FI108730B - Menetelmä konjugoidun linolihapon valmistamiseksi - Google Patents
Menetelmä konjugoidun linolihapon valmistamiseksi Download PDFInfo
- Publication number
- FI108730B FI108730B FI992477A FI19992477A FI108730B FI 108730 B FI108730 B FI 108730B FI 992477 A FI992477 A FI 992477A FI 19992477 A FI19992477 A FI 19992477A FI 108730 B FI108730 B FI 108730B
- Authority
- FI
- Finland
- Prior art keywords
- linoleic acid
- cla
- detergent
- acid
- process according
- Prior art date
Links
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 title claims description 227
- JBYXPOFIGCOSSB-GOJKSUSPSA-N 9-cis,11-trans-octadecadienoic acid Chemical compound CCCCCC\C=C\C=C/CCCCCCCC(O)=O JBYXPOFIGCOSSB-GOJKSUSPSA-N 0.000 title claims description 131
- 229940108924 conjugated linoleic acid Drugs 0.000 title claims description 128
- 238000000034 method Methods 0.000 title claims description 37
- 230000008569 process Effects 0.000 title claims description 20
- 238000002360 preparation method Methods 0.000 title claims description 16
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 105
- 235000020778 linoleic acid Nutrition 0.000 claims description 100
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 40
- 241000894006 Bacteria Species 0.000 claims description 26
- 230000001580 bacterial effect Effects 0.000 claims description 25
- 230000012010 growth Effects 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 23
- 239000000693 micelle Substances 0.000 claims description 21
- 235000019260 propionic acid Nutrition 0.000 claims description 20
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 16
- 241000186428 Propionibacterium freudenreichii Species 0.000 claims description 15
- 239000004094 surface-active agent Substances 0.000 claims description 12
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 10
- 229920000053 polysorbate 80 Polymers 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 235000013305 food Nutrition 0.000 claims description 8
- 239000001963 growth medium Substances 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 4
- 244000005700 microbiome Species 0.000 claims description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 239000003599 detergent Substances 0.000 description 45
- 210000004027 cell Anatomy 0.000 description 29
- 235000010633 broth Nutrition 0.000 description 26
- 239000002609 medium Substances 0.000 description 22
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- 150000004665 fatty acids Chemical class 0.000 description 13
- 238000007792 addition Methods 0.000 description 12
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- 230000000694 effects Effects 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 230000009422 growth inhibiting effect Effects 0.000 description 9
- 206010028980 Neoplasm Diseases 0.000 description 7
- 241000030538 Thecla Species 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 239000012466 permeate Substances 0.000 description 6
- 229950004959 sorbitan oleate Drugs 0.000 description 6
- 239000011550 stock solution Substances 0.000 description 6
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000012138 yeast extract Substances 0.000 description 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
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- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 2
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- MGGVALXERJRIRO-UHFFFAOYSA-N 4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-2-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-1H-pyrazol-5-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)O MGGVALXERJRIRO-UHFFFAOYSA-N 0.000 description 1
- ARSRBNBHOADGJU-UHFFFAOYSA-N 7,12-dimethyltetraphene Chemical compound C1=CC2=CC=CC=C2C2=C1C(C)=C(C=CC=C1)C1=C2C ARSRBNBHOADGJU-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 241000186012 Bifidobacterium breve Species 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 101100192881 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) pyr8 gene Proteins 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
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- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
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- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6431—Linoleic acids [18:2[n-6]]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI992477A FI108730B (fi) | 1999-11-19 | 1999-11-19 | Menetelmä konjugoidun linolihapon valmistamiseksi |
| US10/130,426 US6960456B1 (en) | 1999-11-19 | 2000-11-16 | Method for preparing conjugated linoleic acid |
| NZ518902A NZ518902A (en) | 1999-11-19 | 2000-11-16 | Method for preparing conjugated linoleic acid |
| EEP200200253A EE200200253A (et) | 1999-11-19 | 2000-11-16 | Konjugeeritud linoleenhappe valmistamise meetod |
| PCT/FI2000/001004 WO2001036653A1 (en) | 1999-11-19 | 2000-11-16 | Method for preparing conjugated linoleic acid |
| PL00355658A PL355658A1 (en) | 1999-11-19 | 2000-11-16 | Method for preparing conjugated linoleic acid |
| HU0204173A HU224704B1 (en) | 1999-11-19 | 2000-11-16 | Method for preparing conjugated linoleic acid |
| CN00815851A CN1391613A (zh) | 1999-11-19 | 2000-11-16 | 制备共轭亚油酸的方法 |
| AU17093/01A AU770113B2 (en) | 1999-11-19 | 2000-11-16 | Method for preparing conjugated linoleic acid |
| RU2002116367/13A RU2265664C2 (ru) | 1999-11-19 | 2000-11-16 | Способ получения конъюгированной линолевой кислоты |
| JP2001538531A JP2003514535A (ja) | 1999-11-19 | 2000-11-16 | 複合リノール酸を製造する方法 |
| KR1020027006376A KR20020065523A (ko) | 1999-11-19 | 2000-11-16 | 콘쥬게이티드 리놀산을 제조하는 방법 |
| CA002390572A CA2390572A1 (en) | 1999-11-19 | 2000-11-16 | Method for preparing conjugated linoleic acid |
| CZ20021637A CZ20021637A3 (cs) | 1999-11-19 | 2000-11-16 | Způsob přípravy konjugované kyseliny linolové z kyseliny linolové prostřednictvím mikroorganismů a tímto získaný výrobek |
| BR0015663-9A BR0015663A (pt) | 1999-11-19 | 2000-11-16 | Processo de preparação de ácido linoléico conjugado |
| EP00979692A EP1240348A1 (en) | 1999-11-19 | 2000-11-16 | Method for preparing conjugated linoleic acid |
| ZA200203539A ZA200203539B (en) | 1999-11-19 | 2002-05-03 | Method for preparing conjugated linoleic acid. |
| HR20020427 HRP20020427B1 (en) | 1999-11-19 | 2002-05-15 | Method for preparing conjugated linoleic acid |
| NO20022361A NO20022361L (no) | 1999-11-19 | 2002-05-16 | Fremgangsmåte for fremstilling av konjugert linolsyre |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI992477A FI108730B (fi) | 1999-11-19 | 1999-11-19 | Menetelmä konjugoidun linolihapon valmistamiseksi |
| FI992477 | 1999-11-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI19992477A FI19992477A (fi) | 2001-05-20 |
| FI108730B true FI108730B (fi) | 2002-03-15 |
Family
ID=8555617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI992477A FI108730B (fi) | 1999-11-19 | 1999-11-19 | Menetelmä konjugoidun linolihapon valmistamiseksi |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6960456B1 (no) |
| EP (1) | EP1240348A1 (no) |
| JP (1) | JP2003514535A (no) |
| KR (1) | KR20020065523A (no) |
| CN (1) | CN1391613A (no) |
| AU (1) | AU770113B2 (no) |
| BR (1) | BR0015663A (no) |
| CA (1) | CA2390572A1 (no) |
| CZ (1) | CZ20021637A3 (no) |
| EE (1) | EE200200253A (no) |
| FI (1) | FI108730B (no) |
| HR (1) | HRP20020427B1 (no) |
| HU (1) | HU224704B1 (no) |
| NO (1) | NO20022361L (no) |
| NZ (1) | NZ518902A (no) |
| PL (1) | PL355658A1 (no) |
| RU (1) | RU2265664C2 (no) |
| WO (1) | WO2001036653A1 (no) |
| ZA (1) | ZA200203539B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI115842B (fi) * | 2002-03-27 | 2005-07-29 | Valio Oy | Menetelmä konjugoidun linolihapon valmistamiseksi |
| KR100686557B1 (ko) * | 2004-08-16 | 2007-02-23 | 씨제이 주식회사 | 체지방 저하 기능성 락토바실러스 람노서스와 이를 함유한 식품 |
| EP1831389A1 (en) * | 2004-12-23 | 2007-09-12 | Isotechnika Inc. | Method for biotransformation of the clyclosporin compound isa247 |
| ES2277546B1 (es) * | 2005-11-21 | 2008-06-16 | Natraceutical, S.A. | Procedimiento microbiano de produccion de isomeros especificos de acidos linoleicos conjugados. |
| WO2008128765A1 (en) * | 2007-04-24 | 2008-10-30 | Lipid Nutrition B.V. | Beverage composition comprising cla |
| EP2148573A2 (en) * | 2007-04-24 | 2010-02-03 | Lipid Nutrition B.V. | Low sugar yoghurt |
| CN106578140A (zh) * | 2016-12-13 | 2017-04-26 | 青岛嘉瑞生物技术有限公司 | 一种海蓬子保健香油 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856149A (en) * | 1995-06-01 | 1999-01-05 | Wisconsin Alumni Research Foundation | Method of producing conjugated fatty acids |
| SE9704584L (sv) * | 1997-12-05 | 1999-07-19 | Lennart Bjoerck | Framställning av konjugerad linolsyra |
| AU2015099A (en) | 1997-12-23 | 1999-07-12 | Dcv, Inc. Doing Business As Bio-Technical Resources | Linoleate isomerase |
| US6706501B1 (en) * | 1999-06-30 | 2004-03-16 | Arkion Life Sciences Llc | Polynucleotide encoding a propionibacterium linoleate isomerase and uses thereof |
-
1999
- 1999-11-19 FI FI992477A patent/FI108730B/fi active
-
2000
- 2000-11-16 BR BR0015663-9A patent/BR0015663A/pt not_active IP Right Cessation
- 2000-11-16 NZ NZ518902A patent/NZ518902A/en unknown
- 2000-11-16 HU HU0204173A patent/HU224704B1/hu not_active IP Right Cessation
- 2000-11-16 EE EEP200200253A patent/EE200200253A/xx unknown
- 2000-11-16 RU RU2002116367/13A patent/RU2265664C2/ru not_active IP Right Cessation
- 2000-11-16 JP JP2001538531A patent/JP2003514535A/ja active Pending
- 2000-11-16 KR KR1020027006376A patent/KR20020065523A/ko not_active Application Discontinuation
- 2000-11-16 EP EP00979692A patent/EP1240348A1/en not_active Withdrawn
- 2000-11-16 CZ CZ20021637A patent/CZ20021637A3/cs unknown
- 2000-11-16 US US10/130,426 patent/US6960456B1/en not_active Expired - Fee Related
- 2000-11-16 WO PCT/FI2000/001004 patent/WO2001036653A1/en not_active Application Discontinuation
- 2000-11-16 AU AU17093/01A patent/AU770113B2/en not_active Ceased
- 2000-11-16 CA CA002390572A patent/CA2390572A1/en not_active Abandoned
- 2000-11-16 CN CN00815851A patent/CN1391613A/zh active Pending
- 2000-11-16 PL PL00355658A patent/PL355658A1/xx not_active Application Discontinuation
-
2002
- 2002-05-03 ZA ZA200203539A patent/ZA200203539B/en unknown
- 2002-05-15 HR HR20020427 patent/HRP20020427B1/xx not_active IP Right Cessation
- 2002-05-16 NO NO20022361A patent/NO20022361L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20020427B1 (en) | 2004-12-31 |
| HRP20020427A2 (en) | 2003-08-31 |
| JP2003514535A (ja) | 2003-04-22 |
| US6960456B1 (en) | 2005-11-01 |
| CN1391613A (zh) | 2003-01-15 |
| EE200200253A (et) | 2003-06-16 |
| NZ518902A (en) | 2003-07-25 |
| FI19992477A (fi) | 2001-05-20 |
| WO2001036653A1 (en) | 2001-05-25 |
| KR20020065523A (ko) | 2002-08-13 |
| PL355658A1 (en) | 2004-05-04 |
| ZA200203539B (en) | 2003-08-04 |
| NO20022361D0 (no) | 2002-05-16 |
| CA2390572A1 (en) | 2001-05-25 |
| AU770113B2 (en) | 2004-02-12 |
| RU2265664C2 (ru) | 2005-12-10 |
| HUP0204173A2 (hu) | 2003-03-28 |
| NO20022361L (no) | 2002-07-10 |
| AU1709301A (en) | 2001-05-30 |
| RU2002116367A (ru) | 2004-02-10 |
| BR0015663A (pt) | 2002-07-23 |
| CZ20021637A3 (cs) | 2002-11-13 |
| EP1240348A1 (en) | 2002-09-18 |
| HU224704B1 (en) | 2006-01-30 |
| HUP0204173A3 (en) | 2004-07-28 |
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