DE69122281D1 - 6-Substituierte Hexahydrobenz[cd]indole - Google Patents

6-Substituierte Hexahydrobenz[cd]indole

Info

Publication number
DE69122281D1
DE69122281D1 DE69122281T DE69122281T DE69122281D1 DE 69122281 D1 DE69122281 D1 DE 69122281D1 DE 69122281 T DE69122281 T DE 69122281T DE 69122281 T DE69122281 T DE 69122281T DE 69122281 D1 DE69122281 D1 DE 69122281D1
Authority
DE
Germany
Prior art keywords
indoles
hexahydrobenz
substituted
substituted hexahydrobenz
benefited
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69122281T
Other languages
English (en)
Other versions
DE69122281T2 (de
Inventor
Thomas Joseph Kress
Michael John Martinelli
Michael Edward Flaugh
Marvin Robert Leanna
Barry Curtis Peterson
Mark Mortensen Foreman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/482,811 external-priority patent/US5204340A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69122281D1 publication Critical patent/DE69122281D1/de
Application granted granted Critical
Publication of DE69122281T2 publication Critical patent/DE69122281T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69122281T 1990-02-26 1991-02-26 6-Substituierte Hexahydrobenz[cd]indole Expired - Fee Related DE69122281T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48519490A 1990-02-26 1990-02-26
US07/482,811 US5204340A (en) 1989-04-11 1990-02-26 Tetrahydrobenz(c,d)indole serotonin agonists
US56798690A 1990-08-15 1990-08-15

Publications (2)

Publication Number Publication Date
DE69122281D1 true DE69122281D1 (de) 1996-10-31
DE69122281T2 DE69122281T2 (de) 1997-03-06

Family

ID=27413631

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69122281T Expired - Fee Related DE69122281T2 (de) 1990-02-26 1991-02-26 6-Substituierte Hexahydrobenz[cd]indole

Country Status (16)

Country Link
EP (1) EP0444854B1 (de)
JP (1) JP3135591B2 (de)
AT (1) ATE143362T1 (de)
AU (1) AU645779B2 (de)
BR (1) BR9100769A (de)
DE (1) DE69122281T2 (de)
DK (1) DK0444854T3 (de)
ES (1) ES2094789T3 (de)
FI (1) FI102173B (de)
GR (1) GR3021930T3 (de)
HU (1) HU224213B1 (de)
IE (1) IE76285B1 (de)
IL (1) IL97308A (de)
NO (1) NO176757C (de)
NZ (3) NZ247226A (de)
PT (1) PT96862B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
US5229410A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
EP0502418A1 (de) * 1991-02-26 1992-09-09 Basf Corporation Verwendung von Levemopamil zur Herstellung eines Arzneimittels zur Behandlung von Alkoholmissbrauch
NZ260667A (en) * 1993-06-10 1997-05-26 Lilly Co Eli Preventing emesis or treating sexual dysfunction using tetrahydrobenz[cd]indole 6-carboxamides
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5039820A (en) * 1990-02-26 1991-08-13 Eli Lilly And Company 4-amino-6-iodo-hexahydrobenz(cd)indoles
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
TW219933B (de) * 1990-02-26 1994-02-01 Lilly Co Eli

Also Published As

Publication number Publication date
FI910896A (fi) 1991-08-27
PT96862A (pt) 1991-10-31
FI102173B1 (fi) 1998-10-30
HUT56541A (en) 1991-09-30
IE76285B1 (en) 1997-10-08
JP3135591B2 (ja) 2001-02-19
JPH04211654A (ja) 1992-08-03
NO910736D0 (no) 1991-02-25
AU645779B2 (en) 1994-01-27
FI910896A0 (fi) 1991-02-25
BR9100769A (pt) 1991-10-29
NO176757C (no) 1995-05-24
HU224213B1 (hu) 2005-06-28
DK0444854T3 (da) 1996-11-11
IL97308A (en) 1996-10-31
NO176757B (no) 1995-02-13
NZ247226A (en) 1994-06-27
NZ247227A (en) 1994-06-27
EP0444854A3 (en) 1992-02-26
EP0444854B1 (de) 1996-09-25
ATE143362T1 (de) 1996-10-15
NO910736L (no) 1991-08-27
EP0444854A2 (de) 1991-09-04
FI102173B (fi) 1998-10-30
GR3021930T3 (en) 1997-03-31
ES2094789T3 (es) 1997-02-01
AU7197091A (en) 1991-08-29
IL97308A0 (en) 1992-05-25
DE69122281T2 (de) 1997-03-06
IE910626A1 (en) 1991-08-28
NZ237213A (en) 1994-06-27
PT96862B (pt) 1998-07-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee