FI102964B - Menetelmä terapeuttisesti käyttökelpoisen 4-substituoitu-1-(9,10-dihyd ro-9,10-metanoantrasen-9-yylimetyyli)piperidin-4-olijohdannaisen tuott amiseksi sekä menetelmän välituotteet - Google Patents
Menetelmä terapeuttisesti käyttökelpoisen 4-substituoitu-1-(9,10-dihyd ro-9,10-metanoantrasen-9-yylimetyyli)piperidin-4-olijohdannaisen tuott amiseksi sekä menetelmän välituotteetInfo
- Publication number
- FI102964B FI102964B FI923663A FI923663A FI102964B FI 102964 B FI102964 B FI 102964B FI 923663 A FI923663 A FI 923663A FI 923663 A FI923663 A FI 923663A FI 102964 B FI102964 B FI 102964B
- Authority
- FI
- Finland
- Prior art keywords
- methanoanthracen
- piperidin
- ylmethyl
- dihydro
- intermediates
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- -1 4-substituted-1- (9,10-dihydro-9,10-methanoanthracen-9-ylmethyl) piperidin-4-ol Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919117639A GB9117639D0 (en) | 1991-08-15 | 1991-08-15 | Therapeutic compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI923663A0 FI923663A0 (fi) | 1992-08-14 |
| FI923663A7 FI923663A7 (fi) | 1993-02-16 |
| FI102964B1 FI102964B1 (fi) | 1999-03-31 |
| FI102964B true FI102964B (fi) | 1999-03-31 |
Family
ID=10700033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI923663A FI102964B (fi) | 1991-08-15 | 1992-08-14 | Menetelmä terapeuttisesti käyttökelpoisen 4-substituoitu-1-(9,10-dihyd ro-9,10-metanoantrasen-9-yylimetyyli)piperidin-4-olijohdannaisen tuott amiseksi sekä menetelmän välituotteet |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0533344B1 (enExample) |
| JP (1) | JP2889056B2 (enExample) |
| KR (1) | KR100245955B1 (enExample) |
| AT (1) | ATE144253T1 (enExample) |
| AU (1) | AU658905B2 (enExample) |
| BG (1) | BG61893B2 (enExample) |
| CA (1) | CA2076191A1 (enExample) |
| CZ (1) | CZ283848B6 (enExample) |
| DE (1) | DE69214588T2 (enExample) |
| DK (1) | DK0533344T3 (enExample) |
| ES (1) | ES2092646T3 (enExample) |
| FI (1) | FI102964B (enExample) |
| GB (2) | GB9117639D0 (enExample) |
| GR (1) | GR3021398T3 (enExample) |
| HK (1) | HK83697A (enExample) |
| HU (2) | HUT66625A (enExample) |
| IE (1) | IE922588A1 (enExample) |
| IL (1) | IL102807A (enExample) |
| NO (1) | NO301008B1 (enExample) |
| NZ (1) | NZ243955A (enExample) |
| RU (1) | RU2099328C1 (enExample) |
| SG (1) | SG48140A1 (enExample) |
| SK (1) | SK280356B6 (enExample) |
| TW (1) | TW221808B (enExample) |
| ZA (1) | ZA926148B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9314250D0 (en) * | 1993-07-09 | 1993-08-18 | Zeneca Ltd | Piperidinyl compounds |
| GB9216298D0 (en) * | 1991-08-15 | 1992-09-16 | Ici Plc | Piperidine derivatives |
| GB9216297D0 (en) * | 1991-08-15 | 1992-09-16 | Ici Plc | Therapeutic agents |
| CA2181759A1 (en) * | 1995-07-26 | 1997-01-27 | Mira A. Kanzelberger | (thiophen-2-yl)-piperidin or tetrahydropyridin azabicyclocarboxamides |
| US6211199B1 (en) | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
| US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
| US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
| US5998439A (en) | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
| US5922737A (en) * | 1996-02-21 | 1999-07-13 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases |
| US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| CA2580856A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| EP1799667B1 (en) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| EP1804799B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7767677B2 (en) | 2004-09-20 | 2010-08-03 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| EP2029138A1 (en) | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5911576B2 (ja) * | 1975-07-07 | 1984-03-16 | 住友化学工業株式会社 | 新規なメタノ−アントラセン誘導体の製造法 |
| US4358620A (en) * | 1974-12-13 | 1982-11-09 | Sumitomo Chemical Company, Limited | 9-Formyl-9,10-dihydro-9,10-methanoanthracene |
| GB1508669A (en) * | 1974-12-13 | 1978-04-26 | Sumitomo Chemical Co | Methanoanthracene derivative and a process for the preparation thereof |
| GB1531278A (en) * | 1975-12-15 | 1978-11-08 | Shionogi & Co | 9,10-dihydro-9,10-methanoanthracene n-oxide derivatives and the production thereof |
| JPS5910654B2 (ja) * | 1976-04-07 | 1984-03-10 | 住友化学工業株式会社 | 新規なメタノ−アントラセン誘導体 |
-
1991
- 1991-08-15 GB GB919117639A patent/GB9117639D0/en active Pending
-
1992
- 1992-07-31 GB GB929216296A patent/GB9216296D0/en active Pending
- 1992-08-11 EP EP92307356A patent/EP0533344B1/en not_active Expired - Lifetime
- 1992-08-11 DK DK92307356.3T patent/DK0533344T3/da active
- 1992-08-11 ES ES92307356T patent/ES2092646T3/es not_active Expired - Lifetime
- 1992-08-11 DE DE69214588T patent/DE69214588T2/de not_active Expired - Lifetime
- 1992-08-11 AT AT92307356T patent/ATE144253T1/de not_active IP Right Cessation
- 1992-08-11 SG SG1996007285A patent/SG48140A1/en unknown
- 1992-08-14 CA CA002076191A patent/CA2076191A1/en not_active Abandoned
- 1992-08-14 AU AU21014/92A patent/AU658905B2/en not_active Ceased
- 1992-08-14 ZA ZA926148A patent/ZA926148B/xx unknown
- 1992-08-14 IL IL10280792A patent/IL102807A/en not_active IP Right Cessation
- 1992-08-14 CZ CS922519A patent/CZ283848B6/cs not_active IP Right Cessation
- 1992-08-14 NO NO923199A patent/NO301008B1/no not_active IP Right Cessation
- 1992-08-14 IE IE258892A patent/IE922588A1/en unknown
- 1992-08-14 SK SK2519-92A patent/SK280356B6/sk unknown
- 1992-08-14 NZ NZ243955A patent/NZ243955A/en unknown
- 1992-08-14 RU SU925052467A patent/RU2099328C1/ru active
- 1992-08-14 FI FI923663A patent/FI102964B/fi active
- 1992-08-14 JP JP4216998A patent/JP2889056B2/ja not_active Expired - Lifetime
- 1992-08-14 HU HU9202643A patent/HUT66625A/hu unknown
- 1992-08-14 KR KR1019920014726A patent/KR100245955B1/ko not_active Expired - Fee Related
- 1992-08-19 TW TW081106555A patent/TW221808B/zh active
-
1993
- 1993-12-02 BG BG098271A patent/BG61893B2/bg unknown
-
1995
- 1995-06-23 HU HU95P/P00415P patent/HU211661A9/hu unknown
-
1996
- 1996-10-17 GR GR960402629T patent/GR3021398T3/el unknown
-
1997
- 1997-06-19 HK HK83697A patent/HK83697A/en not_active IP Right Cessation
Also Published As
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| EP0802179A4 (en) | DERIVATE SUBSTITUTED AMIDINONAPHTHYLESTER | |
| SE8403168L (sv) | Karboxylsyraamidforeningar och derivat derav | |
| PT91613A (pt) | Process for the preparation of antihypertensive 3-piperidinyl-indazole derivatives | |
| DE69011174D1 (de) | Catecholaminester. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: ZENECA LIMITED |