ES8802470A1 - Un procedimiento para la preparacion de un nuevo agente antitrombosico a base de una mezcla de glicosaminoglicanos. - Google Patents

Un procedimiento para la preparacion de un nuevo agente antitrombosico a base de una mezcla de glicosaminoglicanos.

Info

Publication number
ES8802470A1
ES8802470A1 ES556740A ES556740A ES8802470A1 ES 8802470 A1 ES8802470 A1 ES 8802470A1 ES 556740 A ES556740 A ES 556740A ES 556740 A ES556740 A ES 556740A ES 8802470 A1 ES8802470 A1 ES 8802470A1
Authority
ES
Spain
Prior art keywords
content
milliequivalents
preparation
pharmaceutical compositions
agent based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556740A
Other languages
English (en)
Other versions
ES556740A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of ES556740A0 publication Critical patent/ES556740A0/es
Publication of ES8802470A1 publication Critical patent/ES8802470A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

SE OBTIENE UN AGENTE ANTITROMBOSICO A BASE DE GLICOSAMINOGLICANOS, AGREGANDO AT III, UNIDO COVALENTEMENTE A UNA COLUMNA PORTADORA, A UNA SOLUCION ACUOSA TAMPONADA A PH 7,8-8,0 DE UN AGENTE ANTITROMBOSICO (HEF) A BASE DE MEZCLA DE OLIGO Y POLISACARIDO, CON CARACTERISTICAS DESCRITAS, DESPUES SE AGITA DURANTE UN TIEMPO A 37GC, SE SEPARA EL COMPLEJO FORMADO ENTRE EL AT III Y HEF Y EL HEF SIN COMPLEJAR, POR ULTRFILTRACION, CROMATOGRAFIA POR PERMEACION DEL GEL O DE INTERCAMBIO IONICO, SE DESCOMPONE EL COMPLEJO Y SE AISLA EL HA-HEF DESEADO. 0
ES556740A 1985-07-12 1986-06-25 Un procedimiento para la preparacion de un nuevo agente antitrombosico a base de una mezcla de glicosaminoglicanos. Expired ES8802470A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8502009 1985-07-12

Publications (2)

Publication Number Publication Date
ES556740A0 ES556740A0 (es) 1988-06-16
ES8802470A1 true ES8802470A1 (es) 1988-06-16

Family

ID=19846291

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556740A Expired ES8802470A1 (es) 1985-07-12 1986-06-25 Un procedimiento para la preparacion de un nuevo agente antitrombosico a base de una mezcla de glicosaminoglicanos.

Country Status (10)

Country Link
EP (1) EP0209924A1 (es)
JP (1) JPS6219520A (es)
KR (1) KR870000930A (es)
AU (1) AU5910686A (es)
DK (1) DK325186A (es)
ES (1) ES8802470A1 (es)
FI (1) FI862897A (es)
GR (1) GR861563B (es)
PT (1) PT82972B (es)
ZA (1) ZA864487B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0421508T3 (da) * 1989-10-04 1994-04-11 Akzo Nobel Nv Sulfateret glycosaminoglycuronan med antithrombotisk aktivitet
IT1270823B (it) * 1993-06-04 1997-05-13 Italfarmaco Spa Polisaccaridi ad elevata attivita' antitrombotica e anticoagulante
DE19646901A1 (de) * 1996-11-13 1998-05-14 Helmut Prof Dr Heusinger Verfahren zum Herstellen von Abbauprodukten polymerer Glycosaminoglycane mittels Ultraschall
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
EP0048898B1 (en) * 1980-09-30 1985-04-17 Bayer Ag Method for the production of an antithrombin-heparin complex and pharmaceutical compositions containing the complex
FR2504928A1 (fr) * 1981-04-29 1982-11-05 Choay Sa Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments

Also Published As

Publication number Publication date
ES556740A0 (es) 1988-06-16
DK325186A (da) 1987-01-13
EP0209924A1 (en) 1987-01-28
GR861563B (en) 1986-10-15
FI862897A0 (fi) 1986-07-09
JPS6219520A (ja) 1987-01-28
ZA864487B (en) 1987-02-25
FI862897A (fi) 1987-01-13
KR870000930A (ko) 1987-03-10
PT82972B (en) 1987-12-30
AU5910686A (en) 1987-01-15
PT82972A (en) 1986-08-01
DK325186D0 (da) 1986-07-08

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