FI108638B - Menetelmä D-vitamiinianalogin uuden kiteisen muodon valmistamiseksi - Google Patents

Menetelmä D-vitamiinianalogin uuden kiteisen muodon valmistamiseksi Download PDF

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Publication number
FI108638B
FI108638B FI952797A FI952797A FI108638B FI 108638 B FI108638 B FI 108638B FI 952797 A FI952797 A FI 952797A FI 952797 A FI952797 A FI 952797A FI 108638 B FI108638 B FI 108638B
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FI
Finland
Prior art keywords
calcipotriol
crystalline
att
water
eller
Prior art date
Application number
FI952797A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI952797A0 (fi
FI952797A (fi
Inventor
Erik Torngaard Hansen
Andersen Niels Smidt Rastrup
Lene Hoffmeyer Ringborg
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of FI952797A0 publication Critical patent/FI952797A0/fi
Publication of FI952797A publication Critical patent/FI952797A/fi
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Publication of FI108638B publication Critical patent/FI108638B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/02—Apparatus characterised by being constructed of material selected for its chemically-resistant properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/32—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
    • C07C5/321—Catalytic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/32—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
    • C07C5/327—Formation of non-aromatic carbon-to-carbon double bonds only
    • C07C5/333—Catalytic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/32—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
    • C07C5/327—Formation of non-aromatic carbon-to-carbon double bonds only
    • C07C5/333—Catalytic processes
    • C07C5/3335—Catalytic processes with metals
    • C07C5/3337—Catalytic processes with metals of the platinum group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/0204—Apparatus characterised by their chemically-resistant properties comprising coatings on the surfaces in direct contact with the reactive components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/0204—Apparatus characterised by their chemically-resistant properties comprising coatings on the surfaces in direct contact with the reactive components
    • B01J2219/0236—Metal based
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/025—Apparatus characterised by their chemically-resistant properties characterised by the construction materials of the reactor vessel proper
    • B01J2219/0277—Metal based
    • B01J2219/0286—Steel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2523/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00
    • C07C2523/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00 of noble metals
    • C07C2523/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00 of noble metals of the platinum group metals
    • C07C2523/42—Platinum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI952797A 1993-01-15 1995-06-07 Menetelmä D-vitamiinianalogin uuden kiteisen muodon valmistamiseksi FI108638B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB939300763A GB9300763D0 (en) 1993-01-15 1993-01-15 Chemical compound
GB9300763 1993-01-15
PCT/DK1994/000011 WO1994015912A1 (en) 1993-01-15 1994-01-07 New crystalline form of a vitamin d analogue
DK9400011 1994-01-07

Publications (3)

Publication Number Publication Date
FI952797A0 FI952797A0 (fi) 1995-06-07
FI952797A FI952797A (fi) 1995-06-07
FI108638B true FI108638B (fi) 2002-02-28

Family

ID=10728784

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952797A FI108638B (fi) 1993-01-15 1995-06-07 Menetelmä D-vitamiinianalogin uuden kiteisen muodon valmistamiseksi

Country Status (17)

Country Link
US (2) USRE39706E1 (es)
EP (1) EP0679154B1 (es)
JP (1) JP3729847B2 (es)
KR (1) KR100309751B1 (es)
CN (1) CN1040746C (es)
AT (1) ATE159717T1 (es)
AU (1) AU663249B2 (es)
CA (1) CA2151730C (es)
DE (1) DE69406529T2 (es)
DK (1) DK0679154T3 (es)
ES (1) ES2111287T3 (es)
FI (1) FI108638B (es)
GB (1) GB9300763D0 (es)
GR (1) GR3025668T3 (es)
NZ (1) NZ259679A (es)
RU (1) RU2128646C1 (es)
WO (1) WO1994015912A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU710931B2 (en) * 1996-02-28 1999-09-30 Sumitomo Pharmaceuticals Company, Limited Crystalline vitamin D derivative
US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
SI2915534T1 (sl) 1999-04-23 2018-10-30 Leo Pharma A/S Farmacevtski sestavek za dermalno uporabo za zdravljenje psoriaze, ki vsebuje vitamin D in kortikosteroid
US20090098065A1 (en) * 2000-01-11 2009-04-16 Avikam Harel Composition and methods for the treatment of skin disorders
AU2003291810A1 (en) * 2002-11-18 2004-06-15 Teva Pharmaceutical Industries Ltd. A crystallization method for purification of calcipotriene
MY139521A (en) * 2004-03-18 2009-10-30 Leo Pharma As Stereoselective synthesis of vitamin d analogues
FR2871696B1 (fr) * 2004-06-17 2006-11-10 Galderma Sa Composition topique pour le traitement du psoriasis
TWI318203B (en) * 2004-09-01 2009-12-11 Leo Pharma As Epimerization of allylic alcohols
PL2526930T3 (pl) * 2005-06-01 2014-05-30 Glaxosmithkline Ip Dev Ltd Formulacja witaminowa
EP1987023B1 (en) * 2006-02-10 2010-11-24 Amgen, Inc Hydrate forms of amg706
WO2007082533A1 (en) * 2006-03-17 2007-07-26 Leo Pharma A/S Isomerisation of pharmaceutical intermediates
WO2008027532A2 (en) * 2006-08-29 2008-03-06 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions including vitamin d and corticosteroid
US20100056644A1 (en) * 2006-11-29 2010-03-04 Nilendu Sen Pharmaceutical compositions containing anhydrous calcipotriene
ES2272198B1 (es) * 2006-12-28 2008-06-01 Laboratorios Viñas S.A. Procedimiento para la obtencion de hidrato de calcipotriol.
EP1970048A1 (en) * 2007-03-15 2008-09-17 Drug Delivery Solutions Limited Polyaphron topical composition with vitamin D
US10265265B2 (en) * 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
EP2008651A1 (en) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited A bioerodible patch
CA2723540C (en) * 2008-05-08 2016-01-05 United Therapeutics Corporation Treprostinil monohydrate
WO2011002756A2 (en) * 2009-07-01 2011-01-06 Vitamin Derivatives, Inc. Vitamin d compounds and methods for preparing same
US9254296B2 (en) 2009-12-22 2016-02-09 Leo Pharma A/S Pharmaceutical composition comprising vitamin D analogue and cosolvent-surfactant mixture
CN102770125B (zh) * 2009-12-22 2015-02-11 利奥制药有限公司 钙泊三醇一水化合物纳米晶体
JP5873439B2 (ja) 2009-12-22 2016-03-01 レオ ファーマ アクティーゼルスカブ ビタミンｄ類似体および溶媒と界面活性剤の混合物を含む皮膚組成物
NZ601001A (en) * 2009-12-22 2014-07-25 Leo Pharma As Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue
NZ601002A (en) * 2009-12-22 2014-09-26 Leo Pharma As Pharmaceutical composition comprising vitamin d analogue and cosolvent-surfactant mixture
RS53809B1 (en) 2010-06-11 2015-06-30 Leo Pharma A/S PHARMACEUTICAL COMPOSITION SKIN SPRAY CONTAINING VITAMIN D ANALYSIS AND CORTICOSTEROID
ES2736256T3 (es) 2011-03-14 2019-12-27 Drug Delivery Solutions Ltd Composición oftálmica
RU2602171C2 (ru) 2011-03-24 2016-11-10 Лео Фарма А/С Композиция, содержащая липидные наночастицы и кортикостероид или производное витамина d
JP5652723B2 (ja) * 2012-08-17 2015-01-14 フォーモサ・ラボラトリーズ・インコーポレーテッド マキサカルシトールの新しい結晶形態
CN103724162A (zh) * 2014-01-07 2014-04-16 成都医路康医学技术服务有限公司 一种银屑病治疗药物卡泊三醇溶剂化物的制备方法
MA41818A (fr) 2015-03-27 2018-01-30 Leo Pharma As Timbre à micro-aiguilles pour administration d'un principe actif à la peau
EP3542788A1 (en) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topical composition comprising calcipotriol and betamethasone dipropionate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457282A1 (fr) * 1979-05-23 1980-12-19 Roussel Uclaf Nouveau derive du 1a,25 dihydroxy cholecalciferol, son procede de preparation et son application comme medicament
JPS59104358A (ja) 1982-12-03 1984-06-16 Teijin Ltd １α，２４−ジヒドロキシコレカルシフエロ−ルの一水塩及びその製造法
EP0227826B1 (en) * 1985-08-02 1989-10-25 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
GB9004544D0 (en) * 1990-03-01 1990-04-25 Leo Pharm Prod Ltd Novel treatment ii

Also Published As

Publication number Publication date
GR3025668T3 (en) 1998-03-31
NZ259679A (en) 1996-11-26
GB9300763D0 (en) 1993-03-03
JP3729847B2 (ja) 2005-12-21
CN1040746C (zh) 1998-11-18
USRE39706E1 (en) 2007-06-26
EP0679154A1 (en) 1995-11-02
JPH08505612A (ja) 1996-06-18
CN1115979A (zh) 1996-01-31
EP0679154B1 (en) 1997-10-29
ATE159717T1 (de) 1997-11-15
DK0679154T3 (da) 1998-03-30
AU663249B2 (en) 1995-09-28
WO1994015912A1 (en) 1994-07-21
KR950704249A (ko) 1995-11-17
KR100309751B1 (ko) 2002-11-08
RU95116650A (ru) 1997-06-10
US5763426A (en) 1998-06-09
AU5857394A (en) 1994-08-15
DE69406529T2 (de) 1998-05-28
CA2151730A1 (en) 1994-07-21
RU2128646C1 (ru) 1999-04-10
FI952797A0 (fi) 1995-06-07
FI952797A (fi) 1995-06-07
DE69406529D1 (de) 1997-12-04
CA2151730C (en) 2005-01-04
ES2111287T3 (es) 1998-03-01

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