ES8802572A1 - Un procedimiento para preparar 3-ariloxi-n-(aminoalquil)-1-pirrolidin- y piperidin-carboxamidas y carbotiamidas - Google Patents

Un procedimiento para preparar 3-ariloxi-n-(aminoalquil)-1-pirrolidin- y piperidin-carboxamidas y carbotiamidas

Info

Publication number
ES8802572A1
ES8802572A1 ES555591A ES555591A ES8802572A1 ES 8802572 A1 ES8802572 A1 ES 8802572A1 ES 555591 A ES555591 A ES 555591A ES 555591 A ES555591 A ES 555591A ES 8802572 A1 ES8802572 A1 ES 8802572A1
Authority
ES
Spain
Prior art keywords
carbon atoms
lower alkyl
phenyl
aminoalkyl
pyrrolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555591A
Other languages
English (en)
Other versions
ES555591A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of ES555591A0 publication Critical patent/ES555591A0/es
Publication of ES8802572A1 publication Critical patent/ES8802572A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Abstract

METODO DE PREPARAR 3-ARILOXI-N-(AMINOALQUIL)-1-PIRROLIDINY PIPERIDIN-CARBOXAMIDAS Y CARBOTIAMIDAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON HIDRAZINA, PARA OBTENER EL COMPUESTO DESEADO DE FORMULA (I), DONDE AR ES 1-NAFTILO, 2-NAFTILO, 2,3-DIHIDRO-1H-INDEN-4-ILO, 2, 4-DIHIDRO-1H-INDEN-5-ILO, FENILO SUSTITUIDO, ALQUILOXI Y OTROS; M Y N SON 1 O 2, PERO NUNCA SON 2 A LA VEZ; P ES 1, 2, 3 O 4; R ES H, ALQUILO INFERIOR DE C 1 A 3; R ELEVADO A 1 Y R ELEVADO A 2 SON AMBOS HIDROGENO; Y X ES OXIGENO O AZUFRE. TIENEN UTILIDAD PARA PREPARAR COMPOSICIONES FARMACEUTICAS POR SU ACTIVIDAD ANTIARRITMICA. *FORMULA*
ES555591A 1983-12-05 1986-06-02 Un procedimiento para preparar 3-ariloxi-n-(aminoalquil)-1-pirrolidin- y piperidin-carboxamidas y carbotiamidas Expired ES8802572A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/557,885 US4547514A (en) 1983-12-05 1983-12-05 Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity

Publications (2)

Publication Number Publication Date
ES555591A0 ES555591A0 (es) 1987-07-01
ES8802572A1 true ES8802572A1 (es) 1987-07-01

Family

ID=24227270

Family Applications (4)

Application Number Title Priority Date Filing Date
ES529364A Granted ES529364A0 (es) 1983-12-05 1984-02-01 Un procedimiento para preparar carboxamidas y carbotiamidas de 3-ariloxi-n-(aminoalquil)-1-pirrolidina y piperidina
ES544169A Expired ES8802021A1 (es) 1983-12-05 1985-06-14 Un procedimiento para preparar 3-ariloxi-n-(aminoalquil)-1- pirrolidin-y piperidin-carboxamidas y carbotiamidas
ES555590A Expired ES8802571A1 (es) 1983-12-05 1986-06-02 Un procedimiento para preparar 3-ariloxi-n-(aminoalquil)-1-pirrolidin- y piperidin-carbotiamidas
ES555591A Expired ES8802572A1 (es) 1983-12-05 1986-06-02 Un procedimiento para preparar 3-ariloxi-n-(aminoalquil)-1-pirrolidin- y piperidin-carboxamidas y carbotiamidas

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES529364A Granted ES529364A0 (es) 1983-12-05 1984-02-01 Un procedimiento para preparar carboxamidas y carbotiamidas de 3-ariloxi-n-(aminoalquil)-1-pirrolidina y piperidina
ES544169A Expired ES8802021A1 (es) 1983-12-05 1985-06-14 Un procedimiento para preparar 3-ariloxi-n-(aminoalquil)-1- pirrolidin-y piperidin-carboxamidas y carbotiamidas
ES555590A Expired ES8802571A1 (es) 1983-12-05 1986-06-02 Un procedimiento para preparar 3-ariloxi-n-(aminoalquil)-1-pirrolidin- y piperidin-carbotiamidas

Country Status (15)

Country Link
US (1) US4547514A (es)
EP (1) EP0147909B1 (es)
JP (1) JPS60123466A (es)
KR (1) KR900005133B1 (es)
AT (1) ATE48413T1 (es)
AU (1) AU572747B2 (es)
CA (1) CA1227797A (es)
DE (1) DE3480651D1 (es)
DK (1) DK52784A (es)
ES (4) ES529364A0 (es)
HU (1) HU193719B (es)
IL (1) IL70823A (es)
PH (1) PH20831A (es)
PT (1) PT78090B (es)
ZA (1) ZA84697B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810703A (en) * 1984-10-19 1989-03-07 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
US4812452A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
US4812451A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha.
US5151418A (en) * 1985-02-28 1992-09-29 A. H. Robins Company, Incorporated Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
US5183902A (en) * 1985-02-28 1993-02-02 A. H. Robins Company, Incorporated Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
DE3800868A1 (de) * 1988-01-14 1989-07-27 Thomae Gmbh Dr K Mittel zur behandlung von bradycardien und bradyarrhythmien
US5192776A (en) * 1988-03-14 1993-03-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-subsituted-4-pentafluorophenoxypiperidines
US5212184A (en) * 1988-03-14 1993-05-18 Hoechst-Roussel Pharmaceuticals Inc. 1-substituted-4-pentafluorophenoxypiperidines
JP5374377B2 (ja) * 2007-10-18 2013-12-25 武田薬品工業株式会社 複素環化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2831862A (en) * 1956-02-27 1958-04-22 Lakeside Lab Inc Ethers of n-alkyl-3-hydroxypiperidine and salts thereof
US3577432A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-phenoxypyrrolidines
US3577415A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-substituted phenoxypyrrolidines
FR2315274A1 (fr) * 1975-06-27 1977-01-21 Parcor Nouveaux derives de la thieno (2,3-c) pyridine, leur preparation et leurs applications
US4036957A (en) * 1975-11-18 1977-07-19 A. H. Robins Company, Inc. Phenoxy compounds in combinations to suppress gastric bleeding in aspirin therapy
MX6634E (es) * 1979-01-09 1985-09-12 Robins Co Inc A H Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas

Also Published As

Publication number Publication date
AU572747B2 (en) 1988-05-12
ES555591A0 (es) 1987-07-01
PT78090A (en) 1984-03-01
HUT35648A (en) 1985-07-29
CA1227797A (en) 1987-10-06
ES8601876A1 (es) 1985-11-16
DK52784A (da) 1985-06-06
JPS60123466A (ja) 1985-07-02
ES555590A0 (es) 1987-07-01
PH20831A (en) 1987-04-30
US4547514A (en) 1985-10-15
IL70823A (en) 1987-10-20
EP0147909A1 (en) 1985-07-10
IL70823A0 (en) 1984-04-30
DE3480651D1 (de) 1990-01-11
EP0147909B1 (en) 1989-12-06
ES8802571A1 (es) 1987-07-01
ES529364A0 (es) 1985-11-16
HU193719B (en) 1987-11-30
ES544169A0 (es) 1987-01-16
PT78090B (en) 1986-04-17
ZA84697B (en) 1984-09-26
KR850004959A (ko) 1985-08-19
ATE48413T1 (de) 1989-12-15
KR900005133B1 (ko) 1990-07-20
DK52784D0 (da) 1984-02-06
AU2397684A (en) 1985-06-13
ES8802021A1 (es) 1987-01-16

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