ATE48413T1 - Aryloxy-n-(aminoalkyl)-1-pyrrolidin und piperidincarboxamide und carbothioamide die antiarrhythmische wirkung hervorrufen. - Google Patents
Aryloxy-n-(aminoalkyl)-1-pyrrolidin und piperidincarboxamide und carbothioamide die antiarrhythmische wirkung hervorrufen.Info
- Publication number
- ATE48413T1 ATE48413T1 AT84303995T AT84303995T ATE48413T1 AT E48413 T1 ATE48413 T1 AT E48413T1 AT 84303995 T AT84303995 T AT 84303995T AT 84303995 T AT84303995 T AT 84303995T AT E48413 T1 ATE48413 T1 AT E48413T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- lower alkyl
- phenyl
- aminoalkyl
- pyrrolidine
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- -1 2,3-dihydro1H-inden-4-yl Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical compound NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/557,885 US4547514A (en) | 1983-12-05 | 1983-12-05 | Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity |
| EP84303995A EP0147909B1 (de) | 1983-12-05 | 1984-06-13 | Aryloxy-N-(Aminoalkyl)-1-pyrrolidin und Piperidincarboxamide und Carbothioamide die antiarrhythmische Wirkung hervorrufen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE48413T1 true ATE48413T1 (de) | 1989-12-15 |
Family
ID=24227270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84303995T ATE48413T1 (de) | 1983-12-05 | 1984-06-13 | Aryloxy-n-(aminoalkyl)-1-pyrrolidin und piperidincarboxamide und carbothioamide die antiarrhythmische wirkung hervorrufen. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4547514A (de) |
| EP (1) | EP0147909B1 (de) |
| JP (1) | JPS60123466A (de) |
| KR (1) | KR900005133B1 (de) |
| AT (1) | ATE48413T1 (de) |
| AU (1) | AU572747B2 (de) |
| CA (1) | CA1227797A (de) |
| DE (1) | DE3480651D1 (de) |
| DK (1) | DK52784A (de) |
| ES (4) | ES529364A0 (de) |
| HU (1) | HU193719B (de) |
| IL (1) | IL70823A (de) |
| PH (1) | PH20831A (de) |
| PT (1) | PT78090B (de) |
| ZA (1) | ZA84697B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810703A (en) * | 1984-10-19 | 1989-03-07 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| US4812451A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha. |
| US4812452A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| US5183902A (en) * | 1985-02-28 | 1993-02-02 | A. H. Robins Company, Incorporated | Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides |
| US5151418A (en) * | 1985-02-28 | 1992-09-29 | A. H. Robins Company, Incorporated | Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides |
| DE3800868A1 (de) * | 1988-01-14 | 1989-07-27 | Thomae Gmbh Dr K | Mittel zur behandlung von bradycardien und bradyarrhythmien |
| US5192776A (en) * | 1988-03-14 | 1993-03-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-subsituted-4-pentafluorophenoxypiperidines |
| US5212184A (en) * | 1988-03-14 | 1993-05-18 | Hoechst-Roussel Pharmaceuticals Inc. | 1-substituted-4-pentafluorophenoxypiperidines |
| EP2202223B1 (de) * | 2007-10-18 | 2017-01-25 | Takeda Pharmaceutical Company Limited | Heterocyclische verbindung als blut-rbp4 senkende agent |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2831862A (en) * | 1956-02-27 | 1958-04-22 | Lakeside Lab Inc | Ethers of n-alkyl-3-hydroxypiperidine and salts thereof |
| US3577415A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-substituted phenoxypyrrolidines |
| US3577432A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-phenoxypyrrolidines |
| FR2315274A1 (fr) * | 1975-06-27 | 1977-01-21 | Parcor | Nouveaux derives de la thieno (2,3-c) pyridine, leur preparation et leurs applications |
| US4036957A (en) * | 1975-11-18 | 1977-07-19 | A. H. Robins Company, Inc. | Phenoxy compounds in combinations to suppress gastric bleeding in aspirin therapy |
| MX6634E (es) * | 1979-01-09 | 1985-09-12 | Robins Co Inc A H | Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas |
-
1983
- 1983-12-05 US US06/557,885 patent/US4547514A/en not_active Expired - Fee Related
-
1984
- 1984-01-30 ZA ZA84697A patent/ZA84697B/xx unknown
- 1984-01-30 IL IL70823A patent/IL70823A/xx unknown
- 1984-02-01 ES ES529364A patent/ES529364A0/es active Granted
- 1984-02-01 AU AU23976/84A patent/AU572747B2/en not_active Ceased
- 1984-02-06 DK DK52784A patent/DK52784A/da not_active Application Discontinuation
- 1984-02-09 PH PH30213A patent/PH20831A/en unknown
- 1984-02-10 PT PT78090A patent/PT78090B/pt not_active IP Right Cessation
- 1984-03-23 JP JP59055975A patent/JPS60123466A/ja active Pending
- 1984-05-10 KR KR1019840002526A patent/KR900005133B1/ko not_active Expired
- 1984-06-13 EP EP84303995A patent/EP0147909B1/de not_active Expired
- 1984-06-13 DE DE8484303995T patent/DE3480651D1/de not_active Expired - Fee Related
- 1984-06-13 AT AT84303995T patent/ATE48413T1/de not_active IP Right Cessation
- 1984-06-18 CA CA000456806A patent/CA1227797A/en not_active Expired
- 1984-12-04 HU HU844476A patent/HU193719B/hu not_active IP Right Cessation
-
1985
- 1985-06-14 ES ES544169A patent/ES8802021A1/es not_active Expired
-
1986
- 1986-06-02 ES ES555591A patent/ES8802572A1/es not_active Expired
- 1986-06-02 ES ES555590A patent/ES8802571A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES555590A0 (es) | 1987-07-01 |
| ES8601876A1 (es) | 1985-11-16 |
| EP0147909B1 (de) | 1989-12-06 |
| ES8802572A1 (es) | 1987-07-01 |
| ES544169A0 (es) | 1987-01-16 |
| DE3480651D1 (de) | 1990-01-11 |
| HUT35648A (en) | 1985-07-29 |
| EP0147909A1 (de) | 1985-07-10 |
| IL70823A (en) | 1987-10-20 |
| PH20831A (en) | 1987-04-30 |
| ZA84697B (en) | 1984-09-26 |
| JPS60123466A (ja) | 1985-07-02 |
| AU572747B2 (en) | 1988-05-12 |
| AU2397684A (en) | 1985-06-13 |
| ES8802021A1 (es) | 1987-01-16 |
| DK52784A (da) | 1985-06-06 |
| IL70823A0 (en) | 1984-04-30 |
| ES8802571A1 (es) | 1987-07-01 |
| US4547514A (en) | 1985-10-15 |
| KR850004959A (ko) | 1985-08-19 |
| CA1227797A (en) | 1987-10-06 |
| PT78090B (en) | 1986-04-17 |
| ES529364A0 (es) | 1985-11-16 |
| PT78090A (en) | 1984-03-01 |
| HU193719B (en) | 1987-11-30 |
| DK52784D0 (da) | 1984-02-06 |
| ES555591A0 (es) | 1987-07-01 |
| KR900005133B1 (ko) | 1990-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU589427B2 (en) | Pyridonecarboxylic acid derivatives and process for their preparation | |
| HUT52059A (en) | Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components | |
| ATE120462T1 (de) | 1-indolylalkyl-4-(alkoxy-pyrimidinyl)piperazine | |
| PL309874A1 (en) | Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives | |
| ATE67995T1 (de) | Flavonkarbonsaeure-derivate. | |
| HUT40101A (en) | Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents | |
| AU572747B2 (en) | Aryloxy-n-(aminoalkyl)-1-pyrrolide and piperidine carboxamides and carbothiomides having antiarrythmic activity | |
| ES8700857A1 (es) | Un procedimiento para la produccion de dihidropiridinas | |
| EP0156331A3 (en) | Benzuforan derivatives, processes for preparing the same and antihypertensive agents containing the same | |
| HUT54668A (en) | Process for producing acriloyl-piperazine derivatives and pharmaceutical compositions containing them | |
| AU537086B2 (en) | 4-amino-2,6-diaryl-tetrahydrothiopyrans | |
| GR860045B (en) | Novel piperazine derivatives processes for production thereof and pharmaceutical compositions comprising said compounds as active ingredient |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |