FI120333B - Poröst medicinskt medel och förfarande för dess tillverkning - Google Patents

Poröst medicinskt medel och förfarande för dess tillverkning Download PDF

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Publication number
FI120333B
FI120333B FI20031174A FI20031174A FI120333B FI 120333 B FI120333 B FI 120333B FI 20031174 A FI20031174 A FI 20031174A FI 20031174 A FI20031174 A FI 20031174A FI 120333 B FI120333 B FI 120333B
Authority
FI
Finland
Prior art keywords
layers
bioactive
bioabsorbable
structure according
matrix
Prior art date
Application number
FI20031174A
Other languages
English (en)
Finnish (fi)
Other versions
FI20031174A (sv
FI20031174A0 (sv
Inventor
Pertti Toermaelae
Esa Suokas
Mikko Hupa
Nureddin Ashammakhi
Heimo Ylaenen
Original Assignee
Bioretec Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioretec Oy filed Critical Bioretec Oy
Priority to FI20031174A priority Critical patent/FI120333B/sv
Publication of FI20031174A0 publication Critical patent/FI20031174A0/sv
Priority to US10/568,890 priority patent/US7964206B2/en
Priority to PCT/FI2004/050117 priority patent/WO2005018698A1/en
Priority to AT04767137T priority patent/ATE416725T1/de
Priority to DE200460018328 priority patent/DE602004018328D1/de
Priority to EP20040767137 priority patent/EP1660146B1/en
Publication of FI20031174A publication Critical patent/FI20031174A/sv
Application granted granted Critical
Publication of FI120333B publication Critical patent/FI120333B/sv

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/22—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed
    • B32B5/24—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer
    • B32B5/26—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by the presence of two or more layers which are next to each other and are fibrous, filamentary, formed of particles or foamed one layer being a fibrous or filamentary layer another layer next to it also being fibrous or filamentary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • D—TEXTILES; PAPER
    • D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
    • D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
    • D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
    • D02G3/44—Yarns or threads characterised by the purpose for which they are designed
    • D02G3/448—Yarns or threads for use in medical applications
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04B—KNITTING
    • D04B1/00—Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
    • D04B1/14—Other fabrics or articles characterised primarily by the use of particular thread materials
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04C—BRAIDING OR MANUFACTURE OF LACE, INCLUDING BOBBIN-NET OR CARBONISED LACE; BRAIDING MACHINES; BRAID; LACE
    • D04C1/00—Braid or lace, e.g. pillow-lace; Processes for the manufacture thereof
    • D04C1/06—Braid or lace serving particular purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30065—Properties of materials and coating materials thermoplastic, i.e. softening or fusing when heated, and hardening and becoming rigid again when cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30907—Nets or sleeves applied to surface of prostheses or in cement
    • A61F2002/30909—Nets
    • A61F2002/30914—Details of the mesh structure, e.g. disposition of the woven warp and weft wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30907—Nets or sleeves applied to surface of prostheses or in cement
    • A61F2002/30909—Nets
    • A61F2002/30915—Nets made of a stack of bonded perforated sheets, grids or wire meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30971—Laminates, i.e. layered products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0071—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof thermoplastic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/02—Coating on the layer surface on fibrous or filamentary layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/26—Polymeric coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/10—Inorganic fibres
    • B32B2262/105—Ceramic fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2305/00—Condition, form or state of the layers or laminate
    • B32B2305/08—Reinforcements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2556/00—Patches, e.g. medical patches, repair patches
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2509/00—Medical; Hygiene
    • D10B2509/08—Hernia repair mesh
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
    • Y10T442/2525—Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Textile Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Medicinal Preparation (AREA)

Claims (26)

1. Porös, bioabsorberbar, bioaktiv och lastbärande medicinisk komposit-medelstruktur med en bioabsorberbar matris och en armeringsstruktur, 5 kännetecknad av, att den innefattar: flera planartade textilskikt (1a, 1b, 1c) vilka bestär av kontinuerliga fiber-element (3), varvid de sagda skikten är placerade ovanpa varandra för att bilda en struktur med tvä dimensioner (x, y) i olika riktningar med varandra 10 och en tredje dimension (z) som är resultat av stapling av de sagda planartade skikten pä varandra; flera öppningar (2) som sträcker sig genom sagda skikt och som begränsas av sektioner av de sagda kontinuerliga fiberelementen (3) vilka sträcker sig 15 väsentligen parallels med det sagda planet, varvid sagda öppningar finns i de sagda planartade textilskikten (1a, 1b, 1c) fore deras placering ovanpa varandra; flera kanaler som sträcker sig genom den sagda strukturen, vilka bestär av 20 öppningar (2) i de olika planartade textilstrukturerna (1a, 1b, 1c) som är placerade pä varandra; en armeringsstruktur som bestär av bioaktiva keramiska armeringselement (5) som ingär i de sagda kontinuerliga fiberelementen (3); och 25 en bioabsorberbar matris (4) som bestär av ett bioabsorberbart polymer-matrismaterial som ocksä ingär i de sagda kontinuerliga fiberelementen (3); varvid läget av skikten (1a, 1b, 1d) relativt varandra är fast, när den sagda 30 bioabsorberbara polymermatrisen (4) sammanfogar de sagda sektionerna av de kontinuerliga fiberelementen (3) som begränsar de sagda öppningarna (2) och sammanfogar de sagda skikten (1a, 1b, 1c) och samtidigt styvar strukturen.
2. Struktur enligt patentkrav 1, kännetecknad av, att de sagda planartade textilskikten (1a, 1b, 1c) är regelbundna planartade textilskikt, vars öppningar (2) görde planartade skikten regelbundna till strukturen. 34
3. Struktur enligt patentkrav2, kännetecknad av, att de regelbundna plan-artade textilskikten är valda bland stickade, vävda och flätade skikt.
4. Struktur enligt patentkrav 3, kännetecknad av, att de sagda regelbundna planartade textilskikten (1a, 1b, 1c) omfattar stickade skikt, varvid de sagda kanalerna bestär av maskar (2) i olika skikt bland de sagda stickade skikten.
5. Struktur enligt patentkrav 3, kännetecknat av, att de sagda regelbundna 10 planartade textilskikten (1a, 1b, 1c) omfattar vävda skikt med väft- och varp- garn (3a, 3b); och de sagda kanalerna bestär av öppningar (2) mellan de sagda väft- och varpgarnen.
6. Struktur enligt patentkrav 1 eller 2, kännetecknad av, att strukturen 15 omfattar tvä eller flera olika typer av planartade textilskikt som är valda bland stickade, vävda eller flätade skikt, eller strukturen omfattar en struktur av blandtextilskikt med bioaktiva keramiska armeringsfibrer och en bioabsor-berbar polymermatris.
7. Struktur enligt nägot av de föregäende patentkraven, kännetecknad av, att de bioaktiva keramiska armeringselementen (5) är fibrer.
8. Struktur enligt patentkrav 7, kännetecknad av, attde bioaktiva keramiska armeringselementen (5) är filament. 25
9. Struktur enligt patentkrav 7 eller 8, kännetecknad av, att de kontinuerliga fiberelementen (3) är hybridgarn som omfattar bade bioaktiva keramiska armeringsfibrer och en bioaktiv polymermatris.
10. Struktur enligt patentkrav 9, kännetecknad av, att de sagda kontinuerliga fiberelementen (3) omfattar ett kontinuerligt bioabsorberbart polymer-matrisfilament (4) och ett bioaktivt keramiskt armeringsfilament (5).
11. Struktur enligt patentkrav 9, kännetecknad av, att de sagda kontinuerliga 35 fiberelementen (3) omfattar ett bioaktivt keramiskt armeringsfilament (5) och en pä detta befintlig bioabsorberbar polymermatrisbeläggning (4). 35
12. Struktur enligt patentkrav 9, kännetecknad av, att de sagda kontinuerliga fiberelementen (3) omfattar hopspunna bioaktiva keramiska armerande stapelfibrer och stapelfibrer av en bioabsorberbar polymermatris.
13. Struktur enligt nägot av patentkraven 1-12, kännetecknad av, att den sagda polymermatrisen omfattar en bioabsorberande termoplastisk polymermatris eller en polymerblandningsmatris, och de sagda kontinuerliga fiberelementen (3) som begränsar de sagda öppningarna (2) är samman-fogade och strukturen är armerad med det sagda bioabsorberande 10 termoplastiska polymermaterialet som har gjorts mjuk eller smalts genom värmebehandling och stelnats.
14. Struktur enligt nägot av de föregäende patentkraven, kännetecknad av, att de sagda bioaktiva keramiska armeringselementen (5) utgörs av bioaktivt 15 glas eller kalciumfosfater.
15. Struktur enligt nägot av de föregäende patentkraven, kännetecknad av, att komponenten som utgör det bioaktiva keramiska elementet är anordnad att inducera växt av en vävnad, och komponenten som utgör den bioabsor- 20 berbara polymermatrisen är anordnad att samtidigt inducera fästande eller att stöda hällfasthet av ett implanterat medicinskt medel.
16. Struktur enligt nägot av de föregäende patentkraven, kännetecknad av, att i strukturen har inneslutits bioaktiva ämnen, tili exempel cytokiner och/eller 25 läkemedel, och/eller levande celler och/eller mikroorganismer.
17. Struktur enligt patentkrav 16, kännetecknad av, att i strukturens porer har impregnerats eller ympats levande celler, tili exempel genetiskt modifie-rade eller omodifierade celler. 30
18. Struktur enligt patentkrav 16 eller 17, kännetecknad av, att i strukturens porer bärs bäde bioaktiva ämnen, tili exempel cytokiner, säsom lämpliga växtfaktorer (t.ex. BMP, fibroblasttillväxtfaktorer osv.) och/eller läkemedel och/eller gener eller genvektorer, genetiska material eller kromosomer frän 35 biogena eller syntetiska källor, och i strukturernas porer har ympats levande celler (genetiskt modifierade eller omodifierade). 36
19. Struktur enligt patentkrav 16, kännetecknad av, att i den bioabsorbe-rande polymerkomponenten av det medicinska medlet har dispergerats bio-aktiva ämnen, t.ex. cytokiner och/eller läkemedel.
20. Struktur enligt patentkrav 16, kännetecknad av, att i strukturens bio- absorberbara polymerkomponent har dispergerats bioaktiva keramiska par-tiklar, säsom kalciumfosfater (till exempel hydroxiapatit och/eller β-trikalciumfosfat).
21. Struktur enligt patentkrav 16, kännetecknad av, att i strukturens porer har impregnerats bioaktiva eller levande celler tillsammans med bioaktiva ämnen, säsom läkemedel, som dispergerats i strukturens bioabsorberbara polymerkomponent.
22. Struktur enligt patentkrav 16, kännetecknad av, att i strukturens porer har impregnerats mikroorganismer, som är kapabla att förebygga eller bota inflammation, och/eller bioaktiva ämnen.
23. Struktur enligt patentkrav 20, kännetecknad av, att i strukturens porer 20 har impregnerats bioaktiva eller levande celler tillsammans med bioaktiva keramiska partiklar, säsom kalciumfosfat (till exempel hydroxiapatit och/eller β-trikalciumfosfat), som dispergerats i strukturens bioabsorberbara polymerkomponent.
24. Struktur enligt patentkrav 20, kännetecknad av, att i strukturens bio absorberbara polymerkomponent har dispergerats bioaktiva ämnen, t.ex. cytokiner och/eller läkemedel, tillsammans med bioaktiva ämnen, säsom läkemedel, och med bioaktiva keramiska partiklar, säsom kalciumfosfater (till exempel hydroxiapatit och/eller β-trikalciumfosfat), som dispergerats i 30 strukturens bioabsorberbara polymerkomponent.
25. Förfarande för tillverkning av ett poröst, bioabsorberbart, bioaktivt och lastbärande medicinskt kompositmedel, kännetecknat av, att förfarandet omfattar följande steg: man anordnar flera planartade textilskikt (1a, 1b...) vilka bestär av kontinuer-liga fiberelement (3) och vilka omfattar flera öppningar (2) som begränsas av 35 37 sektioner av de sagda fiberelementen (3), varvid de sagda fiberelementen (3) omfattar en bioabsorberbar matris (4) som bestär av ett bioabsorberbart polymermatrismaterial och keramiska armeringselement (5); 5 man placerar de sagda planartade textilskikten ovanpä varandra för att bilda en stapelstruktur med tvä dimensioner i en rät vinkel med varandra och en tredje dimension som är vinkelrät mot dessa och bildas av stapling av de sagda textilskikten pä varandra, varvid den staplade strukturen omfattar kanaler som sträcker sig genom den sagda strukturen och som bestär av 10 öppningar (2) i de olika planarartade textilskikten (1a, 1b...); man faster skikten (1a, 1b...) pä varandra med hjälp av värme och möjligtvis tryck genom att använda ett bioabsorberbart termoplastiskt polymermatrismaterial genom att rikta värme mot det och genom avkylning därefter. 15
26. Struktur enligt nägot av patentkraven 1-24 för att användas som ett bioabsorberbart, bioaktivt och lastbärande medicinskt kompositmedel eller en del av detta i en begärd form för att reparera härd vävnad (t.ex. för fästning av ben), för att öka den, för att regenerera den (t.ex. för styrd regeneration av 20 ben) eller för att bilda härd vävnad (t.ex. för uppbyggning av härd vävnad) eller för att öka den.
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PCT/FI2004/050117 WO2005018698A1 (en) 2003-08-20 2004-08-20 Porous medical device and method for its manufacture
AT04767137T ATE416725T1 (de) 2003-08-20 2004-08-20 Poröses medizinprodukt und herstellungsverfahren dafür
DE200460018328 DE602004018328D1 (de) 2003-08-20 2004-08-20 Poröses medizinprodukt und herstellungsverfahren dafür
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US20070141111A1 (en) 2007-06-21
FI20031174A (sv) 2005-02-21
FI20031174A0 (sv) 2003-08-20
EP1660146B1 (en) 2008-12-10
ATE416725T1 (de) 2008-12-15
US7964206B2 (en) 2011-06-21
EP1660146A1 (en) 2006-05-31
WO2005018698A1 (en) 2005-03-03

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