FI102616B1 - Förfarande för framställning av ett vaccin mot typ 3 av mänskligt parainfluensavirus och i förfarandet användbart expressionssystem - Google Patents
Förfarande för framställning av ett vaccin mot typ 3 av mänskligt parainfluensavirus och i förfarandet användbart expressionssystemInfo
- Publication number
- FI102616B1 FI102616B1 FI905184A FI905184A FI102616B1 FI 102616 B1 FI102616 B1 FI 102616B1 FI 905184 A FI905184 A FI 905184A FI 905184 A FI905184 A FI 905184A FI 102616 B1 FI102616 B1 FI 102616B1
- Authority
- FI
- Finland
- Prior art keywords
- human parainfluenza
- parainfluenza virus
- producing
- expression system
- vaccine against
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 3
- 108090000288 Glycoproteins Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241000712003 Human respirovirus 3 Species 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000011081 inoculation Methods 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18464888A | 1988-04-22 | 1988-04-22 | |
| US18464888 | 1988-04-22 | ||
| US8900814 | 1989-03-03 | ||
| PCT/US1989/000814 WO1989010405A1 (en) | 1988-04-22 | 1989-03-03 | Chimeric glycoproteins containig immunogenic segments of human parainfluenza virus type 3 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI905184A0 FI905184A0 (fi) | 1990-10-19 |
| FI102616B1 true FI102616B1 (sv) | 1999-01-15 |
| FI102616B FI102616B (sv) | 1999-01-15 |
Family
ID=22677770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI905184A FI102616B (sv) | 1988-04-22 | 1990-10-19 | Förfarande för framställning av ett vaccin mot typ 3 av mänskligt para influensavirus och i förfarandet användbart expressionssystem |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5169628A (sv) |
| EP (1) | EP0413695B1 (sv) |
| KR (1) | KR970009347B1 (sv) |
| AT (1) | ATE105334T1 (sv) |
| AU (1) | AU611784B2 (sv) |
| CA (1) | CA1306709C (sv) |
| DE (1) | DE68915165T2 (sv) |
| DK (1) | DK172635B1 (sv) |
| FI (1) | FI102616B (sv) |
| HK (1) | HK37397A (sv) |
| NO (1) | NO303499B1 (sv) |
| WO (1) | WO1989010405A1 (sv) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486599A (en) * | 1989-03-29 | 1996-01-23 | The Board Of Trustees Of The Leland Stanford Junior University | Construction and use of synthetic constructs encoding syndecan |
| GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| JP2649285B2 (ja) * | 1990-11-29 | 1997-09-03 | 藤倉化成株式会社 | ヒトパラインフルエンザ４ａ型ウイルスフュージョンプロテイン遺伝子及び該遺伝子を含む物質 |
| GB9120221D0 (en) * | 1991-09-23 | 1991-11-06 | Smithkline Beecham Biolog | Novel compounds |
| GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
| US6479055B1 (en) * | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| US5550017A (en) * | 1993-10-12 | 1996-08-27 | Emory University | Anti-paramyxovirus screening method and vaccine |
| DK0744027T3 (da) * | 1994-01-14 | 2005-06-13 | Matthias Dr Med Rath | Anvendelse af fremgangsmåder til identifikation af hydrofile signaloligopeptider |
| US7300918B2 (en) | 1994-01-14 | 2007-11-27 | Matthias Rath | Method of producing vaccines from protein signal oligopeptides |
| US5869036A (en) * | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
| KR19990082085A (ko) * | 1996-01-29 | 1999-11-15 | 위리엄 제이 하트만 | 발현된 재조합 단백질로부터의 반응 증폭 |
| FR2751229B1 (fr) * | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins |
| US6060308A (en) | 1997-09-04 | 2000-05-09 | Connaught Laboratories Limited | RNA respiratory syncytial virus vaccines |
| US20030180257A1 (en) | 1997-11-14 | 2003-09-25 | Mark Parrington | Alphavirus vectors for paramyxovirus vaccines |
| CN101173295A (zh) * | 1999-05-06 | 2008-05-07 | 威克福雷大学 | 用于鉴定引起免疫反应的抗原的组合物和方法 |
| US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
| US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| EP1351981B1 (en) | 2001-01-19 | 2012-08-08 | Vironovative B.V. | A virus causing respiratory tract illness in susceptible mammals |
| CA2477234C (en) | 2002-02-21 | 2014-12-30 | Medimmune Vaccines, Inc. | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences |
| US7704720B2 (en) | 2003-04-25 | 2010-04-27 | Medimmune, Llc | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
| BRPI0411099A (pt) * | 2003-06-05 | 2006-07-18 | Wyeth Corp | composições imunogênicas que compreendem os vetores de replicon do vìrus da encefalite eqüina venezuelana e antìgenos de proteìnas de paramixovìrus |
| SI3718565T1 (sl) | 2015-10-22 | 2022-08-31 | Modernatx, Inc. | Cepiva za respiratorni virus |
| US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| US20230036213A1 (en) * | 2019-12-10 | 2023-02-02 | Children's National Medical Center | T-cell epitopes of human parainfluenza virus 3 for adoptive t-cell immunotherapy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743553A (en) * | 1984-07-18 | 1988-05-10 | W. R. Grace & Co. | Synthetic genes for bovine parainfluenza virus |
| JP2564268B2 (ja) * | 1985-08-28 | 1996-12-18 | 協和醗酵工業株式会社 | 融合抗原ポリペプチド |
| US4790987A (en) * | 1985-11-15 | 1988-12-13 | Research Corporation | Viral glycoprotein subunit vaccine |
| NZ230425A (en) * | 1988-09-02 | 1992-07-28 | Molecular Eng Ass | Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector |
-
1989
- 1989-03-03 AT AT8989903005T patent/ATE105334T1/de not_active IP Right Cessation
- 1989-03-03 DE DE68915165T patent/DE68915165T2/de not_active Expired - Lifetime
- 1989-03-03 WO PCT/US1989/000814 patent/WO1989010405A1/en active IP Right Grant
- 1989-03-03 EP EP89903005A patent/EP0413695B1/en not_active Expired - Lifetime
- 1989-03-03 US US07/582,891 patent/US5169628A/en not_active Expired - Lifetime
- 1989-03-03 AU AU31975/89A patent/AU611784B2/en not_active Expired
- 1989-03-13 CA CA000593516A patent/CA1306709C/en not_active Expired - Lifetime
- 1989-12-21 KR KR89702416A patent/KR970009347B1/ko not_active IP Right Cessation
-
1990
- 1990-10-18 DK DK199002518A patent/DK172635B1/da not_active IP Right Cessation
- 1990-10-19 FI FI905184A patent/FI102616B/sv not_active IP Right Cessation
- 1990-10-19 NO NO904538A patent/NO303499B1/no not_active IP Right Cessation
-
1992
- 1992-09-04 US US07/941,027 patent/US5284764A/en not_active Expired - Lifetime
-
1997
- 1997-03-27 HK HK37397A patent/HK37397A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK37397A (en) | 1997-04-04 |
| EP0413695B1 (en) | 1994-05-04 |
| NO303499B1 (no) | 1998-07-20 |
| NO904538D0 (no) | 1990-10-19 |
| DK251890A (da) | 1990-10-18 |
| EP0413695A1 (en) | 1991-02-27 |
| US5169628A (en) | 1992-12-08 |
| FI102616B (sv) | 1999-01-15 |
| KR970009347B1 (en) | 1997-06-10 |
| AU611784B2 (en) | 1991-06-20 |
| DK251890D0 (da) | 1990-10-18 |
| CA1306709C (en) | 1992-08-25 |
| NO904538L (no) | 1990-12-27 |
| DE68915165T2 (de) | 1994-09-08 |
| KR900700613A (ko) | 1990-08-16 |
| DE68915165D1 (de) | 1994-06-09 |
| ATE105334T1 (de) | 1994-05-15 |
| FI905184A0 (fi) | 1990-10-19 |
| US5284764A (en) | 1994-02-08 |
| WO1989010405A1 (en) | 1989-11-02 |
| AU3197589A (en) | 1989-11-24 |
| JPH03503760A (ja) | 1991-08-22 |
| DK172635B1 (da) | 1999-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Name/ company changed in application |
Owner name: PHARMACIA & UPJOHN COMPANY |
|
| FG | Patent granted |
Owner name: PHARMACIA & UPJOHN COMPANY |
|
| MA | Patent expired |