FI103727B1 - Förfarande för framställning av terapeutiskt användbara 2-amino-4-substituerad-fenyl-4H-pyrano[3,2-h]kinolin-3-karbonitriler - Google Patents

Förfarande för framställning av terapeutiskt användbara 2-amino-4-substituerad-fenyl-4H-pyrano[3,2-h]kinolin-3-karbonitriler

Info

Publication number
FI103727B1
FI103727B1 FI935065A FI935065A FI103727B1 FI 103727 B1 FI103727 B1 FI 103727B1 FI 935065 A FI935065 A FI 935065A FI 935065 A FI935065 A FI 935065A FI 103727 B1 FI103727 B1 FI 103727B1
Authority
FI
Finland
Prior art keywords
carbonitriles
pyrano
quinoline
phenyl
amino
Prior art date
Application number
FI935065A
Other languages
English (en)
Finnish (fi)
Other versions
FI935065A (fi
FI935065A0 (fi
FI103727B (sv
Inventor
Colin Peter Dell
Andrew Caerwyn Williams
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929224169A external-priority patent/GB9224169D0/en
Priority claimed from GB939302367A external-priority patent/GB9302367D0/en
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of FI935065A0 publication Critical patent/FI935065A0/fi
Publication of FI935065A publication Critical patent/FI935065A/fi
Application granted granted Critical
Publication of FI103727B1 publication Critical patent/FI103727B1/sv
Publication of FI103727B publication Critical patent/FI103727B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI935065A 1992-11-18 1993-11-16 Förfarande för framställning av terapeutiskt användbara 2-amino-4-substituerad-fenyl-4H-pyrano£3,2-h|kinolin-3-karbonitriler FI103727B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9224169 1992-11-18
GB929224169A GB9224169D0 (en) 1992-11-18 1992-11-18 Pharmaceutical compounds
GB939302367A GB9302367D0 (en) 1993-02-06 1993-02-06 Pharmaceutical compounds
GB9302367 1993-02-06

Publications (4)

Publication Number Publication Date
FI935065A0 FI935065A0 (fi) 1993-11-16
FI935065A FI935065A (fi) 1994-05-19
FI103727B1 true FI103727B1 (sv) 1999-08-31
FI103727B FI103727B (sv) 1999-08-31

Family

ID=26301995

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935065A FI103727B (sv) 1992-11-18 1993-11-16 Förfarande för framställning av terapeutiskt användbara 2-amino-4-substituerad-fenyl-4H-pyrano£3,2-h|kinolin-3-karbonitriler

Country Status (16)

Country Link
US (1) US5434160A (sv)
EP (2) EP1004584A3 (sv)
JP (1) JPH06199862A (sv)
KR (1) KR940011465A (sv)
CN (1) CN1040982C (sv)
AU (1) AU668602B2 (sv)
CA (1) CA2103203A1 (sv)
CO (1) CO4130335A1 (sv)
CZ (1) CZ243493A3 (sv)
FI (1) FI103727B (sv)
HU (1) HU9303261D0 (sv)
IL (1) IL107627A (sv)
NO (1) NO304890B1 (sv)
NZ (1) NZ250195A (sv)
PL (1) PL301059A1 (sv)
TW (1) TW289755B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306062D0 (en) * 1993-03-24 1993-05-12 Lilly Industries Ltd Pharmaceutical compounds
FR2795071B1 (fr) * 1999-06-16 2001-07-27 Adir Nouveaux derives de carboxylate de 7-oxo-2,3,7,14- tetrahydro-1h-benzo[b]pyrano[3,2,h] acridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2390164C (en) 1999-11-05 2011-03-29 Cytovia, Inc. Substituted 4h-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
US6858607B1 (en) 2001-05-16 2005-02-22 Cytovia, Inc. 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
CN100564377C (zh) 2001-05-16 2009-12-02 西托维亚公司 用作半胱天冬酶激活剂和细胞凋亡诱导剂的取代的4h-色烯和类似物及其应用
US7015328B2 (en) 2001-05-16 2006-03-21 Cytovia, Inc. Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
AU2003230411A1 (en) 2002-05-16 2003-12-02 Cytovia, Inc. Substituted 4-aryl-4h-pyrrolo(2,3-h)chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1513515A2 (en) 2002-05-16 2005-03-16 Cytovia, Inc. Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2006026832A1 (en) 2004-09-09 2006-03-16 Howard Florey Institute Of Experimental Physiology And Medicine Enzyme inhibitors and uses thereof
US7843312B2 (en) * 2006-12-12 2010-11-30 Honeywell International Inc. Wireless control of security system with key-operated key fob
EP2262797A4 (en) 2007-11-19 2011-11-30 Howard Florey Inst INHIBITORS OF INSULIN-REGULATED AMINOPEPTIDASE (IRAP) AND THEIR APPLICATIONS
EP2638026B1 (en) * 2010-11-12 2018-07-11 Deutsches Krebsforschungszentrum (DKFZ) Chromene derivatives and their analoga as wnt pathway antagonists
WO2023099589A1 (en) * 2021-12-01 2023-06-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Irap inhibitors for use in the treatment of inflammatory diseases
CN115028643B (zh) * 2022-06-10 2024-03-22 中国药科大学 吡喃并喹啉衍生物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243674A (en) * 1978-06-12 1981-01-06 Pfizer Inc. 9-Hydroxydibenzo[b,d]pyrans and intermediates therefore
EP0181351A4 (en) * 1984-05-09 1989-06-21 Univ Australian METHOD FOR MODULATING IMMUNE REACTION.
JP2631710B2 (ja) * 1988-08-16 1997-07-16 日本ヘキスト・マリオン・ルセル株式会社 ピラノ〔ｆ〕キノリノン誘導体及び該化合物を有効成分とする医薬組成物
US4931221A (en) * 1988-12-30 1990-06-05 Ppg Industries, Inc. Photochromic spiropyran compounds
US5284868A (en) * 1991-10-09 1994-02-08 Eli Lilly And Company Pharmaceutical compounds
GB9306062D0 (en) * 1993-03-24 1993-05-12 Lilly Industries Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
TW289755B (sv) 1996-11-01
FI935065A (fi) 1994-05-19
EP1004584A2 (en) 2000-05-31
EP0599514A3 (en) 1994-07-06
NZ250195A (en) 1995-12-21
CN1092072A (zh) 1994-09-14
CN1040982C (zh) 1998-12-02
CA2103203A1 (en) 1994-05-19
KR940011465A (ko) 1994-06-21
NO304890B1 (no) 1999-03-01
FI935065A0 (fi) 1993-11-16
IL107627A0 (en) 1994-02-27
PL301059A1 (en) 1994-05-30
HU9303261D0 (en) 1994-03-28
US5434160A (en) 1995-07-18
IL107627A (en) 1997-04-15
JPH06199862A (ja) 1994-07-19
NO934145L (no) 1994-05-19
FI103727B (sv) 1999-08-31
AU668602B2 (en) 1996-05-09
EP0599514A2 (en) 1994-06-01
CZ243493A3 (en) 1994-06-15
AU5067193A (en) 1994-06-02
EP1004584A3 (en) 2000-07-05
CO4130335A1 (es) 1995-02-13
NO934145D0 (no) 1993-11-16

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