 |
| JP7457302B2 (ja) | 2024-03-28 |
| HRP20240806T1 (hr) | 2024-12-06 |
| AU2025200803A1 (en) | 2025-03-20 |
| AU2018258061B2 (en) | 2024-11-07 |
| HUE069314T2 (hu) | 2025-03-28 |
| CA3061614A1 (en) | 2018-11-01 |
| JP2020517289A (ja) | 2020-06-18 |
| US20240327862A1 (en) | 2024-10-03 |
| US20200199616A1 (en) | 2020-06-25 |
| SI3615674T1 (sl) | 2025-03-31 |
| ES2981611T3 (es) | 2024-10-09 |
| EP3615674A1 (en) | 2020-03-04 |
| DK3615674T3 (da) | 2024-06-17 |
| EP4400175A3 (en) | 2024-09-25 |
| EP4400175A2 (en) | 2024-07-17 |
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