FI102173B1 - Förfarande för framställning av terapeutiskt användbara hexahydrobens[CD]indoler - Google Patents

Förfarande för framställning av terapeutiskt användbara hexahydrobens[CD]indoler

Info

Publication number
FI102173B1
FI102173B1 FI910896A FI910896A FI102173B1 FI 102173 B1 FI102173 B1 FI 102173B1 FI 910896 A FI910896 A FI 910896A FI 910896 A FI910896 A FI 910896A FI 102173 B1 FI102173 B1 FI 102173B1
Authority
FI
Finland
Prior art keywords
hexahydrobenz
indoles
preparation
therapeutically useful
useful
Prior art date
Application number
FI910896A
Other languages
English (en)
Finnish (fi)
Other versions
FI910896A0 (fi
FI102173B (sv
FI910896A (fi
Inventor
Thomas Joseph Kress
Marvin Robert Leanna
Michael John Martinelli
Barry Curtis Peterson
Michael Edward Flaugh
Mark Mortensen Foreman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/482,811 external-priority patent/US5204340A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI910896A0 publication Critical patent/FI910896A0/fi
Publication of FI910896A publication Critical patent/FI910896A/fi
Application granted granted Critical
Publication of FI102173B1 publication Critical patent/FI102173B1/sv
Publication of FI102173B publication Critical patent/FI102173B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI910896A 1990-02-26 1991-02-25 Förfarande för framställning av terapeutiskt användbara hexahydrobens£ CD|indoler FI102173B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US48519490A 1990-02-26 1990-02-26
US48281190 1990-02-26
US07/482,811 US5204340A (en) 1989-04-11 1990-02-26 Tetrahydrobenz(c,d)indole serotonin agonists
US48519490 1990-02-26
US56798690A 1990-08-15 1990-08-15
US56798690 1990-08-15

Publications (4)

Publication Number Publication Date
FI910896A0 FI910896A0 (fi) 1991-02-25
FI910896A FI910896A (fi) 1991-08-27
FI102173B1 true FI102173B1 (sv) 1998-10-30
FI102173B FI102173B (sv) 1998-10-30

Family

ID=27413631

Family Applications (1)

Application Number Title Priority Date Filing Date
FI910896A FI102173B (sv) 1990-02-26 1991-02-25 Förfarande för framställning av terapeutiskt användbara hexahydrobens£ CD|indoler

Country Status (16)

Country Link
EP (1) EP0444854B1 (sv)
JP (1) JP3135591B2 (sv)
AT (1) ATE143362T1 (sv)
AU (1) AU645779B2 (sv)
BR (1) BR9100769A (sv)
DE (1) DE69122281T2 (sv)
DK (1) DK0444854T3 (sv)
ES (1) ES2094789T3 (sv)
FI (1) FI102173B (sv)
GR (1) GR3021930T3 (sv)
HU (1) HU224213B1 (sv)
IE (1) IE76285B1 (sv)
IL (1) IL97308A (sv)
NO (1) NO176757C (sv)
NZ (3) NZ237213A (sv)
PT (1) PT96862B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
US5229410A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
EP0502418A1 (en) * 1991-02-26 1992-09-09 Basf Corporation Use of levemopamil for the manufacture of a medicament for the treatment of alcohol abuse
NZ314570A (en) * 1993-06-10 2000-11-24 Lilly Co Eli Treatment of emesis using tetrahydrobenz[cd]indole-6-carboxamides
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5039820A (en) * 1990-02-26 1991-08-13 Eli Lilly And Company 4-amino-6-iodo-hexahydrobenz(cd)indoles
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
TW219933B (sv) * 1990-02-26 1994-02-01 Lilly Co Eli

Also Published As

Publication number Publication date
FI910896A0 (fi) 1991-02-25
NO910736D0 (no) 1991-02-25
EP0444854B1 (en) 1996-09-25
NO176757B (no) 1995-02-13
FI102173B (sv) 1998-10-30
FI910896A (fi) 1991-08-27
NZ247226A (en) 1994-06-27
PT96862A (pt) 1991-10-31
BR9100769A (pt) 1991-10-29
NZ237213A (en) 1994-06-27
IE76285B1 (en) 1997-10-08
PT96862B (pt) 1998-07-31
DK0444854T3 (da) 1996-11-11
HU224213B1 (hu) 2005-06-28
DE69122281D1 (de) 1996-10-31
HUT56541A (en) 1991-09-30
JP3135591B2 (ja) 2001-02-19
ES2094789T3 (es) 1997-02-01
AU645779B2 (en) 1994-01-27
EP0444854A3 (en) 1992-02-26
JPH04211654A (ja) 1992-08-03
GR3021930T3 (en) 1997-03-31
AU7197091A (en) 1991-08-29
NO910736L (no) 1991-08-27
DE69122281T2 (de) 1997-03-06
EP0444854A2 (en) 1991-09-04
NZ247227A (en) 1994-06-27
ATE143362T1 (de) 1996-10-15
IL97308A (en) 1996-10-31
NO176757C (no) 1995-05-24
IE910626A1 (en) 1991-08-28
IL97308A0 (en) 1992-05-25

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