FI116793B - Menetelmä terapeuttisesti tehokkaan vasta-aineen, sen fragmentin tai johdannaisen tai peptidin, joka sitoutuu alfa4beta1:een, valitsemiseksi - Google Patents

Menetelmä terapeuttisesti tehokkaan vasta-aineen, sen fragmentin tai johdannaisen tai peptidin, joka sitoutuu alfa4beta1:een, valitsemiseksi Download PDF

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Publication number
FI116793B
FI116793B FI920899A FI920899A FI116793B FI 116793 B FI116793 B FI 116793B FI 920899 A FI920899 A FI 920899A FI 920899 A FI920899 A FI 920899A FI 116793 B FI116793 B FI 116793B
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Prior art keywords
cells
fibronectin
receptor
cell
adhesion
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FI920899A
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English (en)
Finnish (fi)
Swedish (sv)
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FI920899A0 (fi
Inventor
Elizabeth Wayner
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Hutchinson Fred Cancer Res
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Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546Integrin superfamily
    • C07K14/7055Integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI920899A 1989-09-01 1992-02-28 Menetelmä terapeuttisesti tehokkaan vasta-aineen, sen fragmentin tai johdannaisen tai peptidin, joka sitoutuu alfa4beta1:een, valitsemiseksi FI116793B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40238989A 1989-09-01 1989-09-01
US40238989 1989-09-01
US9004978 1990-08-31
PCT/US1990/004978 WO1991003252A1 (en) 1989-09-01 1990-08-31 Inhibition of lymphocyte adherence to vascular endothelium utilizing a novel extracellular matrix receptor-ligand interaction

Publications (2)

Publication Number Publication Date
FI920899A0 FI920899A0 (fi) 1992-02-28
FI116793B true FI116793B (fi) 2006-02-28

Family

ID=23591680

Family Applications (2)

Application Number Title Priority Date Filing Date
FI920899A FI116793B (fi) 1989-09-01 1992-02-28 Menetelmä terapeuttisesti tehokkaan vasta-aineen, sen fragmentin tai johdannaisen tai peptidin, joka sitoutuu alfa4beta1:een, valitsemiseksi
FI20050941A FI118842B (fi) 1989-09-01 2005-09-21 Menetelmä terapeuttisesti tehokkaan aineen, joka sitoutuu alfa4beeta1:een, tai sen ligandin, valitsemiseksi käytettäväksi lymfosyyttien migraation inhiboimiseksi vaskulaaristen endoteelisolukerrosten

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20050941A FI118842B (fi) 1989-09-01 2005-09-21 Menetelmä terapeuttisesti tehokkaan aineen, joka sitoutuu alfa4beeta1:een, tai sen ligandin, valitsemiseksi käytettäväksi lymfosyyttien migraation inhiboimiseksi vaskulaaristen endoteelisolukerrosten

Country Status (19)

Country Link
EP (2) EP1366769A1 (ko)
JP (1) JP3357359B2 (ko)
KR (1) KR100188459B1 (ko)
AT (1) ATE253642T1 (ko)
AU (1) AU654657B2 (ko)
CA (1) CA2065292C (ko)
DD (1) DD297562A5 (ko)
DE (3) DE122006000044I2 (ko)
DK (1) DK0489837T4 (ko)
ES (1) ES2210225T5 (ko)
FI (2) FI116793B (ko)
GR (2) GR1001372B (ko)
IE (2) IE20040028A1 (ko)
IL (3) IL95501A (ko)
LU (1) LU91273I2 (ko)
NL (1) NL300240I2 (ko)
NZ (1) NZ235131A (ko)
PT (1) PT95180A (ko)
WO (1) WO1991003252A1 (ko)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730978A (en) * 1989-09-01 1998-03-24 Fred Hutchinson Cancer Research Center Inhibition of lymphocyte adherence with α4β1-specific antibodies
US7238668B1 (en) 1989-09-01 2007-07-03 Fred Hutchinson Cancer Research Center Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof
US6033665A (en) * 1989-09-27 2000-03-07 Elan Pharmaceuticals, Inc. Compositions and methods for modulating leukocyte adhesion to brain endothelial cells
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
AU3420693A (en) * 1991-12-24 1993-07-28 Fred Hutchinson Cancer Research Center Competitive inhibition of high-avidity alpha4-beta1 receptor using tripeptide ldv
ATE150319T1 (de) * 1992-01-13 1997-04-15 Biogen Inc Behandlung von asthma
US5871734A (en) * 1992-01-13 1999-02-16 Biogen, Inc. Treatment for asthma with VLA-4 blocking agents
US5932214A (en) * 1994-08-11 1999-08-03 Biogen, Inc. Treatment for inflammatory bowel disease with VLA-4 blockers
IL102646A (en) * 1992-07-26 1996-05-14 Yeda Res & Dev Non-peptidic surrogates of the ldv sequence and pharmaceutical compositions comprising them
USRE40811E1 (en) 1992-11-13 2009-06-30 Board Of Regents Of The University Of Washington Peripheralization of hematopoietic stem cells
NZ262615A (en) 1993-02-09 1996-02-27 Biogen Inc Treating insulin dependent diabetes (type i) with anti vla4 (very late antigen) antibodies
EP0689609B2 (en) 1993-03-18 2005-04-13 N.V. Innogenetics S.A. Process for typing hla-b using specific primers and probes sets
ZA947006B (en) * 1993-09-15 1995-05-02 Univ Emory Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions
US5821231A (en) * 1993-12-06 1998-10-13 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using same
US5770573A (en) * 1993-12-06 1998-06-23 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
AU693143B2 (en) * 1993-12-06 1998-06-25 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US5936065A (en) * 1993-12-06 1999-08-10 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US7435802B2 (en) 1994-01-25 2008-10-14 Elan Pharaceuticals, Inc. Humanized anti-VLA4 immunoglobulins
DK1759709T3 (da) * 1994-01-25 2013-06-10 Elan Pharm Inc Humaniserede antistoffer mod leukocytadhæsionsmolekyle VLA-4
US5840299A (en) * 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
FR2724393A1 (fr) * 1994-09-12 1996-03-15 Inst Nat Sante Rech Med Obtention d'un anticorps monoclonal recombinant humanise a partir d'un anticorps monoclonal murin, sa production en cellules d'insecte, et ses utilisations
WO1997035557A1 (en) * 1996-03-22 1997-10-02 Kao Corporation External skin-care composition
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
MY157727A (en) 2002-02-25 2016-07-15 Biogen Idec Inc Administration of agents for the treatment of inflamation
US7125650B2 (en) 2004-07-20 2006-10-24 Roberts David H Method for bump exposing relief image printing plates
UA116189C2 (uk) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
WO2012151247A2 (en) 2011-05-02 2012-11-08 Millennium Pharmaceuticals, Inc. FORMULATION FOR ANTI-α4β7 ANTIBODY

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
WO1990008833A1 (en) * 1989-02-02 1990-08-09 Massachusetts Institute Of Technology Expression of recombinant fibronectin in genetically engineered cells

Also Published As

Publication number Publication date
PT95180A (pt) 1991-05-22
KR100188459B1 (ko) 1999-06-01
EP0489837A1 (en) 1992-06-17
IL113261A (en) 1996-10-16
DE122006000044I1 (de) 2007-04-19
ES2210225T3 (es) 2004-07-01
ATE253642T1 (de) 2003-11-15
CA2065292C (en) 2001-05-29
FI20050941A (fi) 2005-09-21
DD297562A5 (de) 1992-01-16
WO1991003252A1 (en) 1991-03-21
NZ235131A (en) 1993-03-26
FI118842B (fi) 2008-04-15
IL113261A0 (en) 1995-07-31
NL300240I1 (nl) 2006-10-02
ES2210225T5 (es) 2014-02-04
DE122006000044I2 (de) 2011-01-13
DE69034116T3 (de) 2014-06-18
GR1001161B (el) 1993-05-24
IE20040028A1 (en) 2004-05-05
AU654657B2 (en) 1994-11-17
GR900100648A (en) 1992-01-20
IL95501A (en) 1997-04-15
NL300240I2 (nl) 2007-03-01
LU91273I2 (fr) 2006-10-10
FI920899A0 (fi) 1992-02-28
AU6354290A (en) 1991-04-08
DK0489837T4 (da) 2013-11-18
JP3357359B2 (ja) 2002-12-16
EP0489837B1 (en) 2003-11-05
DE69034116T2 (de) 2004-08-26
JPH05503070A (ja) 1993-05-27
DE69034116D1 (de) 2003-12-11
IE903169A1 (en) 1991-03-13
EP0489837B2 (en) 2013-11-13
DK0489837T3 (da) 2004-03-01
EP0489837A4 (en) 1993-06-16
CA2065292A1 (en) 1991-03-02
GR1001372B (el) 1993-10-29
KR920703086A (ko) 1992-12-17
EP1366769A1 (en) 2003-12-03

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