ES8802466A1 - Un metodo para formar una tableta no comprimida que tiene una densidad menor que uno y capaz de flotar en el fluido gastrico "in vivo". - Google Patents

Un metodo para formar una tableta no comprimida que tiene una densidad menor que uno y capaz de flotar en el fluido gastrico "in vivo".

Info

Publication number
ES8802466A1
ES8802466A1 ES557776A ES557776A ES8802466A1 ES 8802466 A1 ES8802466 A1 ES 8802466A1 ES 557776 A ES557776 A ES 557776A ES 557776 A ES557776 A ES 557776A ES 8802466 A1 ES8802466 A1 ES 8802466A1
Authority
ES
Spain
Prior art keywords
sustained release
therapeutic compositions
release therapeutic
floating sustained
floating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557776A
Other languages
English (en)
Other versions
ES557776A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forest Laboratories LLC
Original Assignee
Forest Laboratories LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forest Laboratories LLC filed Critical Forest Laboratories LLC
Publication of ES557776A0 publication Critical patent/ES557776A0/es
Publication of ES8802466A1 publication Critical patent/ES8802466A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO PARA FORMAR UNA TABLETA NO COMPRIMIDA QUE TIENE UNA DENSIDAD MENOR QUE UNO Y CAPAZ DE FLOTAR EN EL FLUIDO GASTRICO <<IN VIVO>>, EN EL QUE: 1) SE PREPARA UNA SOLUCION ACUOSA CON 18 A 69,5 PARTES EN PESO DE AGUA Y 0,5 A 2 PARTES EN PESO DE UN AGENTE GELIFICANTE; 2) DICHA SOLUCION SE ENFRIA POR ENCIMA DEL PUNTO DE GELIFICACION; 3) SE PRODUCE UNA EMULSION AÑADIENDO CON AGITACION UNA MEZCLA DE 25 A 50 PARTES EN PESO DE UN AGENTE TERAPEUTICO, PREFERENTEMENTE DEL GURPO TEOFILINA, CAPTOPRIL Y AMPICILINA, Y 5 A 30 PARTES EN PESO DE ACEITE MINERAL LIGERO, MANTENIENDOSE LA TEMPERATURA POR ENCIMA DE LA DE GELIFICACION; 4) SE VIERTE LA EMULSION EN UN MOLDE PARA TABLETAS A UNA TEMPERATURA DE 50 A 70GC Y SE DEJA ENFRIAR FORMANDO TABLETAS DE GEL; Y 5) DICHAS TABLETAS SE SECAN PARA PRODUCIR TABLETAS SECAS NO COMPRIMIDAS CON: DE 0,5 A 4 PARTES EN PESO DE AGENTE GELIFICANTE, DE 10 A 20 DE ACEITE INERTE, DE 50 A 75 DE AGENTE TERAPEUTICO Y EL RESTO AGUA.
ES557776A 1985-04-12 1987-12-02 Un metodo para formar una tableta no comprimida que tiene una densidad menor que uno y capaz de flotar en el fluido gastrico "in vivo". Expired ES8802466A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72283285A 1985-04-12 1985-04-12

Publications (2)

Publication Number Publication Date
ES557776A0 ES557776A0 (es) 1988-07-16
ES8802466A1 true ES8802466A1 (es) 1988-07-16

Family

ID=24903574

Family Applications (2)

Application Number Title Priority Date Filing Date
ES553900A Expired ES8800594A1 (es) 1985-04-12 1986-04-11 Un metodo para formar una tableta no comprimida que tiene una densidad menor que uno y capaz de flotar en jugo gastrico in vivo
ES557776A Expired ES8802466A1 (es) 1985-04-12 1987-12-02 Un metodo para formar una tableta no comprimida que tiene una densidad menor que uno y capaz de flotar en el fluido gastrico "in vivo".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES553900A Expired ES8800594A1 (es) 1985-04-12 1986-04-11 Un metodo para formar una tableta no comprimida que tiene una densidad menor que uno y capaz de flotar en jugo gastrico in vivo

Country Status (8)

Country Link
US (1) US4814179A (es)
JP (1) JPS61246120A (es)
BE (1) BE904899A (es)
DK (1) DK162986A (es)
ES (2) ES8800594A1 (es)
PL (1) PL149493B1 (es)
SU (1) SU1679965A3 (es)
YU (1) YU58386A (es)

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DE3803482A1 (de) * 1988-02-05 1989-08-17 Lohmann Therapie Syst Lts Schwimmfaehiges orales therapeutisches system
US5158777A (en) * 1990-02-16 1992-10-27 E. R. Squibb & Sons, Inc. Captopril formulation providing increased duration of activity
US5198229A (en) * 1991-06-05 1993-03-30 Alza Corporation Self-retaining gastrointestinal delivery device
US5169638A (en) * 1991-10-23 1992-12-08 E. R. Squibb & Sons, Inc. Buoyant controlled release powder formulation
IN186245B (es) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
DE10014588A1 (de) 2000-03-27 2001-10-04 Basf Ag Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
US7985420B2 (en) * 2000-04-28 2011-07-26 Reckitt Benckiser Inc. Sustained release of guaifenesin combination drugs
US6955821B2 (en) * 2000-04-28 2005-10-18 Adams Laboratories, Inc. Sustained release formulations of guaifenesin and additional drug ingredients
US7838032B2 (en) * 2000-04-28 2010-11-23 Reckitt Benckiser Inc. Sustained release of guaifenesin
US8012504B2 (en) * 2000-04-28 2011-09-06 Reckitt Benckiser Inc. Sustained release of guaifenesin combination drugs
AU2008255254B2 (en) * 2001-03-31 2010-12-09 Jagotec Ag A pharmaceutical tablet system that floats on gastric fluid for multipulse release of active substance and respective processes of producing same and a cup-shaped envelope of same
EP1245227A1 (en) * 2001-03-31 2002-10-02 Jagotec Ag A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same
US20030138486A1 (en) * 2001-10-29 2003-07-24 King Pharmaceuticals Research Methods and dosage forms for improving the bioavailability of therapeutic agents
BE1015608A6 (fr) * 2003-07-15 2005-06-07 Messadek Jallal Traitement des arterites.
AU2002302890A1 (en) * 2002-02-04 2003-12-02 Ranbaxy Laboratories Limited Hydrodynamically balancing oral drug delivery system with biphasic release
WO2003089506A1 (en) * 2002-04-22 2003-10-30 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
US20040109889A1 (en) * 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
NZ523946A (en) * 2003-01-31 2004-06-25 Carl Ernest Alexander Portable hygiene compositions comprising a semi-solid gel and active ingredients in bead form for use in personal oral, dental or skin care
ATE347358T1 (de) * 2003-04-17 2006-12-15 Jallal Messadek Schwimmende orale formulierungen mit kontrollierter freisetzung von betain
US20060128657A1 (en) * 2003-08-04 2006-06-15 Jallal Messadek Selected betaines and their uses
BE1016128A6 (fr) * 2004-07-22 2006-03-07 Messadek Jallal Combinaisons therapeutiques
WO2006050581A2 (en) * 2004-11-10 2006-05-18 Jallal Messadek Betaine as agent against arthropod - or mosquito -borne diseases
WO2006086856A1 (en) 2005-02-15 2006-08-24 Messadek, Jallal Combination therapeutic compositions and method of use
EP1885392B1 (en) * 2005-04-27 2012-01-11 Jallal Messadek Insulins combinations
US20070178155A1 (en) * 2006-01-31 2007-08-02 Jiang David Yihai Preparation for gastric buoyant sustained drug release dosage form
AT505225A1 (de) 2007-04-26 2008-11-15 Sanochemia Pharmazeutika Ag 0erfahren zur herstellung von hoch reinem 2,4'-dimethyl-3-piperidino-propiophenon (tolperison), dieses enthaltende pharmazeutische zusammensetzungen, sowie tolperison enthaltende wirkstoffformulierungen
WO2009065193A1 (en) * 2007-11-21 2009-05-28 Jallal Messadek Treatment of aspirin resistance with betaine and/or betaine enriched molasses
EP2133071A1 (en) 2008-06-09 2009-12-16 Université de la Méditerranée Process for making gastroretentive dosage forms
US20100249423A1 (en) * 2009-03-09 2010-09-30 Sanochemia Pharmazeutika Ag Tolperisone controlled release tablet
EP2444064A1 (en) 2010-10-22 2012-04-25 Meliatys Process for making multiparticulate gastroretentive dosage forms
US9452135B2 (en) 2012-03-20 2016-09-27 Particle Dynamics International, Llc Gelling agent-based dosage form
RS54024B1 (en) 2012-10-12 2015-10-30 Omya International Ag GASTRORETENCY FORMULATION OF MEDICINES AND SYSTEMS FOR DELIVERY AND METHODS OF THEIR PREPARATION USING FUNCTIONALIZED CALCIUM CARBONATE
PL235144B1 (pl) 2014-06-03 2020-06-01 Univ Medyczny Im Piastow Slaskich We Wroclawiu Sposób wytwarzania tabletki flotacyjnej o przedłużonym oddziaływaniu substancji leczniczych z błoną śluzową żołądka oraz kompozycja farmaceutyczna
EP3034070A1 (en) 2014-12-18 2016-06-22 Omya International AG Method for the production of a pharmaceutical delivery system
EP3069713A1 (en) 2015-03-20 2016-09-21 Omya International AG Dispersible dosage form
EP3364955B1 (en) 2015-10-09 2022-04-20 RB Health (US) LLC Pharmaceutical formulation
EP3269361A1 (en) 2016-07-14 2018-01-17 Omya International AG Dosage form
CA3139217A1 (en) 2019-05-14 2020-11-19 Clexio Biosciences Ltd. Treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease
WO2022195476A1 (en) 2021-03-15 2022-09-22 Clexio Biosciences Ltd. Gastroretentive devices for assessment of intragastric conditions

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US3323922A (en) * 1965-08-09 1967-06-06 Pillsbury Co Protective coatings
US3483002A (en) * 1966-11-15 1969-12-09 Kohnstamm & Co Inc H Gelatinous coloring composition and process
US4126672A (en) * 1976-02-04 1978-11-21 Hoffmann-La Roche Inc. Sustained release pharmaceutical capsules
US4167558A (en) * 1976-02-13 1979-09-11 Hoffmann-La Roche Inc. Novel sustained release tablet formulations
US4140755A (en) * 1976-02-13 1979-02-20 Hoffmann-La Roche Inc. Sustained release tablet formulations
US4089981A (en) * 1976-06-04 1978-05-16 Maxfibe Foods, Inc. Fibrous simulated food product with gel structure
US4434153A (en) * 1982-03-22 1984-02-28 Alza Corporation Drug delivery system comprising a reservoir containing a plurality of tiny pills
US4451260A (en) * 1982-03-26 1984-05-29 Minnesota Mining And Manufacturing Company Sustained release oral medicinal delivery device
FR2537844B1 (fr) * 1982-12-17 1985-08-23 Roquette Freres Pastilles du type lozenge a base de sorbitol ou de fructose cristallise et leur procede de fabrication
JPS6124516A (ja) * 1984-07-12 1986-02-03 Fujisawa Pharmaceut Co Ltd 持続性錠剤
JPS6143108A (ja) * 1984-08-03 1986-03-01 Nippon Shinyaku Co Ltd 医薬品製剤及びその製造法
GB8507779D0 (en) * 1985-03-26 1985-05-01 Fujisawa Pharmaceutical Co Drug carrier

Also Published As

Publication number Publication date
DK162986A (da) 1986-10-13
ES553900A0 (es) 1987-11-01
US4814179A (en) 1989-03-21
ES557776A0 (es) 1988-07-16
ES8800594A1 (es) 1987-11-01
YU58386A (en) 1987-10-31
PL149493B1 (en) 1990-02-28
SU1679965A3 (ru) 1991-09-23
JPS61246120A (ja) 1986-11-01
BE904899A (fr) 1986-10-01
DK162986D0 (da) 1986-04-10

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