FI120267B - Förfarande för framställning av terapeutiskt användbara peptider - Google Patents

Förfarande för framställning av terapeutiskt användbara peptider Download PDF

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Publication number
FI120267B
FI120267B FI20065064A FI20065064A FI120267B FI 120267 B FI120267 B FI 120267B FI 20065064 A FI20065064 A FI 20065064A FI 20065064 A FI20065064 A FI 20065064A FI 120267 B FI120267 B FI 120267B
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FI
Finland
Prior art keywords
fermentation
milk
peptides
lactic acid
lactase
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Application number
FI20065064A
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English (en)
Finnish (fi)
Other versions
FI20065064A0 (sv
FI20065064A (sv
Inventor
Kirsi Rajakari
Olli Tossavainen
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Valio Oy
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Publication date
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Priority to FI20065064A priority Critical patent/FI120267B/sv
Publication of FI20065064A0 publication Critical patent/FI20065064A0/sv
Publication of FI20065064A publication Critical patent/FI20065064A/sv
Application granted granted Critical
Publication of FI120267B publication Critical patent/FI120267B/sv

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
    • A23C21/023—Lactose hydrolysing enzymes, e.g. lactase, B-galactosidase
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
    • A23C21/026—Whey; Whey preparations containing, or treated with, microorganisms or enzymes containing, or treated only with, lactic acid producing bacteria, bifidobacteria or propionic acid bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/127—Fermented milk preparations; Treatment using microorganisms or enzymes using microorganisms of the genus lactobacteriaceae and other microorganisms or enzymes, e.g. kefir, koumiss
    • A23C9/1275—Fermented milk preparations; Treatment using microorganisms or enzymes using microorganisms of the genus lactobacteriaceae and other microorganisms or enzymes, e.g. kefir, koumiss using only lactobacteriaceae for fermentation in combination with enzyme treatment of the milk product; using enzyme treated milk products for fermentation with lactobacteriaceae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dairy Products (AREA)

Claims (11)

1. FÖrfarande för framstäilning av en produkt innehallande terapeu-tiskt användbara, framför ailt blodtryckssänkande peptider genom fermenterlng s av mjölkprotein med mjölksyrabakterier, k ä n n e tee k n a t av att mjölksyra-bakterien är en mjölksyrabakterie som producerar terapeutiskt användbara, framför alit blodtryckssänkande peptider, ooh att fermenferingen utförs i närva-ro av iilisatt laktas,
2. FÖrfarande eniigt patentkrav 1, k ä nnetecknat av att mjöik- 10 proteinkältan är mjölk eiler en mjöikbaserad produkt.
3. FÖrfarande eniigt patentkrav 2, k ä n n e t e c k n a t av att mjöik-proteinkällan är kasein,
4. FÖrfarande eniigt nägot av patentkraven 1-3, känneteck-n a t av att I fermenteringen används en blandning av mjöiksyrabakterier och 15 andra mikrober.
5. FÖrfarande eniigt nägot av patentkraven 1-4, kän neteck-n a t av att i fermenteringen används mikroorganismen Lactobacillus helveii~ cus.
6. FÖrfarande eniigt patentkrav 5, k ä n n e t e g k n a t av att mikro- 20 organismen är Lactobacillus helveiicus-stammen LB 1936, DSM 17754.
7. FÖrfarande eniigt nägot av patentkraven 1-6, k ä n n e t e e k -n a t av att fermenteringen utförs med pH-reglering.
8. FÖrfarande eniigt patentkrav 7, kannetecknat av att pH hills Vid värdet ea 4,6-7, fördelaktigt värdet oa 4,8-6, mera fördelaktigt värdet 25 ca 5-5,5 ooh mest fördelaktigt värdet ca 5,1-5,3.
9. FÖrfarande eniigt nägot av patentkraven 1-8, känneteck-n a t av att i fermenteringen biidas en blandning av kortkedjade peptider.
10. FÖrfarande eniigt patentkrav 9, k ä n n e f e c k n a t av att pepti-derna är di- och tripeptider, speciellt l!e-Pro-Pro och /eiler Val-Pro-Pro.
11. Lactobacillus heiveticus-sta m men LB 1936, DS M 17754 .
FI20065064A 2006-01-30 2006-01-30 Förfarande för framställning av terapeutiskt användbara peptider FI120267B (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI20065064A FI120267B (sv) 2006-01-30 2006-01-30 Förfarande för framställning av terapeutiskt användbara peptider

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20065064A FI120267B (sv) 2006-01-30 2006-01-30 Förfarande för framställning av terapeutiskt användbara peptider
FI20065064 2006-01-30

Publications (3)

Publication Number Publication Date
FI20065064A0 FI20065064A0 (sv) 2006-01-30
FI20065064A FI20065064A (sv) 2007-07-31
FI120267B true FI120267B (sv) 2009-08-31

Family

ID=35883961

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20065064A FI120267B (sv) 2006-01-30 2006-01-30 Förfarande för framställning av terapeutiskt användbara peptider

Country Status (1)

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FI (1) FI120267B (sv)

Also Published As

Publication number Publication date
FI20065064A0 (sv) 2006-01-30
FI20065064A (sv) 2007-07-31

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