FI118755B - Trifenyylietyleenejä käytettäväksi osteoporoosin ehkäisyyn ja hoitoon - Google Patents

Trifenyylietyleenejä käytettäväksi osteoporoosin ehkäisyyn ja hoitoon Download PDF

Info

Publication number
FI118755B
FI118755B FI970920A FI970920A FI118755B FI 118755 B FI118755 B FI 118755B FI 970920 A FI970920 A FI 970920A FI 970920 A FI970920 A FI 970920A FI 118755 B FI118755 B FI 118755B
Authority
FI
Finland
Prior art keywords
compound
compounds
estrogen
formula
osteoporosis
Prior art date
Application number
FI970920A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI970920A0 (fi
FI970920A (fi
Inventor
Lauri Veikko Matti Kangas
Pirkko Haerkoenen
Kalervo Vaeaenaenen
Michael Degregorio
Aire Laine
Valerie Wiebe
Original Assignee
Orion Yhtymae Oy
Pirkko Haerkoenen
Kalervo Vaeaenaenen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy, Pirkko Haerkoenen, Kalervo Vaeaenaenen filed Critical Orion Yhtymae Oy
Publication of FI970920A0 publication Critical patent/FI970920A0/fi
Publication of FI970920A publication Critical patent/FI970920A/fi
Application granted granted Critical
Publication of FI118755B publication Critical patent/FI118755B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
FI970920A 1994-09-07 1997-03-04 Trifenyylietyleenejä käytettäväksi osteoporoosin ehkäisyyn ja hoitoon FI118755B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9418067 1994-09-07
GB9418067A GB9418067D0 (en) 1994-09-07 1994-09-07 Triphenylethylenes for the prevention and treatment of osteoporosis
FI9500475 1995-09-06
PCT/FI1995/000475 WO1996007402A1 (en) 1994-09-07 1995-09-06 Triphenylethylenes for the prevention and treatment of osteoporosis

Publications (3)

Publication Number Publication Date
FI970920A0 FI970920A0 (fi) 1997-03-04
FI970920A FI970920A (fi) 1997-03-04
FI118755B true FI118755B (fi) 2008-03-14

Family

ID=10761007

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970920A FI118755B (fi) 1994-09-07 1997-03-04 Trifenyylietyleenejä käytettäväksi osteoporoosin ehkäisyyn ja hoitoon

Country Status (17)

Country Link
US (2) US5750576A (no)
EP (1) EP0779808B1 (no)
JP (1) JP3910211B2 (no)
AT (1) ATE183389T1 (no)
CA (1) CA2198389C (no)
DE (1) DE69511566T2 (no)
DK (1) DK0779808T3 (no)
ES (1) ES2135083T3 (no)
FI (1) FI118755B (no)
GB (1) GB9418067D0 (no)
GR (1) GR3031109T3 (no)
IL (1) IL115171A (no)
NO (1) NO315785B1 (no)
NZ (1) NZ291836A (no)
SI (1) SI0779808T1 (no)
WO (1) WO1996007402A1 (no)
ZA (1) ZA957481B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
GB9609171D0 (en) * 1996-05-02 1996-07-03 Orion Yhtymae Oy Antioxidant compounds
US6117911A (en) * 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
GB9803521D0 (en) 1998-02-19 1998-04-15 Orion Yhtymo Oy New compounds and pharmaceutical compositions thereof
US20040186185A1 (en) * 1998-05-07 2004-09-23 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
EP1705169A3 (en) * 1999-11-16 2006-11-15 Hormos Medical Ltd. Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US6245819B1 (en) * 2000-07-21 2001-06-12 Hormos Medical Oy, Ltd. Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause
US20040214898A1 (en) * 2001-11-29 2004-10-28 Steiner Mitchell S. Methods for treating hot flashes
US20060269611A1 (en) * 2001-11-29 2006-11-30 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20050080143A1 (en) * 2001-11-29 2005-04-14 Steiner Mitchell S. Treatment of androgen-deprivation induced osteoporosis
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
US8236861B2 (en) 2004-02-13 2012-08-07 Hormos Medical Corporation Method for enhancing the bioavailablity of ospemifene
US20050187302A1 (en) * 2004-02-23 2005-08-25 Hormos Medical Corporation Method for treatment or prevention of osteoporosis in individuals with high bone turnover
US8642079B2 (en) 2004-02-23 2014-02-04 Hormos Medical Corporation Solid formulations of ospemifene
US8758821B2 (en) 2004-05-04 2014-06-24 Hormos Medical Ltd. Oral formulations of ospemifene
ES2391626T3 (es) 2004-05-04 2012-11-28 Hormos Medical Ltd. Nuevas composiciones orales de ospemifeno
US20060293294A1 (en) * 2004-09-03 2006-12-28 Hormos Medical Corporation Method for treatment or prevention of androgen deficiency
US20060270641A1 (en) * 2005-05-31 2006-11-30 Steiner Mitchell S Method for chemoprevention of prostate cancer
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8158828B2 (en) 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8637706B2 (en) 2005-11-28 2014-01-28 Gtx, Inc. Nuclear receptor binding agents
MX2008014825A (es) * 2006-05-22 2008-12-01 Hormos Medical Ltd Moduladores selectivos del receptor de estrogeno o inhibidores de aromatasa para tratar prostatitis cronica no bacteriana.
US20080176255A1 (en) * 2007-01-23 2008-07-24 Edward Sobek Mold detection composition and methods
PL2121553T3 (pl) 2007-02-14 2012-11-30 Hormos Medical Ltd Sposób wytwarzania cennych terapeutycznie pochodnych trifenylobutenu
US7504530B2 (en) 2007-02-14 2009-03-17 Hormos Medical Ltd. Methods for the preparation of fispemifene from ospemifene
WO2008157335A2 (en) 2007-06-13 2008-12-24 Quatrx Pharmaceuticals Company Methods for the treatment of erectile dysfunction using fispemifene
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
PL2526080T3 (pl) * 2010-01-19 2014-08-29 Cambrex Karlskoga Ab Nowe sposoby wytwarzania pochodnych benzofenonu
JP2015532309A (ja) * 2012-10-19 2015-11-09 フェルミオン オサケ ユキチュア オスペミフェンの製造方法
WO2014060639A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene
CN103739456A (zh) * 2013-12-03 2014-04-23 镇江圣安医药有限公司 2-（对-（（z-4-氯-1,2-二苯基-1-丁烯基）苯氧基）乙醇的新型衍生物及其应用
WO2016108172A1 (en) 2014-12-29 2016-07-07 Olon S.P.A. Process for the preparation of ospemifene and fispemifene
WO2016110805A1 (en) * 2015-01-09 2016-07-14 Glenmark Pharmaceuticals Limited Process for preparation of ospemifene
ES2960344T3 (es) 2015-03-10 2024-03-04 Shionogi Inc Dispersiones sólidas que comprenden ospemifeno
KR102052133B1 (ko) 2017-08-10 2019-12-05 고려대학교 산학협력단 당 부가된 오스페미펜, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물
GR1009542B (el) 2018-04-25 2019-06-07 Φαρματεν Α.Β.Ε.Ε. Καψουλα μαλακης γελης που περιλαμβανει εναν εκλεκτικο ρυθμιστη οιστρογονικων υποδοχεων
KR20220115062A (ko) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9207437D0 (en) * 1992-04-03 1992-05-20 Orion Yhtymae Oy Topical administration of toremifene and its metabolites

Also Published As

Publication number Publication date
DK0779808T3 (da) 2000-03-13
EP0779808B1 (en) 1999-08-18
AU699845B2 (en) 1998-12-17
SI0779808T1 (en) 1999-10-31
ATE183389T1 (de) 1999-09-15
IL115171A0 (en) 1995-12-31
DE69511566T2 (de) 2000-04-27
US5750576A (en) 1998-05-12
WO1996007402A1 (en) 1996-03-14
CA2198389C (en) 2007-02-20
ES2135083T3 (es) 1999-10-16
GR3031109T3 (en) 1999-12-31
JP3910211B2 (ja) 2007-04-25
FI970920A0 (fi) 1997-03-04
NZ291836A (en) 1998-06-26
NO971037L (no) 1997-04-29
JPH10505079A (ja) 1998-05-19
FI970920A (fi) 1997-03-04
NO315785B1 (no) 2003-10-27
DE69511566D1 (de) 1999-09-23
US5912273A (en) 1999-06-15
CA2198389A1 (en) 1996-03-14
EP0779808A1 (en) 1997-06-25
AU3347895A (en) 1996-03-27
ZA957481B (en) 1996-04-09
NO971037D0 (no) 1997-03-06
GB9418067D0 (en) 1994-10-26
IL115171A (en) 2001-08-26

Similar Documents

Publication Publication Date Title
FI118755B (fi) Trifenyylietyleenejä käytettäväksi osteoporoosin ehkäisyyn ja hoitoon
CN100441556C (zh) 三苯基烯烃衍生物和它们作为选择性雌激素受体调制剂的用途
JP5629746B2 (ja) 閉経期または閉経後の女性における更年期障害の治療方法
JPH08231540A (ja) エストロゲン作動薬
CA2841572C (en) Trans-clomiphene metabolites and uses thereof
JP5014332B2 (ja) 非ステロイド型男性ホルモン受容体作用剤、その調製における化合物あるいはその薬学的に受容可能な塩の用途
NO336612B1 (no) Anvendelse av en forbindelse for fremstilling av en farmasøytisk sammensetning for hemming av urininkontinens i en kvinne
KR20030027052A (ko) 의료용 10-아릴-11Ｈ-벤조[ｂ]플루오렌 유도체 및 유사체
EP1056701B1 (en) E-2- 4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol and pharmaceutical compositions thereof
US20160271143A1 (en) Estrogen receptor modulators for reducing body weight
AU699845C (en) Triphenylethylenes for the prevention and treatment of osteoporosis
Gauthier et al. Synthesis and structure–activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution
EP2363132B1 (en) Sophoricoside for use in the treatment of cartilage degeneration
CA2356624A1 (en) Endocrine therapy for breast cancer: combined treatment with tamoxifen plus alkyl pcdfs
WO2008060397A2 (en) Method of treating thermoregulatory disfunction
Sorbera et al. CP-336156
Blazej et al. Selective Estrogen Receptor Modulators. Current and Future Treatment Options for Osteoporosis
NZ621892B2 (en) Trans-clomiphene metabolites and uses thereof

Legal Events

Date Code Title Description
MA Patent expired