FI114443B - Menetelmä mikrobisidaalisen silmälääkeliuoksen valmistamiseksi - Google Patents
Menetelmä mikrobisidaalisen silmälääkeliuoksen valmistamiseksi Download PDFInfo
- Publication number
- FI114443B FI114443B FI922906A FI922906A FI114443B FI 114443 B FI114443 B FI 114443B FI 922906 A FI922906 A FI 922906A FI 922906 A FI922906 A FI 922906A FI 114443 B FI114443 B FI 114443B
- Authority
- FI
- Finland
- Prior art keywords
- solution
- iodine
- amount
- pvp
- months
- Prior art date
Links
- 230000003641 microbiacidal effect Effects 0.000 title claims abstract description 12
- 239000002997 ophthalmic solution Substances 0.000 title claims description 23
- 229940054534 ophthalmic solution Drugs 0.000 title claims description 21
- 238000004519 manufacturing process Methods 0.000 title description 4
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims abstract description 103
- 239000011630 iodine Substances 0.000 claims abstract description 101
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 101
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 32
- 239000011521 glass Substances 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 19
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000243 solution Substances 0.000 claims description 152
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 39
- 238000002360 preparation method Methods 0.000 claims description 36
- 230000003113 alkalizing effect Effects 0.000 claims description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 19
- 229920000153 Povidone-iodine Polymers 0.000 claims description 13
- -1 iodine ions Chemical class 0.000 claims description 13
- 231100000344 non-irritating Toxicity 0.000 claims description 12
- 229960001621 povidone-iodine Drugs 0.000 claims description 12
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 239000003732 agents acting on the eye Substances 0.000 claims description 8
- 229940023490 ophthalmic product Drugs 0.000 claims description 8
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- 231100000252 nontoxic Toxicity 0.000 claims description 5
- 230000003000 nontoxic effect Effects 0.000 claims description 5
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 2
- 235000019800 disodium phosphate Nutrition 0.000 claims description 2
- 235000011118 potassium hydroxide Nutrition 0.000 claims description 2
- 235000012976 tarts Nutrition 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 1
- FAAHNQAYWKTLFD-UHFFFAOYSA-N 1-butan-2-ylpyrrolidin-2-one Chemical compound CCC(C)N1CCCC1=O FAAHNQAYWKTLFD-UHFFFAOYSA-N 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 86
- 235000013675 iodine Nutrition 0.000 description 86
- 230000008859 change Effects 0.000 description 17
- 230000000845 anti-microbial effect Effects 0.000 description 11
- 229940012356 eye drops Drugs 0.000 description 10
- 244000005700 microbiome Species 0.000 description 10
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Substances [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 10
- 238000012360 testing method Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 8
- 230000002147 killing effect Effects 0.000 description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 8
- 229920003102 Methocel™ E4M Polymers 0.000 description 7
- 229940064804 betadine Drugs 0.000 description 7
- 239000003889 eye drop Substances 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 6
- 239000004599 antimicrobial Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- QSDSSSQWVNLFIG-UHFFFAOYSA-N Neosporin Natural products CC(O)CC1=C(OC)C(=O)C2=CC(O)=C3OCOC4=C(O)C=C5C6=C4C3=C2C1=C6C(CC(C)O)=C(OC)C5=O QSDSSSQWVNLFIG-UHFFFAOYSA-N 0.000 description 5
- 108010046161 drug combination polymyxin B neomycin sulfate bacitracin zinc Proteins 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229940072360 garamycin Drugs 0.000 description 5
- 229940049337 neosporin Drugs 0.000 description 5
- 241000894007 species Species 0.000 description 5
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 3
- 239000002085 irritant Substances 0.000 description 3
- 231100000021 irritant Toxicity 0.000 description 3
- 239000000644 isotonic solution Substances 0.000 description 3
- 229920000620 organic polymer Polymers 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000005361 soda-lime glass Substances 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010015946 Eye irritation Diseases 0.000 description 2
- 244000038458 Nepenthes mirabilis Species 0.000 description 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000003139 biocide Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000008366 buffered solution Substances 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 231100000013 eye irritation Toxicity 0.000 description 2
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 2
- 229940006461 iodide ion Drugs 0.000 description 2
- 150000004694 iodide salts Chemical class 0.000 description 2
- OKJPEAGHQZHRQV-UHFFFAOYSA-N iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 229940069328 povidone Drugs 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000011345 viscous material Substances 0.000 description 2
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- UNMYWSMUMWPJLR-UHFFFAOYSA-L Calcium iodide Chemical compound [Ca+2].[I-].[I-] UNMYWSMUMWPJLR-UHFFFAOYSA-L 0.000 description 1
- 240000007524 Camellia sinensis var. sinensis Species 0.000 description 1
- 235000001258 Cinchona calisaya Nutrition 0.000 description 1
- 206010010725 Conjunctival irritation Diseases 0.000 description 1
- 206010056476 Corneal irritation Diseases 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 241000200696 Halictus simplex Species 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 229940046413 calcium iodide Drugs 0.000 description 1
- 229910001640 calcium iodide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000000937 inactivator Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-N iodic acid Chemical class OI(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 description 1
- 239000001230 potassium iodate Substances 0.000 description 1
- 235000006666 potassium iodate Nutrition 0.000 description 1
- 229940093930 potassium iodate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73046291 | 1991-07-16 | ||
US07/730,462 US5126127A (en) | 1991-07-16 | 1991-07-16 | Stabilized PVP-I solutions |
Publications (3)
Publication Number | Publication Date |
---|---|
FI922906A0 FI922906A0 (fi) | 1992-06-22 |
FI922906A FI922906A (fi) | 1993-01-17 |
FI114443B true FI114443B (fi) | 2004-10-29 |
Family
ID=24935466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI922906A FI114443B (fi) | 1991-07-16 | 1992-06-22 | Menetelmä mikrobisidaalisen silmälääkeliuoksen valmistamiseksi |
Country Status (16)
Country | Link |
---|---|
US (1) | US5126127A (no) |
EP (1) | EP0526695B1 (no) |
JP (1) | JP3531945B2 (no) |
KR (1) | KR100191873B1 (no) |
AT (1) | ATE163130T1 (no) |
AU (1) | AU646745B2 (no) |
CA (1) | CA2062001C (no) |
DE (1) | DE69224416T2 (no) |
DK (1) | DK0526695T3 (no) |
EG (1) | EG19995A (no) |
ES (1) | ES2111581T3 (no) |
FI (1) | FI114443B (no) |
IE (1) | IE920796A1 (no) |
IL (1) | IL101079A (no) |
NO (1) | NO306379B1 (no) |
ZA (1) | ZA921365B (no) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993006911A1 (en) * | 1991-10-08 | 1993-04-15 | Isp Investments Inc. | Method of treating blood |
GB9306296D0 (en) * | 1993-03-26 | 1993-05-19 | Diversey Corp | Improved iodophors,production and use thereof |
DE9312509U1 (de) * | 1993-08-20 | 1993-10-28 | Euro-Celtique S.A., Luxemburg/Luxembourg | Präparate zur äußeren Verabreichung von antiseptischen und/oder die Wundheilung fördernden Wirkstoffen |
JP3108262B2 (ja) * | 1993-12-22 | 2000-11-13 | 明治製菓株式会社 | 研磨剤を含有しない口腔用半練状製剤 |
US6605110B2 (en) | 2001-06-29 | 2003-08-12 | Advanced Cardiovascular Systems, Inc. | Stent with enhanced bendability and flexibility |
PT1479379E (pt) | 2003-05-19 | 2007-10-23 | Euro Celtique Sa | ''composições lipossomais secas de pvp-iodo'' |
US20050262811A1 (en) * | 2004-05-27 | 2005-12-01 | Mahmood Mohiuddin | Sterilization process for iodine-containing antimicrobial topical solutions |
US7767217B2 (en) * | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
AU2013203462B2 (en) * | 2006-03-14 | 2016-08-04 | Cls Pharmaceuticals, Inc. | Ophthalmic compositions comprising povidone-iodine |
AU2016253668B2 (en) * | 2006-03-14 | 2018-12-06 | Cls Pharmaceuticals, Inc. | Ophthalmic compositions comprising povidone-iodine |
JP5083502B2 (ja) * | 2006-12-25 | 2012-11-28 | ライオン株式会社 | 眼科用組成物 |
US20080172032A1 (en) * | 2007-01-11 | 2008-07-17 | James Pitzer Gills | Method for preventing tissue damage associated with irrigation of tissue with an antimicrobial solution |
US20120027716A1 (en) * | 2008-06-12 | 2012-02-02 | Foresight Biotherapeutics, Inc. | Povidone Iodine, A Novel Alternative Preservative For Ophthalmic Compositions |
EP2512230A4 (en) * | 2009-12-15 | 2013-05-22 | Foresight Biotherapeutics Inc | NON-REFRACTORY OPHTHALMIC POVIDONE IOD COMPOSITIONS |
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IT201700068170A1 (it) * | 2017-06-20 | 2018-12-20 | Iromed Group S R L | Composizione disinfettante per uso oftalmico |
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AU2019358249B2 (en) | 2018-10-12 | 2024-02-22 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
KR20200081160A (ko) | 2018-12-27 | 2020-07-07 | 유한회사 플루켐 | 염화나트륨 함유 포비돈 요오드 안정 조성물 및 방법 |
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WO2021034421A1 (en) * | 2019-08-18 | 2021-02-25 | Iview Therapeutics, Inc. | Stable pharmaceutical articles containing dilute povidone iodine formulations |
EP4171583A4 (en) * | 2020-06-10 | 2024-06-26 | Firebrick Pharma Limited | IMPROVED VIRUCIDAL FORMULATIONS |
AU2021203846B2 (en) * | 2021-06-10 | 2022-11-24 | Firebrick Pharma Limited | Virucidal formulations containing povidone-iodine |
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US4364929A (en) * | 1979-04-02 | 1982-12-21 | The Purdue Frederick Company | Germicidal colloidal lubricating gels and method of producing the same |
SE7902893L (sv) * | 1979-04-02 | 1980-10-03 | Astra Chem Prod Ab | Desinfektionsmedel |
US4401651A (en) * | 1979-04-18 | 1983-08-30 | Knutson Richard A | Wound-healing compositions containing povidone-iodine |
US4526751A (en) * | 1983-12-09 | 1985-07-02 | Gartner William J | Germicidal solutions effective for solid surface disinfection |
WO1989000044A1 (en) * | 1987-07-07 | 1989-01-12 | Santen Pharmaceutical Co., Ltd. | Artificial lacrima |
CA1303503C (en) * | 1987-11-10 | 1992-06-16 | Marc Plamondon | Ophthalmic solution comprising iodine-polyvinylpyrrolidone complex |
DE3882042T2 (de) * | 1987-12-25 | 1993-09-30 | Santen Pharma Co Ltd | Antiallergische augentropfen. |
US4939272A (en) * | 1989-05-05 | 1990-07-03 | Gaf Chemicals Corporation | Water soluble complexes of polyvinylpyrrolidone, hydrogen chloride and iodine and process for making the same |
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-
1991
- 1991-07-16 US US07/730,462 patent/US5126127A/en not_active Expired - Lifetime
-
1992
- 1992-02-25 ZA ZA921365A patent/ZA921365B/xx unknown
- 1992-02-27 IL IL10107992A patent/IL101079A/xx not_active IP Right Cessation
- 1992-02-27 CA CA002062001A patent/CA2062001C/en not_active Expired - Fee Related
- 1992-03-12 IE IE079692A patent/IE920796A1/en not_active IP Right Cessation
- 1992-03-23 JP JP06448592A patent/JP3531945B2/ja not_active Expired - Fee Related
- 1992-04-15 DK DK92106500T patent/DK0526695T3/da active
- 1992-04-15 EP EP92106500A patent/EP0526695B1/en not_active Expired - Lifetime
- 1992-04-15 AT AT92106500T patent/ATE163130T1/de not_active IP Right Cessation
- 1992-04-15 DE DE69224416T patent/DE69224416T2/de not_active Expired - Fee Related
- 1992-04-15 ES ES92106500T patent/ES2111581T3/es not_active Expired - Lifetime
- 1992-06-15 KR KR1019920010355A patent/KR100191873B1/ko not_active IP Right Cessation
- 1992-06-22 FI FI922906A patent/FI114443B/fi not_active IP Right Cessation
- 1992-07-02 AU AU19427/92A patent/AU646745B2/en not_active Ceased
- 1992-07-14 EG EG39192A patent/EG19995A/xx active
- 1992-07-15 NO NO922793A patent/NO306379B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
IE920796A1 (en) | 1993-01-27 |
EP0526695A1 (en) | 1993-02-10 |
NO922793L (no) | 1993-01-18 |
ATE163130T1 (de) | 1998-02-15 |
AU1942792A (en) | 1994-01-13 |
EP0526695B1 (en) | 1998-02-11 |
FI922906A0 (fi) | 1992-06-22 |
IL101079A (en) | 1997-01-10 |
FI922906A (fi) | 1993-01-17 |
NO922793D0 (no) | 1992-07-15 |
CA2062001C (en) | 1999-03-02 |
CA2062001A1 (en) | 1993-01-17 |
DK0526695T3 (da) | 1998-09-23 |
JPH0570356A (ja) | 1993-03-23 |
NO306379B1 (no) | 1999-11-01 |
ZA921365B (en) | 1992-11-25 |
IL101079A0 (en) | 1992-11-15 |
DE69224416T2 (de) | 1998-07-30 |
DE69224416D1 (de) | 1998-03-19 |
US5126127A (en) | 1992-06-30 |
EG19995A (en) | 1997-01-30 |
KR100191873B1 (ko) | 1999-06-15 |
ES2111581T3 (es) | 1998-03-16 |
KR930001914A (ko) | 1993-02-22 |
JP3531945B2 (ja) | 2004-05-31 |
AU646745B2 (en) | 1994-03-03 |
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